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Cited by 117Advanced MRI Techniques and ApplicationsBarrier Structure and Function StudiesAdvanced Neuroimaging Techniques and Applications

Accurate Determination of Blood–Brain Barrier Permeability Using Dynamic Contrast-Enhanced T1-Weighted MRI: A Simulation and in vivo Study on Healthy Subjects and Multiple Sclerosis Patients

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Cramer, Stig P, Larsson, Henrik BW·2014·Journal of Cerebral Blood Flow & Metabolism
DOI 10.1038/jcbfm.2014.126PMC PMC4269724
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Abstract

Dynamic contrast-enhanced magnetic resonance imaging (DCE–MRI) is increasingly used to estimate permeability in situations with subtle blood–brain barrier (BBB) leakage. However, the method's ability to differentiate such low values from zero is unknown, and no consensus exists on optimal selection of total measurement duration, temporal resolution, and modeling approach under varying physiologic circumstances. To estimate accuracy and precision of the DCE–MRI method we generated simulated data using a two-compartment model and progressively down-sampled and truncated the data to mimic low temporal resolution and short total measurement duration. Model fit was performed with the Patlak, the extended Tofts, and the Tikhonov two-compartment (Tik-2CM) models. Overall, 17 healthy controls were scanned to obtain in vivo data. Long total measurement duration (15 minutes) and high temporal resolution (1.25 seconds) greatly improved accuracy and precision for all three models, enabling us to differentiate values of permeability as low as 0.1 ml/100 g/min from zero. The Patlak model yielded highest accuracy and precision for permeability values <0.3 ml/100 g/min, but for higher values the Tik-2CM performed best. Our results emphasize the importance of optimal parameter setup and model selection when characterizing low BBB permeability.

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  • In multiple sclerosis patients, increased blood-brain barrier permeability has been shown by DCE-MRI in the cortex and adjacent white matter, corpus callosum and internal capsule, and thalamic gray matter.

    “More recently, an increase in BBB permeability has been shown in MS patients by DCE-MRI in the cortex and adjacent white matter (392), corpus callosum and internal capsule (121-123, 421, 574), as well as thalamic gray matter (123).”

    From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [121]

    The Results (page not supplied) report DCE-MRI permeability estimates in contrast-enhancing MS lesions, supporting the general point that BBB permeability was assessed in MS patients. The Materials and methods (page not supplied) describe lesion locations only as periventricular, juxtacortical, or infratentorial; the paper does not report increased permeability specifically in the corpus callosum, internal capsule, or thalamic gray matter. The cortex and adjacent white matter are attached to a different citation in the citing sentence. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Cramer, S. P., & Larsson, H. B.
Affiliations
University of Copenhagen (DK)
Corresponding author
Larsson, Henrik BW
ORCID
Venue
Journal of Cerebral Blood Flow & Metabolism
Publisher
SAGE Publications
Published
2014-07-30
Volume
34
Issue
10
Pages
1655-1665
ISSN
  • 0271-678X (ISSN-L)
  • 1559-7016
DOI
10.1038/jcbfm.2014.126
PMC
PMC4269724
OpenAlex
W2083426712
Cited by
117
References
1
Citations by year
2026: 9 · 2025: 9 · 2024: 9 · 2023: 4 · 2022: 6 · 2021: 14 · 2020: 20 · 2019: 4 · 2018: 10 · 2017: 11 · 2016: 12 · 2015: 7 · 2014: 2
FWCI
8.33
Type
journal article
Language
en
Open access
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Keywords
blood-brain barrier permeability, dynamic contrast-enhanced MRI, T1-weighted imaging, multiple sclerosis, Patlak model, extended Tofts model, two-compartment model, measurement time, temporal resolution, simulation study
MeSH terms
Adult, Algorithms, Blood-Brain Barrier, Computer Simulation, Female, Humans, Magnetic Resonance Imaging, Male, Models, Biological, Multiple Sclerosis, Permeability, Sensitivity and Specificity, Young Adult

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