The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
The Content and Size of Hyaluronan in Biological Fluids and Tissues
Open accessAbstract
Hyaluronan is a simple repeating disaccharide polymer, synthesized at the cell surface by integral membrane synthases. The repeating sequence is perfectly homogeneous, and is the same in all vertebrate tissues and fluids. The polymer molecular mass is more variable. Most commonly, hyaluronan is synthesized as a high-molecular mass polymer, with an average molecular mass of approximately 1000-8000 kDa. There are a number of studies showing increased hyaluronan content, but reduced average molecular mass with a broader range of sizes present, in tissues or fluids when inflammatory or tissue-remodeling processes occur. In parallel studies, exogenous hyaluronan fragments of low-molecular mass (generally, <200 kDa) have been shown to affect cell behavior through binding to receptor proteins such as CD44 and RHAMM (gene name HMMR), and to signal either directly or indirectly through toll-like receptors. These data suggest that receptor sensitivity to hyaluronan size provides a biosensor of the state of the microenvironment surrounding the cell. Sensitive methods for isolation and characterization of hyaluronan and its fragments have been developed and continue to improve. This review provides an overview of the methods and our current state of knowledge of hyaluronan content and size distribution in biological fluids and tissues.
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Cites
Hyaluronan: from extracellular glue to pericellular cue
Toole, B. P. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1391 · Cited by 2,125
Hyaluronan: its nature, distribution, functions and turnover.
Fraser, J. R. E., Laurent, T. C., & Laurent, U. B. G. (1997) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.1997.00170.x · Cited by 2,031
Hyaluronan fragments: An information-rich system
Stern, R., Asari, A. A., & Sugahara, K. N. (2006) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2006.05.009 · Cited by 1,132
Hyaluronan as an Immune Regulator in Human Diseases
Jiang, D., Liang, J., & Noble, P. W. (2011) · Physiological Reviews · doi:10.1152/physrev.00052.2009 · Cited by 1,060
Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties
Itano, N., Sawai, T., Yoshida, M., Lenas, P., Yamada, Y., Imagawa, M., Shinomura, T., Hamaguchi, M., Yoshida, Y., Ohnuki, Y., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.35.25085 · Cited by 901
Chemistry and molecular biology of the intercellular matrix
Lacy, D. (1970) · Micron (1969) · doi:10.1016/0047-7206(70)90033-6 · Cited by 853
McKee, C. M., Penno, M. B., Cowman, M., Burdick, M. D., Strieter, R. M., Bao, C., & Noble, P. W. (1996) · Journal of Clinical Investigation · doi:10.1172/jci119054 · Cited by 806
Self-citationHigh-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat
Tian, X., Azpurua, J., Hine, C., Vaidya, A., Myakishev-Rempel, M., Ablaeva, J., Mao, Z., Nevo, E., Gorbunova, V., & Seluanov, A. (2013) · Nature · doi:10.1038/nature12234 · Cited by 784
Aggregation of Cartilage Proteoglycans
Hascall, V. C., & Heinegård, D. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42507-6 · Cited by 562
Dahl, L. B., Dahl, I. M., Engström-Laurent, A., & Granath, K. (1985) · Annals of the Rheumatic Diseases · doi:10.1136/ard.44.12.817 · Cited by 547
Cited by
Carcinoma Cell Hyaluronan as a “Portable” Cancerized Prometastatic Microenvironment
Turley, E. A., Wood, D. K., & McCarthy, J. B. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-3114 · Cited by 71
Self-citationHyaluronan in adipogenesis, adipose tissue physiology and systemic metabolism
Zhu, Y., Kruglikov, I. L., Akgul, Y., & Scherer, P. E. (2019) · Matrix Biology · doi:10.1016/j.matbio.2018.02.012 · Cited by 68
Liu, X.-Q., Chen, X.-T., Liu, Z.-Z., Gu, S.-S., He, L.-J., Wang, K.-P., & Tang, R.-Z. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c00669 · Cited by 26
Metadata
- Authors
- Cowman, M. K., Lee, H.-G., Schwertfeger, K. L., McCarthy, J. B., & Turley, E. A.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2015-06-02
- Volume
- 6
- Pages
- 261-261
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W2142011208
- Cited by
- 346
- References
- 80
- FWCI
- 6.47
- Type
- journal article
- Language
- en
- Open access
- gold
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- Cowman, M. K., Lee, H.-G., Schwertfeger, K. L., McCarthy, J. B., & Turley, E. A. (2015). The Content and Size of Hyaluronan in Biological Fluids and Tissues. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2015.00261
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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