Selective DNA Methylation of BDNF Promoter in Bipolar Disorder: Differences Among Patients with BDI and BDII
Open accessAbstract
The etiology of bipolar disorder (BD) is still poorly understood, involving genetic and epigenetic mechanisms as well as environmental contributions. This study aimed to investigate the degree of DNA methylation at the promoter region of the brain-derived neurotrophic factor (BDNF) gene, as one of the candidate genes associated with major psychoses, in peripheral blood mononuclear cells isolated from 94 patients with BD (BD I=49, BD II=45) and 52 healthy controls. A significant BDNF gene expression downregulation was observed in BD II 0.53±0.11%; P<0.05), but not in BD I (1.13±0.19%) patients compared with controls (CONT: 1±0.2%). Consistently, an hypermethylation of the BDNF promoter region was specifically found in BD II patients (CONT: 24.0±2.1%; BDI: 20.4±1.7%; BDII: 33.3±3.5%, P<0.05). Of note, higher levels of DNA methylation were observed in BD subjects on pharmacological treatment with mood stabilizers plus antidepressants (34.6±4.2%, predominantly BD II) compared with those exclusively on mood-stabilizing agents (21.7±1.8%; P<0.01, predominantly BD I). Moreover, among the different pharmacological therapies, lithium (20.1±3.8%, P<0.05) and valproate (23.6±2.9%, P<0.05) were associated with a significant reduction of DNA methylation compared with other drugs (35.6±4.6%). Present findings suggest selective changes in DNA methylation of BDNF promoter in subjects with BD type II and highlight the importance of epigenetic factors in mediating the onset and/or susceptibility to BD, providing new insight into the mechanisms of gene expression. Moreover, they shed light on possible mechanisms of action of mood-stabilizing compounds vs antidepressants in the treatment of BD, pointing out that BDNF regulation might be a key target for their effects.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Altered patterns of BDNF DNA methylation have been found in patients with cognitive impairments.
“and altered patterns of BDNF DNA methylation has been found in patients with cognitive impairments [ 167 , 169 , 170 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [170]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
A new depression scale designed to be sensitive to change
Montgomery, S. A., & Åsberg, M. (1979) · British Journal of Psychiatry · doi:10.1192/bjp.134.4.382 · Cited by 13,962 · see citing works
Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,949 · see citing works
A Rating Scale for Mania: Reliability, Validity and Sensitivity
Young, R. C., Biggs, J. T., Ziegler, V. E., & Meyer, D. A. (1978) · British Journal of Psychiatry · doi:10.1192/bjp.133.5.429 · Cited by 8,744 · see citing works
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,501 · see citing works
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works
Nan, X., Ng, H.-H., Johnson, C. A., Laherty, C. D., Turner, B. M., Eisenman, R. N., & Bird, A. (1998) · Nature · doi:10.1038/30764 · Cited by 3,440 · see citing works
(1997) · American Psychiatric Press eBooks · Cited by 3,056 · see citing works
Genomic DNA methylation: the mark and its mediators.
Klose, R. J., & Bird, A. P. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.12.008 · Cited by 2,501 · see citing works
Environmental epigenomics and disease susceptibility
Jirtle, R. L., & Skinner, M. K. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2045 · Cited by 2,492 · see citing works
Nibuya, M., Morinobu, S., & Duman, R. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07539.1995 · Cited by 2,109 · see citing works
Chomczyński, P., & Sacchi, N. (2006) · Nature Protocols · doi:10.1038/nprot.2006.83 · Cited by 2,084 · see citing works
Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression
Shirayama, Y., Chen, A. C.-H., Nakagawa, S., Russell, D. S., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03251.2002 · Cited by 1,654 · see citing works
DNA Methylation-Related Chromatin Remodeling in Activity-Dependent <i>Bdnf</i> Gene Regulation
Martinowich, K., Hattori, D., Wu, H., Fouse, S., He, F., Hu, Y., Fan, G., & Sun, Y. E. (2003) · Science · doi:10.1126/science.1090842 · Cited by 1,405 · see citing works
