Measuring normal and pathological anxiety-like behaviour in mice: a review

The use of a plus-maze to measure anxiety in the mouse

Lister, R. G. (1987) · Psychopharmacology · doi:10.1007/bf00177912 · Cited by 2,617 · see citing works

DSM-IV: Diagnostic and Statistical Manual of Mental Disorders

Bell, C. C. (1994) · JAMA · doi:10.1001/jama.1994.03520100096046 · Cited by 2,608 · see citing works

Contingencies of reinforcement : a theoretical analysis

Skinner, B. F. (1969) · Medical Entomology and Zoology · Cited by 1,560 · see citing works

Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat

Caldji, C., Tannenbaum, B., Sharma, S., Francis, D., Plotsky, P. M., & Meaney, M. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5335 · Cited by 1,437 · see citing works

The Conduct of Inquiry

Salas, M. D. L. N. J., & Kaplan, A. (1967) · Revista española de la opinión pública · doi:10.2307/40180865 · Cited by 1,362 · see citing works

Le normal et le pathologique

Canguilhem, G. (2013) · Presses Universitaires de France eBooks · doi:10.3917/puf.cangu.2013.01 · Cited by 1,301 · see citing works

A review of the validity and variability of the Elevated Plus-Maze as an animal model of anxiety

Hogg, S. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)02126-4 · Cited by 1,169 · see citing works

Chronic mild stress-induced anhedonia: A realistic animal model of depression

Willner, P., Muscat, R., & Papp, M. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80194-0 · Cited by 1,160 · cited 1× · see citing works

The Conduct of Inquiry: Methodology for Behavioral Science.

Nagel, E., & Kaplan, A. (1965) · American Sociological Review · doi:10.2307/2091353 · Cited by 1,155 · see citing works

Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor

Ledent, C. A., Vaugeois, J., Schiffmann, S. N., Pedrazzini, T., Yacoubi, M. E., Vanderhaeghen, J. J., Costentin, J., Heath, J. K., Vassart, G., & Parmentier, M. (1997) · Nature · doi:10.1038/41771 · Cited by 918 · see citing works

Ethologically-based animal models of anxiety disorders.

Lister, R. (1990) · Pharmacology and Therapeutics · doi:10.1016/0163-7258(90)90021-s · Cited by 894 · see citing works

Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype?

Gerlai, R. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)20020-7 · Cited by 881 · see citing works

Catechol- <i>O</i> -methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior

Gogos, J. A., Morgan, M., Luine, V., Santha, M., Ogawa, S., Pfaff, D., & Karayiorgou, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.9991 · Cited by 864 · see citing works

Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor

Ichiki, T., Labosky, P. A., Shiota, C., Okuyama, S., Imagawa, Y., Fogo, A., Niimura, F., Ichikawa, I., Hogan, B. L. M., & lnagami, T. (1995) · Nature · doi:10.1038/377748a0 · Cited by 855 · see citing works

Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress

Bale, T. L., Contarino, A., Smith, G. W., Chan, R. K. W., Gold, L. H., Sawchenko, P. E., Koob, G. F., Vale, W. W., & Lee, K. (2000) · Nature Genetics · doi:10.1038/74263 · Cited by 850 · see citing works

Serotonin receptor 1A knockout: An animal model of anxiety-related disorder

Ramboz, S., Oosting, R. S., Amara, D. A., Kung, H. F., Blier, P., Mendelsohn, M. M., Mann, J. J., Brunner, D., & Hen, R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14476 · Cited by 813 · see citing works

Factor analysis of spatiotemporal and ethological measures in the murine elevated plus-maze test of anxiety

Rodgers, R. J., & Johnson, N. J. (1995) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)00138-m · Cited by 793 · see citing works

Animal Model of Depression

McKinney, W. T. (1969) · Archives of General Psychiatry · doi:10.1001/archpsyc.1969.01740200112015 · Cited by 710 · see citing works

Elevated anxiety and antidepressant-like responses in serotonin 5-HT 1A receptor mutant mice

Heisler, L. K., Chu, H.-M., Brennan, T. J., Danao, J. A., Bajwa, P., Parsons, L. H., & Tecott, L. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.15049 · Cited by 704 · see citing works

Increased anxiety of mice lacking the serotonin 1A receptor

Parks, C. L., Robinson, P. S., Sibille, E. L., Shenk, T. E., & Tóth, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10734 · Cited by 691 · see citing works

Animal models of anxiety: an ethological perspective

Rodgers, R. J., Cao, B.-J., Dalvi, A., & Holmes, A. (1997) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x1997000300002 · Cited by 642 · see citing works

Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2

Coste, S. C., Kesterson, R. A., Heldwein, K. A., Stevens, S. L., Heard, A. D., Hollis, J. H., Murray, S., Hill, J. K., Pantely, G. A., Hohimer, A. R., et al. (2000) · Nature Genetics · doi:10.1038/74255 · Cited by 588 · see citing works

Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cues

Crestani, F., Lorez, M., Baer, K., Essrich, C., Benke, D., Laurent, J. P., Belzung, C., Fritschy, J.-M., Lüscher, B., & Mohler, H. (1999) · Nature Neuroscience · doi:10.1038/12207 · Cited by 550 · see citing works

Deletion of Crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2

Kishimoto, T., Radulović, J., Radulović, M., Lin, C. R., Schrick, C., Hooshmand, F., Hermanson, O., Rosenfeld, M. G., & Spiess, J. (2000) · Nature Genetics · doi:10.1038/74271 · Cited by 502 · see citing works

Behavioral effects of estrogen receptor gene disruption in male mice

Ogawa, S., Lubahn, D. B., Korach, K. S., & Pfaff, D. W. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1476 · Cited by 498 · see citing works

5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: More than 30 years of research

Griebel, G. (1995) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(95)98597-j · Cited by 487 · see citing works

Pain responses, anxiety and aggression in mice deficient in pre-proenkephalin

König, M., Zimmer, A. M., Steiner, H., Holmes, P. V., Crawley, J. N., Brownstein, M., & Zimmer, A. (1996) · Nature · doi:10.1038/383535a0 · Cited by 486 · see citing works

