Cited by 264Advanced MRI Techniques and ApplicationsOptical Imaging and Spectroscopy TechniquesTraumatic Brain Injury and Neurovascular Disturbances

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Persistent resetting of the cerebral oxygen/glucose uptake ratio by brain activation: evidence obtained with the Kety-Schmidt technique

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Madsen, Peter Lund, Hasselbalch, Steen G., Hagemann, Lars P., Olsen, Karsten Skovgaard, Bülow, Jens, Holm, Søren, Wildschiødtz, Gordon, Paulson, Olaf B., Lassen, Niels A.·1995·Journal of Cerebral Blood Flow & Metabolism

DOI 10.1038/jcbfm.1995.60

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Abstract

Global cerebral blood flow (CBF), global cerebral metabolic rates for oxygen (CMRO 2 ), and for glucose (CMR glc ), and lactate efflux were measured during rest and during cerebral activation induced by the Wisconsin card sorting test. Measurements were performed in healthy volunteers using the Kety–Schmidt technique. Global CMRO 2 was unchanged during cerebral activation, whereas global CBF and global CMR glc both increased by 12%, reducing the molar ratio of oxygen to glucose consumption from 6.0 during baseline conditions to 5.4 during activation. Data obtained in the period following cerebral activation showed that the activation-induced resetting of the relation between CMR glc and CMRO 2 persisted virtually unaltered for ≥40 min after the mental activation task was terminated. The activation-induced increase in cerebral lactate efflux measured over the same time period accounted for only a small fraction of the activation-induced excess glucose uptake. These data confirm earlier reports that brain activation can induce resetting of the cerebral oxygen/glucose consumption ratio, and indicate that the resetting persists for a long period after cerebral activation has been terminated and physiologic stress indicators returned to baseline values. Activation-induced resetting of the cerebral oxygen/glucose uptake ratio is not necessarily accounted for by increased lactate production from nonoxidative glucose metabolism.

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Authors: Madsen, P. L., Hasselbalch, S. G., Hagemann, L. P., Olsen, K. S., Bülow, J., Holm, S., Wildschiødtz, G., Paulson, O. B., & Lassen, N. A.
Affiliations: Bispebjerg Hospital (DK)
Department of Neurology, Copenhagen, Denmark
Department of Anesthesia, Copenhagen, Denmark
Department of Clinical Physiology and Nuclear Medicine, Copenhagen, Denmark
Rigshospitalet (DK)
ORCID: Hasselbalch, Steen G.
Bülow, Jens
Holm, Søren
Paulson, Olaf B.
Venue: Journal of Cerebral Blood Flow & Metabolism
Publisher: SAGE Publications
Published: 1995-05
Volume: 15
Issue: 3
Pages: 485-491
ISSN: 0271-678X (ISSN-L)
1559-7016
DOI: 10.1038/jcbfm.1995.60
OpenAlex: W2005536744
Cited by: 264
References: 22
Citations by year: 2026: 6 · 2025: 7 · 2024: 7 · 2023: 12 · 2022: 6 · 2021: 8 · 2020: 5 · 2019: 5 · 2018: 9 · 2017: 12 · 2016: 9 · 2015: 8 · 2014: 20 · 2013: 11 · 2012: 13
FWCI: 8.07
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords: cerebral blood flow, cerebral oxygen consumption, cerebral metabolic rate of glucose, lactate efflux, brain activation, Wisconsin Card Sorting Test, nonoxidative glucose metabolism, brain glucose metabolism
MeSH terms: Adult, Brain, Cerebrovascular Circulation, Female, Glucose, Humans, Male, Methods, Neuropsychological Tests, Oxygen Consumption

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Persistent resetting of the cerebral oxygen/glucose uptake ratio by brain activation: evidence obtained with the Kety-Schmidt technique

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