Blood-brain barrier permeability abnormalities in vascular cognitive impairment
Open accessAbstract
Background and Purpose—: Disruption of the blood–brain barrier has been proposed to be important in vascular cognitive impairment. Increased cerebrospinal fluid albumin and contrast-enhanced MRI provide supporting evidence, but quantification of the blood–brain barrier permeability in patients with vascular cognitive impairment is lacking. Therefore, we acquired dynamic contrast-enhanced MRI to quantify blood–brain barrier permeability in vascular cognitive impairment. Method—: We studied 60 patients with suspected vascular cognitive impairment. They had neurological and neuropsychological testing, permeability measurements with dynamic contrast-enhanced MRI, and lumbar puncture to measure albumin index. Patients were separated clinically into subcortical ischemic vascular disease (SIVD), multiple and lacunar infarcts, and leukoaraiosis. Twenty volunteers were controls for the dynamic contrast-enhanced MRI studies, and control cerebrospinal fluid was obtained from 20 individuals undergoing spinal anesthesia for nonneurological problems. Results—: Thirty-six patients were classified as SIVD, 8 as multiple and lacunar infarcts, and 9 as leukoaraiosis. The albumin index was significantly increased in the SIVD group compared with 20 control subjects. Permeabilities for the patients with vascular cognitive impairment measured by dynamic contrast-enhanced MRI were significantly increased over control subjects ( P <0.05). Patient age did not correlate with either the blood–brain barrier permeability or albumin index. Highest albumin index values were seen in the SIVD group ( P <0.05) and were significantly increased over multiple and lacunar infarcts. K i values were elevated over control subjects in SIVD but were similar to multiple and lacunar infarcts. Conclusions—: There was abnormal permeability in white matter in patients with SIVD as shown by dynamic contrast-enhanced MRI and albumin index. Future studies will be needed to determine the relationship of blood–brain barrier damage and development of white matter hyperintensities.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Permeability to MRI tracers is increased in white matter lesions and in normal-appearing white matter.
“Third, the permeability to MRI tracers is increased in white matter lesions (Hanyu et al., 2002; Taheri et al., 2011; Wardlaw et al., 2009) and in normal appearing white matter (Topakian et al., 2010).”
From The Pathobiology of Vascular Dementia (2013) · cites this paper as Taheri et al., 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Hachinski, V., Iadecola, C., Petersen, R. C., Breteler, M. M., Nyenhuis, D. L., Black, S. E., Powers, W. J., DeCarli, C., Merino, J. G., Kalaria, R. N., et al. (2006) · Stroke · doi:10.1161/01.str.0000237236.88823.47 · Cited by 1,722 · see citing works
Self-citationSilent brain infarcts: a systematic review
Vermeer, S. E., Longstreth, W. T., & Koudstaal, P. J. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70170-9 · Cited by 1,221 · see citing works
Blood–brain barrier: Ageing and microvascular disease – systematic review and meta-analysis
Farrall, A. J., & Wardlaw, J. M. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.07.015 · Cited by 882 · see citing works
Hachinski, V. C., Potter, P., & Merskey, H. (1987) · Archives of Neurology · doi:10.1001/archneur.1987.00520130013009 · Cited by 755 · see citing works
Blood brain barrier: ageing and microvascular disease-systematic review and meta-analysis
Farrall, A., & Wardlaw, J. M. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.02.089 · Cited by 639 · see citing works
Matrix metalloproteinases and their multiple roles in neurodegenerative diseases
Rosenberg, G. A. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70016-x · Cited by 594 · see citing works
Self-citationFernando, M. S., Simpson, J. E., Matthews, F., Brayne, C., Lewis, C. E., Barber, R., Kalaria, R. N., Forster, G., Esteves, F., Wharton, S. B., et al. (2006) · Stroke · doi:10.1161/01.str.0000221308.94473.14 · Cited by 587 · see citing works
Moody, D. M., Bell, M. A., & CHALLA, V. R. (1990) · PubMed · Cited by 416 · see citing works
Lacunar stroke is associated with diffuse blood-brain barrier dysfunction
Wardlaw, J. M., Doubal, F., Armitage, P., Chappell, F., Carpenter, T., Muñoz Maniega, S., Farrall, A., Sudlow, C., Dennis, M., & Dhillon, B. (2009) · Annals of Neurology · doi:10.1002/ana.21549 · Cited by 364 · see citing works
Neuropathological assessment of the lesions of significance in vascular dementia
Esiri, M. M., Wilcock, G. K., & Morris, J. H. (1997) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.63.6.749 · Cited by 347 · see citing works
Neuropathologic correlates of white matter hyperintensities
Young, V. G., Halliday, G. M., & Kril, J. J. (2008) · Neurology · doi:10.1212/01.wnl.0000319691.50117.54 · Cited by 336 · see citing works
Periventricular venous collagenosis: association with leukoaraiosis.
