Mammalian viviparity: a complex niche in the evolution of genomic imprinting
Open accessAbstract
Evolution of mammalian reproductive success has witnessed a strong dependence on maternal resources through placental in utero development. Genomic imprinting, which has an active role in mammalian viviparity, also reveals a biased role for matrilineal DNA in its regulation. The co-existence of three matrilineal generations as one (mother, foetus and post-meiotic oocytes) has provided a maternal niche for transgenerational co-adaptive selection pressures to operate. In utero foetal growth has required increased maternal feeding in advance of foetal energetic demands; the mammary glands are primed for milk production in advance of birth, while the maternal hypothalamus is hormonally primed by the foetal placenta for nest building and post-natal care. Such biological forward planning resulted from maternal-foetal co-adaptation facilitated by co-expression of the same imprinted allele in the developing hypothalamus and placenta. This co-expression is concurrent with the placenta interacting with the adult maternal hypothalamus thereby providing a transgenerational template on which selection pressures may operate ensuring optimal maternalism in this and the next generation. Invasive placentation has further required the maternal immune system to adapt and positively respond to the foetal allotype. Pivotal to these mammalian evolutionary developments, genomic imprinting emerged as a monoallelic gene dosage regulatory mechanism of tightly interconnected gene networks providing developmental genetic stability for in utero development.
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This leads to differential selection pressures on maternally and paternally inherited alleles in the conceptus with respect to resource allocation and is manifested as genomic imprinting, a mechanism for monoallelically regulating gene dosage in a parent-of-origin fashion.
“This leads to differential selection pressures on maternally and paternally inherited alleles in the conceptus with respect to resource allocation and is manifested as genomic imprinting, a mechanism for monoallelically regulating gene dosage in a parent-of-origin fashion (305, 391).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [305]
Changes in placental phenotype in response to environmental cues can be seen as a co-adaptive response mutually beneficial to the mother and fetus in the successful outcome of pregnancy.
“Changes in placental phenotype in response to environmental cues can, therefore, be seen as a co-adaptive response mutually beneficial to the mother and fetus in the successful outcome of pregnancy (305).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [305]
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- Authors
- Keverne, E. B.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Keverne, E B
- Venue
- Heredity
- Published
- 2014-02-26
- Volume
- 113
- Issue
- 2
- Pages
- 138-144
- ISSN
- 0018-067X (ISSN-L)
- 1365-2540
- PMC
- PMC4105457
- OpenAlex
- W1968011921
- Cited by
- 17
- References
- 59
- Citations by year
- 2026: 1 · 2024: 2 · 2022: 1 · 2021: 1 · 2019: 2 · 2018: 1 · 2017: 6 · 2016: 2 · 2014: 1
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Heredity (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Keywords
- genomic imprinting, placenta, fetal growth, mammary gland development, placental hormones, maternal-fetal immune tolerance, monoallelic expression, in utero development
- MeSH terms
- Adaptation, Biological, Alleles, Animals, Biological Evolution, Female, Gene Expression Regulation, Humans, Male, Mammals, Reproduction, Genomic Imprinting, Gene Regulatory Networks
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