CoChat
Sign Up
Cited by 44Sodium Intake and HealthBlood Pressure and Hypertension StudiesRenin-Angiotensin System Studies

The time course of salt-induced hypertension, and why it matters

Van Vliet, B N, Montani, J-P·2008·International Journal of Obesity
DOI 10.1038/ijo.2008.205
Open this paper in CoChat — free account

Abstract

The epidemiology of salt-induced hypertension has been explored in detail in animal studies, in some cases involving exposures to excess dietary salt for much of the animal's lifespan. The results of these studies demonstrate the presence of two distinct time courses of the blood pressure response to a high salt intake: an acute (rapid) blood pressure response occurring over days to weeks, and a slow and progressive blood pressure response that develops over extremely long periods of time, amounting to a significant fraction of the lifespan in normal individuals. The acute form of salt sensitivity is well known in humans, having often been demonstrated as a fall in blood pressure during the period of salt restriction. The slow and progressive form of salt sensitivity has been demonstrated directly in rats and chimpanzees and is also evident in analyses of human cross-population data as a salt dependency of age-associated changes of blood pressure. This slow and progressive component of salt-induced hypertension may be attributable, at least in part, to a progressive rise in the acute salt sensitivity of blood pressure during sustained exposure to high salt. However, a progressively irreversible or 'self sustaining' component of salt-induced hypertension has also been demonstrated in rat studies. This irreversible component has not been completely characterized, but its presence raises the possibility that blood pressure responses to salt restriction may not fully reveal the contribution of salt to blood pressure or the epidemiology of hypertension. These various components of salt sensitivity (acute vs slow, reversible vs irreversible) should be considered in any comprehensive explanation of the effects of salt on blood pressure and especially in experimental studies of the genetic and physiological mechanisms underlying salt-induced hypertension.

Integrity signals

Registry

Crossref · 10.1038/ijo.2008.205

Cites

107 of 107 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Chronically high dietary sodium may induce other, blood-pressure-independent effects, such as increasing myocardial, arterial, and renal fibrosis and dysfunction.

    “and also induce other, BP-independent effects, for example increasing myocardial, arterial, and renal fibrosis and dysfunction.29,30”

    From Global Sodium Consumption and Death from Cardiovascular Causes (2014) · cites this paper as [30]

Cites

Flagged first, then by citations

1 of the 108 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Van Vliet, B. N., & Montani, J.-P.
Affiliations
University of Fribourg (CH)
Venue
International Journal of Obesity
Publisher
Springer Science and Business Media LLC
Published
2008-12-01
Volume
32
Issue
S6
Pages
S35-S47
ISSN
  • 0307-0565 (ISSN-L)
  • 1476-5497
DOI
10.1038/ijo.2008.205
OpenAlex
W2066588394
Cited by
44
References
108
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 6 · 2013: 3 · 2012: 2
FWCI
0.12
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • International Journal of Obesity (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Health Canada
  • Canadian Institutes of Health Research
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Keywords
salt-induced hypertension, dietary salt, salt sensitivity, blood pressure response, salt restriction, hypertension epidemiology
MeSH terms
Adult, Age Factors, Aged, Animals, Blood Pressure, Chickens, Dogs, Female, Humans, Hypertension, Male, Middle Aged, Primates, Rabbits, Swine, Time Factors, Rats, Sprague-Dawley, Sodium Chloride, Dietary, Rats, Inbred Dahl, Mice, Rats, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review