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Cited by 243Gestational Diabetes Research and ManagementBirth, Development, and HealthPregnancy and preeclampsia studies

The DOI matches its Crossref record; 79 of the 80 references it cites were found in a registry or an index.

Maternal obesity and metabolic risk to the offspring: why lifestyle interventions may have not achieved the desired outcomes

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Catalano, P, deMouzon, S H·2015·International Journal of Obesity
DOI 10.1038/ijo.2015.15PMC PMC4700513
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Abstract

Obesity during pregnancy is associated with an increased risk of short- and long-term metabolic dysfunction in the mother and her offspring. Both higher maternal pregravid body mass index (kg m(-2)) and excessive gestational weight gain (GWG) have been associated with adverse pregnancy outcomes such as gestational diabetes, preeclampsia and fetal adiposity. Multiple lifestyle intervention trials consisting of weight management using various diets, increased physical activity and behavioral modification techniques have been employed to avoid excessive GWG and improve perinatal outcomes. These randomized controlled trials (RCTs) have achieved modest success in decreasing excessive GWG, although the decrease in GWG was often not within the current Institute of Medicine guidelines. RCTs have generally not had any success with decreasing the risk of maternal gestational diabetes (GDM), preeclampsia or excessive fetal growth often referred to as macrosomia. Although the lack of success for these trials has been attributed to lack of statistical power and poor compliance with study protocols, our own research suggests that maternal pregravid and early pregnancy metabolic condition programs early placenta function and gene expression. These alterations in maternal/placental function occur in the first trimester of pregnancy prior to when most intervention trials are initiated. For example, maternal accrural of adipose tissue relies on prior activation of genes controlling lipogenesis and low-grade inflammation in early pregnancy. These metabolic alterations occur prior to any changes in maternal phenotype. Therefore, trials of lifestyle interventions before pregnancy are needed to demonstrate the safety and efficacy for both the mother and her offspring.

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Metadata

Authors
Catalano, P., & deMouzon, S. H.
Affiliations
MetroHealth Medical Center (US)
Corresponding author
Catalano, P
ORCID
Catalano, P
Venue
International Journal of Obesity
Publisher
Springer Science and Business Media LLC
Published
2015-02-05
Volume
39
Issue
4
Pages
642-649
ISSN
  • 0307-0565 (ISSN-L)
  • 1476-5497
DOI
10.1038/ijo.2015.15
PMC
PMC4700513
OpenAlex
W2055861509
Cited by
243
References
80
Citations by year
2026: 8 · 2025: 16 · 2024: 10 · 2023: 16 · 2022: 27 · 2021: 22 · 2020: 30 · 2019: 28 · 2018: 24 · 2017: 26 · 2016: 27 · 2015: 9
FWCI
4.24
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Obesity (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (UL1TR000439)
  • National Center for Advancing Translational Sciences
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-22965-19, R01HD022965)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Keywords
maternal obesity, gestational weight gain, lifestyle intervention, gestational diabetes mellitus, preeclampsia, macrosomia, fetal adiposity, placental function, early pregnancy, lipogenesis, low-grade inflammation, placental gene expression
MeSH terms
Adult, Birth Weight, Blood Glucose, Body Composition, Female, Humans, Male, Mothers, Obesity, Pregnancy, Pregnancy Complications, United States, Weight Gain, Body Mass Index, Randomized Controlled Trials as Topic, Diabetes, Gestational, Risk Reduction Behavior

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