Epigenetic regulation in psychiatric disorders
Tsankova, N., Renthal, W., Kumar, A., & Nestler, E. J. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2132 · Cited by 1,400 · see citing works
Sen, S., Duman, R., & Sanacora, G. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.005 · Cited by 1,232 · see citing works
Increased hippocampal bdnf immunoreactivity in subjects treated with antidepressant medication
Chen, B., Dowlatshahi, D., MacQueen, G. M., Wang, J.-F., & Young, L. T. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01083-6 · Cited by 1,164 · see citing works
The Methyl-CpG-binding Protein MeCP2 Links DNA Methylation to Histone Methylation
Fuks, F., Hurd, P. J., Wolf, D., Nan, X., Bird, A. P., & Kouzarides, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210256200 · Cited by 994 · see citing works
DNA methyltransferase Dnmt1 associates with histone deacetylase activity
Fuks, F., Burgers, W. A., Brehm, A., Hughes‐Davies, L., & Kouzarides, T. (2000) · Nature Genetics · doi:10.1038/71750 · Cited by 988 · see citing works
Brunoni, A. R., Lopes, M., & Fregni, F. (2008) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009309 · Cited by 972 · see citing works
Effectiveness of Adjunctive Antidepressant Treatment for Bipolar Depression
Sachs, G. S., Nierenberg, A. A., Calabrese, J. R., Marangell, L. B., Wisniewski, S. R., Gyulai, L., Friedman, E. S., Bowden, C. L., Fossey, M. D., Ostacher, M. J., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa064135 · Cited by 937 · see citing works
Dwivedi, Y., Rizavi, H. S., Conley, R. R., Roberts, R. C., Tamminga, C. A., & Pandey, G. N. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.8.804 · Cited by 875 · see citing works
Castrén, E., & Rantamäki, T. (2010) · Developmental Neurobiology · doi:10.1002/dneu.20758 · Cited by 864 · see citing works
Multiple promoters direct tissue-specific expression of the rat BDNF gene
Timmusk, T., Palm, K., Metsis, M., Reintam, T., Paalme, V., Saarma, M., & Persson, H. (1993) · Neuron · doi:10.1016/0896-6273(93)90335-o · Cited by 858 · see citing works
Epigenomic Profiling Reveals DNA-Methylation Changes Associated with Major Psychosis
Mill, J., Tang, T., Kaminsky, Z., Khare, T., Yazdanpanah, S., Bouchard, L., Jia, P., Assadzadeh, A., Flanagan, J., Schumacher, A., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.01.008 · Cited by 773 · see citing works
Evidence That DNA (Cytosine-5) Methyltransferase Regulates Synaptic Plasticity in the Hippocampus
Levenson, J. M., Roth, T. L., Lubin, F. D., Miller, C. A., Huang, I.-C., Desai, P., Malone, L. M., & Sweatt, J. D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511767200 · Cited by 615 · see citing works
Karege, F., Vaudan, G., Schwald, M., Perroud, N., & La Harpe, R. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.12.020 · Cited by 600 · see citing works
Neves-Pereira, M., Mundo, E., Muglia, P., King, N. A., Macciardi, F. M., & Kennedy, J. L. (2002) · The American Journal of Human Genetics · doi:10.1086/342288 · Cited by 594 · see citing works
Sklar, P. B., Gabriel, S., McInnis, M. G., Bennett, P., Lim, Y.-M., Tsan, G., Schaffner, S. F., Kirov, G., Jones, I. R., Owen, M. J., et al. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001058 · Cited by 563 · see citing works
Reelin promoter hypermethylation in schizophrenia
Grayson, D. R., Jia, X., Chen, Y., Sharma, R. P., Mitchell, C. P., Guidotti, A., & Costa, E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503736102 · Cited by 553 · see citing works
Critical Role of Brain-Derived Neurotrophic Factor in Mood Disorders
Hashimoto, K., Shimizu, E., & Iyo, M. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.02.003 · Cited by 522 · see citing works
The Role of the Extracellular Signal-Regulated Kinase Signaling Pathway in Mood Modulation
Einat, H., Yuan, P., Gould, T. D., Li, J., Du, J., Zhang, L., Manji, H. K., & Chen, G. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-19-07311.2003 · Cited by 475 · see citing works
Garcia‐Manero, G., Kantarjian, H. M., Sánchez‐González, B., Yang, H., Rosner, G. L., Verstovšek, S., Rytting, M., Wierda, W. G., Ravandi, F., Koller, C. A., et al. (2006) · Blood · doi:10.1182/blood-2006-03-009142 · Cited by 466 · see citing works
