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Glucose Metabolic Rate Kinetic Model Parameter Determination in Humans: The Lumped Constants and Rate Constants for [18F]Fluorodeoxyglucose and [11C]Deoxyglucose
Abstract
The rate constants and lumped constants (LCs) for [18 F]fluorodeoxyglucose ([18 F]FDG) and [11 C]deoxyglucose ([11 C]DG) were determined in humans for the glucose metabolic rate kinetic model used to measure local cerebral glucose consumption. The mean values (±SE) of the LCs for [18 F]FDG and [11 C]DG are 0.52 ± 0.028 (n = 9) and 0.56 ± 0.043 (n = 6), respectively. The mean values (±SE) of the rate constants k*1, k*2, k*3, and k*4 for [18 F]FDG for gray matter are 0.095 ± 0.005, 0.125 ± 0.002, 0.069 ± 0.002, and 0.0055 ± 0.0003, respectively. The corresponding values for white matter are 0.065 ± 0.005, 0.126 ± 0.003, 0.066 ± 0.002, and 0.0054 ± 0.0006, respectively. Using these values and previously published values for the rate constants for [11 C]DG, the average whole-brain metabolic rates for glucose in normal subjects measured with [18 F]FDG and [11 C]DG are 5.66 ± 0.37 (n = 6) and 4.99 ± 0.23 (n = 6) mg/100 g/min, respectively. These values are not significantly different ( t = 1.56, p > 0.10) and agree well with reported values in the literature determined by means of the Kety-Schmidt technique.
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Sokoloff, L., Reivich, M., Kennedy, C., Rosiers, M. H. D., Patlak, C. S., Pettigrew, K. D., Sakurada, O., & Shinohara, M. (1977) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1977.tb10649.x · Cited by 6,000
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Cited by
Nonoxidative Glucose Consumption During Focal Physiologic Neural Activity
Fox, P. T., Raichle, M. E., Mintun, M. A., & Dence, C. (1988) · Science · doi:10.1126/science.3260686 · Cited by 1,796
de Leon, M. J., Convit, A., Wolf, O. T., Tarshish, C. Y., DeSanti, S., Rusinek, H., Tsui, W., Kandil, E., Scherer, A. J., Roche, A., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191044198 · Cited by 629
Self-citationHippocampal formation glucose metabolism and volume losses in MCI and AD
De Santi, S., de Leon, M. J., Rusinek, H., Convit, A., Tarshish, C. Y., Roche, A., Tsui, W. H., Kandil, E., Boppana, M., Daisley, K., et al. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00230-5 · Cited by 548
Self-citationMosconi, L., Mistur, R., Switalski, R., Tsui, W. H., Glodzik, L., Li, Y., Pirraglia, E., De Santi, S., Reisberg, B., Wisniewski, T., et al. (2009) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-008-1039-z · Cited by 487
Negative Symptoms and Hypofrontality in Chronic Schizophrenia
Wolkin, A. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820120047007 · Cited by 393
Metadata
- Authors
- Reivich, M., Alavi, A., Wolf, A., Fowler, J., Russell, J., Arnett, C., MacGregor, R. R., Shiue, C. Y., Atkins, H., Anand, A., Dann, R., & Greenberg, J. H.
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 1985-06
- Volume
- 5
- Issue
- 2
- Pages
- 179-192
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2157271972
- Cited by
- 415
- References
- 1
- FWCI
- 18.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Reivich, M., Alavi, A., Wolf, A., Fowler, J., Russell, J., Arnett, C., MacGregor, R. R., Shiue, C. Y., Atkins, H., Anand, A., Dann, R., & Greenberg, J. H. (1985). Glucose Metabolic Rate Kinetic Model Parameter Determination in Humans: The Lumped Constants and Rate Constants for [18F]Fluorodeoxyglucose and [11C]Deoxyglucose. Journal of Cerebral Blood Flow & Metabolism. https://doi.org/10.1038/jcbfm.1985.24
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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