Animal models for the study of anti-anxiety agents: A review

Treit, D. (1985) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(85)90046-6 · Cited by 449 · see citing works

Dopamine D4 Receptor-Knock-Out Mice Exhibit Reduced Exploration of Novel Stimuli

Dulawa, S. C., Grandy, D. K., Low, M. J., Paulus, M. P., & Geyer, M. A. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-21-09550.1999 · Cited by 432 · see citing works

Le Normal et le Pathologique

Marcelli, D. (2009) · Elsevier eBooks · doi:10.1016/b978-2-294-70703-2.50001-2 · Cited by 430 · see citing works

Animal models of depression: An overview

Willner, P. (1990) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(90)90076-e · Cited by 428 · see citing works

Differences in anxiety-related behaviours and in sensitivity to diazepam in inbred and outbred strains of mice

Griebel, G., Belzung, C., Perrault, G., & Sanger, D. J. (2000) · Psychopharmacology · doi:10.1007/s002130050038 · Cited by 420 · see citing works

The characterization and modelling of antipredator defensive behavior

Blanchard, R. J., Blanchard, D. C., Rodgers, J., & Weiss, S. Μ. (1990) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80069-7 · Cited by 366 · see citing works

Ethology and psychopharmacology

(1995) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(95)90084-5 · Cited by 317 · see citing works

Behavioral characterization of neuropeptide Y knockout mice

Bannon, A. W., Seda, J., Carmouché, M., Francis, J. M., Norman, M. H., Karbon, B., & McCaleb, M. L. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02285-x · Cited by 288 · see citing works

Discovery of the antidepressant and anti-emetic efficacy of substance P receptor (NK1) antagonists

Rupniak, N. M. J., & Kramer, M. S. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01396-6 · Cited by 278 · see citing works

Differentiation of anxiolytic and panicolytic drugs by effects on rat and mouse defense test batteries

Blanchard, R. J., Griebel, G., Henrie, J. A., & Blanchard, D. C. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00062-0 · Cited by 276 · see citing works

Targeted disruption of the orphanin FQ/nociceptin gene increases stress susceptibility and impairs stress adaptation in mice

Koster, A. M., Montkowski, A., Schulz, S., Stübe, E., Knaudt, K., Jenck, F., Moreau, J., Nothacker, H., Civelli, O., & Reinscheid, R. K. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.18.10444 · Cited by 247 · see citing works

Advances in the Study of Aggression

(1984) · Elsevier eBooks · doi:10.1016/c2013-0-07098-3 · Cited by 244 · see citing works

Life without neuropeptide Y.

Palmiter, R. D., Erickson, J. C., Hollopeter, G., Baraban, S. C., & Schwartz, M. W. (1998) · PubMed · Cited by 242 · see citing works

The free-exploratory paradigm

Griebel, G., Belzung, C., Misslin, R., & Vogel, E. (1993) · Behavioural Pharmacology · doi:10.1097/00008877-199312000-00009 · Cited by 239 · see citing works

Increased anxiety and altered responses to anxiolytics in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase

Kash, S. F., Tecott, L. H., Hodge, C. W., & Bækkeskov, S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1698 · Cited by 216 · see citing works

Phenotypic Characterization of an α₄ Neuronal Nicotinic Acetylcholine Receptor Subunit Knock-Out Mouse

Ross, S. A., Wong, J. Y. F., Clifford, J. J., Kinsella, A., Massalas, J. S., Horne, M. K., Scheffer, I. E., Kola, I., Waddington, J. L., Berkovic, S. F., et al. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-17-06431.2000 · Cited by 204 · see citing works

Sardinian alcohol-preferring rats: A genetic animal model of anxiety

Colombo, G., Agabio, R., Lobina, C., Reali, R., Zocchi, A., Fadda, F., & GESSA, G. L. (1995) · Physiology & Behavior · doi:10.1016/0031-9384(94)00382-f · Cited by 197 · see citing works

Sustained Long Term Potentiation and Anxiety in Mice Lacking theMas Protooncogene

Walther, T., Balschun, D., Voigt, J., Fink, H., Zuschratter, W., Birchmeier, C., Ganten, D., & Bäder, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.19.11867 · Cited by 196 · see citing works

Is There a Future for Neuropeptide Receptor Ligands in the Treatment of Anxiety Disorders?

Griebel, G. (1999) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(98)00041-2 · Cited by 171 · see citing works

Altered anxiety and weight gain in corticotropin-releasing hormone-binding protein-deficient mice

Karolyi, I. J., Burrows, H. L., Ramesh, T., Nakajima, M., Lesh, J., Seong, E., Camper, S. A., & Seasholtz, A. F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11595 · Cited by 154 · see citing works

Link between emotional memory and anxiety states: A study by principal component analysis

Beuzen, A. (1995) · Physiology & Behavior · doi:10.1016/0031-9384(95)00013-9 · Cited by 152 · see citing works

Affect and Aggression: An Animal Model Applied to Human Behavior

Blanchard, D. C., & Blanchard, R. J. (1984) · Elsevier eBooks · doi:10.1016/b978-0-12-037701-5.50006-4 · Cited by 144 · see citing works

Disruption of the midkine gene ( Mdk ) resulted in altered expression of a calcium binding protein in the hippocampus of infant mice and their abnormal behaviour

Nakamura, E., Kadomatsu, K., Yuasa, S., Muramatsu, H., Mamiya, T., NABESHIMA, T., Fan, Q., Ishiguro, K., Igakura, T., Matsubara, S., et al. (1998) · Genes to Cells · doi:10.1046/j.1365-2443.1998.00231.x · Cited by 143 · see citing works

Anxiogenic-like effects of fluprazine and eltoprazine in the mouse elevated plus-maze

Rodgers, R. J., Cole, J. C., Cobain, M. R., Daly, P., Doran, P. J., Eells, J. R., & Wallis, P. (1992) · Behavioural Pharmacology · doi:10.1097/00008877-199212000-00009 · Cited by 134 · see citing works

Does neophobia necessarily imply fear or anxiety?

