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Age Dependency of Changes in Cerebral Hemoglobin Oxygenation during Brain Activation: A Near-Infrared Spectroscopy Study
Open accessAbstract
We used near-infrared spectroscopy (NIRS) to study noninvasively the influence of aging on changes in the local concentration of oxygenated hemoglobin ([HbO 2]), reduced hemoglobin ([HbR]), and total hemoglobin ([HbT] = [HbR] + [HbO 2]) during activation of brain function. Young subjects ( n = 12; age, 28 ± 4 years) performing calculation tasks showed an increase in [HbO 2] [mean (arbitrary units) ± SD, 2.36 ± 1.07] and [HbT] (2.24 ± 1.13) in the frontal cortex, while [HbR] (−0.11 ± 0.48) decreased. Elderly subjects ( n = 17; age, 52 ± 10 years) showed a significantly lower mean increase ( p < 0.05) in [HbO 2] and [HbT] levels (1.21 ± 1.38 and 0.72 ± 1.41, respectively). Regression analysis supports the hypothesis of an age-dependent decline in the activation-induced local increase in [HbO 2] ( y = −0.241 x + 20.062; r = −0.431, p < 0.05) as well as [HbT] ( y = −0.346x + 22.496; r = −0.568, p < 0.05). We conclude that NIRS is a promising approach for studying changes in Hb oxygenation during brain activation in physiological aging.
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Cites
Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation.
Kwong, K. K., Belliveau, J. W., Chesler, D. A., Goldberg, I. E., Weisskoff, R. M., Poncelet, B. P., Kennedy, D. N., Hoppel, B. E., Cohen, M. S., & Turner, R. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5675 · Cited by 4,212
Fox, P. T., & Raichle, M. E. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.4.1140 · Cited by 2,056
Regional cerebral blood flow and oxygen consumption in human aging
Pantano, P., Baron, J. C., Lebrun-Grandié, P., Duquesnoy, N., Bousser, M. G., & Comar, D. (1984) · Stroke · doi:10.1161/01.str.15.4.635 · Cited by 341
Cited by
Ferrari, M., & Quaresima, V. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.03.049 · Cited by 2,274
Mehagnoul‐Schipper, D. J., van der Kallen, B. F. W., Colier, W. N. J. M., van der Sluijs, M. C., van Erning, L. J. T. O., Thijssen, H. O. M., Oeseburg, B., Hoefnagels, W. H. L., & Jansen, R. W. M. M. (2002) · Human Brain Mapping · doi:10.1002/hbm.10026 · Cited by 264
Ehlis, A.-C., Bähne, C. G., Jacob, C. P., Herrmann, M. J., & Fallgatter, A. J. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2007.11.011 · Cited by 209
Metadata
- Authors
- Hock, C., Müller-Spahn, F., Schuh-Hofer, S., Hofmann, M., Dirnagl, U., & Villringer, A.
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 1995-11
- Volume
- 15
- Issue
- 6
- Pages
- 1103-1108
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W1981270256
- Cited by
- 166
- References
- 3
- FWCI
- 8.63
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Age Dependency of Changes in Cerebral Hemoglobin Oxygenation during Brain Activation: A Near-Infrared Spectroscopy Study. https://app.cochat.ai/papers/10.1038/jcbfm.1995.137
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- Hock, C., Müller-Spahn, F., Schuh-Hofer, S., Hofmann, M., Dirnagl, U., & Villringer, A. (1995). Age Dependency of Changes in Cerebral Hemoglobin Oxygenation during Brain Activation: A Near-Infrared Spectroscopy Study. Journal of Cerebral Blood Flow & Metabolism. https://doi.org/10.1038/jcbfm.1995.137
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