A 3-year intervention with a Mediterranean diet modified the association between the rs9939609 gene variant in FTO and body weight changes
Abstract
Introduction The aim of this study was to analyze the effects of the rs9939609 (T/A) gene variant in fat mass and obesity-associated gene (FTO) on body weight changes after 3 years and its modification by a randomized nutritional intervention with a Mediterranean-style diet in a population of subjects at high cardiovascular risk.Design A substudy of PREDIMED, which is a randomized trial aimed at assessing the effect of the Mediterranean diet (MD) for primary cardiovascular disease prevention. There were three nutritional intervention groups: two of them with a Mediterranean-style diet and the third was a control group advised to follow a conventional low-fat diet.Subjects A total of 776 high cardiovascular risk subjects aged 55-80 years.Measurements Anthropometric measurements were recorded at baseline and at 3 years. The participants were genotyped by RT-PCR, followed by allelic discrimination.Results Homozygous subjects had the highest baseline body weight. The dominant model showed that subjects carrying the A allele had the lowest body weight gain (B=-0.685; P=0.022) after 3 years of nutritional intervention compared with nonmutated subjects (TT genotype) regardless of the nutritional intervention. Moreover, this effect was statistically significant in carriers of the A allele only among those allocated to the MD groups (B=-0.830; P=0.018), but it was not significant among those allocated to the control group (P for interaction=0.649).Conclusion This study confirmed the association between body weight and the FTO rs9939609 polymorphism. Interestingly, our results showed that, although at baseline the A allele was associated with higher body weight, after 3 years of nutritional intervention with a Mediterranean-style-diet, A-allele carriers had lower body weight gain than wild type subjects. No interaction between nutritional intervention and the polymorphism was found.
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The PREDIMED 14-point score identified 14 dietary components characterizing the MD and showed higher MD scores were linked to up to 30% lower cardiovascular event incidence.
“The latter identified 14 dietary components that best characterized the MD and demonstrated that higher MD scores were associated with up to 30% lower incidence of cardiovascular events (15,17).”
From Effect of an Internet-based, personalized nutrition randomized trial on dietary changes associated with the Mediterranean diet: the Food4Me Study (2016) · cites this paper as [15]
Cites
Frayling, T. M., Timpson, N. J., Weedon, M. N., Zeggini, E., Freathy, R. M., Lindgren, C. M., Perry, J. R. B., Elliott, K. S., Lango, H., Rayner, N. W., et al. (2007) · Science · doi:10.1126/science.1141634 · Cited by 4,531 · see citing works
Weight Loss with a Low-Carbohydrate, Mediterranean, or Low-Fat Diet
Shai, I., Schwarzfuchs, D., Henkin, Y., Shahar, D. R., Witkow, S., Greenberg, I., Golan, R., Fraser, D., Bolotin, A., Vardi, H., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0708681 · Cited by 2,143 · see citing works
Scuteri, A., Sanna, S., Chen, W.-M., Uda, M., Albai, G., Strait, J., Najjar, S., Nagaraja, R., Orrú, M., Usala, G., et al. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030115 · Cited by 1,724 · see citing works
Effects of a Mediterranean-Style Diet on Cardiovascular Risk Factors: A Randomized Trial
Estruch, R., Martínez-González, M. Á., Corella, D., Salas-Salvadó, J., Ruiz-Gutiérrez, V., Covas, M. I., Fiol, M., Gómez-Gracia, E., López-Sabater, M. C., Vinyoles, E., et al. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-145-1-200607040-00004 · Cited by 1,704 · see citing works
Development and Validation of a Food Frequency Questionnaire in Spain