Misslin, R., & Cigrang, M. (1986) · Behavioural Processes · doi:10.1016/0376-6357(86)90069-0 · Cited by 129 · see citing works

Anxiety and increased 5-HT1A receptor response in NCAM null mutant mice

Stork, O., Welzl, H., Wotjak, C. T., Hoyer, D., Delling, M., Cremer, H., & Schachner, M. (1999) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(19990905)40:3 · Cited by 127 · see citing works

Benzodiazepine receptors in “emotional” and “non-emotional” mice: Comparison of four strains

Robertson, H. A. (1979) · European Journal of Pharmacology · doi:10.1016/0014-2999(79)90447-3 · Cited by 120 · see citing works

Anxiety-like behavior in mice lacking the angiotensin II type-2 receptor

Okuyama, S., Sakagawa, T., Chaki, S., Imagawa, Y., Ichiki, T., & Inagami, T. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01098-7 · Cited by 116 · see citing works

The Effects of Childhood Parental Death and Divorce on Six-Month History of Anxiety Disorders

Tweed, J. L., Schoenbach, V. J., George, L. K., & Blazer, D. G. (1989) · The British Journal of Psychiatry · doi:10.1192/bjp.154.6.823 · Cited by 113 · see citing works

Animal models of depression: an overview.

Wt, M. (1984) · PubMed · Cited by 110 · see citing works

Normal electrophysiological and behavioral responses to ethanol in mice lacking the long splice variant of the γ2 subunit of the γ-aminobutyrate type A receptor

Homanics, G. E., Harrison, N. L., Quinlan, J. J., Krasowski, M. D., Rick, C., Blas, A. L. D., Mehta, A. K., Kist, F., Mihalek, R., Aul, J. J., et al. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(98)00177-4 · Cited by 106 · see citing works

Anti-sexual and anxiogenic behavioral consequences of corticotropin-releasing factor overexpression are centrally mediated

Heinrichs, S. C., Min, H., Tamraz, S., Carmouché, M., Boehme, S. A., & Vale, W. (1997) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(97)00030-9 · Cited by 106 · see citing works

Mice trisomic for a bacterial artificial chromosome with the single-minded 2 gene (Sim2) show phenotypes similar to some of those present in the partial trisomy 16 mouse models of Down syndrome

Chrast, R. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.12.1853 · Cited by 102 · see citing works

Difference in the reactivity of the mesocortical dopaminergic neurons to stress in the balb/c and C57 BL/6 mice

Hervé, D., Tassin, J., Barthélémy, C., Blanc, G., Lavielle, S., & Glowinski, J. (1979) · Life Sciences · doi:10.1016/0024-3205(79)90407-7 · Cited by 97 · see citing works

Anxiety-induced antinociception in mice: effects of systemic and intra-amygdala administration of 8-OH-DPAT and midazolam

Nunes‐de‐Souza, R. L., Canto‐de‐Souza, A., da-Costa, M., Fornari, R. V., Graeff, F. G., & Pelá, I. R. (2000) · Psychopharmacology · doi:10.1007/s002130000428 · Cited by 96 · see citing works

Superior Water Maze Performance and Increase in Fear-Related Behavior in the Endothelial Nitric Oxide Synthase-Deficient Mouse Together with Monoamine Changes in Cerebellum and Ventral Striatum

Frisch, C., Dere, E., Silva, M. A. D. S., Gödecke, A., Schrader, J., & Huston, J. P. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-17-06694.2000 · Cited by 96 · see citing works

Animal models of human emotion and cognition.

Haug, M., & Whalen, R. E. (1999) · American Psychological Association eBooks · doi:10.1037/10335-000 · Cited by 82 · see citing works

Increased fearfulness of Fyn tyrosine kinase deficient mice

Miyakawa, T., Yagi, T., Watanabe, S., & Niki, H. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90201-1 · Cited by 81 · see citing works

Differences in Drug-Induced Place Conditioning Between BALB/c and C57Bl/6 Mice

Belzung, C. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00212-9 · Cited by 80 · see citing works

A model of ???antipredator??? defense in Swiss-Webster mice

Griebel, G., Blanchard, D. C., Jung, Á. H., & Blanchard, R. J. (1995) · Behavioural Pharmacology · doi:10.1097/00008877-199511000-00009 · Cited by 79 · see citing works

IL-6 deficiency leads to increased emotionality in mice: evidence in transgenic mice carrying a null mutation for IL-6.

Armario, A., Hernández, J., Bluethmann, H., & Hidalgo, J. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00199-4 · Cited by 76 · see citing works

Increased Anxiety and Impaired Pain Response in Puromycin-Sensitive Aminopeptidase Gene-Deficient Mice Obtained by a Mouse Gene-Trap Method

Osada, T., Ikegami, S., Takiguchi‐Hayashi, K., Yamazaki, Y., Fukui, Y., Higashinakagawa, T., Sakaki, Y., & Takeuchi, T. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-14-06068.1999 · Cited by 74 · see citing works

Emotional reactivity in mice, a case of nongenetic heredity?

