Dissecting mammalian immunity through mutation

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J. A., & Charpentier, E. (2012) · Science · doi:10.1126/science.1225829 · Cited by 17,116 · see citing works

Multiplex Genome Engineering Using CRISPR/Cas Systems

Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., et al. (2013) · Science · doi:10.1126/science.1231143 · Cited by 15,339 · see citing works

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442 · see citing works

RNA-Guided Human Genome Engineering via Cas9

Mali, P., Yang, L., Esvelt, K. M., Aach, J., Guell, M., DiCarlo, J. E., Norville, J. E., & Church, G. M. (2013) · Science · doi:10.1126/science.1232033 · Cited by 9,210 · see citing works

Pattern Recognition Receptors and Inflammation

Takeuchi, O., & Akira, S. (2010) · Cell · doi:10.1016/j.cell.2010.01.022 · Cited by 8,895 · see citing works

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in <i>Tlr4</i> Gene

Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631 · see citing works

Initial sequencing and comparative analysis of the mouse genome

Mouse Genome Sequencing Consortium (2002) · Nature · doi:10.1038/nature01262 · Cited by 7,187 · see citing works

Genome-scale CRISPR-Cas9 knockout screening in human cells

Shalem, O., Sanjana, N. E., Hartenian, E., Shi, X., Scott, D. A., Mikkelsen, T. S., Heckl, D., Ebert, B. L., Root, D. E., Doench, J. G., et al. (2014) · Science · doi:10.1126/science.1247005 · Cited by 5,234 · see citing works

The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer

Zhang, L., Xu, J., Zhang, X., Zhang, Y., Wang, L., Huang, X., & Xu, Z. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479442 · Cited by 4,090 · see citing works

One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering

Wang, H., Yang, H., Shivalila, C. S., Dawlaty, M. M., Cheng, A. W., Zhang, F., & Jaenisch, R. (2013) · Cell · doi:10.1016/j.cell.2013.04.025 · Cited by 3,495 · see citing works

Genetic screens in human cells using the CRISPR-Cas9 system

Wang, T., Wei, J. J., Sabatini, D. M., & Lander, E. S. (2014) · Science · doi:10.1126/science.1246981 · Cited by 2,856 · see citing works

The Wellcome Trust Case Control Consortium, U.K.

Mossman, K. (2008) · Scientific American · doi:10.1038/scientificamerican0108-42a · Cited by 2,714 · see citing works

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

Brunkow, M. E., Jeffery, E. W., Hjerrild, K. A., Paeper, B. W., Clark, L. B., Yasayko, S.-A., Wilkinson, J. E., Galas, D. J., Ziegler, S. F., & Ramsdell, F. (2001) · Nature Genetics · doi:10.1038/83784 · Cited by 2,628 · see citing works

Nanobodies: natural single-domain antibodies

Muyldermans, S. (2013) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-063011-092449 · Cited by 2,304 · see citing works

Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum

Bendall, S. C., Simonds, E. F., Qiu, P., Amir, E.-A. D., Krutzik, P. O., Finck, R., Bruggner, R. V., Melamed, R., Trejo, A., Ornatsky, O. I., et al. (2011) · Science · doi:10.1126/science.1198704 · Cited by 2,279 · see citing works

Rate of de novo mutations and the importance of father’s age to disease risk

Kong, A., Frigge, M. L., Masson, G., Besenbacher, S., Sulem, P., Magnusson, G., Gudjonsson, S. A., Sigurdsson, A., Jonasdottir, A., Jonasdottir, A., et al. (2012) · Nature · doi:10.1038/nature11396 · Cited by 2,134 · see citing works

The challenge of emerging and re-emerging infectious diseases

Morens, D. M., Folkers, G. K., & Fauci, A. S. (2004) · Nature · doi:10.1038/nature02759 · Cited by 2,107 · see citing works

A conditional knockout resource for the genome-wide study of mouse gene function

Skarnes, W. C., Rosen, B., West, A. P., Koutsourakis, M., Bushell, W., Iyer, V., Mujica, A. O., Thomas, M., Harrow, J., Cox, T., et al. (2011) · Nature · doi:10.1038/nature10163 · Cited by 1,708 · see citing works

Exome sequencing as a tool for Mendelian disease gene discovery

Bamshad, M. J., Ng, S. B. H., Bigham, A. W., Tabor, H. K., Emond, M. J., Nickerson, D. A., & Shendure, J. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3031 · Cited by 1,659 · see citing works

Evolution and functional impact of rare coding variation from deep sequencing of human exomes

