The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Assessing Post-Stroke Behavior in Mouse Models of Focal Ischemia
Open accessAbstract
Experimental treatment strategies and neuroprotective drugs that showed therapeutic promise in animal models of stroke have failed to produce beneficial effects in human stroke patients. The difficulty in translating preclinical findings to humans represents a major challenge in cerebrovascular research. The reasons behind this translational road block might be explained by a number of factors, including poor quality control in various stages of the research process, the validity of experimental stroke models, and differences in drug administration and pharmacokinetics. Another major difference between animal studies and clinical trials is the choice of end point or outcome measures. Here, we discuss the necessity of poststroke behavioral testing to bridge the gap between clinical and experimental end points. We review established sensory-motor tests for outcome determination after focal ischemia based on the published literature as well as our own personal experience. Selected tests are described in more detail and good laboratory practice standards for behavioral testing are discussed. This review is intended for stroke researchers planning to use behavioral testing in mice.
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Cites
Bederson, J. B., Pitts, L. H., Tsuji, M., Nishimura, M. C., Davis, R. L., & Bartkowski, H. (1986) · Stroke · doi:10.1161/01.str.17.3.472 · Cited by 2,681
Measuring normal and pathological anxiety-like behaviour in mice: a review
Belzung, C., & Griebel, G. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00291-1 · Cited by 912
Good Laboratory Practice: Preventing Introduction of Bias at the Bench
Macleod, M. R., Fisher, M., O'Collins, V., Sena, E. S., Dirnagl, U., Bath, P. M. W., Buchan, A., van der Worp, H. B., Traystman, R., Minematsu, K., et al. (2009) · Stroke · doi:10.1161/strokeaha.108.525386 · Cited by 331
Dénes, Á., Ferenczi, S., Halász, J., Környei, Z., & Kovács, K. J. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.64 · Cited by 276
Jin, K., Wang, X., Xie, L., Mao, X. O., & Greenberg, D. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000154107 · Cited by 225
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Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery
Ito, M., Komai, K., Mise-Omata, S., Iizuka-Koga, M., Noguchi, Y., Kondo, T., Sakai, R., Matsuo, K., Nakayama, T., Yoshie, O., et al. (2019) · Nature · doi:10.1038/s41586-018-0824-5 · Cited by 784
TREM2 regulates microglial lipid droplet formation and represses post-ischemic brain injury
Wei, W., Zhang, L., Xin, W., Pan, Y., Tatenhorst, L., Hao, Z., Gerner, S. T., Huber, S., Juenemann, M., Butz, M., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115962 · Cited by 122
Wu, J., Kung, J., Dong, J., Chang, L., Xie, C., Habib, A., Hawes, S., Yang, N., Chen, V., Liu, Z., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.095 · Cited by 87
Xin, W., Pan, Y., Wei, W., Tatenhorst, L., Graf, I., Popa-Wagner, A., Gerner, S. T., Huber, S., Kilic, E., Hermann, D. M., et al. (2023) · Theranostics · doi:10.7150/thno.84059 · Cited by 77
Kumar, A., Karuppagounder, S. S., Chen, Y., Corona, C., Kawaguchi, R., Cheng, Y., Balkaya, M., Sagdullaev, B. T., Wen, Z., Stuart, C., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.06.013 · Cited by 64
Self-citation
Metadata
- Authors
- Balkaya, M., Kröber, J. M., Rex, A., & Endres, M.
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2012-12-12
- Volume
- 33
- Issue
- 3
- Pages
- 330-338
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2002729523
- Cited by
- 307
- References
- 5
- FWCI
- 6.25
- Type
- journal article
- Language
- en
- Open access
- green
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