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Persistent resetting of the cerebral oxygen/glucose uptake ratio by brain activation: evidence obtained with the Kety-Schmidt technique
Open accessAbstract
Global cerebral blood flow (CBF), global cerebral metabolic rates for oxygen (CMRO 2 ), and for glucose (CMR glc ), and lactate efflux were measured during rest and during cerebral activation induced by the Wisconsin card sorting test. Measurements were performed in healthy volunteers using the Kety–Schmidt technique. Global CMRO 2 was unchanged during cerebral activation, whereas global CBF and global CMR glc both increased by 12%, reducing the molar ratio of oxygen to glucose consumption from 6.0 during baseline conditions to 5.4 during activation. Data obtained in the period following cerebral activation showed that the activation-induced resetting of the relation between CMR glc and CMRO 2 persisted virtually unaltered for ≥40 min after the mental activation task was terminated. The activation-induced increase in cerebral lactate efflux measured over the same time period accounted for only a small fraction of the activation-induced excess glucose uptake. These data confirm earlier reports that brain activation can induce resetting of the cerebral oxygen/glucose consumption ratio, and indicate that the resetting persists for a long period after cerebral activation has been terminated and physiologic stress indicators returned to baseline values. Activation-induced resetting of the cerebral oxygen/glucose uptake ratio is not necessarily accounted for by increased lactate production from nonoxidative glucose metabolism.
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“Aerobic glycolysis (AG), i.e., non-oxidative metabolism of glucose despite the presence of abundant oxygen, accounts for 10–12% of glucose used by the adult human brain.”
From Aerobic glycolysis in the human brain is associated with development and neotenous gene expression (2014) · cites this paper as Madsen et al., 1995
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“Curiously, AG persists for at least 40 minutes following cognitive demanding task performance, despite the return of blood flow and lactate production to control levels”
From Aerobic glycolysis in the human brain is associated with development and neotenous gene expression (2014) · cites this paper as Madsen et al., 1995
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Metadata
- Authors
- Madsen, P. L., Hasselbalch, S. G., Hagemann, L. P., Olsen, K. S., Bülow, J., Holm, S., Wildschiødtz, G., Paulson, O. B., & Lassen, N. A.
- Affiliations
- Bispebjerg Hospital (DK)
- Department of Neurology, Copenhagen, Denmark
- Department of Anesthesia, Copenhagen, Denmark
- Department of Clinical Physiology and Nuclear Medicine, Copenhagen, Denmark
- Rigshospitalet (DK)
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 1995-05
- Volume
- 15
- Issue
- 3
- Pages
- 485-491
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2005536744
- Cited by
- 264
- References
- 22
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 7 · 2023: 12 · 2022: 6 · 2021: 8 · 2020: 5 · 2019: 5 · 2018: 9 · 2017: 12 · 2016: 9 · 2015: 8 · 2014: 20 · 2013: 11 · 2012: 13
- FWCI
- 8.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- cerebral blood flow, cerebral oxygen consumption, cerebral metabolic rate of glucose, lactate efflux, brain activation, Wisconsin Card Sorting Test, nonoxidative glucose metabolism, brain glucose metabolism
- MeSH terms
- Adult, Brain, Cerebrovascular Circulation, Female, Glucose, Humans, Male, Methods, Neuropsychological Tests, Oxygen Consumption
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