Calatayud, F., & Belzung, C. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00566-2 · Cited by 70 · see citing works

CRH Overproduction in Transgenic Mice

Stenzel‐Poore, M. P., Duncan, J. E., Rittenberg, M. B., Bakke, A. C., & Heinrichs, S. C. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb15110.x · Cited by 69 · see citing works

Flumazenil induces benzodiazepine partial agonist-like effects in BALB/c but not C57BL/6 mice

Belzung, C., Guisquet, A. M. L., & Crestani, F. (2000) · Psychopharmacology · doi:10.1007/s002130050021 · Cited by 63 · see citing works

Exploratory and Displacement Behavior in Transgenic Mice Expressing High Levels of Brain TNF-α

Fiore, M., Alleva, E., Probert, L., Kollias, G. A., Angelucci, F., & Aloe, L. (1998) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00514-3 · Cited by 58 · see citing works

Measurement of Anxiety in Transgenic Mice

Weiss, S. Μ., Lightowler, S., Stanhope, K. J., Kennett, G. A., & Dourish, C. T. (2000) · Reviews in the Neurosciences · doi:10.1515/revneuro.2000.11.1.59 · Cited by 55 · see citing works

The Influence of a Targeted Deletion of the IFNγ Gene on Emotional Behaviors

Kustova, Y., Sei, Y., Morse, H. C., & Basile, A. S. (1998) · Brain Behavior and Immunity · doi:10.1006/brbi.1998.0546 · Cited by 53 · see citing works

Paradoxical differences in animal models of anxiety among the Roman rat lines

Chaouloff, F., Castanon, N., & Mormède, P. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90801-x · Cited by 48 · see citing works

Anxiety-like behavior in transgenic mice with brain expression of neuropeptide Y.

Inui, A., Okita, M., Nakajima, M., Momose, K., Ueno, N., Teranishi, A., Miura, M., Hirosue, Y., Sano, K., Sato, M., et al. (1998) · PubMed · Cited by 48 · see citing works

Stimulation of 5-HT1A receptors by systemic or medial septum injection induces anxiogenic-like effects and facilitates acquisition of a spatial discrimination task in mice

Miheau, J., & Barbara, V. M. (1999) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(99)00057-3 · Cited by 47 · see citing works

Comparison of anxiety measured in the elevated plus-maze, open-field and social interaction tests between spontaneously hypertensive rats and Wistar EPM-1 rats.

Goto, S., Conceição, I. M., Ribeiro, R. A., & Frussa‐Filho, R. (1993) · PubMed · Cited by 47 · see citing works

Genetic difference in sensitivity to β-carboline: Evidence for the involvement of brain benzodiazepine receptors

Chapouthier, G., Bondoux, D., Martin, B., Desforges, C., & Launay, J. (1991) · Brain Research · doi:10.1016/0006-8993(91)90847-o · Cited by 41 · see citing works

Temporal structure of open field behavior in inbred strains of mice

Makino, J., Kato, K., & Maes, F. W. (1991) · Japanese Psychological Research · doi:10.4992/psycholres1954.33.145 · Cited by 36 · see citing works

Naloxone potentiates the anxiolytic but not the amnestic action of chlordiazepoxide in C57BL/6 mice

Belzung, C., & Dubreuil, D. (1998) · Behavioural Pharmacology · doi:10.1097/00008877-199812000-00005 · Cited by 29 · see citing works

Naloxone potentiates the effects of subeffective doses of anxiolytic agents in mice

Belzung, C., & Ågmo, A. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)00142-8 · Cited by 28 · see citing works

Naloxone blocks anxiolytic-like effects of benzodiazepines in Swiss but not in Balb/c mice

Belzung, C., & �gmo, A. (1997) · Psychopharmacology · doi:10.1007/s002130050336 · Cited by 27 · see citing works

Effects of buspirone on antinociceptive and behaviourial responses to the elevated plus-maze in mice

Lee, C., & Rodgers, R. J. (1991) · Behavioural Pharmacology · doi:10.1097/00008877-199112000-00006 · Cited by 26 · see citing works

Animal models of anxiety and the development of novel anxiolytic drugs

Sanger, D. J., Perrault, G., Morel, E., Joly, D., & Živković, B. (1991) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(91)90082-c · Cited by 25 · see citing works

β-carboline-induced seizures in mice: Genetic analysis

Desforges, C., Venault, P., Dodd, R. H., Chapouthier, G., & Roubertoux, P. L. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90267-0 · Cited by 23 · see citing works

Diazepam disposition in mature and aged rabbits and rats.

Tsang, C. F., & Wilkinson, G. R. (1982) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)07905-x · Cited by 21 · see citing works

Anxiolysis by ethanol, diazepam and buspirone in a novel murine behavioral assay

Seale, T. W., Niekrasz, I., & Garrett, K. M. (1996) · Neuroreport · doi:10.1097/00001756-199607290-00023 · Cited by 20 · see citing works

Blockade of anxiolytic-like actions of chlordiazepoxide by naloxone in the elevated plus-maze: Comparisons between Swiss, C57BL/6, and BALB/c mice

Ågmo, A., Belzung, C., Deloire, X., Grassin, M., & Lewis, S. (1999) · Psychobiology · doi:10.3758/bf03332104 · Cited by 19 · see citing works

The Mouse Defense Test Battery: An experimental model of different emotional states.

Griebel, G., & Sanger, D. J. (2004) · American Psychological Association eBooks · doi:10.1037/10335-005 · Cited by 9 · see citing works

The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review.

Prut, L., & Belzung, C. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01272-x · Cited by 3,190 · see citing works

The use of the elevated plus maze as an assay of anxiety-related behavior in rodents

Walf, A. A., & Frye, C. A. (2007) · Nature Protocols · doi:10.1038/nprot.2007.44 · Cited by 3,035 · see citing works

The mouse light/dark box test

Bourin, M., & Hascoët, M. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01274-3 · Cited by 1,440 · see citing works

The ascent of mouse: advances in modelling human depression and anxiety

Cryan, J. F., & Holmes, A. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1825 · Cited by 1,198 · see citing works

Ethological and temporal analyses of anxiety-like behavior: The elevated plus-maze model 20 years on

Carobrez, A. P., & Bertoglio, L. J. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.04.017 · Cited by 993 · see citing works

The neurobiology and control of anxious states

Millan, M. J. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00087-x · Cited by 963 · see citing works

The biology of fear- and anxiety-related behaviors

Steimer, T. J. (2002) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2002.4.3/tsteimer · Cited by 796 · see citing works

Mouse behavioral tasks relevant to autism: Phenotypes of 10 inbred strains

MOY, S., NADLER, J., YOUNG, N., PEREZ, A., HOLLOWAY, L., BARBARO, R., BARBARO, J., WILSON, L., THREADGILL, D., & LAUDER, J. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.07.030 · Cited by 776 · see citing works

