The DOI matches its Crossref record; 119 of the 119 references it cites were found in a registry or an index.
Epigenetics and gene expression
Open accessAbstract
Transcription, translation and subsequent protein modification represent the transfer of genetic information from the archival copy of DNA to the short-lived messenger RNA, usually with subsequent production of protein. Although all cells in an organism contain essentially the same DNA, cell types and functions differ because of qualitative and quantitative differences in their gene expression. Thus, control of gene expression is at the heart of differentiation and development. Epigenetic processes, including DNA methylation, histone modification and various RNA-mediated processes, are thought to influence gene expression chiefly at the level of transcription; however, other steps in the process (for example, translation) may also be regulated epigenetically. The following paper will outline the role epigenetics is believed to have in influencing gene expression.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“There are three main types of epigenetic modifications: DNA methylation, histone modifications, and various RNA-mediated processes (39, 40).”
From Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma (2019) · cites this paper as [40]
In the citing paper
“As these modifications accumulate and interact with one-another to produce tightly regulated changes in gene expression, it is not sufficient to only study differences in single DNA methylation loci.9”
From The role of epigenetics in psychological resilience (2021) · cites this paper as [9]
In the citing paper
“As these modifications accumulate and interact with one-another to produce tightly regulated changes in gene expression, it is not sufficient to only study differences in single DNA methylation loci.9”
From The role of epigenetics in psychological resilience (2021) · cites this paper as [9]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Noncoding RNAs of Trithorax Response Elements Recruit Drosophila Ash1 to Ultrabithorax
Sánchez-Elsner, T., Gou, D., Kremmer, E., & Sauer, F. (2006) · Science · doi:10.1126/science.1117705 · Cited by 236
RetractedMicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
Chromatin modifications and their function
Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883
Alberts, B., Johnson, A., Lewis, J. H., Morgan, D. O., RAFF, M. C., Roberts, K. J., & Walter, P. (2017) · W.W. Norton eBooks · doi:10.1201/9781315735368 · Cited by 7,937
High-Resolution Profiling of Histone Methylations in the Human Genome
Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Schones, D. E., Wang, Z., Wei, G., Chepelev, I., & Zhao, K. (2007) · Cell · doi:10.1016/j.cell.2007.05.009 · Cited by 6,845
Origins and Mechanisms of miRNAs and siRNAs
Carthew, R. W., & Sontheimer, E. J. (2009) · Cell · doi:10.1016/j.cell.2009.01.035 · Cited by 5,161
Alberts, B., Johnson, A. D., Lewis, J. H., RAFF, M. C., Roberts, K. J., & Walter, P. (2007) · W.W. Norton eBooks · doi:10.1201/9780203833445 · Cited by 4,591
Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs
Rinn, J. L., Kertesz, M., Wang, J. K., Squazzo, S. L., Xu, X. H., Brugmann, S. A., Goodnough, L. H., Helms, J. A., Farnham, P., Segal, E., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.022 · Cited by 4,246
Evolution and Functions of Long Noncoding RNAs
Ponting, C. P., Oliver, P. L., & Reik, W. (2009) · Cell · doi:10.1016/j.cell.2009.02.006 · Cited by 4,208
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
Mikkelsen, T. S., Ku, M., Jaffe, D. B., Issac, B., Lieberman, E., Giannoukos, G., Alvarez, P., Brockman, W., Kim, T.-K., Koche, R. P., et al. (2007) · Nature · doi:10.1038/nature06008 · Cited by 4,129
Flagged first, then by citations
Research works printed but not linked: 2
- Allis CD, Jenuwein T, Reinberg D (2007). Overview and concepts. In: Allis CD, Jenuwein T, Reinberg D (eds). Epigenetics. CSHL Press: New York. pp 23–61.
- Kouzarides T, Berger SL (2007). Chromatin modifications and their mechanism of action. In: Allis CD, Jenuwein T, Reinberg D (eds). Epigenetics. CSHL Press: New York. pp 191–209.
Cited by
Sorted by citations
Ohkura, N., Hamaguchi, M., Morikawa, H., Sugimura, K., Tanaka, A., Ito, Y., Osaki, M., Tanaka, Y., Yamashita, R., Nakano, N., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.09.010 · Cited by 756
“It has been postulated that DNA methylation inhibits the recognition of DNA by some proteins (Prokhortchouk and Defossez, 2008), and is generally associated with gene repression (Gibney and Nolan, 2010).”