Tennessen, J. A., Bigham, A. W., O’Connor, T. D., Fu, W., Kenny, E. E., Gravel, S., McGee, S., Do, R., Liu, X., Jun, G., et al. (2012) · Science · doi:10.1126/science.1219240 · Cited by 1,613 · see citing works

One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering

Yang, H., Wang, H., Shivalila, C. S., Cheng, A. W., Shi, L., & Jaenisch, R. (2013) · Cell · doi:10.1016/j.cell.2013.08.022 · Cited by 1,596 · see citing works

Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

Carette, J. E., Raaben, M., Wong, A., Herbert, A. S., Obernosterer, G., Mulherkar, N., Kuehne, A. I., Kranzusch, P. J., Griffin, A. M., Ruthel, G. T., et al. (2011) · Nature · doi:10.1038/nature10348 · Cited by 1,309 · see citing works

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

Hoebe, K. H. N., Du, X., Georgel, P., Janssen, E. M., Tabeta, K., Kim, S. O., Goode, J., Lin, P., Mann, N., Mudd, S., et al. (2003) · Nature · doi:10.1038/nature01889 · Cited by 1,232 · see citing works

Complementation Cloning of NEMO, a Component of the IκB Kinase Complex Essential for NF-κB Activation

Yamaoka, S., Courtois, G., Chable-Bessia, C., Whiteside, S. T., Weil, R., Agou, F., Kirk, H., Kay, R. J., & Israël, A. (1998) · Cell · doi:10.1016/s0092-8674(00)81466-x · Cited by 1,077 · see citing works

Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library

Koike-Yusa, H., Li, Y., Tan, E.-P., Velasco-Herrera, M. D. C., & Yusa, K. (2014) · Nature Biotechnology · doi:10.1038/nbt.2800 · Cited by 1,064 · see citing works

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

Straus, D. B. (1992) · Cell · doi:10.1016/0092-8674(92)90428-f · Cited by 1,045 · see citing works

CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea

Marraffini, L. A., & Sontheimer, E. J. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2749 · Cited by 1,011 · see citing works

A Scan for Positively Selected Genes in the Genomes of Humans and Chimpanzees

Nielsen, R., Bustamante, C. D., Clark, A. G., Glanowski, S., Sackton, T. B., Hubisz, M. J., Fledel-Alon, A., Tanenbaum, D. M., Civello, D., White, T. J., et al. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030170 · Cited by 998 · see citing works

Rare Variants of <i>IFIH1</i> , a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes

Nejentsev, S., Walker, N., Riches, D., Egholm, M., & Todd, J. A. (2009) · Science · doi:10.1126/science.1167728 · Cited by 958 · see citing works

Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants

Fu, W., O’Connor, T. D., Jun, G., Kang, H. M., Abecasis, G. R., Leal, S. M., Gabriel, S., Rieder, M. J., Altshuler, D., Shendure, J., et al. (2012) · Nature · doi:10.1038/nature11690 · Cited by 951 · see citing works

A protein tyrosine kinase in the interferon alpha/beta signaling pathway.

Velazquez, L., Fellous, M., Stark, G., & Pellegrini, S. (1992) · Cell · doi:10.1016/0092-8674(92)90105-l · Cited by 777 · see citing works

Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey

Pancer, Z., Amemiya, C. T., Ehrhardt, G. R. A., Ceitlin, J., Gartland, G. L., & Cooper, M. D. (2004) · Nature · doi:10.1038/nature02740 · Cited by 678 · see citing works

Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency

Lucas, C. L., Kuehn, H. S., Zhao, F. R., Niemela, J. E., Deenick, E. K., Palendira, U., Avery, D. T., Moens, L., Cannons, J. L., Biancalana, M., et al. (2013) · Nature Immunology · doi:10.1038/ni.2771 · Cited by 677 · see citing works

Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage

Angulo, I., Vadas, O., Garçon, F., Banham-Hall, E., Plagnol, V., Leahy, T. R., Baxendale, H., Coulter, T. I., Curtis, J. W., Wu, C., et al. (2013) · Science · doi:10.1126/science.1243292 · Cited by 639 · see citing works

A loss-of-function RNA interference screen for molecular targets in cancer

Ngo, V. N., Davis, R. E., Lamy, L., Yu, X., Zhao, H. G., Lenz, G., Lam, L. T., Davé, S. S., Yang, L., Powell, J. I., et al. (2006) · Nature · doi:10.1038/nature04687 · Cited by 606 · see citing works

