Proof of Concept: Pharmacological Preconditioning with a Toll-like Receptor Agonist Protects against Cerebrovascular Injury in a Primate Model of Stroke
Open accessAbstract
Cerebral ischemic injury is a significant portion of the burden of disease in developed countries; rates of mortality are high and the costs associated with morbidity are enormous. Recent therapeutic approaches have aimed at mitigating the extent of damage and/or promoting repair once injury has occurred. Often, patients at high risk of ischemic injury can be identified in advance and targeted for antecedent neuroprotective therapy. Agents that stimulate the innate pattern recognition receptor, Toll-like receptor 9, have been shown to induce tolerance (precondition) to ischemic brain injury in a mouse model of stroke. Here, we demonstrate for the first time that pharmacological preconditioning against cerebrovascular ischemic injury is also possible in a nonhuman primate model of stroke in the rhesus macaque. The model of stroke used is a minimally invasive transient vascular occlusion, resulting in brain damage that is primarily localized to the cortex and as such, represents a model with substantial clinical relevance. Finally, K-type (also referred to as B-type) cytosine-guanine-rich DNA oligonucleotides, the class of agents employed in this study, are currently in use in human clinical trials, underscoring the feasibility of this treatment in patients at risk of cerebral ischemia.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Such context-specific signaling is a hallmark of TGFβ in its role in cancer, where it switches from inhibition of tumor growth and metastasis to promotion of endothelial to mesenchymal transition and metastasis as the local tumor environment evolves.
“Such context-specific signaling is a hallmark of TGFβ in its role in cancer, where it switches from inhibition of tumor growth and metastasis to promotion of endothelial to mesenchymal transition and metastasis as the local tumor environment evolves14,43.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [43]
Split into 2 atoms — 0 confirmed, 0 partially supported, 0 disputed, 0 misattributed, 2 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations
Fisher, M., Feuerstein, G., Howells, D. W., Hurn, P. D., Kent, T. A., Savitz, S. I., & Lo, E. H. (2009) · Stroke · doi:10.1161/strokeaha.108.541128 · Cited by 1,352 · see citing works
Therapeutic potential of Toll-like receptor 9 activation
Krieg, A. Μ. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2059 · Cited by 1,244 · see citing works
Cerebral White Matter Is Highly Vulnerable to Ischemia
Pantoni, L., García, J. H., & Gutierrez, J. A. (1996) · Stroke · doi:10.1161/01.str.27.9.1641 · Cited by 610 · see citing works
Human Peripheral Blood Cells Differentially Recognize and Respond to Two Distinct CpG Motifs
Verthelyi, D. I., Ishii, K. J., Gürsel, M., Takeshita, F., & Klinman, D. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.4.2372 · Cited by 524 · see citing works
Smith, C. J., Emsley, H. C. A., Gavin, C. M., Georgiou, R. F., Vail, A., Barberan, E. M., del Zoppo, G. J., Hallenbeck, J. M., Rothwell, N. J., Hopkins, S. J., et al. (2004) · BMC Neurology · doi:10.1186/1471-2377-4-2 · Cited by 480 · see citing works
Early Intrathecal Production of Interleukin-6 Predicts the Size of Brain Lesion in Stroke
Tarkowski, E., Rosengren, L., Blomstrand, C., Wikkelsø, C., Jensen, C., EKHOLM, S. E., & Tarkowski, A. (1995) · Stroke · doi:10.1161/01.str.26.8.1393 · Cited by 384 · see citing works
Early Neutrophilia Is Associated With Volume of Ischemic Tissue in Acute Stroke
Buck, B. H., Liebeskind, D. S., Saver, J. L., Bang, O. Y., Yun, S. W., Starkman, S., Ali, L. K., Kim, D., Villablanca, J. P., Salamon, N., et al. (2007) · Stroke · doi:10.1161/strokeaha.107.490128 · Cited by 314 · see citing works
"Tolerosomes" are produced by intestinal epithelial cells