BackgroundDevelopment and Maintenance of Regulatory T cells
Ohkura, N., Kitagawa, Y., & Sakaguchi, S. (2013) · Immunity · doi:10.1016/j.immuni.2013.03.002 · Cited by 742
“Epigenetic Changes in Treg Cells Epigenetic modifications, which include histone modifications, DNA methylation, microRNAs, nucleosome positioning, chromatin interaction, and chromosome conformational changes, play indispensable roles in cell differentiation, especially for cell-lineage stabilization (Gibney and Nolan…”
BackgroundRönn, T., Volkov, P., Davegårdh, C., Dayeh, T., Hall, E., Olsson, A. H., Nilsson, E., Tornberg, Å. B., Nitert, M. D., Eriksson, K., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003572 · Cited by 637
“It should be noted that epigenetic processes are likely to influence more aspects of gene expression, including accessibility of the gene, posttranscriptional RNA processing and stability, splicing and also translation [49].”
Karimi, M., Sahandi Zangabad, P., Ghasemi, A., Amiri, M., Bahrami, M., Malekzad, H., Ghahramanzadeh Asl, H., Mahdieh, Z., Bozorgomid, M., Ghasemi, A., et al. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b00371 · Cited by 500
Micronuclei in genotoxicity assessment: from genetics to epigenetics and beyond
Luzhna, L., Kathiria, P., & Kovalchuk, O. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00131 · Cited by 459
“Epigenetic regulation includes at least four outlined mechanisms: DNA methylation, histone modifications, chromatin remodeling, and non-coding RNA expression (Bonasio et al., 2010; Gibney and Nolan, 2010).”
BackgroundThe many faces of estrogen signaling
Vrtačnik, P., Ostanek, B., Mencej-Bedrač, S., & Marc, J. (2014) · Biochemia Medica · doi:10.11613/bm.2014.035 · Cited by 403
Recommendations for the design and analysis of epigenome-wide association studies
Michels, K. B., Binder, A. M., Dedeurwaerder, S., Epstein, C. B., Greally, J. M., Gut, I., Houseman, E. A., Izzi, B., Kelsey, K. T., Meissner, A., et al. (2013) · Nature Methods · doi:10.1038/nmeth.2632 · Cited by 378
Grosse‐Gehling, P., Fargeas, C. A., Dittfeld, C., Garbe, Y., Alison, M. R., Corbeil, D., & Kunz‐Schughart, L. A. (2012) · The Journal of Pathology · doi:10.1002/path.4086 · Cited by 299
“G lio bl as to m a, m ed ul lo bl as to m a CD 13 3/ 1, 29 3C 3 (M B) × × × – Ye s Ye s [1 19 ]”
BackgroundInfluentialEpigenetic Modifications in Stress Response Genes Associated With Childhood Trauma
Jiang, S., Postovit, L., Cattaneo, A., Binder, E. B., & Aitchison, K. J. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00808 · Cited by 288
“There are three main types of epigenetic modifications: DNA methylation, histone modifications, and various RNA-mediated processes (39, 40).”
BackgroundEpigenetic Mechanisms of Depression and Antidepressant Action
Vialou, V., Feng, J., Robison, A. J., & Nestler, E. J. (2013) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010611-134540 · Cited by 277
“Numerous mechanisms that underlie epigenetic regulation have been described, including (a) direct modification of DNA’s transcriptional potential by methylation of cytosine bases and (b) indirect regulation of DNA’s accessibility through several types of chemical modification of the proteins involved in chromatin stru…”
BackgroundThe central role of RNA in human development and cognition
Mattick, J. S. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.05.001 · Cited by 283
“ment [165–170], long-term responses to environmental variables [171,172], and brain function [173–179].”
BackgroundParental Advisory: Maternal and Paternal Stress Can Impact Offspring Neurodevelopment
Chan, J. C., Nugent, B. M., & Bale, T. L. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.10.005 · Cited by 241
“Epigenetic control of gene expression, including DNA methylation, histone posttranslational modifications (PTMs), and noncoding RNAs, evolved to regulate and establish cell- and tissue-specific gene expression programs and to control normal cellular functions (8,9).”
BackgroundEpigenetic switch from repressive to permissive chromatin in response to cold stress
Park, J., Lim, C. J., Shen, M., Park, H. J., Cha, J., Iniesto, E., Rubio, V., Mengiste, T. D., Zhu, J., Bressan, R. A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1721241115 · Cited by 232
“The factors controlling how chromatin remodeling enzymes are targeted to specific loci is an area of intense research (59), and the extension of our model to other gene regulons could explain in mechanistic terms how specific chromatin sites are chosen to be remodeled for transcriptional regulation.”
