The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Inter-species transplantation of gut microbiota from human to pigs
Open accessAbstract
Direct research on gut microbiota for understanding its role as ‘an important organ’ in human individuals is difficult owing to its vast diversity and host specificity as well as ethical concerns. Transplantation of human gut microbiota into surrogate hosts can significantly facilitate the research of human gut ecology, metabolism and immunity but rodents-based model provides results with low relevance to humans. A new human flora-associated (HFA) piglet model was hereby established taking advantage of the high similarity between pigs and humans with respect to the anatomy, physiology and metabolism of the digestive system. Piglets were delivered via cesarean section into a SPF-level barrier system and were inoculated orally with a whole fecal suspension from one healthy 10-year-old boy. The establishment and composition of the intestinal microbiota of the HFA piglets were analyzed and compared with that of the human donor using enterobacterial repetitive intergenic consensus sequence-PCR fingerprinting-based community DNA hybridization, group-specific PCR-temperature gradient gel electrophoresis and real-time PCR. Molecular profiling demonstrated that transplantation of gut microbiota from a human to germfree piglets produced a donor-like microbial community with minimal individual variation. And the microbial succession with aging of those ex-germfree piglets was also similar to that observed in humans. This HFA model provides a significantly improved system for research on gut ecology in human metabolism, nutrition and drug discovery.
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Cites
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245
Gut microorganisms, mammalian metabolism and personalized health care
Nicholson, J. K., Holmes, E., & Wilson, I. D. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1152 · Cited by 945
Pharmaco-metabonomic phenotyping and personalized drug treatment
Andrew Clayton, T., Lindon, J. C., Cloarec, O., Antti, H., Charuel, C., Hanton, G., Provost, J.-P., Le Net, J.-L., Baker, D., Walley, R. J., et al. (2006) · Nature · doi:10.1038/nature04648 · Cited by 824 · cited 2×
“Genetically homogenous animals can have different metabolisms if they have structurally different gut microbiota, which in turn determines their individualized drug responses (Nicholson et al., 2005; Clayton et al., 2006).”
BackgroundBartosch, S., Fite, A., Macfarlane, G. T., & McMurdo, M. E. T. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.6.3575-3581.2004 · Cited by 762 · cited 1×
“Enumeration of bifidobacteria and Bacteroides spp using real-time PCR Plasmid DNA standards for real-time PCR were prepared according to Bartosch et al. (2004).”
MethodReview article: bifidobacteria as probiotic agents – physiological effects and clinical benefits
PICARD, C., FIORAMONTI, J., FRANCOIS, A., ROBINSON, T., NEANT, F., & MATUCHANSKY, C. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02615.x · Cited by 618
Cited by
The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice
Turnbaugh, P. J., Ridaura, V. K., Faith, J. J., Rey, F. E., Knight, R., & Gordon, J. I. (2009) · Science Translational Medicine · doi:10.1126/scitranslmed.3000322 · Cited by 3,058
Safety assessment of probiotics for human use
Sanders, M. E., Akkermans, L. M. A., Haller, D., Hammerman, C., Heimbach, J. T., Hörmannsperger, G., & Huys, G. (2010) · Gut Microbes · doi:10.4161/gmic.1.3.12127 · Cited by 816
Microbial Ecology along the Gastrointestinal Tract
Hillman, E. T., Lu, H., Yao, T., & Nakatsu, C. H. (2017) · Microbes and environments · doi:10.1264/jsme2.me17017 · Cited by 580
Zheng, D.-W., Dong, X., Pan, P., Chen, K.-W., Fan, J.-X., Cheng, S.-X., & Zhang, X.-Z. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0423-2 · Cited by 495
The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus
Kootte, R. S., Vrieze, A., Holleman, F., Dallinga‐Thie, G. M., Zoetendal, E. G., de Vos, W. M., Groen, A. K., Hoekstra, J. B. L., Stroes, E. S., & Nieuwdorp, M. (2012) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01483.x · Cited by 351
Metadata
- Authors
- Pang, X., Hua, X., Yang, Q., Ding, D., Che, C., Cui, L., Jia, W., Bucheli, P., & Zhao, L.
- Venue
- The ISME Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-05-17
- Volume
- 1
- Issue
- 2
- Pages
- 156-162
- ISSN
- 1751-7362 (ISSN-L)
- 1751-7370
- OpenAlex
- W2037077881
- Cited by
- 178
- References
- 5
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- green
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- Pang, X., Hua, X., Yang, Q., Ding, D., Che, C., Cui, L., Jia, W., Bucheli, P., & Zhao, L. (2007). Inter-species transplantation of gut microbiota from human to pigs. The ISME Journal. https://doi.org/10.1038/ismej.2007.23
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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