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Cited by 71MicroRNA in disease regulationNeuroinflammation and Neurodegeneration MechanismsCancer-related molecular mechanisms research

Non-Coding RNAs in Stroke and Neuroprotection

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Saugstad, Julie A.·2015·Frontiers in Neurology
DOI 10.3389/fneur.2015.00050PMC PMC4358219
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Abstract

This review will focus on the current state of knowledge regarding non-coding RNAs (ncRNA) in stroke and neuroprotection. There will be a brief introduction to microRNAs (miRNA), long ncRNAs (lncRNA), and piwi-interacting RNAs (piRNA), followed by evidence for the regulation of ncRNAs in ischemia. This review will also discuss the effect of neuroprotection induced by a sublethal duration of ischemia or other stimuli given before a stroke (preconditioning) on miRNA expression and the role of miRNAs in preconditioning-induced neuroprotection. Experimental manipulation of miRNAs and/or their targets to induce pre- or post-stroke protection will also be presented, as well as discussion on miRNA responses to current post-stroke therapies. This review will conclude with a brief discussion of future directions for ncRNAs studies in stroke, such as new approaches to model complex ncRNA datasets, challenges in ncRNA studies, and the impact of extracellular RNAs on human diseases such as stroke.

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Authors
Saugstad, J. A.
Affiliations
Oregon Health & Science University (US)
Corresponding author
Saugstad, Julie A.
ORCID
Saugstad, Julie A.
Venue
Frontiers in Neurology
Publisher
Frontiers Media SA
Published
2015-03-13
Volume
6
Pages
50-50
ISSN
1664-2295 (ISSN-L)
DOI
10.3389/fneur.2015.00050
PMC
PMC4358219
OpenAlex
W2074093758
Cited by
71
References
122
Citations by year
2025: 1 · 2024: 2 · 2023: 5 · 2022: 4 · 2021: 7 · 2020: 8 · 2019: 8 · 2018: 9 · 2017: 15 · 2016: 12
FWCI
1.17
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Neurology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Institutes of Health
  • National Institute of Neurological Disorders and Stroke (R21NS082832, R01NS064270, R42NS065515)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords
non-coding RNA, stroke, neuroprotection, microRNA, long non-coding RNA, piRNA, ischemia, preconditioning, ischemic stroke, extracellular RNA

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