Cited by 1,058Gut microbiota and healthOral microbiology and periodontitis researchProbiotics and Fermented Foods

The resilience of the intestinal microbiota influences health and disease

Sommer, Felix, Anderson, Jacqueline Moltzau, Bharti, Richa, Raes, Jeroen, Rosenstiel, Philip·2017·Nature Reviews Microbiology

Abstract

The composition of the intestinal microbiota varies among individuals and throughout development, and is dependent on host and environmental factors. However, although the microbiota is constantly exposed to environmental challenges, its composition and function in an individual are stable against perturbations, as microbial communities are resilient and resistant to change. The maintenance of a beneficial microbiota requires a homeostatic equilibrium within microbial communities, and also between the microorganisms and the intestinal interface of the host. The resilience of the healthy microbiota protects us from dysbiosis-related diseases, such as inflammatory bowel disease (IBD) or metabolic disorder. By contrast, a resilient dysbiotic microbiota may cause disease. In this Opinion article, we propose that microbial resilience has a key role in health and disease. We will discuss the concepts and mechanisms of microbial resilience against dietary, antibiotic or bacteriotherapy-induced perturbations and the implications for human health.

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Crossref · 10.1038/nrmicro.2017.58

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Authors
Sommer, F., Anderson, J. M., Bharti, R., Raes, J., & Rosenstiel, P.
Affiliations
  • Christian-Albrechts-Universität zu Kiel (DE)
  • Vrije Universiteit Brussel (BE)
Corresponding author
  • Sommer, Felix
  • Rosenstiel, Philip
Venue
Nature Reviews Microbiology
Published
2017-06-19
Volume
15
Issue
10
Pages
630-638
ISSN
  • 1740-1526 (ISSN-L)
  • 1740-1534
OpenAlex
W2626195186
Cited by
1,058
References
113
Citations by year
2026: 65 · 2025: 113 · 2024: 160 · 2023: 154 · 2022: 149 · 2021: 129 · 2020: 140 · 2019: 80 · 2018: 57 · 2017: 11
FWCI
7.36
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Microbiology (publishedVersion)
  • PubMed (publishedVersion)
  • Lirias (submittedVersion)
Funders
  • European Commission
  • Deutsche Forschungsgemeinschaft
  • Bundesministerium für Bildung und Forschung
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords
gut microbiota, microbial resilience, dysbiosis, microbiota homeostasis, bacterial therapy, inflammatory bowel disease, metabolic disorders, host-microbe interactions, microbiome stability
MeSH terms
Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Homeostasis, Humans, Intestines, Inflammatory Bowel Diseases, Dysbiosis

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