Resolving the neural circuits of anxiety

Calhoon, G. G., & Tye, K. M. (2015) · Nature Neuroscience · doi:10.1038/nn.4101 · Cited by 766 · see citing works

Differential Control of Learning and Anxiety along the Dorsoventral Axis of the Dentate Gyrus

Kheirbek, M. A., Drew, L. J., Burghardt, N. S., Costantini, D. O., Tannenholz, L., Ahmari, S. E., Zeng, H., Fenton, A. A., & Hen, R. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.038 · Cited by 713 · see citing works

Ovarian cycle–linked changes in GABAA receptors mediating tonic inhibition alter seizure susceptibility and anxiety

Maguire, J. L., Stell, B. M., Rafizadeh, M., & Mody, I. (2005) · Nature Neuroscience · doi:10.1038/nn1469 · Cited by 644 · see citing works

Growing up in a bubble: using germ-free animals to assess the influence of the gut microbiota on brain and behavior

Luczynski, P., McVey Neufeld, K.-A., Oriach, C. S., Clarke, G., Dinan, T. G., & Cryan, J. F. (2016) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw020 · Cited by 632 · see citing works

Metabotropic glutamate receptors as novel targets for anxiety and stress disorders

Swanson, C. J., Bures, M., Johnson, M. P., Linden, A.-M., Monn, J. A., & Schoepp, D. D. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1630 · Cited by 607 · see citing works

Stress, depression, and anhedonia: caveats concerning animal models

Anisman, H., & Matheson, K. (2005) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.007 · Cited by 569 · see citing works

Scototaxis as anxiety-like behavior in fish

Maximino, C., Brito, T. M., Dias, C. A. G. D. M., Gouvêia, A., & Morato, S. (2010) · Nature Protocols · doi:10.1038/nprot.2009.225 · Cited by 549 · see citing works

Neurobiological links between stress and anxiety

Daviu, N., Bruchas, M. R., Moghaddam, B., Sandi, C., & Beyeler, A. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100191 · Cited by 528 · see citing works

Oxidative Stress and Anxiety: Relationship and Cellular Pathways

Bouayed, J., Rammal, H., & Soulimani, R. (2009) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.2.2.7944 · Cited by 517 · see citing works

Stress During Gestation Alters Postpartum Maternal Care and the Development of the Offspring in a Rodent Model

Champagne, F. A., & Meaney, M. J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.016 · Cited by 510 · see citing works

Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice

Hovatta, I., Tennant, R. S., Helton, R., Marr, R. A., Singer, O., Redwine, J. M., Ellison, J. A., Schadt, E. E., Verma, I. M., Lockhart, D. J., et al. (2005) · Nature · doi:10.1038/nature04250 · Cited by 498 · see citing works

Measuring thigmotaxis in larval zebrafish

Schnörr, S. J., Steenbergen, P. J., Richardson, M. K., & Champagne, D. L. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.12.016 · Cited by 471 · see citing works

Adult brain and behavioral pathological markers of prenatal immune challenge during early/middle and late fetal development in mice

Meyer, U., Nyffeler, M., Yee, B. K., Knuesel, I., & Feldon, J. (2008) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.09.012 · Cited by 457 · see citing works

Age-related changes in behavior in C57BL/6J mice from young adulthood to middle age

Shoji, H., Takao, K., Hattori, S., & Miyakawa, T. (2016) · Molecular Brain · doi:10.1186/s13041-016-0191-9 · Cited by 452 · see citing works

The microbiome: stress, health and disease

Moloney, R. D., Desbonnet, L., Clarke, G., Dinan, T. G., & Cryan, J. F. (2014) · Mammalian Genome · doi:10.1007/s00335-013-9488-5 · Cited by 430 · see citing works

<i> <scp>B</scp> ifidobacteria </i> exert strain‐specific effects on stress‐related behavior and physiology in <scp>BALB</scp> /c mice

Savignac, H. M., Kiely, B., Dinan, T. G., & Cryan, J. F. (2014) · Neurogastroenterology &amp; Motility · doi:10.1111/nmo.12427 · Cited by 418 · see citing works

50 years of hurdles and hope in anxiolytic drug discovery

Griebel, G., & Holmes, A. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4075 · Cited by 414 · see citing works

Accelerating Amyloid-β Fibrillization Reduces Oligomer Levels and Functional Deficits in Alzheimer Disease Mouse Models

Cheng, I. H.-J., Scearce-Levie, K. A., Legleiter, J. A., Palop, J. J., Gerstein, H., Bien‐Ly, N., Puolivaöli, J., Lesné, S., Ashe, K. H., Muchowski, P. J., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701078200 · Cited by 403 · see citing works

Effects of repeated maternal separation on anxiety- and depression-related phenotypes in different mouse strains.

Millstein, R. A., & Holmes, A. (2007) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.05.003 · Cited by 407 · see citing works

Transgenerational effects of social environment on variations in maternal care and behavioral response to novelty

Champagne, F. A., & Meaney, M. J. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.6.1353 · Cited by 381 · see citing works

Translating rodent behavioral repertoire to zebrafish (Danio rerio): Relevance for stress research

Champagne, D. L., Hoefnagels, C. C. M., de Kloet, E. R., & Richardson, M. K. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.06.001 · Cited by 381 · see citing works

The V1a Vasopressin Receptor Is Necessary and Sufficient for Normal Social Recognition: A Gene Replacement Study

Bielsky, I. F., Hu, S.-B., Ren, X., Terwilliger, E. F., & Young, L. J. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.031 · Cited by 367 · see citing works

Bifidobacteria modulate cognitive processes in an anxious mouse strain

Savignac, H. M., Tramullas, M., Kiely, B., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.02.044 · Cited by 365 · see citing works

Genetic and Pharmacological Evidence of a Role for GABAB Receptors in the Modulation of Anxiety- and Antidepressant-Like Behavior

