The resilience of the intestinal microbiota influences health and disease
Abstract
The composition of the intestinal microbiota varies among individuals and throughout development, and is dependent on host and environmental factors. However, although the microbiota is constantly exposed to environmental challenges, its composition and function in an individual are stable against perturbations, as microbial communities are resilient and resistant to change. The maintenance of a beneficial microbiota requires a homeostatic equilibrium within microbial communities, and also between the microorganisms and the intestinal interface of the host. The resilience of the healthy microbiota protects us from dysbiosis-related diseases, such as inflammatory bowel disease (IBD) or metabolic disorder. By contrast, a resilient dysbiotic microbiota may cause disease. In this Opinion article, we propose that microbial resilience has a key role in health and disease. We will discuss the concepts and mechanisms of microbial resilience against dietary, antibiotic or bacteriotherapy-induced perturbations and the implications for human health.
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Functional redundancy allows the host to maintain a healthy gut microbiota to preserve stability and resilience in response to perturbations.
“Functional redundancy allows the host to maintain a healthy gut microbiota to preserve stability and resilience in response to perturbations [13, 14].”
From Role of the gut microbiota in nutrient competition and protection against intestinal pathogen colonization (2023) · cites this paper as [14]
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- Authors
- Sommer, F., Anderson, J. M., Bharti, R., Raes, J., & Rosenstiel, P.
- Affiliations
- Christian-Albrechts-Universität zu Kiel (DE)
- Vrije Universiteit Brussel (BE)
- Corresponding author
- Sommer, Felix
- Rosenstiel, Philip
- Venue
- Nature Reviews Microbiology
- Published
- 2017-06-19
- Volume
- 15
- Issue
- 10
- Pages
- 630-638
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W2626195186
- Cited by
- 1,058
- References
- 113
- Citations by year
- 2026: 65 · 2025: 113 · 2024: 160 · 2023: 154 · 2022: 149 · 2021: 129 · 2020: 140 · 2019: 80 · 2018: 57 · 2017: 11
- FWCI
- 7.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Lirias (submittedVersion)
- Funders
- European Commission
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- gut microbiota, microbial resilience, dysbiosis, microbiota homeostasis, bacterial therapy, inflammatory bowel disease, metabolic disorders, host-microbe interactions, microbiome stability
- MeSH terms
- Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Homeostasis, Humans, Intestines, Inflammatory Bowel Diseases, Dysbiosis
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