Karlsson, M., Lundin, S. B., Dahlgren, U. I., Kahu, H., Pettersson, I., & Telemo, E. (2001) · European Journal of Immunology · doi:10.1002/1521-4141(2001010)31:10 · Cited by 303 · see citing works
Tasaki, K., Ruetzler, C. A., Ohtsuki, T., Martin, D., Nawashiro, H., & Hallenbeck, J. M. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01383-2 · Cited by 281 · see citing works
Whiteley, W. N., Jackson, C., Lewis, S. C., Lowe, G. D. O., Rumley, A., Sandercock, P. A., Wardlaw, J. M., Dennis, M. S., & Sudlow, C. L. M. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000145 · Cited by 280 · see citing works
Hama, T., Miyamoto, M., Tsukui, H., Nishio, C., & Hatanaka, H. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90600-9 · Cited by 252 · see citing works
Akopov, S. E., Simonian, N. A., & Grigorian, G. S. (1996) · Stroke · doi:10.1161/01.str.27.10.1739 · Cited by 251 · see citing works
Rosenzweig, H. L., Lessov, N. S., Henshall, D. C., Minami, M., Simon, R. P., & Stenzel‐Poore, M. P. (2004) · Stroke · doi:10.1161/01.str.0000143450.04438.ae · Cited by 242 · see citing works
Self-citationAnalysis of Lymphocyte Subsets in Patients With Stroke and Their Influence on Infection After Stroke
Vogelgesang, A., Grunwald, U., Langner, S., Jack, R. S., Bröker, B. M., Kessler, C., & Dressel, A. (2007) · Stroke · doi:10.1161/strokeaha.107.493635 · Cited by 235 · see citing works
Differential regional vulnerability in transient focal cerebral ischemia.
Marcoux, F. W., Morawetz, R. B., Crowell, R. M., DeGirolami, U., & Halsey, J. H. (1982) · Stroke · doi:10.1161/01.str.13.3.339 · Cited by 234 · see citing works
Barber, P. A., Hach, S., Tippett, L. J., Ross, L., Merry, A., & Milsom, P. F. (2008) · Stroke · doi:10.1161/strokeaha.107.502989 · Cited by 225 · see citing works
Intrathecal release of pro- and anti-inflammatory cytokines during stroke
Tarkowski, E., Rosengren, L., Blomstrand, C., Wikkelsø, C., JENSEN, C., EKHOLM, S. E., & Tarkowski, A. (1997) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1997.4621483.x · Cited by 225 · see citing works
Cytokine Regulation of Neuronal Survival
Brenneman, D. E., Schultzberg, M., Bartfai, T., & Gozes, I. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09743.x · Cited by 210 · see citing works
CpG Oligodeoxynucleotides as Vaccine Adjuvants in Primates
Verthelyi, D. I., Kenney, R. T., Seder, R. A., Gam, A. A., Friedag, B., & Klinman, D. M. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.4.1659 · Cited by 199 · see citing works
Evolution of Cerebral Tumor Necrosis Factor-α Production During Human Ischemic Stroke
Sairanen, T., Carpén, O., Karjalainen‐Lindsberg, M., Paetau, A. E., Turpeinen, U., Kaste, M., & Lindsberg, P. J. (2001) · Stroke · doi:10.1161/01.str.32.8.1750 · Cited by 191 · see citing works
Lack of Interleukin-6 Expression Is Not Protective Against Focal Central Nervous System Ischemia
Clark, W. M., Rinker, L. G., Lessov, N. S., Hazel, K., Hill, J. K., Stenzel‐Poore, M. P., & Eckenstein, F. P. (2000) · Stroke · doi:10.1161/01.str.31.7.1715 · Cited by 187 · see citing works
Self-citationEmerich, D. F., Dean, R. L., & Bartus, R. T. (2002) · Experimental Neurology · doi:10.1006/exnr.2001.7835 · Cited by 174 · see citing works
Toll-Like Receptor 9: A New Target of Ischemic Preconditioning in the Brain
Stevens, S. L., Ciesielski, T., Marsh, B. J., Yang, T., Homen, D. S., Boule, J.-L., Lessov, N. S., Simon, R. P., & Stenzel‐Poore, M. P. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600606 · Cited by 168 · see citing works
Self-citationIschemic Thresholds for Gray and White Matter
Arakawa, S., Wright, P. M., Koga, M., Phan, T. G., Reutens, D. C., Lim, I., Gunawan, M. R., Ma, H., Perera, N. V., Ly, J. V., et al. (2006) · Stroke · doi:10.1161/01.str.0000217258.63925.6b · Cited by 136 · see citing works
Pharmacokinetics of phosphorothioate antisense oligodeoxynucleotides.