Martin-Moreno, J. M., Boyle, P., Gorgojo, L., Maisonneuve, P., Fernandez‐Rodriguez, J. C., Salvini, S., & Willett, W. C. (1993) · International Journal of Epidemiology · doi:10.1093/ije/22.3.512 · Cited by 909 · see citing works
Hinney, A., Nguyen, T. T., Scherag, A., Friedel, S., Brönner, G., Müller, T. D., Grallert, H., Illig, T., Wichmann, H. ‐., Rief, W., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001361 · Cited by 510 · see citing works
Andreasen, C. H., Stender-Petersen, K. L., Mogensen, M. S., Torekov, S. S., Wegner, L., Andersen, G., Nielsen, A. L., Albrechtsen, A., Borch-Johnsen, K., Rasmussen, S. S., et al. (2008) · Diabetes · doi:10.2337/db07-0910 · Cited by 476 · see citing works
Effect of a Traditional Mediterranean Diet on Lipoprotein Oxidation: A Randomized Controlled Trial
Fitó, M., Guxens, M., Corella, D., Sáez, G., Estruch, R., de la Torre, R., Francés, F., Cabezas, C., López-Sabater, M. D. C., Marrugat, J., et al. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.11.1195 · Cited by 448 · see citing works
Schröder, H., Marrugat, J., Vila, J., Covas, M. I., & Elosua, R. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.12.3355 · Cited by 392 · see citing works
Evidence for Gene-Nutrient Interaction at the PPAR γ Locus
Luan, J., Browne, P. O., Harding, A.-H., Halsall, D. J., O’Rahilly, S., Chatterjee, K., & Wareham, N. J. (2001) · Diabetes · doi:10.2337/diabetes.50.3.686 · Cited by 362 · see citing works
Physical Activity and the Association of Common FTO Gene Variants With Body Mass Index and Obesity
Rampersaud, E., Mitchell, B. D., Pollin, T. I., Fu, M., Shen, H., O’Connell, J. R., Ducharme, J. L., Hines, S., Sack, P., Naglieri, R., et al. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.16.1791 · Cited by 299 · see citing works
Astrup, A. V., Ryan, L., Grunwald, G. K., Storgaard, M., Saris, W. H. M., Melanson, E., & Hill, J. O. (2000) · British Journal Of Nutrition · doi:10.1017/s0007114500000921 · Cited by 290 · see citing works
Adherence to a Mediterranean Diet Is Associated with Reduced 3-Year Incidence of Obesity
Méndez, M. A., Popkin, B. M., Jakszyn, P. G., Berenguer, A., Tormo, M. J., Sánchez, M., Quirós, J. R., Pera, G., Navarro, C., Martínez, C., et al. (2006) · Journal of Nutrition · doi:10.1093/jn/136.11.2934 · Cited by 239 · see citing works
Adherence to a Mediterranean dietary pattern and weight gain in a follow-up study: the SUN cohort
Sánchez-Villegas, A., Bes-Rastrollo, M., Martínez-González, M. A., & Serra-Majem, L. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803118 · Cited by 200 · see citing works
The FTO Gene Is Associated With Adulthood Obesity in the Mexican Population
Villalobos‐Comparán, M., Flores-Dorantes, M. T., Villarreal-Molina, M. T., Rodríguez‐Cruz, M., García-Ulloa, A. C., Robles, L., Huertas‐Vázquez, A., Saucedo‐Villarreal, N., López‐Alarcón, M., Sánchez‐Muñoz, F., et al. (2008) · Obesity · doi:10.1038/oby.2008.367 · Cited by 195 · see citing works
Traditional Mediterranean diet and longevity in the elderly: a review
Trichopoulou, A. (2004) · Public Health Nutrition · doi:10.1079/phn2004558 · Cited by 193 · see citing works
Zazpe, I., Sanchez-Tainta, A., Estruch, R., Lamuela-Raventos, R. M., Schröder, H., Salas-Salvado, J., Corella, D., Fiol, M., Gomez-Gracia, E., Aros, F., et al. (2008) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2008.04.011 · Cited by 193 · see citing works
Robitaille, J., Després, J., Përusse, L., & Vohl, M. (2003) · Clinical Genetics · doi:10.1034/j.1399-0004.2003.00026.x · Cited by 189 · see citing works
Hakanen, M., Raitakari, O. T., Lehtimäki, T. J., Peltonen, N., Pahkala, K., Sillanmäki, L. H., Lagström, H., Viikari, J. S. A., Simell, O., & Rönnemaa, T. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1199 · Cited by 183 · see citing works
Fat Mass–and Obesity-Associated (FTO) Gene Variant Is Associated With Obesity
Qi, L., Kang, K., Zhang, C., van Dam, R. M., Kraft, P. L., Hunter, D., Lee, C., & Hu, F. B. (2008) · Diabetes · doi:10.2337/db08-0006 · Cited by 147 · see citing works
