The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Effects of Human Aging on Patterns of Local Cerebral Glucose Utilization Determined by the [ 18 F] Fluorodeoxyglucose Method
Open accessAbstract
The [ 18 F]fluorodeoxyglucose (FDG) scan method with positron emission computed tomography was used to determine patterns of local cerebral glucose utilization (LCMR glu ) in 40 normal volunteer subjects aged 18 to 78 years. Throughout all the studies, each subject was quiet, without movement, with eyes open and ears unplugged, exposed only to ambient room light and sound. For the entire group, whole brain mean CMR glu was 26.1 ± 6.1 μmol 100 g −1 min −1 (mean ± SD, n = 40). At age 78, mean CMR glu was, on the average, 26% less than at age 18, an alteration of the same order as the variance among subjects at any age. The gradual decline of mean CMR glu with advancing age occurred at a faster rate than was reported for mean cerebral oxygen utilization, possibly due to increasingly altered pathways for glucose utilization, or to increasing oxidation of ketone bodies or other alternative substrates. Glucose utilization in the hemispheres was symmetrical and mean CMR glu of overall cortex, caudate, and thalamus was equal in individuals at all ages. The slopes of decline with age were similar when LCMR glu was averaged over zones corresponding to centrum semiovale, caudate, putamen, and frontal, temporal, parietal, occipital, and primary visual cortex. However, the metabolic ratio of superior frontal cortex to superior parietal cortex declined with age, possibly due to selective degeneration of superior frontal cortex or to differences between age groups in the sensory and cognitive response to the study. These results should be useful in distinguishing age from disease effects when the FDG scan method is used.
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“which PET, [29][30][31]32 and neuropathological studies 33 suggest are preferentially affected during normal aging.”
From Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ε4 Allele for Apolipoprotein E (1996) · cites this paper as [29]
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Self-citationCerebral Blood Flow and Oxygen Consumption in Man
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Self-citationQuantitation in Positron Emission Computed Tomography
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Reiman, E. M., Caselli, R. J., Yun, L. S., Chen, K., Bandy, D., Minoshima, S., Thibodeau, S. N., & Osborne, D. (1996) · New England Journal of Medicine · doi:10.1056/nejm199603213341202 · Cited by 1,366
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Evolving Knowledge of Sex Differences in Brain Structure, Function, and Chemistry
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Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia
Reiman, E. M., Chen, K., Alexander, G. E., Caselli, R. J., Bandy, D., Osborne, D., Saunders, A. M., & Hardy, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2635903100 · Cited by 977
Brain Glucose Metabolism: Integration of Energetics with Function
Dienel, G. A. (2018) · Physiological Reviews · doi:10.1152/physrev.00062.2017 · Cited by 911
Metadata
- Authors
- Kuhl, D. E., Metter, E. J., Riege, W. H., & Phelps, M. E.
- Affiliations
- University of California, Los Angeles (US)
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 1982-06
- Volume
- 2
- Issue
- 2
- Pages
- 163-171
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2011269223
- Cited by
- 338
- References
- 38
- Citations by year
- 2026: 7 · 2025: 4 · 2023: 1 · 2022: 7 · 2021: 3 · 2020: 5 · 2019: 6 · 2018: 4 · 2017: 5 · 2016: 3 · 2015: 4 · 2014: 7 · 2013: 3 · 2012: 6
- FWCI
- 19.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Energy
- National Institutes of Health (5p01ns015654-15)
- U.S. Public Health Service
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- brain aging, brain glucose metabolism, local cerebral glucose utilization, 18F-fluorodeoxyglucose, positron emission tomography, cerebral oxygen consumption, superior frontal cortex, superior parietal cortex, brain regional metabolism, ketone bodies
- MeSH terms
- Adolescent, Adult, Aged, Aging, Brain, Deoxy Sugars, Deoxyglucose, Female, Fluorine, Glucose, Humans, Male, Middle Aged, Radioisotopes, Tissue Distribution, Tomography, Emission-Computed, Fluorodeoxyglucose F18
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