IRF8 Mutations and Human Dendritic-Cell Immunodeficiency

Hambleton, S., Salem, S., Bustamante, J. C., Bigley, V., Boisson‐Dupuis, S., Azevedo, J., Fortin, A., Haniffa, M. A., Ceron‐Gutierrez, L., Bacon, C. M., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1100066 · Cited by 604 · see citing works

Phagocytosis of Aspergillus fumigatus conidia by murine macrophages involves recognition by the dectin-1 beta-glucan receptor and Toll-like receptor 2

Luther, K., Torosantucci, A., Brakhage, A. A., Heesemann, J., & Ebel, F. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00796.x · Cited by 582 · see citing works

Second messenger role for Mg2+ revealed by human T-cell immunodeficiency

Li, F.-Y., Chaigne-Delalande, B., Kanellopoulou, C., Davis, J. C., Matthews, H. F., Douek, D. C., Cohen, J. I., Uzel, G., Su, H. C., & Lenardo, M. J. (2011) · Nature · doi:10.1038/nature10246 · Cited by 564 · see citing works

DNA repair is limiting for haematopoietic stem cells during ageing

Nijnik, A., Woodbine, L., Marchetti, C., Dawson, S., Lambe, T., Liu, C., Rodrigues, N. P., Crockford, T. L., Cabuy, E., Vindigni, A., et al. (2007) · Nature · doi:10.1038/nature05875 · Cited by 518 · see citing works

Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.

White, J. K., Gerdin, A.-K., Karp, N. A., Ryder, E., Buljan, M., Bussell, J. N., Salisbury, J., Clare, S., Ingham, N. J., Podrini, C., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.022 · Cited by 509 · see citing works

Haploid Genetic Screens in Human Cells Identify Host Factors Used by Pathogens

Carette, J., Guimarães, C. P., Varadarajan, M., Park, A. S., Wuethrich, I., Godarova, A., Kotecki, M., Cochran, B., Spooner, E., Ploegh, H., et al. (2009) · Science · doi:10.1126/science.1178955 · Cited by 508 · see citing works

Human genetic susceptibility to infectious disease

Chapman, S. J., & Hill, A. V. S. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3114 · Cited by 499 · see citing works

Cold Urticaria, Immunodeficiency, and Autoimmunity Related to <i>PLCG2</i> Deletions

Ombrello, M. J., Remmers, E. F., Sun, G., Freeman, A. F., Datta, S., Torabi-Parizi, P., Subramanian, N., Bunney, T. D., Baxendale, R. W., Martins, M. S., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1102140 · Cited by 425 · see citing works

A Prescription for Human Immunology

Davis, M. M. (2008) · Immunity · doi:10.1016/j.immuni.2008.12.003 · Cited by 346 · see citing works

Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells

Lafaille, F. G., Pessach, I. M., Zhang, S., Ciancanelli, M. J., Casadio, M., Abhyankar, A., Ying, S., Keros, S., Goldstein, P. A., Mostoslavsky, G., et al. (2012) · Nature · doi:10.1038/nature11583 · Cited by 341 · see citing works

T-bet–dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow

Jenne, C. N., Enders, A., Rivera, R. R., Watson, S. R., Bankovich, A. J., Pereira, J. P., Xu, Y., Roots, C. M., Beilke, J. N., Banerjee, A., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090525 · Cited by 334 · see citing works

An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice

Lewis, M. A., Quint, E., Glazier, A. M., Fuchs, H., De Angelis, M. H., Langford, C., van Dongen, S., Abreu-Goodger, C., Piipari, M., Redshaw, N., et al. (2009) · Nature Genetics · doi:10.1038/ng.369 · Cited by 302 · see citing works

Identifying the MAGUK Protein Carma-1 as a Central Regulator of Humoral Immune Responses and Atopy by Genome-Wide Mouse Mutagenesis

Jun, J. E., Wilson, L. E., Vinuesa, C. G., Lesage, S., Bléry, M., Miosge, L. A., Cook, M., Kucharska, E. M., Hara, H., Penninger, J. M., et al. (2003) · Immunity · doi:10.1016/s1074-7613(03)00141-9 · Cited by 300 · see citing works

Deciphering the Glycosylome of Dystroglycanopathies Using Haploid Screens for Lassa Virus Entry

Jae, L. T., Raaben, M., Riemersma, M., van Beusekom, E., Blomen, V. A., Velds, A., Kerkhoven, R. M., Carette, J. E., Topaloğlu, H., Meinecke, P., et al. (2013) · Science · doi:10.1126/science.1233675 · Cited by 273 · see citing works