Sánchez-Taínta, A., Estruch, R., Bulló, M., Corella, D., Gómez-Gracia, E., Fiol, M., Algorta, J., Covas, M.-I., Lapetra, J., Zazpe, I., et al. (2008) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e328308ba61 · Cited by 144 · see citing works
Self-citationJacobsson, J. A., Danielsson, P., Svensson, V., Kloviņš, J., Gyllensten, U. B., Marcus, C., Schiöth, H. B., & Fredriksson, R. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.01.087 · Cited by 124 · see citing works
Müller, T. D., Hinney, A., Scherag, A., Nguyen, T. T., Schreiner, F., Schäfer, H., Hebebrand, J., Roth, C. L., & Reinehr, T. (2008) · BMC Medical Genetics · doi:10.1186/1471-2350-9-85 · Cited by 109 · see citing works
Lappalainen, T., Tolppanen, A., Kolehmainen, M., Schwab, U., Lindström, J., Tuomilehto, J. O., Pulkkinen, L., Eriksson, J. G., Laakso, M., Gylling, H., et al. (2009) · Obesity · doi:10.1038/oby.2008.618 · Cited by 108 · see citing works
Franks, P. W., Jablonski, K. A., Delahanty, L. M., McAteer, J. B., Kahn, S. E., Knowler, W. C., & Florez, J. C. (2008) · Diabetologia · doi:10.1007/s00125-008-1158-x · Cited by 106 · see citing works
Martínez, J. A., Corbalán, M. S., Forga, L., Martí, A., Sánchez‐Villegas, A., & Martínez‐González, M. Á. (2003) · Journal of Nutrition · doi:10.1093/jn/133.8.2549 · Cited by 98 · see citing works
FTO Polymorphisms Are Associated With Obesity but Not Diabetes Risk in Postmenopausal Women
Song, Y., You, N., Hsu, Y., Howard, B. V., Langer, R. D., Manson, J. E., Nathan, L., Niu, T., Tinker, L. F., & Liu, S. (2008) · Obesity · doi:10.1038/oby.2008.408 · Cited by 82 · see citing works
Grau, K., Hansen, T. F., Holst, J. J., Astrup, A. V., Saris, W. H. M., Arner, P., Rössner, S., Macdonald, I. A., Polak, J., Oppert, J., et al. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.159 · Cited by 70 · see citing works
Cornes, B. K., Lind, P. A., Medland, S. E., Montgomery, G. W., Nyholt, D. R., & Martin, N. G. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.223 · Cited by 60 · see citing works
Variant rs9939609 in the FTO gene is associated with obesity in an adult population from Spain
González‐Sánchez, J. L., Aben, K. K. H., Martínez‐Larrad, M. T., Martínez-Calatrava, M. J., Pérez‐Barba, M., & Serrano‐Ríos, M. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03335.x · Cited by 52 · see citing works
Aggravating effect of INSIG2 and FTO on overweight reduction in a one-year lifestyle intervention
Reinehr, T., Hinney, A., Toschke, A. M., & Hebebrand, J. (2009) · Archives of Disease in Childhood · doi:10.1136/adc.2008.147652 · Cited by 43 · see citing works
Goyenechea, E., Parra, D., Crujeiras, A. B., Abete, I., & Martínez, J. A. (2009) · Annals of Nutrition and Metabolism · doi:10.1159/000205319 · Cited by 42 · see citing works
Razquín, C., Martínez, J. A., Martínez‐González, M. Á., Corella, D., Santos‐Lozano, J. M., & Martí, A. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509289008 · Cited by 41 · see citing works
Goossens, G. H., Petersen, L. V., Blaak, E. E., Hul, G. B. J., Arner, P., Astrup, A. V., Froguel, P., Patel, K., Pedersen, O. B., Polak, J., et al. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.59 · Cited by 39 · see citing works
Rosado, E. L., Bressan, J., Hernández, J. A. M., Martins, M. F., & Cecon, P. R. (2006) · PubMed · Cited by 20 · see citing works
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Cohort Profile: Design and methods of the PREDIMED study
Martinez-Gonzalez, M. A., Corella, D., Salas-Salvado, J., Ros, E., Covas, M. I., Fiol, M., Warnberg, J., Aros, F., Ruiz-Gutierrez, V., Lamuela-Raventos, R. M., et al. (2012) · International Journal of Epidemiology · doi:10.1093/ije/dyq250 · Cited by 671 · see citing works
Reduction in saturated fat intake for cardiovascular disease.
Hooper, L., Martin, N., Jimoh, O., Kirk, C., Foster, E., & Abdelhamid, A. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011737.pub3 · Cited by 42 · see citing works
Genetics of Obesity: What have we Learned?