Mombereau, C., Kaupmann, K., Froestl, W., Sansig, G., van der Putten, H., & Cryan, J. F. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300413 · Cited by 348 · see citing works

Behavioral measures of anxiety in zebrafish (Danio rerio)

Blaser, R. E., Chadwick, L., & McGinnis, G. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.11.009 · Cited by 326 · see citing works

Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network

Harris, J. A., Devidze, N., Verret, L., Ho, K., Halabisky, B., Thwin, M. T., Kim, D., Hamto, P., Lo, I., Yu, G.-Q., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.10.020 · Cited by 319 · see citing works

The age of anxiety: role of animal models of anxiolytic action in drug discovery

Cryan, J. F., & Sweeney, F. F. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01362.x · Cited by 313 · see citing works

Behavioral Effects of Chronic Fluoxetine in BALB/cJ Mice Do Not Require Adult Hippocampal Neurogenesis or the Serotonin 1A Receptor

Holick, K. A., Lee, D. C., Hen, R., & Dulawa, S. C. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301399 · Cited by 313 · see citing works

Assessing Post-Stroke Behavior in Mouse Models of Focal Ischemia

Balkaya, M., Kröber, J., Rex, A., & Endres, M. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.185 · Cited by 305 · see citing works

Early life genetic, epigenetic and environmental factors shaping emotionality in rodents

Holmes, A., Guisquet, A. M. L., Vogel, E., Millstein, R. A., Leman, S., & Belzung, C. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.04.012 · Cited by 296 · see citing works

Evaluation of animal models of neurobehavioral disorders

van der Staay, F. J., Arndt, S. S., & Nordquist, R. E. (2009) · Behavioral and Brain Functions · doi:10.1186/1744-9081-5-11 · Cited by 294 · see citing works

What's wrong with my mouse model?

Kalueff, A. V., Wheaton, M., & Murphy, D. L. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.01.023 · Cited by 285 · see citing works

Stability of inbred mouse strain differences in behavior and brain size between laboratories and across decades

Wahłsten, D., Bachmanov, A. A., Finn, D. A., & Crabbe, J. C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605342103 · Cited by 280 · see citing works

Animal models of anxiety in mice

Bourin, M., Petit‐Demoulière, B., Dhonnchadha, B. Á. N., & Hascoët, M. (2007) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2007.00526.x · Cited by 277 · see citing works

A hitchhiker's guide to behavioral analysis in laboratory rodents

Sousa, N., Almeida, O. F. X., & Wotjak, C. T. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00228.x · Cited by 273 · see citing works

A mouse model of posttraumatic stress disorder that distinguishes between conditioned and sensitised fear

Siegmund, A., & Wotjak, C. T. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.07.017 · Cited by 270 · see citing works

Anxiety-Related Behaviors in Mice

Crawley, J. N., & Bailey, K. (2008) · Frontiers in neuroscience · doi:10.1201/noe1420052343.ch5 · Cited by 266 · see citing works

Tests of unconditioned anxiety — Pitfalls and disappointments

Ennaceur, A. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.05.032 · Cited by 265 · see citing works

Cognitive and Emotional Alterations Are Related to Hippocampal Inflammation in a Mouse Model of Metabolic Syndrome

Dinel, A., André, C., Aubert, A., Ferreira, G., Layé, S., & Castanon, N. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024325 · Cited by 264 · see citing works

Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease

Holmes, A. (2008) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.03.006 · Cited by 264 · see citing works

Behavioral and Locomotor Measurements Using an Open Field Activity Monitoring System for Skeletal Muscle Diseases

Tatem, K. S., Quinn, J. L., Phadke, A., Yu, Q., Gordish‐Dressman, H., & Nagaraju, K. (2014) · Journal of Visualized Experiments · doi:10.3791/51785 · Cited by 256 · see citing works

Adult behavioral and pharmacological dysfunctions following disruption of the fetal brain balance between pro-inflammatory and IL-10-mediated anti-inflammatory signaling

Meyer, U., Murray, P. J., Urwyler, A., Yee, B. K., Schedlowski, M., & Feldon, J. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002042 · Cited by 252 · see citing works

Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress

Qi, X., Lin, W., Li, J., Li, H., Wang, W., Wang, D., & Sun, M. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.05.003 · Cited by 247 · see citing works

Diet-induced obesity progressively alters cognition, anxiety-like behavior and lipopolysaccharide-induced depressive-like behavior: focus on brain indoleamine 2,3-dioxygenase activation

André, C., Dinel, A.-L., Ferreira, G., Layé, S., & Castanon, N. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.03.012 · Cited by 241 · see citing works

Effects of stress on alcohol drinking: a review of animal studies

Becker, H. C., Lopez, M. F., & Doremus‐Fitzwater, T. L. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2443-9 · Cited by 239 · see citing works

Role of Prefrontal Cortex Glucocorticoid Receptors in Stress and Emotion

McKlveen, J. M., Myers, B., Flak, J. N., Bundzikova, J., Solomon, M. B., Seroogy, K. B., & Herman, J. P. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.03.024 · Cited by 237 · see citing works

Real-time analysis of the behaviour of groups of mice via a depth-sensing camera and machine learning

de Chaumont, F., Ey, E., Torquet, N., Lagache, T., Dallongeville, S., Imbert, A., Legou, T., Sourd, A. L., Fauré, P., Bourgeron, T., et al. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0396-1 · Cited by 235 · see citing works

Patterns of avoidance behaviours in the light/dark preference test in young juvenile zebrafish: A pharmacological study

Steenbergen, P. J., Richardson, M. K., & Champagne, D. L. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.03.025 · Cited by 230 · see citing works

Strain Differences in Stress Responsivity Are Associated with Divergent Amygdala Gene Expression and Glutamate-Mediated Neuronal Excitability

Mozhui, K., Karlsson, R.-M., Kash, T. L., Ihne, J., Norcross, M., Patel, S., Farrell, M. R., Hill, E. E., Graybeal, C., Martin, K. P., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5017-09.2010 · Cited by 226 · see citing works