BackgroundEpigenetics in Prostate Cancer: Biologic and Clinical Relevance
Jerónimo, C., Bastian, P. J., Bjartell, A. S., Carbone, G. M., Catto, J. W. F., Clark, S. J., Henrique, R., Nelson, W. G., & Shariat, S. F. (2011) · European Urology · doi:10.1016/j.eururo.2011.06.035 · Cited by 231
“Structurally, histones possess a flexible ‘‘tail’’ that is susceptible to post-translation biochemical modification (such as acetylation, methylation, and phosphorylation) [13–17].”
BackgroundThe RdDM Pathway Is Required for Basal Heat Tolerance in Arabidopsis
Popova, O. V., Dinh, H. Q., Aufsatz, W., & Jonak, C. (2013) · Molecular Plant · doi:10.1093/mp/sst023 · Cited by 229
“The transcriptional capacity of genes is intimately connected to their epigenetic states (Bonasio et al., 2010; Gibney and Nolan, 2010).”
Epigenetics: Principles and Practice
Hamilton, J. P. (2011) · Digestive Diseases · doi:10.1159/000323874 · Cited by 219
Mechanisms Underlying T Cell Immunosenescence: Aging and Cytomegalovirus Infection
Tu, W., & Rao, S. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.02111 · Cited by 192
Epigenetic Control of Skeletal Development by the Histone Methyltransferase Ezh2
Dudakovic, A., Camilleri, E. T., Xu, F., Riester, S. M., McGee‐Lawrence, M. E., Bradley, E. W., Paradise, C. R., Lewallen, E. A., Thaler, R., Deyle, D. R., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.672345 · Cited by 184
Morikawa, H., & Sakaguchi, S. (2014) · Immunological Reviews · doi:10.1111/imr.12174 · Cited by 176
Lightbody, G., Haberland, V., Browne, F., Taggart, L., Zheng, H., Parkes, E., & Blayney, J. K. (2019) · Briefings in Bioinformatics · doi:10.1093/bib/bby051 · Cited by 173
“These levels are connected via genetic data transfer processes, including transcription, translation, binding and protein modification [23, 24].”
BackgroundHIF-1-Independent Mechanisms Regulating Metabolic Adaptation in Hypoxic Cancer Cells
Lee, S.-H., Golinska, M., & Griffiths, J. R. (2021) · Cells · doi:10.3390/cells10092371 · Cited by 169
Cribbs, A. P., Kennedy, A., Penn, H., Amjadi, P., Green, P. A., Read, J. E., Brennan, F. M., Gregory, B., & Williams, R. O. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39031 · Cited by 166
Gene regulatory network inference resources: A practical overview
Mercatelli, D., Scalambra, L., Triboli, L., Ray, F., & Giorgi, F. M. (2019) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2019.194430 · Cited by 169
Epigenetic Drug Discovery: Targeting DNA Methyltransferases
Foulks, J. M., Parnell, K. M., Nix, R. N., Chau, S., Świerczek, K., Saunders, M. J., Wright, K., Hendrickson, T. F., Ho, K.-K., McCullar, M. V., et al. (2011) · SLAS DISCOVERY · doi:10.1177/1087057111421212 · Cited by 166
Plant Volatile Organic Compounds Evolution: Transcriptional Regulation, Epigenetics and Polyploidy
Picazo-Aragonés, J., Terrab, A., & Balao, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21238956 · Cited by 153
“VOCs are differentially—both temporally and spatially—synthesized throughout the development of the plant, due to differences in gene expression in distinct cell types [26].”
BackgroundCayuela, H., Valenzuela‐Sánchez, A., Teulier, L., Martínez-Solano, Í., Léna, J., Merilä, J., Muths, E., Shine, R., Quay, L., Denoël, M., et al. (2020) · The Quarterly Review of Biology · doi:10.1086/707862 · Cited by 148
Eukaryotic mRNA Decay: Methodologies, Pathways, and Links to Other Stages of Gene Expression
Pérez-Ortín, J. E., Alepuz, P. M., Chávez, S., & Choder, M. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.02.029 · Cited by 147
“[mRNA] = [mRNA]0 + e-kd t [7]”
Facial Genetics: A Brief Overview
Richmond, S., Howe, L. J., Lewis, S. J., Stergiakouli, E., & Zhurov, A. I. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00462 · Cited by 146
Ling, C.-W., Miao, Z., Xiao, M.-L., Zhou, H., Jiang, Z., Fu, Y., Xiong, F., Zuo, L.-S.-Y., Liu, Y.-P., Wu, Y.-Y., et al. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab492 · Cited by 138
Genome-wide analysis reveals distinct patterns of epigenetic features in long non-coding RNA loci
Sati, S., Ghosh, S., Jain, V., Scaria, V., & Sengupta, S. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks776 · Cited by 136
“The methylation architecture in and around the protein-coding genes affects their expression and hence influence cell identity (38).”