Geary, R. S., Yu, R. Z., & Levin, A. A. (2001) · PubMed · Cited by 133 · see citing works
Bristow, M., Simon, J. E., Brown, R. A., Eliasziw, M., Hill, M. D., Coutts, S. B., Frayne, R., Demchuk, A. M., & Mitchell, J. R. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600135 · Cited by 113 · see citing works
Chronic Reversible Cerebral Ischemia
Spetzler, R. F., Selman, W. R., Weinstein, P. R., Townsend, J. J., Mehdorn, M., Telles, D., Crumrine, R. C., & Macko, R. F. (1980) · Neurosurgery · doi:10.1227/00006123-198009000-00009 · Cited by 108 · see citing works
Gunzer, M., Riemann, H., Basoglu, Y., Hillmer, A., Weishaupt, C., Balkow, S., Benninghoff, B., Ernst, B., Steinert, M., Scholzen, T. E., et al. (2005) · Blood · doi:10.1182/blood-2005-01-0342 · Cited by 102 · see citing works
The resistance to ischemia of white and gray matter after stroke
Falcão, A. L. E., Reutens, D. C., Markus, R., Koga, M., Read, S. J., Tochon‐Danguy, H., Sachinidis, J. I., Howells, D. W., & Donnan, G. A. (2004) · Annals of Neurology · doi:10.1002/ana.20265 · Cited by 90 · see citing works
Tirilazad Mesylate in Acute Ischemic Stroke
(2000) · Stroke · doi:10.1161/01.str.31.9.2257 · Cited by 79 · see citing works
Tirilazad mesylate in acute ischemic stroke - A systematic review
Bath, P., Blecic, S. A., Bogousslavsky, J., Boysen, G., Davis, S. M., Díez‐Tejedor, E., Ferro, J. M., Gommans, J., Hacke, W., Indredavik, B., et al. (2000) · Stroke · Cited by 69 · see citing works
A New Model of Cortical Stroke in the Rhesus Macaque
West, G. A., Golshani, K. J., Doyle, K. P., Lessov, N. S., Hobbs, T. R., Kohama, S. G., Pike, M. M., Kroenke, C. D., Grafe, M. R., Spector, M. D., et al. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.43 · Cited by 56 · see citing works
Self-citationIredale, S. K., Nevill, C. H., & Lutz, C. K. (2009) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2009.11.002 · Cited by 53 · see citing works
Song, I., Kim, J., Kim, Y.-I., Lee, K.-S., Jeong, D., & Chung, S. (2009) · Cerebrovascular Diseases · doi:10.1159/000247597 · Cited by 53 · see citing works
Hickey, E. J., You, X., Kaimaktchiev, V., Stenzel‐Poore, M. P., & Ungerleider, R. M. (2007) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2006.12.056 · Cited by 50 · see citing works
Self-citationInflammation and the Emerging Role of the Toll-Like Receptor System in Acute Brain Ischemia
Marsh, B. J., Stevens, S. L., Hunter, B. N., & Stenzel‐Poore, M. P. (2008) · Stroke · doi:10.1161/strokeaha.108.534917 · Cited by 47 · see citing works
Self-citationHeterogeneity in the Human Response to Immunostimulatory CpG Oligodeoxynucleotides
Leifer, C. A., Verthelyi, D. I., & Klinman, D. M. (2003) · Journal of Immunotherapy · doi:10.1097/00002371-200307000-00003 · Cited by 41 · see citing works
Effect of Tirilazad Mesylate on Middle Cerebral Artery Occlusion/Reperfusion in Nonhuman Primates
Mori, E., Ember, J. A., Copeland, B. R., Thomas, W. S., Koziol, J. A., & del Zoppo, G. J. (1995) · Cerebrovascular Diseases · doi:10.1159/000107880 · Cited by 32 · see citing works
Polymorphonuclear Leukocyte Behavior in a Nonhuman Primate Focal Ischemia Model
Ember, J. A., del Zoppo, G. J., Mori, E., Thomas, W. S., Copeland, B. R., & Hugli, T. E. (1994) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1994.137 · Cited by 32 · see citing works