Endocannabinoid system and mood disorders: Priming a target for new therapies

Micale, V., Marzo, V. D., Šulcová, A., Wotjak, C. T., & Drago, F. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.12.002 · Cited by 222 · see citing works

Effects of interleukin-1β and lipopolysaccharide on behavior of mice in the elevated plus-maze and open field tests

Swiergiel, A. H., & Dunn, A. J. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.02.010 · Cited by 216 · see citing works

Gut vagal sensory signaling regulates hippocampus function through multi-order pathways

Suarez, A. N., Hsu, T. M., Liu, C. M., Noble, E. E., Cortella, A. M., Nakamoto, E. M., Hahn, J. D., de Lartigue, G., & Kanoski, S. E. (2018) · Nature Communications · doi:10.1038/s41467-018-04639-1 · Cited by 212 · see citing works

Behavioral and physiological mouse assays for anxiety: a survey in nine mouse strains

Bouwknecht, J. A., & Paylor, R. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00200-0 · Cited by 209 · see citing works

The effects of chronic treadmill and wheel running on behavior in rats

Burghardt, P. R., Fulk, L. J., Hand, G. A., & Wilson, M. A. (2004) · Brain Research · doi:10.1016/j.brainres.2004.05.086 · Cited by 204 · see citing works

Strain and Sex Differences in Anxiety-Like and Social Behaviors in C57BL/6J and BALB/cJ Mice

An, X., Jun-Xian, Z. O. U., Wu, R., Yang, Y., Tai, F., Zeng, S., Jia, R., Zhang, X., Liu, E., & Broders, H. G. (2011) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.60.111 · Cited by 203 · see citing works

Understanding stress: Insights from rodent models

Atrooz, F., Alkadhi, K. A., & Salim, S. (2021) · Current Research in Neurobiology · doi:10.1016/j.crneur.2021.100013 · Cited by 201 · see citing works

The use of the zebrafish model in stress research

Steenbergen, P. J., Richardson, M. K., & Champagne, D. L. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.10.010 · Cited by 199 · see citing works

Toward an Animal Model of Posttraumatic Stress Disorder

Siegmund, A., & Wotjak, C. T. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.025 · Cited by 199 · see citing works

Zebrafish antipredatory responses: A future for translational research?

Gerlai, R. T. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.10.008 · Cited by 190 · see citing works

Animal models of depression

Deussing, J. M. (2006) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2006.11.003 · Cited by 190 · see citing works

Impact of nesting material on mouse body temperature and physiology

Gaskill, B. N., Gordon, C. J., Pajor, E. A., Lucas, J. R., Davis, J. K., & Garner, J. P. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.12.018 · Cited by 189 · see citing works

Social enrichment during postnatal development induces transgenerational effects on emotional and reproductive behavior in mice

Curley, J. P. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.025.2009 · Cited by 184 · see citing works

Differential effects of exposure to low-light or high-light open-field on anxiety-related behaviors: Relationship to c-Fos expression in serotonergic and non-serotonergic neurons in the dorsal raphe nucleus

Bouwknecht, J. A., Spiga, F., Staub, D. R., Hale, M. W., Shekhar, A., & Lowry, C. A. (2007) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2006.12.009 · Cited by 183 · see citing works

Environmental Enrichment Produces a Behavioral Phenotype Mediated by Low Cyclic Adenosine Monophosphate Response Element Binding (CREB) Activity in the Nucleus Accumbens

Green, T. A., Alibhai, I. N., Roybal, C. N., Winstanley, C. A., Theobald, D. E. H., Birnbaum, S. G., Graham, A., Unterberg, S., Graham, D. L., Vialou, V., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.06.022 · Cited by 177 · see citing works

What Can We Learn about Autism from Studying Fragile X Syndrome?

Budimirovic, D. B., & Kaufmann, W. E. (2011) · Developmental Neuroscience · doi:10.1159/000330213 · Cited by 176 · see citing works

The exploratory behaviour of rats in the hole-board apparatus: Is head-dipping a valid measure of neophilia?

Brown, G. R., & Nemes, C. (2008) · Behavioural Processes · doi:10.1016/j.beproc.2008.02.019 · Cited by 173 · see citing works

Feeling Strained? Influence of Genetic Background on Depression-Related Behavior in Mice: A Review

Jacobson, L. H., & Cryan, J. F. (2006) · Behavior Genetics · doi:10.1007/s10519-006-9106-3 · Cited by 168 · see citing works

Animal Models of Anxiety

Ohl, F. (2005) · Handbook of experimental pharmacology · doi:10.1007/3-540-28082-0_2 · Cited by 164 · see citing works

Animal models for screening anxiolytic-like drugs: a perspective.

Bourin, M. (2015) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2015.17.3/mbourin · Cited by 163 · see citing works

Genetic basis of anxiety-like behaviour: a critical review

Clément, Y., Calatayud, F., & Belzung, C. (2002) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00637-2 · Cited by 162 · see citing works

Neotic preferences in laboratory rodents: Issues, assessment and substrates

Hughes, R. N. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.11.004 · Cited by 160 · see citing works

Gut Vagal Afferents Differentially Modulate Innate Anxiety and Learned Fear

Klarer, M., Arnold, M., Günther, L., Winter, C., Langhans, W., & Meyer, U. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.0252-14.2014 · Cited by 159 · see citing works

Validation of a simple, ethologically relevant paradigm for assessing anxiety in mice

Merali, Z., Levac, C., & Anisman, H. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01827-9 · Cited by 157 · see citing works

Experimental modeling of anxiety and depression

Kalueff, A. V., & Tuohimaa, P. (2004) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2004-1526 · Cited by 156 · see citing works

Home cage activity and behavioral performance in inbred and hybrid mice

Tang, X., Orchard, S. M., & Sanford, L. D. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00228-0 · Cited by 154 · see citing works