BackgroundCancer immune escape: the role of antigen presentation machinery
Kallingal, A., Olszewski, M., Maciejewska, N., Brankiewicz, W., & Bagiński, M. (2023) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-023-04737-8 · Cited by 133
“Epigenetic modulation of antitumor immunity has been an active area of research in recent years and has been found to have potential applications in cancer immunotherapy (Gibney and Nolan 2010).”
BackgroundPosttraumatic Stress Disorder and Inflammation: Untangling Issues of Bidirectionality
Sumner, J. A., Nishimi, K. M., Koenen, K. C., Roberts, A. L., & Kubzansky, L. D. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.11.005 · Cited by 131
A mutation screen in patients with Kabuki syndrome
Li, Y., Bögershausen, N., Alanay, Y., Şimşek‐Kiper, P. Ö., Plume, N., Keupp, K., Pohl, E., Pawlik, B., Rachwalski, M., Milz, E., et al. (2011) · Human Genetics · doi:10.1007/s00439-011-1004-y · Cited by 130
“Introduction Epigenetic control of developmental processes is a fascinating mechanism by which spatial and temporal expression of distinct genes and pathways are regulated (Gibney and Nolan 2010).”
BackgroundPrasad, M. S., Sauka‐Spengler, T., & LaBonne, C. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.03.014 · Cited by 133
“non-covalent proline isomerization (Gibney and Nolan, 2010).”
BackgroundThe role of DNA methylation in the pathogenesis of type 2 diabetes mellitus
Ahmed, S. A. H., Ansari, S. A., Mensah‐Brown, E. P. K., & Emerald, B. S. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-00896-4 · Cited by 131
CD133: to be or not to be, is this the real question?
Irollo, E., & Pirozzi, G. (2013) · Europe PMC (PubMed Central) · Cited by 122
Epigenetic Mechanisms in Bone Biology and Osteoporosis: Can They Drive Therapeutic Choices?
Marini, F., Cianferotti, L., & Brandi, M. L. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081329 · Cited by 121
“Post-translational histone modifications include a large number of histone changes, such as methylation, acetylation, phosphorylation, ubiquitination, ADP ribosylation, sumoylation, deamination, and non-covalent proline isomerisation [2].”
BackgroundHerrera, C. M., & Bazaga, P. (2012) · Botanical Journal of the Linnean Society · doi:10.1111/boj.12007 · Cited by 118
Epigenetic Mechanisms of Aging and Aging-Associated Diseases
la Torre, A., Vecchio, F. L., & Greco, A. (2023) · Cells · doi:10.3390/cells12081163 · Cited by 129
The polycomb repressive complex 2 governs life and death of peripheral T cells
Zhang, Y., Kinkel, S., Maksimovic, J., Bandala‐Sanchez, E., Tanzer, M. C., Naselli, G., Zhang, J., Zhan, Y., Lew, A. M., Silke, J., et al. (2014) · Blood · doi:10.1182/blood-2013-12-544106 · Cited by 118
Quantitative epigenetics and evolution
Banta, J. A., & Richards, C. L. (2018) · Heredity · doi:10.1038/s41437-018-0114-x · Cited by 116
Molecular Mechanisms of Muscle Plasticity with Exercise
Hoppeler, H. H., Baum, O., Lurman, G. J., & Mueller, M. (2011) · Comprehensive physiology · doi:10.1002/cphy.c100042 · Cited by 131
Biomarkers Associated With Migraine and Their Potential Role in Migraine Management
Durham, P. L., & Papapetropoulos, S. (2013) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12174 · Cited by 111
“alterations in gene expression that are not caused by changes in DNA sequence; as heritable changes in gene activity and expression; and as stable, long-term alterations in the transcriptional potential of a cell that are not necessarily heritable.(83,84) Epigenetic mechanisms that can stably influence gene expression…”
BackgroundThe role of epigenetics in psychological resilience
Smeeth, D., Beck, S., Karam, E. G., & Pluess, M. (2021) · The Lancet Psychiatry · doi:10.1016/s2215-0366(20)30515-0 · Cited by 108
Vitamin D and the risk for cancer: A molecular analysis
Carlberg, C., & Velleuer, E. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114735 · Cited by 114
Mishra, M., Zhong, Q. P. W., & Kowluru, R. A. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.07.001 · Cited by 108
“the genes and these modifications, in addition to allowing cells to quickly respond to the changing stimuli, also result in long-lasting changes in gene activity (17, 30, 31).”
