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Cited by 145Barrier Structure and Function StudiesNeuroinflammation and Neurodegeneration MechanismsEpilepsy research and treatment

Blood–brain barrier dysfunction–induced inflammatory signaling in brain pathology and epileptogenesis

Open access
Kim, Soo Young, Buckwalter, Marion, Soreq, Hermona, Vezzani, Annamaria, Kaufer, Daniela·2012·Epilepsia
DOI 10.1111/j.1528-1167.2012.03701.xPMC PMC3703535
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Abstract

Summary: The protection of the brain from blood‐borne toxins, proteins, and cells is critical to the brain’s normal function. Accordingly, a compromise in the blood–brain barrier (BBB) function accompanies many neurologic disorders, and is tightly associated with brain inflammatory processes initiated by both infiltrating leukocytes from the blood, and activation of glial cells. Those inflammatory processes contribute to determining the severity and prognosis of numerous neurologic disorders, and can both cause, and result from BBB dysfunction. In this review we examine the role of BBB and inflammatory responses, in particular activation of transforming grown factor β (TGFβ) signaling, in epilepsy, stroke, and Parkinson’s disease.

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  • The connection between epilepsy and blood-brain barrier breakdown is known to be bidirectional.

    “The connection between epilepsy and BBB breakdown is known to be bidirectional (316).”

    From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [316]

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Authors
Kim, S. Y., Buckwalter, M., Soreq, H., Vezzani, A., & Kaufer, D.
Affiliations
  • University of California, Berkeley (US)
  • Stanford Medicine (US)
  • Hebrew University of Jerusalem (IL)
  • Mario Negri Institute for Pharmacological Research (IT)
Corresponding author
Kaufer, Daniela
ORCID
Venue
Epilepsia
Publisher
Wiley
Published
2012-11
Volume
53
Issue
s6
Pages
37-44
ISSN
  • 0013-9580 (ISSN-L)
  • 1528-1167
DOI
10.1111/j.1528-1167.2012.03701.x
PMC
PMC3703535
OpenAlex
W2138989306
Cited by
145
References
8
Citations by year
2026: 7 · 2025: 6 · 2024: 13 · 2023: 14 · 2022: 14 · 2021: 17 · 2020: 14 · 2019: 11 · 2018: 5 · 2017: 12 · 2016: 8 · 2015: 5 · 2014: 12 · 2013: 3 · 2012: 4
FWCI
0.71
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 6 d)
Locations
  • Epilepsia (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Neurological Disorders and Stroke (R01NS066005)
Topics
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
Keywords
blood-brain barrier dysfunction, neuroinflammation, epileptogenesis, TGF-beta signaling, glial activation, leukocyte infiltration, epilepsy, stroke, Parkinson's disease, neurological disorders
MeSH terms
Animals, Blood-Brain Barrier, Encephalitis, Epilepsy, Humans, Signal Transduction

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