Choquet, H., & Meyre, D. (2011) · Current Genomics · doi:10.2174/138920211795677895 · Cited by 238 · see citing works
Benefits of the Mediterranean diet: Epidemiological and molecular aspects
Serra‐Majem, L., Román‐Viñas, B., Sánchez‐Villegas, A., Guasch‐Ferré, M., Corella, D., & Vecchia, C. L. (2019) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2019.06.001 · Cited by 240 · see citing works
Reduction in saturated fat intake for cardiovascular disease
Hooper, L., Martin, N., Jimoh, O. F., Kirk, C., Foster, E., & Abdelhamid, A. S. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011737.pub2 · Cited by 228 · see citing works
The importance of gene–environment interactions in human obesity
Reddon, H., Guéant, J., & Meyre, D. (2016) · Clinical Science · doi:10.1042/cs20160221 · Cited by 198 · see citing works
Reduction in saturated fat intake for cardiovascular disease
Hooper, L., Martin, N., Abdelhamid, A., & Davey Smith, G. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011737 · Cited by 704 · see citing works
Phillips, C. M., Kesse‐Guyot, E., McManus, R., Herçberg, S., Lairon, D., Planells, R., & Roche, H. M. (2012) · Journal of Nutrition · doi:10.3945/jn.111.153460 · Cited by 168 · see citing works
Zhang, X., Qi, Q., Zhang, C., Smith, S. R., Hu, F. B., Sacks, F. M., Bray, G. A., & Qi, L. (2012) · Diabetes · doi:10.2337/db11-1799 · Cited by 163 · see citing works
Livingstone, K. M., Celis-Morales, C. A., Papandonatos, G. D., Erar, B., Florez, J. C., Jablonski, K. A., Razquín, C., Martí, A., Heianza, Y., Huang, T., et al. (2016) · BMJ · doi:10.1136/bmj.i4707 · Cited by 141 · see citing works
Lifestyle and Genetics in Obesity and type 2 Diabetes
Temelkova-Kurktschiev, T. S., & Stefanov, T. (2011) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0031-1285832 · Cited by 121 · see citing works
Livingstone, K. M., Celis-Morales, C., Navas-Carretero, S., San-Cristobal, R., Macready, A. L., Fallaize, R., Forster, H., Woolhead, C., O’Donovan, C. B., Marsaux, C. F., et al. (2016) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.129049 · Cited by 115 · see citing works
Evidences on three relevant obesogenes: MC4R , FTO and PPAR γ. Approaches for personalized nutrition
Razquín, C., Martí, A., & Martínez, J. A. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000445 · Cited by 109 · see citing works
Xiang, L., Wu, H., Pan, A., Patel, B., Xiang, G., Qi, L., Kaplan, R. C., Hu, F. B., Wylie‐Rosett, J., & Qi, Q. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.123448 · Cited by 109 · see citing works
Moleres, A., Ochoa, M. C., Rendo‐Urteaga, T., Martínez‐González, M. Á., Azcona, C., Martínez, J. A., & Martí, A. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511003424 · Cited by 89 · see citing works
Corella, D., Ortega‐Azorín, C., Sorlí, J. V., Covas, M., Carrasco, P., Salas‐Salvadó, J., Martínez‐González, M. Á., Arós, F., Lapetra, J., Serra‐Majem, L., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052344 · Cited by 80 · see citing works
The genetics of childhood obesity and interaction with dietary macronutrients
Garver, W. S., Newman, S. B., Gonzales‐Pacheco, D., Castillo, J., Jelínek, D., Heidenreich, R. A., & Orlando, R. A. (2013) · Genes & Nutrition · doi:10.1007/s12263-013-0339-5 · Cited by 71 · see citing works
Rukh, G., Sonestedt, E., Melander, O., Hedblad, B., Wirfält, E., Ericson, U., & Orho‐Melander, M. (2013) · Genes & Nutrition · doi:10.1007/s12263-013-0352-8 · Cited by 67 · see citing works
Lappalainen, T., Lindström, J., Paananen, J., Eriksson, J. G., Karhunen, L. J., Tuomilehto, J. O., & Uusitupa, M. I. J. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114511007410 · Cited by 65 · see citing works
Dietary Fatty Acid Composition Modulates Obesity and Interacts with Obesity‐Related Genes
Hammad, S. S., & Jones, P. J. H. (2017) · Lipids · doi:10.1007/s11745-017-4291-9 · Cited by 65 · see citing works
Fenwick, P. H., Jeejeebhoy, K. N., Dhaliwal, R., Royall, D., Brauer, P. M., Tremblay, A., Klein, D., & Mutch, D. M. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1437022 · Cited by 64 · see citing works