The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells

Loughran, S. J., Kruse, E., Hacking, D. F., de Graaf, C. A., Hyland, C. D., Willson, T. A., Henley, K. J., Ellis, S. L., Voss, A. K., Metcalf, D., et al. (2008) · Nature Immunology · doi:10.1038/ni.1617 · Cited by 265 · see citing works

Plant and Animal Sensors of Conserved Microbial Signatures

Ronald, P. C., & Beutler, B. (2010) · Science · doi:10.1126/science.1189468 · Cited by 258 · see citing works

The actin regulator coronin 1A is mutant in a thymic egress–deficient mouse strain and in a patient with severe combined immunodeficiency

Shiow, L. R., Roadcap, D. W., Paris, K., Watson, S. R., Grigorova, I., Lebet, T., An, J., Xu, Y., Jenne, C. N., Föger, N., et al. (2008) · Nature Immunology · doi:10.1038/ni.1662 · Cited by 249 · see citing works

Derivation of haploid embryonic stem cells from mouse embryos

Leeb, M., & Wutz, A. (2011) · Nature · doi:10.1038/nature10448 · Cited by 248 · see citing works

Forward and Reverse Genetics through Derivation of Haploid Mouse Embryonic Stem Cells

Elling, U., Taubenschmid, J., Wirnsberger, G., O’Malley, R. C., Demers, S.-P., Vanhaelen, Q., Иванович, Ш. А., Schmauss, G., Schramek, D., Schnütgen, F., et al. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.10.012 · Cited by 232 · see citing works

CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10–driven MARCH1-mediated ubiquitination and degradation

Tze, L. E., Horikawa, K., Domaschenz, H., Howard, D. R., Roots, C. M., Rigby, R. J., Way, D. A., Ohmura‐Hoshino, M., Ishido, S., Andoniou, C. E., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20092203 · Cited by 229 · see citing works

Reshaping Antibody Diversity

Wang, F., Ekiert, D. C., Ahmad, I., Yu, W., Zhang, Y., Bazirgan, O. A., Torkamani, A., Raudsepp, T., Mwangi, W., Criscitiello, M. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.049 · Cited by 224 · see citing works

Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells

Blasius, A. L., Arnold, C. N., Georgel, P., Rutschmann, S., Xia, Y., Lin, P., Ross, C., Li, X., Smart, N. G., & Beutler, B. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014051107 · Cited by 203 · see citing works

Ribosomal Protein SA Haploinsufficiency in Humans with Isolated Congenital Asplenia

Bolze, A., Mahlaoui, N., Byun, M., Turner, B., Trede, N. S., Ellis, S. R., Abhyankar, A., Itan, Y., Patin, É., Brebner, S., et al. (2013) · Science · doi:10.1126/science.1234864 · Cited by 189 · see citing works

Widespread Failure of Hematolymphoid Differentiation Caused by a Recessive Niche-Filling Allele of the Ikaros Transcription Factor

Papathanasiou, P., Perkins, A. C., Cobb, B. S., Ferrini, R., Sridharan, R., Hoyne, G. F., Nelms, K. A., Smale, S. T., & Goodnow, C. C. (2003) · Immunity · doi:10.1016/s1074-7613(03)00168-7 · Cited by 152 · see citing works

Opposing Functions of the T Cell Receptor Kinase ZAP-70 in Immunity and Tolerance Differentially Titrate in Response to Nucleotide Substitutions

Siggs, O. M., Miosge, L. A., Yates, A. L., Kucharska, E. M., Sheahan, D., Brdička, T., Weiss, A., Liston, A., & Goodnow, C. C. (2007) · Immunity · doi:10.1016/j.immuni.2007.11.013 · Cited by 142 · see citing works

ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes

Yabas, M., Teh, C. E., Frankenreiter, S., Lal, D., Roots, C. M., Whittle, B., Andrews, D., Zhang, Y., Teoh, N., Sprent, J., et al. (2011) · Nature Immunology · doi:10.1038/ni.2011 · Cited by 130 · see citing works

Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection

Johnson, A. L., Aravind, L., Shulzhenko, N., Morgun, A., Choi, S., Crockford, T. L., Lambe, T., Domaschenz, H., Kucharska, E. M., Zheng, L., et al. (2009) · Nature Immunology · doi:10.1038/ni.1769 · Cited by 128 · see citing works

Selection and Adaptation in the Human Genome

Fu, W., & Akey, J. M. (2013) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-091212-153509 · Cited by 123 · see citing works

