Nanotechnology-based electrochemical sensors for biomonitoring chemical exposures
Open accessAbstract
The coupling of dosimetry measurements and modeling represents a promising strategy for deciphering the relationship between chemical exposure and disease outcome. To support the development and implementation of biological monitoring programs, quantitative technologies for measuring xenobiotic exposure are needed. The development of portable nanotechnology-based electrochemical (EC) sensors has the potential to meet the needs for low cost, rapid, high-throughput, and ultrasensitive detectors for biomonitoring an array of chemical markers. Highly selective EC sensors capable of pM sensitivity, high-throughput and low sample requirements (<50 microl) are discussed. These portable analytical systems have many advantages over currently available technologies, thus potentially representing the next generation of biomonitoring analyzers. This paper highlights research focused on the development of field-deployable analytical instruments based on EC detection. Background information and a general overview of EC detection methods and integrated use of nanomaterials in the development of these sensors are provided. New developments in EC sensors using various types of screen-printed electrodes, integrated nanomaterials, and immunoassays are presented. Recent applications of EC sensors for assessing exposure to pesticides or detecting biomarkers of disease are highlighted to demonstrate the ability to monitor chemical metabolites, enzyme activity, or protein biomarkers of disease. In addition, future considerations and opportunities for advancing the use of EC platforms for dosimetric studies are discussed.
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The development of electrochemical transducers has been especially promising due to their low cost, simplicity, and portability.
“The development of electrochemical transducers has been especially promising due to their low cost, simplicity, and portability.7,8”
From Wearable sensors for monitoring the physiological and biochemical profile of the athlete (2019) · cites this paper as [7]
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- Authors
- Barry, R. C., Lin, Y., Wang, J., Liu, G., & Timchalk, C. A.
- Affiliations
- Pacific Northwest National Laboratory (US)
- Corresponding author
- Timchalk, Charles A
- Venue
- Journal of Exposure Science & Environmental Epidemiology
- Published
- 2008-11-19
- Volume
- 19
- Issue
- 1
- Pages
- 1-18
- ISSN
- 1559-0631 (ISSN-L)
- 1559-064X
- PMC
- PMC2909474
- OpenAlex
- W2080872105
- Cited by
- 73
- References
- 142
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2023: 5 · 2022: 2 · 2021: 7 · 2020: 7 · 2019: 6 · 2018: 1 · 2017: 3 · 2016: 4 · 2015: 7 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Exposure Science & Environmental Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5u54es016015-04)
- Centers for Disease Control and Prevention
- National Institute of Neurological Disorders and Stroke (U01NS058161)
- National Institute of Environmental Health Sciences (U54 ES16015, U54-ES016015)
- National Institute for Occupational Safety and Health (R01 OH008173)
- Pacific Northwest National Laboratory
- Topics
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Physical Sciences › Chemistry › Electrochemistry › Electrochemical Analysis and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Keywords
- electrochemical sensor, nanotechnology, biomonitoring, chemical exposure, dosimetry, portable analytical devices, screen-printed electrodes, nanomaterials, immunoassay, pesticides, disease biomarkers, enzyme activity, field-deployable detection
- MeSH terms
- Electrochemistry, Environmental Exposure, Environmental Monitoring, Hazardous Substances, Risk Assessment, Nanotechnology
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