Rouskas, K., Kouvatsi, A., Paletas, K., Papazoglou, D., Τσάπας, Α., Lobbens, S., Vatin, V., Durand, E., Labrune, Y., Delplanque, J., et al. (2011) · Obesity · doi:10.1038/oby.2011.177 · Cited by 64 · see citing works
Genetic risk sum score comprised of common polygenic variation is associated with body mass index
Peterson, R. E., MAES, H. H. M., Holmans, P., Sanders, A. R., Levinson, D. F., Shi, J., Kendler, K. S., Gejman, P. V., & Webb, B. T. (2010) · Human Genetics · doi:10.1007/s00439-010-0917-1 · Cited by 63 · see citing works
Roswall, N., Ängquist, L. H., Ahluwalia, T. S., Romaguera, D., Larsen, S. C., Østergaard, J. N., Halkjær, J., Vimaleswaran, K. S., Wareham, N. J., Bendinelli, B., et al. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.089706 · Cited by 61 · see citing works
di Renzo, L., Cioccoloni, G., Falcó, S., Abenavoli, L., Moia, A., Sinibaldi-Salimei, P., & Lorenzo, A. D. (2018) · Journal of Translational Medicine · doi:10.1186/s12967-018-1680-7 · Cited by 52 · see citing works
Hosseini‐Esfahani, F., Koochakpoor, G., DANESHPOUR, M. S., Sedaghati-khayat, B., Mirmiran, P., & Azizi, F. (2017) · Nutrients · doi:10.3390/nu9101064 · Cited by 50 · see citing works
Gene-nutrient interactions and susceptibility to human obesity
Castillo, J., Orlando, R. A., & Garver, W. S. (2017) · Genes & Nutrition · doi:10.1186/s12263-017-0581-3 · Cited by 47 · see citing works
Pepe, R. B., Lottenberg, A. M., Fujiwara, C. T. H., Beyruti, M., Cintra, D. E., Machado, R. M., Rodrigues, A., Jensen, N. S. O., Caldas, A. P. S., Fernandes, A. E., et al. (2023) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-023-01037-6 · Cited by 65 · see citing works
de Luis, D. A., Aller, R., Izaola, O., de la Fuente, B., Conde, R., Sagrado, M. G., & Primo, D. (2012) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2323 · Cited by 45 · see citing works
Vimaleswaran, K. S., Ängquist, L. H., Hansen, R. D., van der A, D. L., Bouatia‐Naji, N., Holst, C., Tjønneland, A. M., Overvad, K., Jakobsen, M. U., Boeing, H., et al. (2012) · Obesity · doi:10.1038/oby.2012.49 · Cited by 44 · see citing works
Łuczyński, W., Zalewski, G., & Bossowski, A. T. (2012) · PubMed · Cited by 41 · see citing works
Fat brains, greedy genes, and parent power: A biobehavioural risk model of child and adult obesity
Carnell, S., Kim, Y., & Pryor, K. P. (2012) · International Review of Psychiatry · doi:10.3109/09540261.2012.676988 · Cited by 40 · see citing works
Rezazadeh, K., Rahmati‐Yamchi, M., Mohammadnejad, L., Ebrahimi‐Mameghani, M., & Delazar, A. (2017) · Phytotherapy Research · doi:10.1002/ptr.5951 · Cited by 39 · see citing works
Dietary Patterns, Genes, and Health: Challenges and Obstacles to be Overcome
Wood, A. C. (2014) · Current Nutrition Reports · doi:10.1007/s13668-014-0110-6 · Cited by 37 · see citing works
San-Cristóbal, R., Navas‐Carretero, S., Livingstone, K. M., Celis-Morales, C. A., Macready, A. L., Fallaize, R., O’Donovan, C. B., Lambrinou, C. P., Moschonis, G., Marsaux, C. F. M., et al. (2017) · Nutrients · doi:10.3390/nu9101107 · Cited by 38 · see citing works
Association of the FTO and ADRB2 genes with body composition and fat distribution in obese women
Rauhio, A., Uusi‐Rasi, K., Nikkari, S. T., Kannus, P., Sievänen, H. T., & Kunnas, T. A. (2013) · Maturitas · doi:10.1016/j.maturitas.2013.07.004 · Cited by 37 · see citing works
de Luis, D. A., Aller, R., Izaola, O., Primo, D., Urdiales, S., & Romero, E. (2015) · Lifestyle Genomics · doi:10.1159/000441142 · Cited by 33 · see citing works
Kalantari, N., Doaei, S., Keshavarz-Mohammadi, N., Gholamalizadeh, M., & Pazan, N. (2016) · Europe PMC (PubMed Central) · Cited by 33 · see citing works
Lauria, F., Siani, A., Bammann, K., Foraita, R., Huybrechts, I., Iacoviello, L., Koni, A. C., Kourides, Y., Mårild, S., Molnár, D., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048876 · Cited by 33 · see citing works
Polymorphism in the CLOCK gene may influence the effect of fat intake reduction on weight loss
Loria‐Kohen, V., Espinosa‐Salinas, I., Marcos-Pasero, H., Lourenço-Nogueira, T., Herránz, J., Molina, S., Reglero, G., & de Molina, A. R. (2015) · Nutrition · doi:10.1016/j.nut.2015.10.013 · Cited by 31 · see citing works
