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Cited by 257Gut microbiota and healthSepsis Diagnosis and TreatmentGastrointestinal motility and disorders

Altered gut flora and environment in patients with severe SIRS

Shimizu, Kentaro, Ogura, Hiroshi, Goto, Miki, Asahara, Takashi, Nomoto, Koji, Morotomi, Masami, Yoshiya, Kazuhisa, Matsushima, Asako +5 more·2006·The Journal of Trauma: Injury, Infection, and Critical Care
DOI 10.1097/01.ta.0000197374.99755.fe
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Abstract

BACKGROUND: The gut is considered an important target organ of injury after severe insult such as sepsis, trauma, and shock. The impact of bacterial translocation or mesenteric lymph on systemic inflammatory response and multiple organ damage has been investigated in animals, but dynamic changes in the gut flora and environment have not been fully clarified in critically ill patients. In the present study, we quantitatively evaluated changes in the gut microflora and environment in patients with severe systemic inflammatory response syndrome (SIRS). METHODS: Twenty-five patients with severe SIRS, who fulfilled the criteria for SIRS, had a serum CRP level >10 mg/dL, and were treated in the intensive care unit for more than 2 days, were included in our study. SIRS was a result of sepsis in 18 patients, trauma in 6, and burn in 1. A fecal sample was used for quantitative evaluation of microflora (bacterial counts of 10 key groups including Bifidobacterium and Lactobacillus) by plate or tube technique and of the gut environment (pH and 9 organic acids by high speed liquid chromatography). Data obtained from patients were compared with corresponding data from healthy volunteers. RESULTS: Analysis of fecal flora confirmed that patients with severe SIRS had significantly lower total anaerobic bacterial counts (especially 2-4 log fewer "beneficial" Bifidobacterium and Lactobacillus) and 2 log higher "pathogenic" Staphylococcus and Pseudomonas group counts than those of healthy volunteers. Concentrations of total organic acids (especially "beneficial" short-chain fatty acids such as acetic acid, propionic acid, and butyric acid) in the feces were significantly decreased in the patients, whereas pH was markedly increased. CONCLUSIONS: The gut flora and environment are significantly altered in patients with severe SIRS. Abnormal gut flora and environment may affect systemic inflammatory response after severe insult.

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Crossref · 10.1097/01.ta.0000197374.99755.fe

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  • P aeruginosa, which is normally low in abundance, grows in prominence in the gut of critically ill patients.

    “P aeruginosa, which is normally low in abundance, grows in prominence.”

    From The microbiome and critical illness (2016) · cites this paper as [71]

  • In studies of the gut microbiome in critically ill patients, butyrate-producing bacteria are uncommon or absent, and butyrate production is at a minimum.

    “In studies of the gut microbiome in critically ill patients, butyrate-producing bacteria are uncommon or absent,20,69–71 and butyrate production is at a minimum.”

    From The microbiome and critical illness (2016) · cites this paper as [71]

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Authors
Shimizu, K., Ogura, H., Goto, M., Asahara, T., Nomoto, K., Morotomi, M., Yoshiya, K., Matsushima, A., Sumi, Y., Kuwagata, Y., Tanaka, H., Shimazu, T., & Sugimoto, H.
Affiliations
  • The University of Osaka (JP)
  • Yakult Central Institute (JP)
ORCID
Venue
The Journal of Trauma: Injury, Infection, and Critical Care
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2006-01
Volume
60
Issue
1
Pages
126-133
ISSN
0022-5282 (ISSN-L)
DOI
10.1097/01.ta.0000197374.99755.fe
OpenAlex
W2166679616
Cited by
257
References
49
Citations by year
2026: 6 · 2025: 17 · 2024: 13 · 2023: 15 · 2022: 20 · 2021: 14 · 2020: 22 · 2019: 10 · 2018: 7 · 2017: 15 · 2016: 14 · 2015: 14 · 2014: 13 · 2013: 18 · 2012: 18
FWCI
2.30
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Trauma: Injury, Infection, and Critical Care (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
systemic inflammatory response syndrome, gut microbiota, fecal microbiota, short-chain fatty acids, gut pH, Bifidobacterium, Lactobacillus, anaerobic bacteria, Staphylococcus, Pseudomonas, sepsis, trauma (physical injury), critically ill patients, bacterial translocation, organic acids
MeSH terms
Adult, Aged, Aged, 80 and over, Bacteria, Anaerobic, Carboxylic Acids, Feces, Female, Humans, Hydrogen-Ion Concentration, Interleukins, Intestines, Male, Middle Aged, Colony Count, Microbial, Case-Control Studies, Thrombomodulin, Systemic Inflammatory Response Syndrome

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