Genome-Wide ENU Mutagenesis to Reveal Immune Regulators

Nelms, K. A., & Goodnow, C. C. (2001) · Immunity · doi:10.1016/s1074-7613(01)00199-6 · Cited by 121 · see citing works

Generation of haploid embryonic stem cells from Macaca fascicularis monkey parthenotes

Yang, H., Liu, Z., Ma, Y., Zhong, C., Yin, Q., Zhou, C., Shi, L., Cai, Y., Zhao, H., Wang, H., et al. (2013) · Cell Research · doi:10.1038/cr.2013.93 · Cited by 115 · see citing works

A Phenotypic Approach for IUIS PID Classification and Diagnosis: Guidelines for Clinicians at the Bedside

Bousfiha, A. A., Jeddane, L., Ailal, F., Al–Herz, W., Conley, M. E., Cunningham‐Rundles, C., Etzioni, A., Fischer, A., Franco, J. L., Geha, R. S., et al. (2013) · Journal of Clinical Immunology · doi:10.1007/s10875-013-9901-6 · Cited by 107 · see citing works

The lymphoid lineage–specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells

Liang, Y., Cucchetti, M., Roncagalli, R., Yokosuka, T., Malzac, A., Bertosio, E., Imbert, J., Nijman, I. J., Suchánek, M., Saito, T., et al. (2013) · Nature Immunology · doi:10.1038/ni.2634 · Cited by 106 · see citing works

A forward genetic screen reveals roles for Nfkbid , Zeb1 , and Ruvbl2 in humoral immunity

Arnold, C. N., PIRIE, E. C., Dosenovic, P., McInerney, G. M., Xia, Y., Wang, N. S., Li, X., Siggs, O. M., Hedestam, G. B. K., & Beutler, B. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209134109 · Cited by 98 · see citing works

The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain

Beisner, D. R., Langerak, P., Parker, A. E., Dahlberg, C. M., Otero, F. J., Sutton, S., Poirot, L., Barnes, W., Young, M. A., Niessen, S., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20121072 · Cited by 92 · see citing works

The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow

Siggs, O. M., Arnold, C. N., Huber, C., PIRIE, E. C., Xia, Y., Lin, P., Nemazee, D. A., & Beutler, B. (2011) · Nature Immunology · doi:10.1038/ni.2012 · Cited by 91 · see citing works

Disruption of Fnip1 Reveals a Metabolic Checkpoint Controlling B Lymphocyte Development

Park, H., Staehling‐Hampton, K., Tsang, M., Appleby, M. W., Brunkow, M. E., Margineantu, D. H., Hockenbery, D. M., Habib, T., Liggitt, D., Carlson, G. A., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.02.019 · Cited by 89 · see citing works

B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8− dendritic cells require the intramembrane endopeptidase SPPL2A

Bergmann, H., Yabas, M., Short, A., Miosge, L. A., Barthel, N., Teh, C. E., Roots, C. M., Bull, K. R., Jeelall, Y. S., Horikawa, K., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20121076 · Cited by 85 · see citing works

Memory T Cell RNA Rearrangement Programmed by Heterogeneous Nuclear Ribonucleoprotein hnRNPLL

Wu, Z., Jia, X., de la Cruz, L., Su, X., Marzolf, B., Troisch, P., Zak, D. E., Hamilton, A., Whittle, B., Yu, D., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.11.004 · Cited by 78 · see citing works

Inositol (1,4,5) trisphosphate 3 kinase B controls positive selection of T cells and modulates Erk activity

Wen, B. G., Pletcher, M. T., Warashina, M., Choe, S. H., Ziaee, N., Wiltshire, T., Sauer, K., & Cooke, M. P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306907101 · Cited by 73 · see citing works

A Novel Gene Essential for the Development of Single Positive Thymocytes

Kakugawa, K., Yasuda, T., Miura, I., Kobayashi, A., Fukiage, H., Satoh, R., Matsuda, M., Koseki, H., Wakana, S., Kawamoto, H., et al. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00793-09 · Cited by 69 · see citing works

Going Forward with Genetics

Moresco, E. M. Y., Li, X., & Beutler, B. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.02.002 · Cited by 66 · see citing works

Analysis of the MCMV resistome by ENU mutagenesis

Crozat, K., Georgel, P., Rutschmann, S., Mann, N., Du, X., Hoebe, K. H. N., & Beutler, B. (2006) · Mammalian Genome · doi:10.1007/s00335-005-0164-2 · Cited by 60 · see citing works

