The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Quorum quenching quandary: resistance to antivirulence compounds
Open accessAbstract
Quorum sensing (QS) is the regulation of gene expression in response to the concentration of small signal molecules, and its inactivation has been suggested to have great potential to attenuate microbial virulence. It is assumed that unlike antimicrobials, inhibition of QS should cause less Darwinian selection pressure for bacterial resistance. Using the opportunistic pathogen Pseudomonas aeruginosa, we demonstrate here that bacterial resistance arises rapidly to the best-characterized compound that inhibits QS (brominated furanone C-30) due to mutations that increase the efflux of C-30. Critically, the C-30-resistant mutant mexR was more pathogenic to Caenorhabditis elegans in the presence of C-30, and the same mutation arises in bacteria responsible for chronic cystic fibrosis infections. Therefore, bacteria may evolve resistance to many new pharmaceuticals thought impervious to resistance.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Wiegand, I., Hilpert, K., & Hancock, R. E. W. (2008) · Nature Protocols · doi:10.1038/nprot.2007.521 · Cited by 6,156
Altered gut flora and environment in patients with severe SIRS
Shimizu, K., Ogura, H., Goto, M., Asahara, T., Nomoto, K., Morotomi, M., Yoshiya, K., Matsushima, A., Sumi, Y., Kuwagata, Y., et al. (2006) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/01.ta.0000197374.99755.fe · Cited by 257
Alverdy, J., Holbrook, C., Rocha, F., Seiden, L., Licheng, R., Wu, Musch, M., Chang, E., Ohman, D., & Suh, S. (2000) · Annals of Surgery · doi:10.1097/00000658-200010000-00003 · Cited by 207
Cited by
Langdon, A., Crook, N., & Dantas, G. (2016) · Genome Medicine · doi:10.1186/s13073-016-0294-z · Cited by 912
Targeting virulence: can we make evolution-proof drugs?
Allen, R. C., Popat, R., Diggle, S. P., & Brown, S. P. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3232 · Cited by 532
Combating Multidrug‐Resistant Bacteria: Current Strategies for the Discovery of Novel Antibacterials
O'Connell, K. M. G., Hodgkinson, J. T., Sore, H. F., Welch, M., Salmond, G. P. C., & Spring, D. R. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201209979 · Cited by 435
Molecular Basis of In Vivo Biofilm Formation by Bacterial Pathogens
Joo, H.-S., & Otto, M. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.10.022 · Cited by 434
Fetzner, S. (2015) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2014.09.001 · Cited by 366
Metadata
- Authors
- Maeda, T., García-Contreras, R., Pu, M., Sheng, L., Garcia, L. R., Tomás, M., & Wood, T. K.
- Venue
- The ISME Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-09-15
- Volume
- 6
- Issue
- 3
- Pages
- 493-501
- ISSN
- 1751-7362 (ISSN-L)
- 1751-7370
- OpenAlex
- W2040605556
- Cited by
- 300
- References
- 3
- FWCI
- 7.29
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Quorum quenching quandary: resistance to antivirulence compounds. https://app.cochat.ai/papers/10.1038/ismej.2011.122
- The paper
- Maeda, T., García-Contreras, R., Pu, M., Sheng, L., Garcia, L. R., Tomás, M., & Wood, T. K. (2012). Quorum quenching quandary: resistance to antivirulence compounds. The ISME Journal. https://doi.org/10.1038/ismej.2011.122
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
