The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Reliable Estimation of Capillary Transit Time Distributions Using DSC-MRI
Abstract
The regional availability of oxygen in brain tissue is traditionally inferred from the magnitude of cerebral blood flow ( CBF) and the concentration of oxygen in arterial blood. Measurements of CBF are therefore widely used in the localization of neuronal response to stimulation and in the evaluation of patients suspected of acute ischemic stroke or flow-limiting carotid stenosis. It was recently demonstrated that capillary transit time heterogeneity ( CTH) limits maximum oxygen extraction fraction ( OEF max ) that can be achieved for a given CBF. Here we present a statistical approach for determining CTH, mean transit time ( MTT), and CBF using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI). Using numerical simulations, we demonstrate that CTH, MTT, and OEF max can be estimated with low bias and variance across a wide range of microvascular flow patterns, even at modest signal-to-noise ratios. Mean transit time estimated by singular value decomposition (SVD) deconvolution, however, is confounded by CTH. The proposed technique readily identifies malperfused tissue in acute stroke patients and appears to highlight information not detected by the standard SVD technique. We speculate that this technique permits the non-invasive detection of tissue with impaired oxygen delivery in neurologic disorders such as acute ischemic stroke and Alzheimer's disease during routine diagnostic imaging.
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“In addition, regional increases in these flow disturbances precede progression of the active demyelination5,9–11.”
From Hematopoietic stem-cell gene therapy is associated with restored white matter microvascular function in cerebral adrenoleukodystrophy (2023) · cites this paper as [10]
Experimental — accuracy not yet measuredIn the citing paper
“Indeed, dynamic susceptibility contrast MR (DSC-MR) perfusion studies in ALD patients have shown that ABCD1 dysfunction alters white matter capillary flow and limits the metabolic rate of oxygen.”
From Hematopoietic stem-cell gene therapy is associated with restored white matter microvascular function in cerebral adrenoleukodystrophy (2023) · cites this paper as [10]
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Cites
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Buxton, R. B., & Frank, L. R. (1997) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199701000-00009 · Cited by 807
Research works printed but not linked: 3
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Cited by
Nielsen, R. B., Egefjord, L., Angleys, H., Mouridsen, K., Gejl, M., Møller, A., Brock, B., Brændgaard, H., Gottrup, H., Rungby, J., et al. (2017) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.02.007 · Cited by 119
Self-citationABCD1 dysfunction alters white matter microvascular perfusion
Lauer, A., Da, X., Hansen, M. B., Boulouis, G., Ou, Y., Cai, X., Liberato Celso Pedrotti, A., Kalpathy-Cramer, J., Caruso, P., Hayden, D. L., et al. (2017) · Brain · doi:10.1093/brain/awx262 · Cited by 48
Self-citationLauer, A., Speroni, S. L., Choi, M., Da, X., Duncan, C., McCarthy, S., Krishnan, V., Lusk, C. A., Rohde, D., Hansen, M. B., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37262-w · Cited by 26
Self-citationDigernes, I., Bjørnerud, A., Vatnehol, S. A. S., Løvland, G., Courivaud, F., Vik-Mo, E., Meling, T. R., & Emblem, K. E. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17694187 · Cited by 22
Metadata
- Authors
- Mouridsen, K., Hansen, M. B., Østergaard, L., & Jespersen, S. N.
- Affiliations
- Center of Functionally Integrative Neuroscience and MINDLab, Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2014-06-18
- Volume
- 34
- Issue
- 9
- Pages
- 1511-1521
- ISSN
- 0271-678X
- 1559-7016
- Cited by
- 133
- References
- 39
- Language
- en
- Licence
- journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
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