Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation

Liu, Yan-Yun; Brent, Gregory A.

doi:10.1016/j.tem.2009.11.004

Cited by 218Thyroid Disorders and TreatmentsPeroxisome Proliferator-Activated ReceptorsCholesterol and Lipid Metabolism

Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation

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Liu, Yan-Yun, Brent, Gregory A.·2010·Trends in Endocrinology & Metabolism

DOI 10.1016/j.tem.2009.11.004PMC PMC2831161

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Abstract

Thyroid hormone influences diverse metabolic pathways important in lipid and glucose metabolism, lipolysis and regulation of body weight. Recently, it has been recognized that thyroid hormone receptor interacts with transcription factors that predominantly respond to nutrient signals including the peroxisome proliferator-activated receptors, liver X receptor and others. Crosstalk between thyroid hormone signaling and these nutrient responsive factors occurs through a variety of mechanisms: competition for retinoid X receptor heterodimer partners, DNA binding sites and transcriptional cofactors. This review focuses on the mechanisms of interaction of thyroid hormone signaling with other metabolic pathways and the importance of understanding these interactions to develop therapeutic agents for treatment of metabolic disorders, such as dyslipidemias, obesity and diabetes.

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Thyroid hormones are major energy expenditure hormones.
“Thus, thyroid hormones are major energy expenditure hormones.”
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Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex
Zamir, I., Dawson, J., Lavinsky, R. M., Glass, C. K., Rosenfeld, M. G., & Lazar, M. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14400 · Cited by 135 · see citing works

Authors: Liu, Y.-Y., & Brent, G. A.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Brent, Gregory A.
ORCID: Liu, Yan-Yun
Brent, Gregory A.
Venue: Trends in Endocrinology & Metabolism
Publisher: Elsevier BV
Published: 2010-03
Volume: 21
Issue: 3
Pages: 166-173
ISSN: 1043-2760 (ISSN-L)
DOI: 10.1016/j.tem.2009.11.004
PMC: PMC2831161
OpenAlex: W1982111232
Cited by: 218
References: 78
Citations by year: 2026: 7 · 2025: 12 · 2024: 18 · 2023: 15 · 2022: 14 · 2021: 19 · 2020: 11 · 2019: 14 · 2018: 18 · 2017: 12 · 2016: 9 · 2015: 16 · 2014: 16 · 2013: 12 · 2012: 10
FWCI: 1.09
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK67233, R01DK067233, R01DK098576)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Keywords: thyroid hormone signaling, thyroid hormone receptor, peroxisome proliferator-activated receptors, liver X receptor, lipid metabolism, glucose metabolism, lipolysis, body weight regulation, dyslipidemia, obesity, diabetes mellitus, metabolic disorders
MeSH terms: Animals, Humans, Metabolic Diseases, Models, Biological, Receptors, Thyroid Hormone, Thyroid Hormones, Transcription Factors, Signal Transduction

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Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation

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