Suzuki, H., Kanamaru, K., Kuroki, M., Sun, H., Waga, S., & Miyazawa, T. (1999) · Stroke · doi:10.1161/01.str.30.2.450 · Cited by 26 · see citing works
Tuttolomondo, A. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208786848829 · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Vartanian, K. B., Stevens, S. L., Marsh, B. J., Williams-Karnesky, R. L., Lessov, N. S., & Stenzel‐Poore, M. P. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-140 · Cited by 183 · see citing works
Self-citationGDF10 is a signal for axonal sprouting and functional recovery after stroke
Li, S., Nie, E. H., Yin, Y., Benowitz, L. I., Tung, S., Vinters, H. V., Bahjat, F. R., Stenzel-Poore, M. P., Kawaguchi, R., Coppola, G., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4146 · Cited by 181 · see citing works
“Non-human primate tissues are taken from a previously reported stroke neuroprotection study in which stroke animals did not receive study drug 44 (control n = 3, stroke n = 2).”
Self-citationToll-like receptors in cerebral ischemic inflammatory injury
Wang, Y., Lin, S., & Yang, Q. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-134 · Cited by 133 · see citing works
Global Cerebral Ischemia: Synaptic and Cognitive Dysfunction
Neumann, J. T., Cohan, C. H., Dave, K. R., Wright, C. B., & Pérez‐Pinzón, M. A. (2012) · Current Drug Targets · doi:10.2174/138945013804806514 · Cited by 135 · see citing works
Toll-Like Receptors and Ischemic Brain Injury
Gesuete, R., Kohama, S. G., & Stenzel‐Poore, M. P. (2014) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000068 · Cited by 117 · see citing works
Self-citationSexually dimorphic microglia and ischemic stroke
Kerr, N. A., Dietrich, D. W., Bramlett, H. M., & Raval, A. P. (2019) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13267 · Cited by 110 · see citing works
Glibenclamide in Cerebral Ischemia and Stroke
Simard, J., Sheth, K. N., Kimberly, W. T., Stern, B., del Zoppo, G. D., Jacobson, S., & Gerzanich, V. (2014) · Neurocritical Care · doi:10.1007/s12028-013-9923-1 · Cited by 88 · see citing works
Wang, P., Xiong, X., Chen, J., Wang, Y., Duan, W., & Yang, Q. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0301-0 · Cited by 78 · see citing works
Simão, F., Matté, A., Pagnussat, A. S., Netto, C. A., & Salbego, C. G. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.06.009 · Cited by 73 · see citing works
Non-Coding RNAs in Stroke and Neuroprotection
Saugstad, J. A. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00050 · Cited by 71 · see citing works
Lu, C., Ha, T., Wang, X., Liu, L., Zhang, X., Kimbrough, E. O., Sha, Z., Guan, M., Schweitzer, J. B., Kalbfleisch, J. H., et al. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.113.000629 · Cited by 64 · see citing works
Neuroimmune Response in Ischemic Preconditioning
McDonough, A., & Weinstein, J. R. (2016) · Neurotherapeutics · doi:10.1007/s13311-016-0465-z · Cited by 62 · see citing works
Immunomodulatory Effect of Toll-Like Receptor-3 Ligand Poly I:C on Cortical Spreading Depression