de Luis, D. A., Aller, R., Conde, R., Izaola, O., Sagrado, M. G., & Castrodeza, J. (2013) · Journal of Investigative Medicine · doi:10.2310/jim.0b013e318276161d · Cited by 30 · see citing works
Dietary Patterns and Their Associations With the FTO and FGF21 Gene Variants Among Emirati Adults
Naja, F., Itani, L., Hammoudeh, S. M., Manzoor, S., Abbas, N., Radwan, H. M., & Saber-Ayad, M. M. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.668901 · Cited by 30 · see citing works
Livingstone, K. M., Celis-Morales, C. A., Navas‐Carretero, S., San-Cristóbal, R., Forster, H., O’Donovan, C. B., Woolhead, C., Marsaux, C. F. M., Macready, A. L., Fallaize, R., et al. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515004675 · Cited by 29 · see citing works
Razquín, C., Martínez, J. A., Martínez‐González, M. Á., Salas‐Salvadó, J., Estruch, R., & Martí, A. (2009) · European Journal of Nutrition · doi:10.1007/s00394-009-0090-2 · Cited by 29 · see citing works
Nutrigenetic variants and response to diet/lifestyle intervention in obese subjects: a pilot study
Franzago, M., Nicola, M. D., Fraticelli, F., Marchioni, M., Stuppia, L., & Vitacolonna, E. (2021) · Acta Diabetologica · doi:10.1007/s00592-021-01787-7 · Cited by 28 · see citing works
Hosseini‐Esfahani, F., Koochakpoor, G., DANESHPOUR, M. S., Mirmiran, P., Sedaghati-khayat, B., & Azizi, F. (2017) · Scientific Reports · doi:10.1038/s41598-017-18386-8 · Cited by 28 · see citing works
RNAs and RNA-Binding Proteins in Immuno-Metabolic Homeostasis and Diseases
Salem, E., Vonberg, A. D., Borra, V. J., Gill, R. K., & Nakamura, T. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00106 · Cited by 26 · see citing works
Nutrigenetics and nutrigenomics—A personalized approach to nutrition
Ahluwalia, M. K. (2021) · Advances in genetics · doi:10.1016/bs.adgen.2021.08.005 · Cited by 26 · see citing works
Nutritional genomics, inflammation and obesity
Corrêa, T. A. F., Quintanilha, B. J., Norde, M. M., Pinhel, M. A. D. S., Nonino, C. B., & Rogero, M. M. (2020) · Archives of Endocrinology and Metabolism · doi:10.20945/2359-3997000000255 · Cited by 30 · see citing works
Tuncay, C., & Ergören, M. Ç. (2020) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2020.04.005 · Cited by 26 · see citing works
The association between FTO genotype with macronutrients and calorie intake in overweight adults
Mehrdad, M., Doaei, S., Gholamalizadeh, M., & Eftekhari, M. H. (2020) · Lipids in Health and Disease · doi:10.1186/s12944-020-01372-x · Cited by 28 · see citing works
Pokushalov, E., Ponomarenko, A., Garcia, C., Алексеевна, П. И., Shrainer, E., Seryakova, M., Johnson, M., & Miller, R. D. (2024) · Nutrients · doi:10.3390/nu16040557 · Cited by 25 · see citing works
Seral-Cortés, M., Larruy‐García, A., Miguel‐Etayo, P. D., Labayen, I., & Moreno, L. A. (2022) · Genes · doi:10.3390/genes13030420 · Cited by 25 · see citing works
Tan, P. Y., Moore, J. B., Bai, L., Tang, G., & Gong, Y. Y. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2131727 · Cited by 24 · see citing works
de Luis, D. A., Aller, R., Conde, R., Izaola, O., Pacheco, D., Sagrado, M. G., & Primo, D. (2012) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-012-1829-2 · Cited by 24 · see citing works
Moleres, A., Martínez, J. A., & Martí, A. (2012) · Current Obesity Reports · doi:10.1007/s13679-012-0036-5 · Cited by 19 · see citing works
Loss‐of‐Function Mutations in MC4R Are Very Rare in the Greek Severely Obese Adult Population
Rouskas, K., Meyre, D., Stutzmann, F., Paletas, K., Papazoglou, D., Vatin, V., Marchand, M., Kouvatsi, A., & Froguel, P. (2012) · Obesity · doi:10.1038/oby.2012.77 · Cited by 19 · see citing works
de Luis, D. A., Aller, R., Izaola, O., & Pacheco, D. (2015) · PubMed · doi:10.3305/nh.2015.32.1.9169 · Cited by 18 · see citing works
The effect of rs9939609 FTO gene polymorphism on weight loss after laparoscopic sleeve gastrectomy
Balasar, Ö., Çakır, T., Erkal, Ö., Aslaner, A., Çekiç, B., Uyar, M., Bülbüller, N., & Oruç, M. T. (2015) · Surgical Endoscopy · doi:10.1007/s00464-015-4169-y · Cited by 18 · see citing works
