Cited by 73Electrochemical sensors and biosensorsElectrochemical Analysis and ApplicationsAdvanced biosensing and bioanalysis techniques

Nanotechnology-based electrochemical sensors for biomonitoring chemical exposures

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Barry, Richard C, Lin, Yuehe, Wang, Jun, Liu, Guodong, Timchalk, Charles A·2009·Journal of Exposure Science & Environmental Epidemiology

Abstract

The coupling of dosimetry measurements and modeling represents a promising strategy for deciphering the relationship between chemical exposure and disease outcome. To support the development and implementation of biological monitoring programs, quantitative technologies for measuring xenobiotic exposure are needed. The development of portable nanotechnology-based electrochemical (EC) sensors has the potential to meet the needs for low cost, rapid, high-throughput, and ultrasensitive detectors for biomonitoring an array of chemical markers. Highly selective EC sensors capable of pM sensitivity, high-throughput and low sample requirements (<50 microl) are discussed. These portable analytical systems have many advantages over currently available technologies, thus potentially representing the next generation of biomonitoring analyzers. This paper highlights research focused on the development of field-deployable analytical instruments based on EC detection. Background information and a general overview of EC detection methods and integrated use of nanomaterials in the development of these sensors are provided. New developments in EC sensors using various types of screen-printed electrodes, integrated nanomaterials, and immunoassays are presented. Recent applications of EC sensors for assessing exposure to pesticides or detecting biomarkers of disease are highlighted to demonstrate the ability to monitor chemical metabolites, enzyme activity, or protein biomarkers of disease. In addition, future considerations and opportunities for advancing the use of EC platforms for dosimetric studies are discussed.

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Authors
Barry, R. C., Lin, Y., Wang, J., Liu, G., & Timchalk, C. A.
Affiliations
Pacific Northwest National Laboratory (US)
Corresponding author
Timchalk, Charles A
Venue
Journal of Exposure Science & Environmental Epidemiology
Published
2008-11-19
Volume
19
Issue
1
Pages
1-18
ISSN
  • 1559-0631 (ISSN-L)
  • 1559-064X
OpenAlex
W2080872105
Cited by
73
References
142
Citations by year
2026: 3 · 2025: 1 · 2024: 3 · 2023: 5 · 2022: 2 · 2021: 7 · 2020: 7 · 2019: 6 · 2018: 1 · 2017: 3 · 2016: 4 · 2015: 7 · 2014: 1 · 2013: 2 · 2012: 3
FWCI
0.48
Type
journal article
Language
en
Open access
Locations
  • Journal of Exposure Science & Environmental Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (5u54es016015-04)
  • Centers for Disease Control and Prevention
  • National Institute of Neurological Disorders and Stroke (U01NS058161)
  • National Institute of Environmental Health Sciences (U54 ES16015, U54-ES016015)
  • National Institute for Occupational Safety and Health (R01 OH008173)
  • Pacific Northwest National Laboratory
Topics
  • Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
  • Physical Sciences › Chemistry › Electrochemistry › Electrochemical Analysis and Applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
Keywords
electrochemical sensor, nanotechnology, biomonitoring, chemical exposure, dosimetry, portable analytical devices, screen-printed electrodes, nanomaterials, immunoassay, pesticides, disease biomarkers, enzyme activity, field-deployable detection
MeSH terms
Electrochemistry, Environmental Exposure, Environmental Monitoring, Hazardous Substances, Risk Assessment, Nanotechnology

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