Ghaemi, A., Sajadian, A., Khodaie, B., Lotfinia, A. A., Lotfinia, M., Aghabarari, A., Ghadiri, M. K., Meuth, S. G., & Gorji, A. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8995-z · Cited by 54 · see citing works
Prophylactic TLR9 stimulation reduces brain metastasis through microglia activation
Benbenishty, A., Gadrich, M., Cottarelli, A., Lubart, A., Kain, D., Amer, M., Shaashua, L., Glasner, A., Erez, N., Agalliu, D., et al. (2019) · PLoS Biology · doi:10.1371/journal.pbio.2006859 · Cited by 50 · see citing works
Identification and Validation of Ifit1 as an Important Innate Immune Bottleneck
McDermott, J., Vartanian, K. B., Mitchell, H. D., Stevens, S. L., Sanfilippo, A. P., & Stenzel‐Poore, M. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036465 · Cited by 47 · see citing works
Self-citationIschemic Preconditioning in White Matter: Magnitude and Mechanism
Hamner, M. A., Ye, Z., Lee, R. V., Colman, J. R., Le, T. H., Gong, D. C., Ransom, B. R., & Weinstein, J. R. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2544-15.2015 · Cited by 47 · see citing works
Irisin Protects Brain against Ischemia/Reperfusion Injury through Suppressing TLR4/MyD88 Pathway
Yu, Q., Li, G., Ding, Q., Lei, T., Li, J., Sun, L., Sun, X., & Yang, Y. (2020) · Cerebrovascular Diseases · doi:10.1159/000505961 · Cited by 46 · see citing works
Ahmadabad, R. A., Ghadiri, M. K., & Gorji, A. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01785-6 · Cited by 44 · see citing works
Toll-Like Receptor Signaling Pathways: Novel Therapeutic Targets for Cerebrovascular Disorders
Ahmadabad, R. A., Mirzaasgari, Z., Gorji, A., & Ghadiri, M. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116153 · Cited by 44 · see citing works
Reprogramming the Response to Stroke by Preconditioning
Stevens, S. L., Vartanian, K. B., & Stenzel‐Poore, M. P. (2014) · Stroke · doi:10.1161/strokeaha.114.002879 · Cited by 42 · see citing works
Self-citationIschemic Transient Neurological Events Identified by Immune Response to Cerebral Ischemia
Jickling, G. C., Zhan, X., Stamova, B. S., Ander, B. P., Tian, Y., Liu, D., Sison, S.-M., Verro, P., Johnston, S. C., & Sharp, F. R. (2012) · Stroke · doi:10.1161/strokeaha.111.638577 · Cited by 38 · see citing works
The role of microglia in ischemic preconditioning
McDonough, A., & Weinstein, J. R. (2019) · Glia · doi:10.1002/glia.23695 · Cited by 38 · see citing works
Zhao, J., Mou, Y., Bernstock, J. D., Klimanis, D., Wang, S., Spatz, M., Maric, D., Johnson, K. R., Klinman, D. M., Li, X., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140772 · Cited by 37 · see citing works
Ye, L., Feng, Z., Doycheva, D. M., Malaguit, J., Dixon, B. J., Xu, N., Zhang, J. H., & Tang, J. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.12.008 · Cited by 29 · see citing works
Steps to Translate Preconditioning from Basic Research to the Clinic
Bahjat, F. R., Gesuete, R., & Stenzel‐Poore, M. P. (2012) · Translational Stroke Research · doi:10.1007/s12975-012-0223-4 · Cited by 25 · see citing works
Self-citationMethod parameters’ impact on mortality and variability in mouse stroke experiments: a meta-analysis
Ingberg, E., Dock, H., Theodorsson, E., Theodorsson, A., & Ström, J. O. (2016) · Scientific Reports · doi:10.1038/srep21086 · Cited by 25 · see citing works