BackgroundInfluentialLanka, G., Begum, D., Banerjee, S., Adhikari, N., Yogeeswari, P., & Ghosh, B. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2023.107481 · Cited by 107
Epigenetic drugs in cancer therapy
Suraweera, A., O'Byrne, K. J., & Richard, D. J. (2025) · Cancer and Metastasis Reviews · doi:10.1007/s10555-025-10253-7 · Cited by 117
“The main epigenetic mechanisms include histone modifications, DNA methylation, chromatin remodelling and non-coding RNA [3, 5, 6].”
Epigenetic biomarkers in urological tumors: A systematic review
Jerónimo, C., & Henrique, R. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.12.026 · Cited by 104
“, acetylation, methylation, glycosylation, sumoylation, phosphorylation, ubiquitylation) [41–45] and the combination of these on specific amino acids produce various structural and translational changes, which are known as ‘‘the histone code’’.”
BackgroundNon-targeted radiation effects—An epigenetic connection
Ilnytskyy, Y., & Kovalchuk, O. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.06.014 · Cited by 108
Large-scale analysis of DFNA5 methylation reveals its potential as biomarker for breast cancer
Croes, L., Beyens, M., Fransén, E., Ibrahim, J., Berghe, W. V., Suls, A., Peeters, M., Pauwels, P., Camp, G. V., & de Beeck, K. O. (2018) · Clinical Epigenetics · doi:10.1186/s13148-018-0479-y · Cited by 104
Transcription factors and evolution: An integral part of gene expression (Review)
Mitsis, Τ., Efthimiadou, Α., Bacopoulou, F., Vlachakis, D., Chrousos, G. P., & Eliopoulos, E. (2020) · World Academy of Sciences Journal · doi:10.3892/wasj.2020.32 · Cited by 97
“Moreover, as an integral part of gene expression, they are closely related to the evolution of epigenetic mechanisms (5).”
InfluentialModulating epigenetic modifications for cancer therapy (Review)
Castro-Muñoz, L. J., Vázquez‐Ulloa, E., Sahlgren, C., Lizano, M., la Cruz-Hernández, E. N. D., & Contreras‐Paredes, A. (2023) · Oncology Reports · doi:10.3892/or.2023.8496 · Cited by 111
Tubulins and brain development – The origins of functional specification
Breuss, M. W., Leca, I., Gstrein, T., Hansen, A. H., & Keays, D. A. (2017) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2017.03.002 · Cited by 107
“4A) (Orphanides and Reinberg, 2002; Gibney and Nolan, 2010).”
Plaza‐Díaz, J., Izquierdo, D., Torres‐Martos, Á., Baig, A. T., Aguilera, C. M., & Ruiz‐Ojeda, F. J. (2022) · Biomedicines · doi:10.3390/biomedicines10010126 · Cited by 121
“The mechanisms involved in the regulation of gene expression are heritable, and the modifications that occur in the nucleotide sequence are reversible [25,26].”
BackgroundEpigenetic Control of the Genome—Lessons from Genomic Imprinting
Aðalsteinsson, B. Þ., & Ferguson‐Smith, A. C. (2014) · Genes · doi:10.3390/genes5030635 · Cited by 101
“islands are generally methylated (reviewed in [1,2])—resulting in a genome-wide methylation pattern that can be described as roughly bimodal.”
BackgroundDudakovic, A., Evans, J. M., Li, Y., Middha, S., McGee‐Lawrence, M. E., van Wijnen, A. J., & Westendorf, J. J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.489732 · Cited by 95
“The major epigenetic mechanisms affecting gene expression are post-translational modifications of histones, methylation of genomic DNA, and activities of noncoding RNAs (1).”
BackgroundVrtačnik, P., Marc, J., & Ostanek, B. (2013) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2013-0770 · Cited by 97
Glomerular Endothelial Cells as Instigators of Glomerular Sclerotic Diseases
Sol, M., Kamps, J. A. A. M., van den Born, J., van den Heuvel, M. C., van der Vlag, J., Krenning, G., & Hillebrands, J. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.573557 · Cited by 99
“DNA methylation at genes can modulate transcriptional elongation and alternative splicing (Gibney and Nolan, 2010; Lu et al., 2017).”