How Stress and Fluoxetine Modulate Serotonin 2C Receptor Pre-mRNA Editing

Englander, M. T., Dulawa, S. C., Bhansali, P., & Schmauss, C. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3895-04.2005 · Cited by 154 · see citing works

Magnesium deficiency induces anxiety and HPA axis dysregulation: Modulation by therapeutic drug treatment

Sartori, S. B., Whittle, N., Hetzenauer, A., & Singewald, N. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.07.027 · Cited by 152 · see citing works

Animal models of anxiety: A comprehensive review

Kumar, V., Bhat, Z. A., & Kumar, D. (2013) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2013.05.003 · Cited by 151 · see citing works

A Central Extended Amygdala Circuit That Modulates Anxiety

Ahrens, S., Wu, M. V., Furlan, A., Hwang, G., Paik, R., Li, H., Penzo, M. A., Tollkühn, J., & Li, B. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0705-18.2018 · Cited by 151 · see citing works

The Vogel conflict test: procedural aspects, γ-aminobutyric acid, glutamate and monoamines

Millan, M. J., & Brocco, M. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01275-5 · Cited by 149 · see citing works

Circadian clock proteins control adaptation to novel environment and memory formation

Kondratova, A. A., Dubrovsky, Y. V., Antoch, M. P., & Kondratov, R. V. (2010) · Aging · doi:10.18632/aging.100142 · Cited by 147 · see citing works

Many Neuronal and Behavioral Impairments in Transgenic Mouse Models of Alzheimer's Disease Are Independent of Caspase Cleavage of the Amyloid Precursor Protein

Harris, J. A., Devidze, N., Halabisky, B., Lo, I., Thwin, M. T., Yu, G.-Q., Bredesen, D. E., Masliah, E., & Mucke, L. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5341-09.2010 · Cited by 146 · see citing works

Maternal Behavior Regulates Benzodiazepine/GABAA Receptor Subunit Expression in Brain Regions Associated with Fear in BALB/c and C57BL/6 Mice

Caldji, C., Diorio, J. C., Anisman, H., & Meaney, M. J. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300436 · Cited by 145 · see citing works

Behavioral changes in male mice fed a high-fat diet are associated with IL-1β expression in specific brain regions

Almeida-Suhett, C. P., Graham, A. M., Chen, Y., & Deuster, P. A. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.11.016 · Cited by 142 · see citing works

Glyoxalase 1 increases anxiety by reducing GABAA receptor agonist methylglyoxal

Distler, M. G., Plant, L. D., Sokoloff, G., Hawk, A. J., Aneas, I., Wuenschell, G. E., Termini, J. S., Meredith, S. C., Nóbrega, M. A., & Palmer, A. A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61319 · Cited by 141 · see citing works

A Human Open Field Test Reveals Thigmotaxis Related to Agoraphobic Fear

Walz, N., Mühlberger, A., & Pauli, P. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.12.016 · Cited by 140 · see citing works

How age, sex and genotype shape the stress response

Novais, A., Monteiro, S., Roque, S., Correia‐Neves, M., & Sousa, N. (2016) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.11.004 · Cited by 140 · see citing works

Impaired explorative behavior and neophobia in genetically modified mice lacking or overexpressing the extracellular serine protease inhibitor neuroserpin

Madani, R., Kozlov, S. V., Akhmedov, A. T., Cinelli, P., Kinter, J., Lipp, H., Sonderegger, P., & Wolfer, D. P. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00077-0 · Cited by 140 · see citing works

Neprilysin Overexpression Inhibits Plaque Formation But Fails to Reduce Pathogenic Aβ Oligomers and Associated Cognitive Deficits in Human Amyloid Precursor Protein Transgenic Mice

Meilandt, W. J., Cissé, M., Ho, K., Wu, T. Z., Esposito, L., Scearce-Levie, K. A., Cheng, I. H.-J., Yu, G.-Q., & Mucke, L. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2984-08.2009 · Cited by 137 · see citing works

Mouse strain differences in autonomic responses to stress

van Bogaert, M. J. V., Groenink, L., Oosting, R. S., Westphal, K. G. C., van der Gugten, J., & Olivier, B. (2005) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2005.00143.x · Cited by 138 · see citing works

Exploratory behaviour in the open field test adapted for larval zebrafish: Impact of environmental complexity

Ahmad, F., & Richardson, M. K. (2012) · Behavioural Processes · doi:10.1016/j.beproc.2012.10.014 · Cited by 137 · see citing works

Novel approach to the behavioural characterization of inbred mice: automated home cage observations

de Visser, L., van den Bos, R., Kuurman, W. W., Kas, M. J., & Spruijt, B. M. (2005) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2005.00181.x · Cited by 135 · see citing works

S.21.05 The beta-3-adrenergic receptor in anxiety disorders and their treatment

Stemmelin, J., Cohen, C., & Griebel, G. (2006) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(06)70105-5

Tests for Anxiety‐Related Behavior in Mice

Hölter, S. M., Einicke, J., Sperling, B., Zimprich, A., Garrett, L., Fuchs, H., Gailus‐Durner, V., de Angelis, M. H., & Wurst, W. (2015) · Current Protocols in Mouse Biology · doi:10.1002/9780470942390.mo150010 · Cited by 49 · see citing works

Anxiety-Related Behaviors in Mice

Crawley, J. N., & Bailey, K. (2008) · Frontiers in neuroscience · doi:10.1201/noe1420052343.ch5 · Cited by 266 · see citing works

[The characteristics of the manifestation of hereditarily induced anxiety in male C57Bl/6J and CBA/Lac mice].

Avgustinovich, D. F., Lipina, T. V., Bondar, N. P., & Nn, K. (1999) · PubMed · Cited by 1 · see citing works

Features of the Genetically Defined Anxiety in Mice

Avgustinovich, D. F., Lipina, T. V., Bondar, N. P., Alekseyenko, O. V., & Kudryavtseva, N. N. (2000) · Behavior Genetics · doi:10.1023/a:1001999020138 · Cited by 81 · see citing works