Halima, M. B., Kallel, A., Baara, A., Wafi, S. B., Sanhagi, H., Slimane, H., Jemaa, R., & Feki, M. (2018) · Biomarkers · doi:10.1080/1354750x.2018.1499129 · Cited by 15 · see citing works
Rola genu podatności na otyłość (FTO) w rozwoju otyłości — przegląd
Zdrojowy-Wełna, A., Tupikowska, M., Kolačkov, K., & Bednarek-Tupikowska, G. (2014) · Endokrynologia Polska · doi:10.5603/ep.2014.0031 · Cited by 15 · see citing works
Ursu, R. I., Badiu, C., Cucu, N., Ursu, G. F., Craciunescu, I., & Severin, E. (2015) · Europe PMC (PubMed Central) · Cited by 15 · see citing works
Effects of Gene-Environment Interaction on Obesity among Chinese Adults Born in the Early 1960s
Gong, W., Li, H., Song, C., Fan, Y., Ma, Y., Chen, Z., Wang, R., Fang, H., & Liu, A. (2021) · Genes · doi:10.3390/genes12020270 · Cited by 15 · see citing works
Zheng, J., Wang, F., Guo, H. Z., Cheng, J., Du, J. C., & Kan, J. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.985723 · Cited by 14 · see citing works
Livingstone, K. M., Brayner, B., Celis-Morales, C. A., Ward, J., Mathers, J. C., & Bowe, S. J. (2022) · Preventive Medicine · doi:10.1016/j.ypmed.2022.107035 · Cited by 13 · see citing works
Livingstone, K. M., Brayner, B., Celis-Morales, C. A., Moschonis, G., Μanios, Y., Traczyk, I., Drevon, C. A., Daniel, H., Saris, W. H. M., Lovegrove, J. A., et al. (2022) · European Journal of Nutrition · doi:10.1007/s00394-022-02858-3 · Cited by 13 · see citing works
Rahimi, R., & Symonds, M. E. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2024.2382346 · Cited by 12 · see citing works
Dietary Fatty Acids and the Metabolic Syndrome: A Personalized Nutrition Approach
O'Connor, S. E., & Rudkowska, I. (2018) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2018.07.004 · Cited by 11 · see citing works
Dubnov‐Raz, G., & Berry, E. M. (2010) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20210 · Cited by 11 · see citing works
Nutritional Genetics and Energy Metabolism in Human Obesity
Conn, C. A., Vaughan, R. A., & Garver, W. S. (2013) · Current Nutrition Reports · doi:10.1007/s13668-013-0046-2 · Cited by 9 · see citing works
Chmielewska, A., & Regulska−Ilow, B. (2017) · PubMed · Cited by 8 · see citing works
Rezazadeh, K., Jafarabadi, M. A., & Ebrahimi-Mameghani, M. (2018) · Advances in Integrative Medicine · doi:10.1016/j.aimed.2018.08.006 · Cited by 8 · see citing works
Dietary diversity modifies the association between FTO polymorphisms and obesity phenotypes
Goodarzi, G., Hosseini‐Esfahani, F., Ataie‐Jafari, A., Haji-Hosseini-Gazestani, N., DANESHPOUR, M. S., Keshavarz, S. A., & Mirmiran, P. (2021) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2021.1890698 · Cited by 8 · see citing works
Transgenic Mouse Models Resistant to Diet-Induced Metabolic Disease: Is Energy Balance the Key?
Gilliam, L. A. A., & Neufer, P. D. (2012) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.192146 · Cited by 8 · see citing works
Nguyen, T., Irwin, M. L., DeWan, A. T., Cartmel, B., Harrigan, M., Ferrucci, L. M., Sanft, T. B., Li, F., Lu, L., & Salinas, Y. D. (2021) · Breast Cancer Research and Treatment · doi:10.1007/s10549-021-06151-5 · Cited by 7 · see citing works
Cho, A., Hong, K., Kwon, Y., Choi, J., Lee, H. S., Kim, H.-M., Bae, S. J., Ahn, S. G., Jeong, J., & Lee, J. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.882717 · Cited by 6 · see citing works
de Luis, D. A., Izaola, O., Primo, D., Gómez, J. J. L., & Pacheco, D. (2022) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2022.10.035 · Cited by 6 · see citing works
Gene–Diet Interactions and Obesity Indices
Papoutsakis, C. (2012) · Current Nutrition Reports · doi:10.1007/s13668-012-0019-x · Cited by 5 · see citing works
Trevisano, R. G., Gregnani, M. F., de Azevedo, B. C., & de Almeida, S. S. (2022) · Current Aging Science · doi:10.2174/1874609815666220331090135 · Cited by 4 · see citing works
Kim, M., Lee, S., Cho, E., Hong, K., You, S.-J., & Choi, H. J. (2023) · Scientific Reports · doi:10.1038/s41598-023-48823-w · Cited by 4 · see citing works
de la Garza, A. L., & Zonenszain-Laiter, Y. (2022) · Acta bioethica · doi:10.4067/s1726-569x2022000200215 · Cited by 3 · see citing works