BackgroundInterpreting omics data with pathway enrichment analysis
Zhao, K., & Rhee, S. Y. (2023) · Trends in Genetics · doi:10.1016/j.tig.2023.01.003 · Cited by 105
DNA methylation, environmental exposures and early embryo development
Breton‐Larrivée, M., Elder, E., & McGraw, S. (2019) · Animal Reproduction · doi:10.21451/1984-3143-ar2019-0062 · Cited by 101
Current status and future prospects for epigenetic psychopharmacology
Boks, M. P., de Jong, N. M., Kas, M. J. H., Vinkers, C. H., Fernandes, C., Kahn, R. S., Mill, J., & Ophoff, R. A. (2012) · Epigenetics · doi:10.4161/epi.7.1.18688 · Cited by 89
Specification and formation of the neural crest: Perspectives on lineage segregation
Prasad, M. S., Charney, R. M., & García‐Castro, M. I. (2018) · genesis · doi:10.1002/dvg.23276 · Cited by 94
“…and H4 that are wrapped by genomic DNA of around 146 bp. Post-translational modifications of histone tails involves methylation, acetylation, phosphorylation, ubiquitination, sumoylation, ADP ribosylation, deimination, and the non-covalent proline isomerization (Berger, 2007; Gibney & Nolan, 2010).”
BackgroundEpigenetic regulation in neural crest development
Hu, N., Strobl‐Mazzulla, P. H., & Bronner-Fraser, M. E. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2014.09.034 · Cited by 95
“Each nucleosome contains eight histones: two of each of the core histones H2A, H2B, H3 and H4 form octameric structures called nucleosome cores around which DNA is wrapped with unstructured tails (Gibney and Nolan, 2010).”
Deep cross-omics cycle attention model for joint analysis of single-cell multi-omics data
Zuo, C., Dai, H., & Chen, L. (2021) · Bioinformatics · doi:10.1093/bioinformatics/btab403 · Cited by 89
Diabetic retinopathy, metabolic memory and epigenetic modifications
Kowluru, R. A. (2017) · Vision Research · doi:10.1016/j.visres.2017.02.011 · Cited by 88
Pandit, M., Kil, Y., Ahn, J.-H., Pokhrel, R. H., Gu, Y., Mishra, S. K., Han, Y., Ouh, Y., Kang, B., Jeong, M. S., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38316-9 · Cited by 90
“The consequences of histone methylation may be positive or negative in termsof transcriptional activity 34 .”
Acevedo, N., Reinius, L. E., Greco, D., Gref, A., Orsmark‐Pietras, C., Persson, H., Pershagen, G., Hedlin, G., Melén, E., Scheynius, A., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu479 · Cited by 85
“Methylation of cytosines in CpG sites is an important epigenetic modification that influences the binding of nuclear proteins (14), regulates geneexpression and might beaffected by environmental exposures such as pollutants and pesticides (15,16).”
BackgroundKofink, D., Boks, M. P. M., Timmers, H. T. M., & Kas, M. J. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.03.020 · Cited by 83
Candler, T. P., Kühnen, P., Prentice, A. M., & Silver, M. J. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100773 · Cited by 86
“Epigenetic processes, including DNA methylation, histone mod-i fi cation, chromatin remodelling and RNA-based mechanisms can a ff ect gene expression (Gibney and Nolan, 2010).”
Genetic and epigenetic factors associated with depression: an updated overview
Alshaya, D. S. (2022) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2022.103311 · Cited by 81
Lugani, Y., Rai, R., Prabhu, A. A., Maan, P., Hans, M., Kumar, V., Kumar, S., Chandel, A. K., & Sengar, R. S. (2020) · Biofuel Research Journal · doi:10.18331/brj2020.7.4.5 · Cited by 80
“There are several factors like methylation, acetylation, and post transcriptional modifications that control expression of genes without incorporating any changes in the gene sequence (Gibney and Nolan, 2010; Mello-de-Sousa et al., 2016; Druzhinina and Kubicek, 2017).”
BackgroundEpigenetic reprogramming in cancer: From diagnosis to treatment
Costa, P. M. S., Sales, S. L. A., Pinheiro, D. P., Pontes, L. Q., Maranhão, S. S., Pessoa, C., Furtado, G. P., & Furtado, C. L. M. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1116805 · Cited by 89
“Lifetime disruption in the epigenetic machinery leads to loss of global epigenetic marks, activation of growth-related genes (oncogenes) and silence of cell cycle control genes (tumor suppressor) and DNA repair genes, thereby initiating and propagating tumorigenesis (Figure 1) (Gibney and Nolan, 2010; Feinberg et al.,…”
BackgroundGene Polymorphisms and Fiber-Type Composition of Human Skeletal Muscle
Ahmetov, I. I., Vinogradova, O. L., & Williams, A. G. (2012) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.22.4.292 · Cited by 81
Toledo, T. T., Nogueira, S. B., Cordenunsi, B. R., Gozzo, F. C., Pilau, E. J., Lajolo, F. M., & do Nascimento, J. R. O. (2012) · Postharvest Biology and Technology · doi:10.1016/j.postharvbio.2012.04.005 · Cited by 79
Chatterjee, B., Ghosh, K. K., & Kanade, S. R. (2019) · BioFactors · doi:10.1002/biof.1544 · Cited by 79
The role of the dynamic epigenetic landscape in senescence: orchestrating SASP expression
Dasgupta, N., Arnold, R., Equey, A., Gandhi, A., & Adams, P. D. (2024) · npj Aging · doi:10.1038/s41514-024-00172-2 · Cited by 93
“…changes in DNA methylation patterns, histone modi fi cation, reduction in overall levels of core histones, accumulation of histone variants, and the dysregulated functioning of non-coding RNAs believed to exert their in fl uence primarily at the level of transcription in gene expression 15 – 18 .”