A hypomorphic mutation in the Gfi1 transcriptional repressor results in a novel form of neutropenia

Ordoñez‐Rueda, D., Jönsson, F., Mancardi, D. A., Zhao, W., Malzac, A., Liang, Y., Bertosio, E., Grenot, P., Blanquet, V., Sabrautzki, S., et al. (2012) · European Journal of Immunology · doi:10.1002/eji.201242589 · Cited by 59 · see citing works

Forward Genetic Dissection of Immunity to Infection in the Mouse

Vidal, S. M., Malo, D., Marquis, J.-F., & Gros, P. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090304 · Cited by 56 · see citing works

A point mutation in the murine <i>Hem1</i> gene reveals an essential role for Hematopoietic Protein 1 in lymphopoiesis and innate immunity

Park, H., Staehling-Hampton, K., Appleby, M. W., Brunkow, M. E., Habib, T., Zhang, Y., Ramsdell, F., Liggitt, H. D., Freie, B., Tsang, M., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080340 · Cited by 55 · see citing works

Analysis of an Ethylnitrosourea-generated Mouse Mutation Defines a Cell Intrinsic Role of Nuclear Factor κB2 in Regulating Circulating B Cell Numbers

Miosge, L. A., Blasioli, J., Bléry, M., & Goodnow, C. C. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020959 · Cited by 53 · see citing works

A mutation in a chromosome condensin II subunit, kleisin β, specifically disrupts T cell development

Gosling, K. M., Makaroff, L., Theodoratos, A., Kim, Y., Whittle, B., Rui, L., Wu, H., Hong, N. A., Kennedy, G. C., Fritz, J.-A., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704870104 · Cited by 48 · see citing works

ZBTB7B (Th-POK) Regulates the Development of IL-17–Producing CD1d-Restricted Mouse NKT Cells

Enders, A., Stankovic, S., Teh, C. E., Uldrich, A. P., Yabas, M., Juelich, T., Altin, J. A., Frankenreiter, S., Bergmann, H., Roots, C. M., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201486 · Cited by 48 · see citing works

ZBTB1 is a determinant of lymphoid development

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ENU-induced phenovariance in mice: inferences from 587 mutations

Arnold, C. N., Barnes, M. J., Berger, M., Blasius, A. L., Brandl, K., Croker, B. A., Crozat, K., Du, X., Eidenschenk, C., Georgel, P., et al. (2012) · BMC Research Notes · doi:10.1186/1756-0500-5-577 · Cited by 47 · see citing works

Unlocking the Bottleneck in Forward Genetics Using Whole-Genome Sequencing and Identity by Descent to Isolate Causative Mutations

Bull, K. R., Rimmer, A. J., Siggs, O. M., Miosge, L. A., Roots, C. M., Enders, A., Bertram, E. M., Crockford, T. L., Whittle, B., Potter, P. K., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003219 · Cited by 44 · see citing works

A Conserved Salt Bridge in the G Loop of Multiple Protein Kinases Is Important for Catalysis and for In Vivo Lyn Function

Barouch‐Bentov, R., Che, J., Lee, C. C., Yang, Y., Herman, A. E., Jia, Y., Velentza, A. V., Watson, J., Sternberg, L., Kim, S., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2008.12.024 · Cited by 42 · see citing works

Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice

Brandl, K., Tomisato, W., Li, X., Neppl, C., PIRIE, E. C., Falk, W., Xia, Y., Moresco, E. M. Y., Baccalà, R., Theofilopoulos, A. N., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210366109 · Cited by 39 · see citing works

Impact of β2 integrin deficiency on mouse natural killer cell development and function

Crozat, K., Eidenschenk, C., Jaeger, B. N., Krebs, P., Guia, S., Beutler, B., Vivier, É., & Ugolini, S. (2011) · Blood · doi:10.1182/blood-2010-10-315457 · Cited by 38 · see citing works

Consequences of Increased CD45RA and RC Isoforms for TCR Signaling and Peripheral T Cell Deficiency Resulting from Heterogeneous Nuclear Ribonucleoprotein L-Like Mutation

Wu, Z., Yates, A. L., Hoyne, G. F., & Goodnow, C. C. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903625 · Cited by 31 · see citing works

A Reporter Screen in a Human Haploid Cell Line Identifies CYLD as a Constitutive Inhibitor of NF-κB

Lee, C. C., Carette, J. E., Brummelkamp, T. R., & Ploegh, H. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070339 · Cited by 31 · see citing works

