The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
DNA methylation of the BDNF gene and its relevance to psychiatric disorders
Abstract
Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor, which is important for neuronal survival, development and synaptic plasticity. Accumulating evidence suggests that epigenetic modifications of BDNF are associated with the pathophysiology of psychiatric disorders, such as schizophrenia and mood disorders. Patients with psychiatric disorders generally show decreased neural BDNF levels, which are often associated with increased DNA methylation at the specific BDNF promoters. Importantly, observed DNA methylation changes are consistent across tissues including brain and peripheral blood, which suggests potential usefulness of these findings as a biomarker of psychiatric disorders. Here we review DNA methylation characteristics of BDNF promoters of cellular, animal and clinical samples and discuss future perspectives.
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In the citing paper
“and altered patterns of BDNF DNA methylation has been found in patients with cognitive impairments [ 167 , 169 , 170 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [167]
In the citing paper
“BDNF transcription is regulated by DNA methylation [ 167 , 168 ] and altered patterns of BDNF DNA methylation has been found in patients with cognitive impairments [ 167 , 169 , 170 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [167]
Citations
Cites
1 retracted
Keleshian, V. L., Modi, H. R., Rapoport, S. I., & Rao, J. S. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12153 · Cited by 53
RetractedTrk Receptors: Roles in Neuronal Signal Transduction
Huang, E. J., & Reichardt, L. F. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161629 · Cited by 2,537
DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation
Martinowich, K., Hattori, D., Wu, H., Fouse, S., He, F., Hu, Y., Fan, G., & Sun, Y. E. (2003) · Science · doi:10.1126/science.1090842 · Cited by 1,405
Lasting epigenetic influence of early-life adversity on the BDNF gene
Roth, T. L., Lubin, F. D., Funk, A. J., & Sweatt, J. D. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.028 · Cited by 1,273
Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2
Chen, W. G., Chang, Q., Lin, Y., Meissner, A., West, A. E., Griffith, E. C., Jaenisch, R., & Greenberg, M. E. (2003) · Science · doi:10.1126/science.1086446 · Cited by 1,232
Sen, S., Duman, R., & Sanacora, G. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.005 · Cited by 1,232
Regional distribution of brain‐derived neurotrophic factor mRNA in the adult mouse brain.
Hofer, M., Pagliusi, S. R., Hohn, A., Leibrock, J., & Barde, Y. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07423.x · Cited by 1,039
ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75NTRand Sortilin
Teng, H. K., Teng, K. K., Lee, R., Wright, S., Tevar, S., Almeida, R. D., Kermani, P., Torkin, R., Chen, Z.-Y., Lee, F. S., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5123-04.2005 · Cited by 1,013
Brunoni, A. R., Lopes, M., & Fregni, F. (2008) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009309 · Cited by 972
Mouse and rat BDNF gene structure and expression revisited
Aid, T., Kazantseva, A., Piirsoo, M., Palm, K., & Timmusk, T. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21139 · Cited by 943
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Yao, B., Christian, K. M., He, C., Jin, P., Ming, G., & Song, H. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.70 · Cited by 406
Smith, A. K., Kilaru, V., Klengel, T., Mercer, K. B., Bradley, B., Conneely, K. N., Ressler, K. J., & Binder, E. B. (2015) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32278 · Cited by 355
Epigenetic basis of mental illness
Nestler, E. J., Peña, C. J., Kundakovic, M., Mitchell, A., & Akbarian, S. (2016) · The Neuroscientist · doi:10.1177/1073858415608147 · Cited by 342
Biomarkers in Psychiatry: Concept, Definition, Types and Relevance to the Clinical Reality
García-Gutiérrez, M. S., Navarrete, F., Sala, F., Gasparyan, A., Austrich-Olivares, A., & Manzanares, J. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00432 · Cited by 331
Prenatal stressors in rodents: Effects on behavior
Weinstock, M. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.08.004 · Cited by 264
Metadata
- Authors
- Ikegame, T., Bundo, M., Murata, Y., Kasai, K., Kato, T., & Iwamoto, K.
- Affiliations
- The University of Tokyo (JP)
- RIKEN Center for Brain Science (JP)
- Japan Science and Technology Agency (JP)
- Corresponding author
- Iwamoto, Kazuya
- Venue
- Journal of Human Genetics
- Published
- 2013-06-06
- Volume
- 58
- Issue
- 7
- Pages
- 434-438
- ISSN
- 1434-5161 (ISSN-L)
- 1435-232X
- OpenAlex
- W1996375332
- Cited by
- 179
- References
- 69
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 14 · 2023: 16 · 2022: 14 · 2021: 11 · 2020: 8 · 2019: 13 · 2018: 13 · 2017: 12 · 2016: 20 · 2015: 21 · 2014: 15 · 2013: 2
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Human Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (CREST)
- Core Research for Evolutional Science and Technology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- brain-derived neurotrophic factor, DNA methylation, epigenetics, mental illness, schizophrenia, mood disorders, promoter methylation, biomarkers, peripheral blood, brain, neurotrophic factors, synaptic plasticity
- MeSH terms
- Animals, Autopsy, Brain, Disease Models, Animal, Humans, Neurons, Promoter Regions, Genetic, Schizophrenia, DNA Methylation, Brain-Derived Neurotrophic Factor
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