Effects of Mediterranean Diet on the Metabolome
Martinez, J. A., Keun, H., & Siskos, A. P. (2016) · Springer eBooks · doi:10.1007/978-3-319-27969-5_10 · Cited by 3 · see citing works
Detopoulou, P., Antonopoulou, S., Douvogianni, P., & Demopoulos, C. A. (2026) · Nutrients · doi:10.3390/nu18091320 · Cited by 2 · see citing works
The Mediterranean Diet and Obesity from a Nutrigenetic and Epigenetics Perspective
Garaulet, M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407849-9.00022-1 · Cited by 2 · see citing works
FTO rs9939609 Gene Polymorphism and Obesity: Lack of Association in Kidney Transplantation
Piancatelli, D., Maccarone, D., Sebastiani, P., Colanardi, A., Iesari, S., Clemente, K., Lai, Q., & Pisani, F. (2018) · Transplantation Proceedings · doi:10.1016/j.transproceed.2018.04.080 · Cited by 2 · see citing works
Sotos, M. (2012) · InTech eBooks · doi:10.5772/31656
Ziemann, F., Moraes, G. G., Barbian, C. D., Borfe, L., Klinger, E. I., Reuter, C. P., Valim, A. R. D. M., & Burgos, M. S. (2016) · Cinergis · doi:10.17058/cinergis.v17i4.8153
Huggins, G. S., Berger, S. E., & McCaffery, J. M. (2015) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-015-0464-3 · Cited by 1 · see citing works
Genetic Variations With Influence on the Individualized Response to Weight Loss Diets
de Luis, D. A., Aller, R., Izaola, O., & Martínez, J. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-804572-5.00023-9 · Cited by 1 · see citing works
Pasanisi, F., Santarpia, L., & Finelli, C. (2015) · Springer eBooks · doi:10.1007/978-3-319-24532-4_2 · Cited by 1 · see citing works
Nutrition and weight loss apps
Weech, M., Fallaize, R., Kelly, E. F. A., Hwang, F., Franco, R. Z., & Lovegrove, J. A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-99271-8.00006-1 · Cited by 1 · see citing works
Hosseini‐Esfahani, F., Rezaei, M., Koochakpoor, G., DANESHPOUR, M. S., Mirmiran, P., & Azizi, F. (2023) · BMC Research Notes · doi:10.1186/s13104-023-06463-3 · Cited by 1 · see citing works
Obesity: Underlying Mechanisms and the Evolving Influence of Diet
Larsen, L. H. (2012) · Current Nutrition Reports · doi:10.1007/s13668-012-0028-9 · Cited by 1 · see citing works
Gene‐Diet Interaction and Weight Management
Qi, L. (2015) · Wiley eBooks · doi:10.1002/9781118930458.ch4
Dietary Management and Genetic Predisposition
Jensen, H. H., & Larsen, L. H. (2013) · Current Nutrition Reports · doi:10.1007/s13668-013-0050-6
Respuesta a la dieta en función del genotipo: hacia una nutriciónpersonalizada en el obeso
Goyenechea, E., Abete, I., Martínez‐Urbistondo, D., & Martínez, J. A. (2010) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/s0214-9168(10)70026-7
Pretorius, J. (2012) · SUNScholar (Stellenbosch University)
Gene–Diet Interaction on Body Weight Maintenance
Li, K., Huang, T., & Li, D. (2015) · Current Nutrition Reports · doi:10.1007/s13668-015-0133-7
- Authors
- Razquin, C., Martinez, J. A., Martinez-Gonzalez, M. A., Bes-Rastrollo, M., Fernández-Crehuet, J., & Marti, A.
- Venue
- International Journal of Obesity
- Published
- 2009-11-17
- Volume
- 34
- Issue
- 2
- Pages
- 266-272
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- OpenAlex
- W2127740924
- Cited by
- 109
- References
- 35
- Citations by year
- 2026: 3 · 2024: 3 · 2023: 5 · 2022: 10 · 2021: 6 · 2020: 7 · 2019: 3 · 2018: 6 · 2017: 8 · 2016: 7 · 2015: 11 · 2014: 5 · 2013: 6 · 2012: 19
- FWCI
- 5.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- International Journal of Obesity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- FTO, rs9939609 polymorphism, Mediterranean diet, weight gain, genetic susceptibility, dietary intervention, cardiovascular risk, PREDIMED trial, gene-diet interaction
- MeSH terms
- Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Aged, Aged, 80 and over, Body Weight, Cardiovascular Diseases, Female, Genotype, Humans, Male, Middle Aged, Obesity, Proteins, Time Factors, Genetic Variation, Weight Gain, Body Mass Index, Treatment Outcome, Diet, Fat-Restricted, Diet, Mediterranean
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