A recessive screen for genes regulating hematopoietic stem cells

Papathanasiou, P., Tunningley, R., Pattabiraman, D. R., Ye, P., Gonda, T. J., Whittle, B., Hamilton, A., Cridland, S. O., Lourie, R., & Perkins, A. C. (2010) · Blood · doi:10.1182/blood-2010-04-269951 · Cited by 29 · see citing works

The Justy mutation identifies Gon4-like as a gene that is essential for B lymphopoiesis

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Fluorescence-Based Phenotypic Selection Allows Forward Genetic Screens in Haploid Human Cells

Duncan, L. M., Timms, R. T., Zavodszky, E., Cano, F., Gordon Dougan, B., Randow, F., & Lehner, P. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039651 · Cited by 25 · see citing works

Novel mouse mutants with primary cellular immunodeficiencies generated by genome-wide mutagenesis

Jakob, T., Köllisch, G. V., Howaldt, M., Bewersdorff, M., Rathkolb, B., Müller, M. L., Sandholzer, N., Nitschke, L., Schiemann, M., Mempel, M., et al. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.07.018 · Cited by 25 · see citing works

A mutation of Ikbkg causes immune deficiency without impairing degradation of IκBα

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Mouse strains with point mutations in TAP1 and TAP2

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An IL-7 splicing-defect lymphopenia mouse model revealed by genome-wide mutagenesis

Huang, H., Chiang, Y.-J., Chung, W., Li, C., & Yen, J. J.-Y. (2006) · Journal of Biomedical Science · doi:10.1007/s11373-006-9135-1 · Cited by 9 · see citing works

Functional Deficiency in IL-7 Caused by an N-Ethyl-N-nitrosourea-Induced Point Mutation

Feng, J., Wang, H., & Morse, H. C. (2006) · Genetics · doi:10.1534/genetics.106.066043 · Cited by 8 · see citing works

Global gene disruption in human cells to assign genes to phenotypes

Carette, J. E., Guimarães, C. P., Wüthrich, I., Blomen, V. A., Varadarajan, M., Sun, C., Bell, G. W., Yuan, B., Muellner, M. K., Nijman, S. M. B., et al. (2011) · PubMed Central · doi:10.1038/nbt.1857

The 2022 outbreak and the pathobiology of the monkeypox virus

Kumar, N., Acharya, A., Gendelman, H. E., & Byrareddy, S. N. (2022) · Journal of Autoimmunity · doi:10.1016/j.jaut.2022.102855 · Cited by 513 · see citing works

CRISPR-Cas9: a new and promising player in gene therapy

Xiao-Jie, L., Hui-Ying, X., Zun-Ping, K., Jin-Lian, C., & Li-Juan, J. (2015) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2014-102968 · Cited by 200 · see citing works

A review on CRISPR/Cas: a versatile tool for cancer screening, diagnosis, and clinic treatment

Yang, X., & Zhang, B. (2023) · Functional & Integrative Genomics · doi:10.1007/s10142-023-01117-w · Cited by 58 · see citing works

The Re-Emergence of Mpox: Old Illness, Modern Challenges

Zinnah, M. A., Uddin, M. B., Hasan, T., Das, S., Khatun, F., Hasan, M. H., Udonsom, R., Rahman, M. M., & Ashour, H. M. (2024) · Biomedicines · doi:10.3390/biomedicines12071457 · Cited by 47 · see citing works

CRISPR/Cas9: the Jedi against the dark empire of diseases

Khan, S., Mahmood, M. S., Rahman, S. U., Zafar, H., Khan, S. H., khan, Z., & Ahmad, A. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0425-5 · Cited by 47 · see citing works

Quantitative Reduction of the TCR Adapter Protein SLP-76 Unbalances Immunity and Immune Regulation

Siggs, O. M., Miosge, L. A., Daley, S. R., Asquith, K. L., Foster, P. S., Liston, A., & Goodnow, C. C. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1400326 · Cited by 34 · see citing works

Expression of Concern: The pathophysiological and immunological background of the monkeypox virus infection: An update

Mukherjee, A. G., Wanjari, U. R., Kannampuzha, S., Das, S., Murali, R., Namachivayam, A., Renu, K., Ramanathan, G., Doss, C. G. P., Vellingiri, B., et al. (2022) · Journal of Medical Virology · doi:10.1002/jmv.28206 · Cited by 29 · see citing works

Global transmission of monkeypox virus—a potential threat under the COVID-19 pandemic

Wang, Y., Leng, P., & Zhou, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1174223 · Cited by 24 · see citing works