Moody, D. M., Brown, W. R., CHALLA, V. R., & Anderson, R. L. (1995) · Radiology · doi:10.1148/radiology.194.2.7824728 · Cited by 310 · see citing works
Topakian, R., Barrick, T. R., Howe, F. A., & Markus, H. S. (2010) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2009.172072 · Cited by 281 · see citing works
Román, G. C., Sachdev, P. S., Royall, D. R., Bullock, R. A., Orgogozo, J., Pousa, S. L., Arizaga, R. L., & Wallin, A. (2004) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2004.09.016 · Cited by 277 · see citing works
A population study on blood-brain barrier function in 85-year-olds
Skoog, I. G., Wallin, A., Fredman, P., Hesse, C., Aevarsson, Ó., Karlsson, I., Gottfries, C. G., & Blennow, K. (1998) · Neurology · doi:10.1212/wnl.50.4.966 · Cited by 238 · see citing works
Binswanger's disease--revisited
Caplan, L. R. (1995) · Neurology · doi:10.1212/wnl.45.4.626 · Cited by 227 · see citing works
Tomimoto, H., Akiguchi, I., Suenaga, T., Nishimura, M., Wakita, H., Nakamura, S., & Kimura, J. (1996) · Stroke · doi:10.1161/01.str.27.11.2069 · Cited by 204 · see citing works
Clinical diagnosis of Binswanger's disease.
Bennett, D. A., Wilson, R. S., Gilley, D. W., & Fox, J. H. (1990) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.53.11.961 · Cited by 195 · see citing works
Binswanger's encephalopathy: a review
Fisher, C. M. (1989) · Journal of Neurology · doi:10.1007/bf00314400 · Cited by 188 · see citing works
Ewing, J. R., Knight, R. A., Nagaraja, T. N., Yee, J. S., Nagesh, V., Whitton, P. A., Li, L., & Fenstermacher, J. D. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10524 · Cited by 181 · see citing works
White matter lesion progression
Schmidt, R., Scheltens, P., Erkinjuntti, T., Pantoni, L., Markus, H. S., Wallin, A., Barkhof, F., & Fazekas, F. (2004) · Neurology · doi:10.1212/01.wnl.0000132635.75819.e5 · Cited by 176 · see citing works
Pathogenesis of Binswanger chronic progressive subcortical encephalopathy
Reuck, J. D., Crevits, L., Coster, W. D., Sieben, G., & Eecken, H. V. (1980) · Neurology · doi:10.1212/wnl.30.9.920 · Cited by 164 · see citing works
Modern concept of vascular cognitive impairment
Bowler, J. V. (2007) · British Medical Bulletin · doi:10.1093/bmb/ldm021 · Cited by 139 · see citing works
Feigin, I., & Popoff, N. A. (1963) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-196307000-00011 · Cited by 138 · see citing works
A new method for fast quantitative mapping of absolute water content in vivo
Neeb, H., Zilles, K., & Shah, N. J. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.12.063 · Cited by 132 · see citing works
Self-citationSood, R., Taheri, S., Candelario‐Jalil, E., Estrada, E. Y., & Rosenberg, G. A. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600534 · Cited by 108 · see citing works
Self-citationTaheri, S., Gasparovic, C., Shah, N. J., & Rosenberg, G. A. (2010) · Magnetic Resonance in Medicine · doi:10.1002/mrm.22686 · Cited by 107 · see citing works
Self-citationBlood-brain barrier dysfunction in Binswanger’s disease; an immunohistochemical study
Akiguchi, I., Tomimoto, H., Suenaga, T., Wakita, H., & Budka, H. (1998) · Acta Neuropathologica · doi:10.1007/s004010050768 · Cited by 104 · see citing works
Wallin, A., Sjögren, M. J. C., Edman, Å., Blennow, K., & Regland, B. (2000) · European Neurology · doi:10.1159/000008242 · Cited by 96 · see citing works
The Consortium to Investigate Vascular Impairment of Cognition: Methods and First Findings
Rockwood, K. J., Davis, H., MacKnight, C., Vandorpe, R. A., Gauthier, S. G., Guzmán, A. E., Montgomery, P. R., Black, S. E., Hogan, D. B., KERTESZ, A. E., et al. (2003) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100002663 · Cited by 94 · see citing works
A New Method for Fast Multislice T1 Mapping
Shah, N. J., Zaitsev, M., Steinhoff, S., & Zilles, K. (2001) · NeuroImage · doi:10.1006/nimg.2001.0886 · Cited by 78 · see citing works
Self-citationSchalin‐Jäntti, C., Laine, T., Valli‐Jaakola, K., Lönnqvist, T. R. I., Kontula, K., & Välimäki, M. J. (2005) · Hormone Research in Paediatrics · doi:10.1159/000084689 · Cited by 61 · see citing works
Hanyu, H., Asano, T., Tanaka, Y., Iwamoto, T., Takasaki, M., & Abe, K. (2002) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000058326 · Cited by 51 · see citing works
Taheri, S., Candelario‐Jalil, E., Estrada, E. Y., & Rosenberg, G. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006597 · Cited by 39 · see citing works
Self-citationWallin, A., Blennow, K., & Rosengren, L. (1999) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199912001-00015 · Cited by 38 · see citing works
Quantitative evaluation of the effect of propylene glycol on BBB permeability
Sood, R., Taheri, S., Estrada, E. Y., & Rosenberg, G. A. (2006) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.20802 · Cited by 25 · see citing works
Self-citationClinical manifestations in neuropathologically defined subgroups of vascular dementia
Andin, U., Gustafson, L., Brun, A. E., & Passant, U. (2006) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1548 · Cited by 15 · see citing works
Wallin, A., Blennow, K., & Rosengren, L. (1999) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199912003-00015 · Cited by 12 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [27]Akiguchi I Tomimoto H Suenaga T Wakita H Budka H Blood-brain barrier dysfunction in binswanger's disease; an immunohistochemical study Acta Neuropathol 1998 95 78 84 9452825
Cited by
Sorted by citations
Blood-brain barrier breakdown in the aging human hippocampus
Montagne, A., Barnes, S. R., Sweeney, M. D., Halliday, M. R., Sagare, A. P., Zhao, Z., Toga, A. W., Jacobs, R. E., Liu, C. Y., Amezcua, L., et al. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.032 · Cited by 2,102 · see citing works
The Pathobiology of Vascular Dementia
Iadecola, C. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.008 · Cited by 1,857 · see citing works
“Third, the permeability to MRI tracers is increased in white matter lesions (Hanyu et al., 2002; Taheri et al., 2011; Wardlaw et al., 2009) and in normal appearing white matter (Topakian et al., 2010).”
Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging
Wardlaw, J. M., Smith, C., & Dichgans, M. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70060-7 · Cited by 1,657 · see citing works
Microbiome–host systems interactions: protective effects of propionate upon the blood–brain barrier
Hoyles, L., Snelling, T., Umlai, U.-K., Nicholson, J. K., Carding, S. R., Glen, R. C., & McArthur, S. (2018) · Microbiome · doi:10.1186/s40168-018-0439-y · Cited by 591 · see citing works
Blood–brain barrier leakage is increased in parkinson’s disease
Al-Bachari, S., Naish, J. H., Parker, G. J. M., Emsley, H. C. A., & Parkes, L. M. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.593026 · Cited by 263 · see citing works
Thrippleton, M. J., Backes, W. H., Sourbron, S., Ingrisch, M., van Osch, M. J. P., Dichgans, M., Fazekas, F., Ropele, S., Frayne, R., van Oostenbrugge, R. J., et al. (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2019.01.013 · Cited by 252 · see citing works
Rabin, J. S., Schultz, A. P., Hedden, T., Viswanathan, A., Marshall, G. A., Kilpatrick, E., Klein, H., Buckley, R. F., Yang, H.-S., Properzi, M., et al. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2018.1123 · Cited by 221 · see citing works
Wardlaw, J. M., Doubal, F. N., Valdes-Hernandez, M., Wang, X., Chappell, F. M., Shuler, K., Armitage, P. A., Carpenter, T. C., & Dennis, M. S. (2013) · Stroke · doi:10.1161/strokeaha.112.669994 · Cited by 183 · see citing works
Geng, J., Wang, L., Zhang, L., Qin, C., Song, Y., Ma, Y., Chen, Y., Chen, S., Wang, Y., Zhang, Z., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00129 · Cited by 123 · see citing works
Basal lamina changes in neurodegenerative disorders
Nguyen, B., Bix, G., & Yao, Y. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00502-y · Cited by 75 · see citing works
McCarty, M. (2015) · Healthcare · doi:10.3390/healthcare3020233 · Cited by 23 · see citing works
- Authors
- Taheri, S., Gasparovic, C., Huisa, B. N., Adair, J. C., Edmonds, E., Prestopnik, J., Grossetete, M., Shah, N. J., Wills, J., Qualls, C., & Rosenberg, G. A.
- Affiliations
- University of New Mexico (US)
- Corresponding author
- Rosenberg, Gary A.
- ORCID
- Venue
- Stroke
- Published
- 2011-08
- Volume
- 42
- Issue
- 8
- Pages
- 2158-2163
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- PMC
- PMC3584170
- OpenAlex
- W1985038074
- Cited by
- 248
- References
- 38
- Citations by year
- 2026: 11 · 2025: 11 · 2024: 23 · 2023: 18 · 2022: 14 · 2021: 24 · 2020: 9 · 2019: 14 · 2018: 21 · 2017: 19 · 2016: 24 · 2015: 22 · 2014: 17 · 2013: 13 · 2012: 7
- FWCI
- 6.72
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- JuSER (Forschungszentrum Jülich) (submittedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS052305)
- National Center for Research Resources (M01RR-00997, M01RR000997)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Neurology › Cerebrovascular and genetic disorders
- Keywords
- blood-brain barrier permeability, vascular cognitive impairment, subcortical ischemic vascular disease, multiple infarcts, lacunar infarction, white matter hyperintensities, dynamic contrast-enhanced MRI, diffusion-weighted imaging
- MeSH terms
- Adult, Aged, Aged, 80 and over, Albumins, Blood-Brain Barrier, Brain, Cognition Disorders, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Fibers, Myelinated, Neurologic Examination, Neuropsychological Tests, Permeability, Dementia, Vascular
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
