Type I iodothyronine 5′-deiodinase mRNA and activity is increased in adipose tissue of obese subjects
Abstract
Differentiation and metabolism of adipose tissue are modulated by thyroid hormones (THs), but relatively little is known about the metabolism of THs in this tissue. Expression of the genes for type I iodothyronine 5'-deiodinase (D1), leptin (LEP) and stearoyl-CoA desaturase 1 (SCD-1) was evaluated in omental (OM) and subcutaneous (SC) fat using a cohort of 70 humans. Activities of iodothyronine deiodinases (D1, D2 and D3) were assessed in a randomly selected subpopulation of 19 subjects. D1 expression was upregulated in both OM (P=0.011) and SC (P=0.003) fat of obese subjects. Concomitantly, OM (P=0.002) and SC (P=0.028) LEP expression were increased in obesity, associated with both D1 mRNA (r=0.315, P=0.014) and activity (r=0.647, P=0.023) and inversely related to SCD-1 (r=-0.266, P=0.034) expression in SC fat. Also D1 (but not D2 and D3) activity was increased in OM (∼fourfold, P=0.010) and SC (∼eightfold, P=0.004) fat of obese when compared with non-obese subjects and correlated in both OM (r=0.528, P=0.036) and SC (r=0.749, P=0.005) fat with body mass index. Our results document increased D1 gene expression and activity in adipose tissue of obese humans and suggest a role of 3,5,3'-triiodo-L-thyronine formed by D1 in response to leptin in the modulation of adipose tissue metabolism.
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Brown adipocytes are differentiated from white adipocytes because of their high expression of type 2 iodothyronine deiodinase (DIO2), the transcription coregulators PRDM16 and PGC-1α, and the lipolytic regulator Cidea.
“Brown adipocytes are also differentiated from white adipocytes because of their high expression of type 2 iodothyronnine deiodinase (DIO2), the transcription coregulators, PRDM16 and PGC-1α, and the lipolytic regulator, Cidea ([52](#B52), [131](#B131)).”
From Mitochondrial fatty acid oxidation in obesity (2013) · cites this paper as [131]
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- Authors
- Ortega, F. J., Jílková, Z. M., Moreno-Navarrete, J. M., Pavelka, S., Rodriguez-Hermosa, J. I., Kopeckỳ, J., & Fernández-Real, J. M.
- Affiliations
- Instituto de Salud Carlos III (ES)
- Czech Academy of Sciences (CZ)
- Masaryk University (CZ)
- Venue
- International Journal of Obesity
- Published
- 2011-05-24
- Volume
- 36
- Issue
- 2
- Pages
- 320-324
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- OpenAlex
- W1978669563
- Cited by
- 80
- References
- 20
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 9 · 2023: 6 · 2022: 7 · 2021: 6 · 2020: 10 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 4 · 2012: 5
- FWCI
- 3.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- International Journal of Obesity (publishedVersion)
- PubMed (publishedVersion)
- ASEP (submittedVersion, public-domain)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- thyroid hormone metabolism, obesity, adipose tissue, omental fat, subcutaneous adipose tissue, leptin, stearoyl-CoA desaturase 1, triiodothyronine, body mass index, gene expression
- MeSH terms
- Cell Differentiation, Cross-Sectional Studies, Female, Humans, Iodide Peroxidase, Male, Obesity, RNA, Messenger, Transcription Factors, Cohort Studies, Down-Regulation, Gene Expression Regulation, Enzymologic, Body Mass Index, Polymerase Chain Reaction, Leptin, Thyroid Hormone Receptors alpha, Adipose Tissue, White
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