CRISPR and KRAS: a match yet to be made

Bender, G., Yamaci, R. F., & Taneri, B. (2021) · Journal of Biomedical Science · doi:10.1186/s12929-021-00772-0 · Cited by 24 · see citing works

Precise and Rapid Validation of Candidate Gene by Allele Specific Knockout With CRISPR/Cas9 in Wild Mice

Chao, T., Liu, Z., Zhang, Y., Zhang, L., Huang, R., He, L. D., Gu, Y., Chen, Z., Zheng, Q., Shi, L., et al. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00124 · Cited by 16 · see citing works

Systems approaches to coronavirus pathogenesis

Schäfer, A., Baric, R. S., & Ferris, M. T. (2014) · Current Opinion in Virology · doi:10.1016/j.coviro.2014.04.007 · Cited by 13 · see citing works

A Narrative Review on the Monkeypox Virus: An Ongoing Global Outbreak Hitting the Non-Endemic Countries

Nisar, H., Saleem, O., Sapna, F., Sham, S., Perkash, R. S., Kiran, N. K., Anjali, F., Mehreen, A., & Ram, B. (2023) · Cureus · doi:10.7759/cureus.43322 · Cited by 10 · see citing works

The prospective outcome of the monkeypox outbreak in 2022 and characterization of monkeypox disease immunobiology

Qudus, M. S., Cui, X., Tian, M., Afaq, U., Muhammad, S., Qureshi, S., Liu, S., Ma, J., Wang, G., Faraz, M., et al. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1196699 · Cited by 9 · see citing works

A point mutation in the extracellular domain of CD4 completely abolishes CD4 T cell development in C57BL/6 mouse

Wang, H., Li, S., Chao, T., Wang, X., Shi, L., Zhang, L., Liang, Y., Zheng, Q., & Lu, L. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.09.015 · Cited by 4 · see citing works

A computational approach to identify natural putative inhibitors to combat monkeypox

Kharwar, R., Bhatt, M., Patel, K., Patel, S., & Daxini, N. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15457-7.00025-3 · Cited by 3 · see citing works

The Novel Insight into the Emergence of Monkeypox: Old Disease, New Fears?Preprint

Zinnah, M. A., Rahman, M. M., Hasan, T., Das, S., Khatun, F., Hasan, M. H., Udonsom, R., & Uddin, M. B. (2022) · Preprints.org · doi:10.20944/preprints202211.0052.v1 · Cited by 3 · see citing works

Complex Genetic Control of Autoimmune Disease

Bull, K. R., & Cornall, R. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-374279-7.15009-x

An IGHG1 Variant Introgressed From Vindija Neanderthal Archaic Hominin Confers Enhanced Antibody Immunity Against SARS-CoV-2Preprint

Sun, W., Yang, T., Sun, F., Liu, P., Lan, X., Chen, X., Pang, Y., Ji, X., Gao, R., Li, Y., et al. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4102635

Complex Genetic Control of Autoimmune Disease

Droscher, E., & Bull, K. R. (2025) · Elsevier eBooks · doi:10.1016/b978-0-12-824465-4.00251-9

Murine Models of Transfusion-Induced Red Blood Cell Alloimmunization

Varadkar, S. P., Ortiz, V., Alton, A. B., Hughes, B. D., Muthusamy, S., Wu, S., Scott, W. O., Li, W., Stowell, S. R., Arthur, C. M., et al. (2026) · Methods in molecular biology · doi:10.1007/978-1-0716-5376-0_27

Genome-Wide ENU Mutagenesis to Reveal Immune Regulators

Nelms, K. A., & Goodnow, C. C. (2001) · Immunity · doi:10.1016/s1074-7613(01)00199-6 · Cited by 121 · see citing works

Finding New Components of the Mammalian Immune System

Beutler, B. (2016) · Rambam Maimonides Medical Journal · doi:10.5041/rmmj.10245 · Cited by 1 · see citing works

Decoding Genome Mutations: Insights from Cutting-Edge Immunology Research

Mia, M. H., & Ali, M. M. (2024) · doi:10.13140/rg.2.2.34022.19528

Forward genetic analysis of mammalian immunity

Siggs, O. M., & Siggs, O. (2012) · Oxford University Research Archive (ORA) (University of Oxford) · doi:10.5287/ora-2zox0d9dd

Understanding the immunological impact of the human mutation explosion

Andrews, T. D., Sjollema, G., & Goodnow, C. C. (2013) · Trends in Immunology · doi:10.1016/j.it.2012.12.001 · Cited by 13 · see citing works