BackgroundSingh, A. V., Bhardwaj, P., Laux, P., Pradeep, P., Busse, M., Luch, A., Hirose, A., Osgood, C. J., & Stacey, M. W. (2024) · Frontiers in Toxicology · doi:10.3389/ftox.2024.1461587 · Cited by 84
“These include DNA methylation, histone modi fi cation, and chromatin remodeling, which collectively alter gene expression patterns without changing the DNA sequence itself (Gibney and Nolan, 2010).”
Regulation of ZEB1 Function and Molecular Associations in Tumor Progression and Metastasis
Pérez‐Oquendo, M., & Gibbons, D. L. (2022) · Cancers · doi:10.3390/cancers14081864 · Cited by 76
“Epigenetic regulation represents an important mechanism by which EMT transcription factors recognize and bind to gene promoter regions [82].”
BackgroundEpigenetic regulation in lung cancer
Ramazi, S., Dadzadi, M., Sahafnejad, Z., & Allahverdi, A. (2023) · MedComm · doi:10.1002/mco2.401 · Cited by 82
“12,13 Studies conducted during recent decades on epigenetic modifications have discovered how epigenetic traits can be influenced by chromatin structure, which directly responds to changes in phenotypic variability via regulation of gene functions.”
BackgroundHa, T. K., Kim, D., Kim, C. L., Grav, L. M., & Lee, G. M. (2022) · Biotechnology Advances · doi:10.1016/j.biotechadv.2021.107831 · Cited by 74
Exercise and epigenetic inheritance of disease risk
Denham, J. (2017) · Acta Physiologica · doi:10.1111/apha.12881 · Cited by 79
Micro RNA as a potential blood-based epigenetic biomarker for Alzheimer's disease
Fransquet, P., & Ryan, J. L. (2018) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2018.05.020 · Cited by 73
Bisphenol S induced epigenetic and transcriptional changes in human breast cancer cell line MCF-7
Huang, W., Zhao, C., Zhong, H., Zhang, S., Xia, Y., & Cai, Z. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.12.084 · Cited by 72
Review: Epigenetic mechanisms in ocular disease.
He, S., Li, X., Chan, N., & Hinton, D. R. (2013) · Europe PMC (PubMed Central) · Cited by 71
Srivastava, A., Dada, O. O., Qian, J., Al-Chalabi, N., Fatemi, A. B., Gerretsen, P., Graff, A., & Luca, V. D. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.114218 · Cited by 75
The Role of Dietary Phenolic Compounds in Epigenetic Modulation Involved in Inflammatory Processes
Číž, M., Dvořáková, A., Skočková, V., & Kubala, L. (2020) · Antioxidants · doi:10.3390/antiox9080691 · Cited by 77
“This reaction is catalyzed by peptidyl arginine deiminases [56].”
BackgroundInfluentialTortora, M. M. C., Brennan, L. D., Karpen, G. H., & Jost, D. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2211855120 · Cited by 69
“The precise and coordinated recruitment of regulatory molecules at specific genomic or molecular targets often gives rise to spatially- and biochemically-distinct compartments, which play essential roles in a variety of cellular activities including DNA repair (2), transcription (3, 4), replication (5) and epigenetic…”
BackgroundEpigenetic Regulation in Oral Squamous Cell Carcinoma Microenvironment: A Comprehensive Review
Mesgari, H., Esmaelian, S., Nasiri, K., Ghasemzadeh, S., Doroudgar, P., & Payandeh, Z. (2023) · Cancers · doi:10.3390/cancers15235600 · Cited by 87
“Epigenetic alterations consist of DNA methylation, modifications to histones, regulation facilitated by non-coding RNA, chromatin remodeling, and genomic imprinting [24].”