Mavroudakis, L., Stevens, S. L., Duncan, K. D., Stenzel‐Poore, M. P., Laskin, J., & Lanekoff, I. (2020) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-020-02987-w · Cited by 25 · see citing works
Self-citationTherapeutic role of toll-like receptor modification in cardiovascular dysfunction
Navi, A., Patel, H., Shaw, S., Baker, D., & Tsui, J. C. S. (2012) · Vascular Pharmacology · doi:10.1016/j.vph.2012.10.001 · Cited by 24 · see citing works
Role of Circulating Immune Cells in Stroke and Preconditioning-Induced Protection
Gesuete, R., Stevens, S. L., & Stenzel‐Poore, M. P. (2016) · Acta neurochirurgica. Supplementum · doi:10.1007/978-3-319-18497-5_7 · Cited by 22 · see citing works
Self-citationNonhuman Primate Models in Translational Regenerative Medicine
Daadi, M. M., Barberi, T., Shi, Q. S., & Lanford, R. E. (2014) · Stem Cells and Development · doi:10.1089/scd.2014.0374 · Cited by 22 · see citing works
Bahjat, F. R., West, G. A., Kohama, S. G., Glynn, C., Urbanski, H. F., Hobbs, T. R., Earl, E., Stevens, S. L., & Stenzel‐Poore, M. P. (2017) · Translational Stroke Research · doi:10.1007/s12975-017-0532-8 · Cited by 20 · see citing works
Self-citationMicroglial depletion abolishes ischemic preconditioning in white matter
Hamner, M. A., McDonough, A., Gong, D. C., Todd, L. J., Rojas, G., Hodecker, S. C., Ransom, C. B., Reh, T. A., Ransom, B. R., & Weinstein, J. R. (2021) · Glia · doi:10.1002/glia.24132 · Cited by 18 · see citing works
Vartanian, K. B., Mitchell, H. D., Stevens, S. L., Conrad, V. K., McDermott, J., & Stenzel‐Poore, M. P. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.193 · Cited by 17 · see citing works
Self-citationCan Genes Modify Stroke Outcome and By What Mechanisms?
Simon, R. P., Meller, R., Zhou, A., & Henshall, D. C. (2011) · Stroke · doi:10.1161/strokeaha.111.622225 · Cited by 16 · see citing works
Packard, A. E. B., Leung, P. Y., Vartanian, K. B., Stevens, S. L., Bahjat, F. R., & Stenzel‐Poore, M. P. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.140 · Cited by 16 · see citing works
Self-citationSun, Y., Zhang, L., Cao, Y. Q., Li, X., Liu, F., Cheng, X., Du, J., Ran, H., Wang, Z., Li, Y., et al. (2023) · Journal of Thrombosis and Haemostasis · doi:10.1016/j.jtha.2023.02.021 · Cited by 13 · see citing works
Pharmacological Treatment of Acute Ischemic Stroke
Mestre, H., Cohen-Minian, Y., Zajarias-Fainsod, D., & Ibarr, A. (2013) · InTech eBooks · doi:10.5772/53774 · Cited by 13 · see citing works
Zhang, Z., Guo, Z., Tu, Z., Yang, H., Li, C., Hu, M., Zhang, Y., Jin, P., & Hou, S. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1056354 · Cited by 13 · see citing works
Stevens, S. L., Liu, T., Bahjat, F. R., Petyuk, V., Schepmoes, A., Sontag, R. L., Gritsenko, M. A., Wu, C., Wang, S., Shukla, A. K., et al. (2018) · Translational Stroke Research · doi:10.1007/s12975-018-0670-7 · Cited by 12 · see citing works
Self-citationDolgin, E. (2012) · Nature Medicine · doi:10.1038/nm0712-1003 · Cited by 11 · see citing works
Correction to: Neuroimmune Response in Ischemic Preconditioning
McDonough, A., & Weinstein, J. R. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0580-5 · Cited by 9 · see citing works
Cerebral conditioning: Mechanisms and potential clinical implications
