The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Longitudinal study of murine microbiota activity and interactions with the host during acute inflammation and recovery
Open accessAbstract
Although alterations in gut microbiota composition during acute colitis have been repeatedly observed, associated functional changes and the recovery from dysbiosis received little attention. In this study, we investigated structure and function of the gut microbiota during acute inflammation and recovery in a dextran sodium sulfate (DSS)-colitis mouse model using metatranscriptomics, bacterial 16S rRNA gene amplicon sequencing and monitoring of selected host markers. Parallel to an increase of host markers of inflammation during acute colitis, we observed relative abundance shifts and alterations in phylotype composition of the dominant bacterial orders Clostridiales and Bacteroidales, and an increase of the low abundant Enterobacteriales, Deferribacterales, Verrucomicrobiales and Erysipelotrichales. During recovery, the microbiota began to resume, but did not reach its original composition until the end of the experiment. Microbial gene expression was more resilient to disturbance, with pre-perturbation-type transcript profiles appearing quickly after acute colitis. The decrease of Clostridiales during inflammation correlated with a reduction of transcripts related to butyrate formation, suggesting a disturbance in host-microbe signalling and mucosal nutrient provision. The impact of acute inflammation on the Clostridiales was also characterized by a significant downregulation of their flagellin-encoding genes. In contrast, the abundance of members of the Bacteroidales increased along with an increase in transcripts related to mucin degradation. We propose that acute inflammation triggered a selective reaction of the immune system against flagella of commensals and temporarily altered murine microbiota composition and functions relevant for the host. Despite changes in specific interactions, the host–microbiota homeostasis revealed a remarkable ability for recovery.
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Cites
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BackgroundBacterial flagellin is a dominant antigen in Crohn disease
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Integrated Metagenomics/Metaproteomics Reveals Human Host-Microbiota Signatures of Crohn's Disease
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Cited by
Gut biogeography of the bacterial microbiota
Donaldson, G. P., Lee, S. M., & Mazmanian, S. K. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro3552 · Cited by 2,535
Deciphering microbial interactions and detecting keystone species with co-occurrence networks
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Self-citationEmerging Pathogenic Links Between Microbiota and the Gut-Lung Axis
Budden, K. F., Gellatly, S. L., Wood, D. L. A., Cooper, M. A., Morrison, M., Hugenholtz, P., & Hansbro, P. M. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.142 · Cited by 1,606
The resilience of the intestinal microbiota influences health and disease
Sommer, F., Anderson, J. M., Bharti, R., Raes, J., & Rosenstiel, P. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.58 · Cited by 1,058
Microbial network disturbances in relapsing refractory Crohn’s disease
Swiss IBD Cohort Investigators, Yilmaz, B., Juillerat, P., Øyås, O., Ramon, C., Bravo, F. D., Franc, Y., Fournier, N., Michetti, P., Mueller, C., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0308-z · Cited by 428
Metadata
- Authors
- Schwab, C., Berry, D., Rauch, I., Rennisch, I., Ramesmayer, J., Hainzl, E., Heider, S., Decker, T., Kenner, L., Müller, M., Strobl, B., Wagner, M., Schleper, C., Loy, A., & Urich, T.
- Venue
- The ISME Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-01-09
- Volume
- 8
- Issue
- 5
- Pages
- 1101-1114
- ISSN
- 1751-7362 (ISSN-L)
- 1751-7370
- OpenAlex
- W1994243307
- Cited by
- 193
- References
- 12
- FWCI
- 7.91
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Schwab, C., Berry, D., Rauch, I., Rennisch, I., Ramesmayer, J., Hainzl, E., Heider, S., Decker, T., Kenner, L., Müller, M., Strobl, B., Wagner, M., Schleper, C., Loy, A., & Urich, T. (2014). Longitudinal study of murine microbiota activity and interactions with the host during acute inflammation and recovery. The ISME Journal. https://doi.org/10.1038/ismej.2013.223
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