The DOI matches its Crossref record; 119 of the 119 references it cites were found in a registry or an index.
Epigenetics and gene expression
Open accessAbstract
Transcription, translation and subsequent protein modification represent the transfer of genetic information from the archival copy of DNA to the short-lived messenger RNA, usually with subsequent production of protein. Although all cells in an organism contain essentially the same DNA, cell types and functions differ because of qualitative and quantitative differences in their gene expression. Thus, control of gene expression is at the heart of differentiation and development. Epigenetic processes, including DNA methylation, histone modification and various RNA-mediated processes, are thought to influence gene expression chiefly at the level of transcription; however, other steps in the process (for example, translation) may also be regulated epigenetically. The following paper will outline the role epigenetics is believed to have in influencing gene expression.
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“There are three main types of epigenetic modifications: DNA methylation, histone modifications, and various RNA-mediated processes (39, 40).”
From Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma (2019) · cites this paper as [40]
In the citing paper
“As these modifications accumulate and interact with one-another to produce tightly regulated changes in gene expression, it is not sufficient to only study differences in single DNA methylation loci.9”
From The role of epigenetics in psychological resilience (2021) · cites this paper as [9]
In the citing paper
“As these modifications accumulate and interact with one-another to produce tightly regulated changes in gene expression, it is not sufficient to only study differences in single DNA methylation loci.9”
From The role of epigenetics in psychological resilience (2021) · cites this paper as [9]
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Citations
Cites
1 retracted
Noncoding RNAs of Trithorax Response Elements Recruit Drosophila Ash1 to Ultrabithorax
Sánchez-Elsner, T., Gou, D., Kremmer, E., & Sauer, F. (2006) · Science · doi:10.1126/science.1117705 · Cited by 236
RetractedMicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
Chromatin modifications and their function
Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883
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High-Resolution Profiling of Histone Methylations in the Human Genome
Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Schones, D. E., Wang, Z., Wei, G., Chepelev, I., & Zhao, K. (2007) · Cell · doi:10.1016/j.cell.2007.05.009 · Cited by 6,845
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Carthew, R. W., & Sontheimer, E. J. (2009) · Cell · doi:10.1016/j.cell.2009.01.035 · Cited by 5,161
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Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs
Rinn, J. L., Kertesz, M., Wang, J. K., Squazzo, S. L., Xu, X. H., Brugmann, S. A., Goodnough, L. H., Helms, J. A., Farnham, P., Segal, E., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.022 · Cited by 4,246
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Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
Mikkelsen, T. S., Ku, M., Jaffe, D. B., Issac, B., Lieberman, E., Giannoukos, G., Alvarez, P., Brockman, W., Kim, T.-K., Koche, R. P., et al. (2007) · Nature · doi:10.1038/nature06008 · Cited by 4,129
Research works printed but not linked: 2
- Allis CD, Jenuwein T, Reinberg D (2007). Overview and concepts. In: Allis CD, Jenuwein T, Reinberg D (eds). Epigenetics. CSHL Press: New York. pp 23–61.
- Kouzarides T, Berger SL (2007). Chromatin modifications and their mechanism of action. In: Allis CD, Jenuwein T, Reinberg D (eds). Epigenetics. CSHL Press: New York. pp 191–209.
Cited by
Sorted by citations
Ohkura, N., Hamaguchi, M., Morikawa, H., Sugimura, K., Tanaka, A., Ito, Y., Osaki, M., Tanaka, Y., Yamashita, R., Nakano, N., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.09.010 · Cited by 756
“It has been postulated that DNA methylation inhibits the recognition of DNA by some proteins (Prokhortchouk and Defossez, 2008), and is generally associated with gene repression (Gibney and Nolan, 2010).”
BackgroundDevelopment and Maintenance of Regulatory T cells
Ohkura, N., Kitagawa, Y., & Sakaguchi, S. (2013) · Immunity · doi:10.1016/j.immuni.2013.03.002 · Cited by 742
“Epigenetic Changes in Treg Cells Epigenetic modifications, which include histone modifications, DNA methylation, microRNAs, nucleosome positioning, chromatin interaction, and chromosome conformational changes, play indispensable roles in cell differentiation, especially for cell-lineage stabilization (Gibney and Nolan…”
BackgroundRönn, T., Volkov, P., Davegårdh, C., Dayeh, T., Hall, E., Olsson, A. H., Nilsson, E., Tornberg, Å. B., Nitert, M. D., Eriksson, K., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003572 · Cited by 637
“It should be noted that epigenetic processes are likely to influence more aspects of gene expression, including accessibility of the gene, posttranscriptional RNA processing and stability, splicing and also translation [49].”
Karimi, M., Sahandi Zangabad, P., Ghasemi, A., Amiri, M., Bahrami, M., Malekzad, H., Ghahramanzadeh Asl, H., Mahdieh, Z., Bozorgomid, M., Ghasemi, A., et al. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b00371 · Cited by 500
Micronuclei in genotoxicity assessment: from genetics to epigenetics and beyond
Luzhna, L., Kathiria, P., & Kovalchuk, O. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00131 · Cited by 459
“Epigenetic regulation includes at least four outlined mechanisms: DNA methylation, histone modifications, chromatin remodeling, and non-coding RNA expression (Bonasio et al., 2010; Gibney and Nolan, 2010).”
Background
Metadata
- Authors
- Gibney, E. R., & Nolan, C. M.
- Affiliations
- University College Dublin (IE)
- Corresponding author
- Nolan, C M
- Venue
- Heredity
- Published
- 2010-05-12
- Volume
- 105
- Issue
- 1
- Pages
- 4-13
- ISSN
- 0018-067X (ISSN-L)
- 1365-2540
- OpenAlex
- W1974450480
- Cited by
- 1,109
- References
- 119
- Citations by year
- 2026: 68 · 2025: 148 · 2024: 175 · 2023: 147 · 2022: 115 · 2021: 102 · 2020: 70 · 2019: 33 · 2018: 42 · 2017: 28 · 2016: 32 · 2015: 22 · 2014: 29 · 2013: 32 · 2012: 31
- FWCI
- 2.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Heredity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Science Foundation Ireland (RFP06)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Keywords
- epigenetics, gene expression regulation, transcriptional regulation, DNA methylation, histone modifications, RNA-mediated gene regulation, cell differentiation, development (biology), translational regulation, protein modification
- MeSH terms
- Animals, Cell Differentiation, Humans, DNA Modification Methylases, Gene Expression, Cell Lineage, Heredity, Epigenesis, Genetic
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