Sheng, R., Chen, J., & Qin, Z. (2021) · Brain Hemorrhages · doi:10.1016/j.hest.2021.08.003 · Cited by 7 · see citing works
Urbanski, H., Kohama, S., West, G., Glynn, C., Williams-Karnesky, R., Earl, E., Neuringer, M. N., Renner, L., Weiss, A., Stenzel-Poore, M., et al. (2012) · Translational Stroke Research · doi:10.1007/s12975-012-0191-8 · Cited by 7 · see citing works
Self-citationNonhuman primate model in clinical modeling of diseases for stem cell therapy
Daadi, M. M., Choudhury, G., Kim, J., Frost, P., & Bastarrachea, R. A. (2016) · Brain Circulation · doi:10.4103/2394-8108.192524 · Cited by 5 · see citing works
B-Cells in Stroke and Preconditioning-Induced Protection Against Stroke
Selvaraj, U. M., Poinsatte, K., & Stowe, A. M. (2016) · Springer series in translational stroke research · doi:10.1007/978-3-319-32337-4_12 · Cited by 2 · see citing works
Nowak, T. S., & Zhao, L. (2012) · Springer eBooks · doi:10.1007/978-1-4419-9695-4_13 · Cited by 2 · see citing works
Toll-Like Receptors in Ischemic Stroke and Other Acute Brain Injuries
Bahjat, F. R., Gesuete, R., & Stenzel‐Poore, M. P. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8915-3_7
Self-citationDave, K. R., Saul, I., Raval, A. P., & Pérez‐Pinzón, M. A. (2019) · PubMed
Bahjat, F. R., Vartanian, K. B., West, G. A., & Stenzel‐Poore, M. P. (2012) · Springer eBooks · doi:10.1007/978-1-4419-9530-8_10
Self-citationGq Signaling in Microglia Triggers Interferon Responses and Improves Outcome After Ischemic Stroke
Bitar, L., Brehme, M.-L., Oldenburg, C., Cainzos, S. I., Kaul, M. G., Mummert, T., Borggrewe, M., Oertner, T. G., & Magnus, T. (2026) · Glia · doi:10.1002/glia.70209
- Authors
- Bahjat, F. R., Williams-Karnesky, R. L., Kohama, S. G., West, G. A., Doyle, K. P., Spector, M. D., Hobbs, T. R., & Stenzel-Poore, M. P.
- Affiliations
- Oregon Health & Science University (US)
- Oregon National Primate Research Center (US)
- Swedish Medical Center (US)
- Stanford Medicine (US)
- Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, USA
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2011-02-02
- Volume
- 31
- Issue
- 5
- Pages
- 1229-1242
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- PMC
- PMC3099644
- OpenAlex
- W2050798868
- Cited by
- 51
- References
- 41
- Citations by year
- 2026: 1 · 2023: 2 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 1 · 2017: 3 · 2016: 5 · 2015: 6 · 2014: 6 · 2013: 4 · 2012: 10
- FWCI
- 5.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns050567-10)
- National Institute of Neurological Disorders and Stroke (F30NS070359, U01NS064953, R01-NS050567, R01NS062381, K08NS043997, NS043997, NS050567)
- National Center for Research Resources (P51RR000163, K01RR000163, RR-00163.)
- Topics
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- pharmacological preconditioning, TLR9, cerebral ischemia, stroke, neuroprotection, rhesus macaque model, transient middle cerebral artery occlusion, innate immunity, pattern recognition receptors, ischemic brain injury
- MeSH terms
- Animals, Disease Models, Animal, DNA, Macaca mulatta, Male, Mice, Inbred C57BL, Oligodeoxyribonucleotides, Ischemic Preconditioning, Recovery of Function, Stroke, Toll-Like Receptors, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
