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Effects of Human Aging on Patterns of Local Cerebral Glucose Utilization Determined by the [ 18 F] Fluorodeoxyglucose Method

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Kuhl, David E., Metter, E. Jeffrey, Riege, Walter H., Phelps, Michael E.·1982·Journal of Cerebral Blood Flow & Metabolism

DOI 10.1038/jcbfm.1982.15

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Abstract

The [ 18 F]fluorodeoxyglucose (FDG) scan method with positron emission computed tomography was used to determine patterns of local cerebral glucose utilization (LCMR glu ) in 40 normal volunteer subjects aged 18 to 78 years. Throughout all the studies, each subject was quiet, without movement, with eyes open and ears unplugged, exposed only to ambient room light and sound. For the entire group, whole brain mean CMR glu was 26.1 ± 6.1 μmol 100 g −1 min −1 (mean ± SD, n = 40). At age 78, mean CMR glu was, on the average, 26% less than at age 18, an alteration of the same order as the variance among subjects at any age. The gradual decline of mean CMR glu with advancing age occurred at a faster rate than was reported for mean cerebral oxygen utilization, possibly due to increasingly altered pathways for glucose utilization, or to increasing oxidation of ketone bodies or other alternative substrates. Glucose utilization in the hemispheres was symmetrical and mean CMR glu of overall cortex, caudate, and thalamus was equal in individuals at all ages. The slopes of decline with age were similar when LCMR glu was averaged over zones corresponding to centrum semiovale, caudate, putamen, and frontal, temporal, parietal, occipital, and primary visual cortex. However, the metabolic ratio of superior frontal cortex to superior parietal cortex declined with age, possibly due to selective degeneration of superior frontal cortex or to differences between age groups in the sensory and cognitive response to the study. These results should be useful in distinguishing age from disease effects when the FDG scan method is used.

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THE [ 14 C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT 1
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Authors: Kuhl, D. E., Metter, E. J., Riege, W. H., & Phelps, M. E.
Affiliations: University of California, Los Angeles (US)
Venue: Journal of Cerebral Blood Flow & Metabolism
Publisher: SAGE Publications
Published: 1982-06
Volume: 2
Issue: 2
Pages: 163-171
ISSN: 0271-678X (ISSN-L)
1559-7016
DOI: 10.1038/jcbfm.1982.15
OpenAlex: W2011269223
Cited by: 338
References: 38
Citations by year: 2026: 7 · 2025: 4 · 2023: 1 · 2022: 7 · 2021: 3 · 2020: 5 · 2019: 6 · 2018: 4 · 2017: 5 · 2016: 3 · 2015: 4 · 2014: 7 · 2013: 3 · 2012: 6
FWCI: 19.71
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Energy
National Institutes of Health (5p01ns015654-15)
U.S. Public Health Service
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
Keywords: brain aging, brain glucose metabolism, local cerebral glucose utilization, 18F-fluorodeoxyglucose, positron emission tomography, cerebral oxygen consumption, superior frontal cortex, superior parietal cortex, brain regional metabolism, ketone bodies
MeSH terms: Adolescent, Adult, Aged, Aging, Brain, Deoxy Sugars, Deoxyglucose, Female, Fluorine, Glucose, Humans, Male, Middle Aged, Radioisotopes, Tissue Distribution, Tomography, Emission-Computed, Fluorodeoxyglucose F18

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Effects of Human Aging on Patterns of Local Cerebral Glucose Utilization Determined by the [ 18 F] Fluorodeoxyglucose Method

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