Mechanisms and consequences of widespread random monoallelic expression
Abstract
Although random monoallelic expression has been known for decades to affect genes on the X chromosome in female placental mammals, until a few years ago it was thought that there were few autosomal genes that were regulated in this manner. New tools for assaying gene expression genome-wide are now revealing that there are perhaps more genes that are subject to random monoallelic expression on mammalian autosomes than there are on the X chromosome and that these expression properties are achieved by diverse molecular mechanisms. This mode of expression has the potential to have an impact on natural selection and on the evolution of gene families.
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fMRI studies using Cyberball have identified a network of brain regions involved in processing exclusion-related distress, most consistently the ACC, anterior insula, and vlPFC.
“Functional Magnetic Resonance Imaging (fMRI) studies using the Cyberball game have identified a network of brain regions involved in processing exclusion-related distress of which three regions are most consistently found: the anterior cingulate cortex (ACC), the anterior insula and the ventrolateral prefrontal cortex (vlPFC)”
From Chronic Childhood Peer Rejection is Associated with Heightened Neural Responses to Social Exclusion During Adolescence (2016) · cites this paper as Eisenberger 2012
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- Authors
- Chess, A.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Chess, Andrew
- ORCID
- Chess, Andrew
- Venue
- Nature Reviews Genetics
- Published
- 2012-05-15
- Volume
- 13
- Issue
- 6
- Pages
- 421-428
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2081808783
- Cited by
- 186
- References
- 49
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 7 · 2023: 5 · 2022: 5 · 2021: 7 · 2020: 7 · 2019: 6 · 2018: 8 · 2017: 20 · 2016: 27 · 2015: 27 · 2014: 27 · 2013: 25 · 2012: 3
- FWCI
- 3.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- X chromosome inactivation, autosomal genes, gene dosage, X inactivation center, natural selection, gene family evolution, mammalian gene regulation, genome-wide expression profiling
- MeSH terms
- Alleles, Animals, Female, Gene Expression Regulation, Humans, Models, Genetic, Selection, Genetic, Evolution, Molecular, Gene Expression Profiling, X Chromosome Inactivation
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