BackgroundPlant hormone ethylene: A leading edge in conferring drought stress tolerance
Nazir, F., Poór, P., Gupta, R., Kumari, S., Nawaz, K., & Khan, M. I. R. (2024) · Physiologia Plantarum · doi:10.1111/ppl.14151 · Cited by 70
Kaut, O., Schmitt, I., Hofmann, A., Hoffmann, P., Schlaepfer, T. E., Wüllner, U., & Hurlemann, R. (2015) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-014-0572-y · Cited by 68
Myostatin: Basic biology to clinical application
Esposito, P. B., Picciotto, D., Battaglia, Y., Costigliolo, F., Viazzi, F. C., & Verzola, D. (2022) · Advances in clinical chemistry · doi:10.1016/bs.acc.2021.09.006 · Cited by 72
A Looking-Glass of Non-Coding RNAs in Oral Cancer
Irimie, A. I., Braicu, C., Sonea, L., Zimța, A., Cojocneanu, R., Tonchev, K., Mehterov, N. H., Diudea, D., Buduru, S. D., & Berindan‐Neagoe, I. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122620 · Cited by 68
“In addition to these, there are most likely other species of small ncRNAs, not yet deciphered and characterized [12].”
BackgroundNext‐generation technologies and data analytical approaches for epigenomics
Mensaert, K., Denil, S. L. I. J., Trooskens, G., Criekinge, W. V., Thas, O., & Meyer, T. D. (2013) · Environmental and Molecular Mutagenesis · doi:10.1002/em.21841 · Cited by 68
“The most well known of these epigenetic players are DNA and histone modifications, but several RNA-and nucleosome position-based mechanisms are generally also considered epigenetic traits [Gibney and Nolan, 2010; Portela and Esteller, 2010; Branco et al., 2012].”
BackgroundEpigenetic regulation and T-cell responses in endometriosis – something other than autoimmunity
Szukiewicz, D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.943839 · Cited by 65
“, translation) may also be regulated epigenetically (51).”
BackgroundHyper-methylation of ABCG1 as an epigenetics biomarker in non-small cell lung cancer
Tran, T.-O., Lam, L. H. T., & Le, N. Q. K. (2023) · Functional & Integrative Genomics · doi:10.1007/s10142-023-01185-y · Cited by 67
AP ‐1 is a regulatory transcription factor of inflammaging in the murine kidney and liver
Yu, X., Wang, Y., Song, Y., Gao, X., & Deng, H. (2023) · Aging Cell · doi:10.1111/acel.13858 · Cited by 63
“Although most studies describe transcriptional signatures, epigenetic alterations are key bridges between genomic information and transcriptional regulation (Gibney & Nolan, 2010; Zhang et al., 2020).”
BackgroundMolecular Regulatory Mechanisms Affecting Fruit Aroma
Lu, H., Zhao, H., Zhong, T., Chen, D., Wu, Y., & Xie, Z. (2024) · Foods · doi:10.3390/foods13121870 · Cited by 64
“During the whole development process of plants, the synthesis of volatile compounds differs in time and space, and these differences are often the result of changes in enzyme levels and activities [40].”
BackgroundMishra, M., & Kowluru, R. A. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-19759 · Cited by 64
“its accessibility for transcriptional factors, play a significant role in regulating gene transcription.(32,33) Experimental models”
BackgroundFibroblast pathology in inflammatory joint disease
Marsh, L., Kemble, S., Nisa, P. R., Singh, R., & Croft, A. P. (2021) · Immunological Reviews · doi:10.1111/imr.12986 · Cited by 68
Metadata
- Authors
- Gibney, E. R., & Nolan, C. M.
- Affiliations
- University College Dublin (IE)
- Corresponding author
- Nolan, C M
- Venue
- Heredity
- Published
- 2010-05-12
- Volume
- 105
- Issue
- 1
- Pages
- 4-13
- ISSN
- 0018-067X (ISSN-L)
- 1365-2540
- OpenAlex
- W1974450480
- Cited by
- 1,109
- References
- 119
- Citations by year
- 2026: 68 · 2025: 148 · 2024: 175 · 2023: 147 · 2022: 115 · 2021: 102 · 2020: 70 · 2019: 33 · 2018: 42 · 2017: 28 · 2016: 32 · 2015: 22 · 2014: 29 · 2013: 32 · 2012: 31
- FWCI
- 2.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Heredity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Science Foundation Ireland (RFP06)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Keywords
- epigenetics, gene expression regulation, transcriptional regulation, DNA methylation, histone modifications, RNA-mediated gene regulation, cell differentiation, development (biology), translational regulation, protein modification
- MeSH terms
- Animals, Cell Differentiation, Humans, DNA Modification Methylases, Gene Expression, Cell Lineage, Heredity, Epigenesis, Genetic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
