The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Neurons Have an Active Glycogen Metabolism that Contributes to Tolerance to Hypoxia
Open accessAbstract
Glycogen is present in the brain, where it has been found mainly in glial cells but not in neurons. Therefore, all physiologic roles of brain glycogen have been attributed exclusively to astrocytic glycogen. Working with primary cultured neurons, as well as with genetically modified mice and flies, here we report that—against general belief—neurons contain a low but measurable amount of glycogen. Moreover, we also show that these cells express the brain isoform of glycogen Phosphorylase, allowing glycogen to be fully metabolized. Most importantly, we show an active neuronal glycogen metabolism that protects cultured neurons from hypoxia-induced death and flies from hypoxia-induced stupor. Our findings change the current view of the role of glycogen in the brain and reveal that endogenous neuronal glycogen metabolism participates in the neuronal tolerance to hypoxic stress.
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Cites
Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation
Suzuki, A., Stern, S. A., Bozdagi, O., Huntley, G. W., Walker, R. H., Magistretti, P. J., & Alberini, C. M. (2011) · Cell · doi:10.1016/j.cell.2011.02.018 · Cited by 1,711
Astrocyte glycogen and brain energy metabolism
Brown, A. M., & Ransom, B. R. (2007) · Glia · doi:10.1002/glia.20557 · Cited by 626
Muscle Glycogen Synthesis after Exercise : an Enhancing Factor localized to the Muscle Cells in Man
BERGSTRÖM, J., & HULTMAN, E. (1966) · Nature · doi:10.1038/210309a0 · Cited by 473
Cited by
Brain Glucose Metabolism: Integration of Energetics with Function
Dienel, G. A. (2019) · Physiological Reviews · doi:10.1152/physrev.00062.2017 · Cited by 865
Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature
Ayata, C., & Lauritzen, M. (2015) · Physiological Reviews · doi:10.1152/physrev.00027.2014 · Cited by 555
Fernandez, C. G., Hamby, M. E., McReynolds, M. L., & Ray, W. J. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00014 · Cited by 277
Falkowska, A., Gutowska, I., Goschorska, M., Nowacki, P., Chlubek, D., & Baranowska-Bosiacka, I. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161125939 · Cited by 277
Han, R., Liang, J., & Zhou, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115887 · Cited by 125
Metadata
- Authors
- Saez, I., Duran, J., Sinadinos, C., Beltran, A., Yanes, O., Tevy, M. F., Martínez-Pons, C., Milán, M., & Guinovart, J. J.
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2014-02-26
- Volume
- 34
- Issue
- 6
- Pages
- 945-955
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2074426246
- Cited by
- 210
- References
- 3
- FWCI
- 13.77
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Saez, I., Duran, J., Sinadinos, C., Beltran, A., Yanes, O., Tevy, M. F., Martínez-Pons, C., Milán, M., & Guinovart, J. J. (2014). Neurons Have an Active Glycogen Metabolism that Contributes to Tolerance to Hypoxia. Journal of Cerebral Blood Flow & Metabolism. https://doi.org/10.1038/jcbfm.2014.33
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