Roceri, M., Hendriks, W. J. A. J., Racagni, G., Ellenbroek, B. A., & Riva, M. A. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001036 · Cited by 465 · see citing works
Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder
Abdolmaleky, H. M., Cheng, K.-H., Faraone, S. V., Wilcox, M., Glatt, S. J., Gao, F., Smith, C. L., Shafa, R., Aeali, B., Carnevale, J., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl253 · Cited by 462 · see citing works
Kauer‐Sant’Anna, M., Kapczinski, F. P., Andreazza, A. C., Bond, D. J., Lam, R. W. M., Young, L. T., & Yatham, L. N. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009310 · Cited by 434 · see citing works
Exercise, Antidepressant Medications, and Enhanced Brain Derived Neurotrophic Factor Expression
Russo-Neustadt, A. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00059-7 · Cited by 411 · see citing works
Mood Stabilizer Valproate Promotes ERK Pathway-Dependent Cortical Neuronal Growth and Neurogenesis
Hao, Y., Creson, T. K., Zhang, L., Li, P., Du, F., Yuan, P., Gould, T. D., Manji, H. K., & Chen, G. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5747-03.2004 · Cited by 405 · see citing works
Grunze, H., Vieta, E., Goodwin, G. M., Bowden, C., Licht, R. W., Möller, H.-J., Kasper, S., & WFSBP Task Force On Treatment Guidelines For Bipolar Disorders (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622970903555881 · Cited by 399 · see citing works
Antidepressants in bipolar disorder: the case for caution
Ghaemi, S. N., Hsu, D. J., Soldani, F., & Goodwin, F. K. (2003) · Bipolar Disorders · doi:10.1046/j.1399-5618.2003.00074.x · Cited by 391 · see citing works
Fuchikami, M., Morinobu, S., Segawa, M., Okamoto, Y., Yamawaki, S., Ozaki, N., Inoue, T., Kusumi, I., Koyama, T., Tsuchiyama, K., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023881 · Cited by 378 · see citing works
Fukumoto, T., Morinobu, S., Okamoto, Y., Kagaya, A., & Yamawaki, S. (2001) · Psychopharmacology · doi:10.1007/s002130100871 · Cited by 377 · see citing works
Finding the Intracellular Signaling Pathways Affected by Mood Disorder Treatments
Coyle, J. T., & Duman, R. S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00195-8 · Cited by 357 · see citing works
Grunze, H., Vieta, E., Goodwin, G. M., Bowden, C. L., Licht, R. W., Möller, H., Kasper, S. F., & WFSBP Task Force on Treatment Guide (2009) · The World Journal of Biological Psychiatry · doi:10.1080/15622970902823202 · Cited by 344 · see citing works
Exploring and explaining epigenetic effects
Henikoff, S., & Matzke, M. A. (1997) · Trends in Genetics · doi:10.1016/s0168-9525(97)01219-5 · Cited by 307 · see citing works
Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation
Dong, E., Nelson, M., Grayson, D. R., Costa, E., & Guidotti, A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805493105 · Cited by 284 · see citing works
Epigenetic Regulation of Neural Gene Expression and Neuronal Function
Feng, J., Fouse, S. D., & Fan, G. (2007) · Pediatric Research · doi:10.1203/pdr.0b013e3180457635 · Cited by 263 · see citing works
Effects of Stress on Neurotrophic Factor Expression in the Rat Brain
SMITH, M. A., Makino, S., Květňanský, R., & Post, R. M. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb44684.x · Cited by 255 · see citing works
Candelaria, M., Gallardo‐Rincón, D., Arce, C., Cetina, L., Aguilar-Ponce, J. L., Arrieta, O. G., González‐Fierro, A., Chávez-Blanco, A. D., de la Cruz-Hernandez, E., Camargo, M. F. V. C., et al. (2007) · Annals of Oncology · doi:10.1093/annonc/mdm204 · Cited by 252 · see citing works
Geller, B., Badner, J. A., Tillman, R., Christian, S. L., Bolhofner, K., & Cook, E. H. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.9.1698 · Cited by 186 · see citing works
Brain-derived neurotrophic factor and neuroplasticity in bipolar disorder
Kapczinski, F., Frey, B. N., Kauer-Sant’Anna, M., & Grassi-Oliveira, R. (2008) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.8.7.1101 · Cited by 181 · see citing works
The Role of BDNF as a Mediator of Neuroplasticity in Bipolar Disorder
Grande, I., Fries, G. R., Kunz, M., & Kapczinski, F. P. (2010) · Psychiatry Investigation · doi:10.4306/pi.2010.7.4.243 · Cited by 161 · see citing works
Brain derived neurotropic factor in first-episode psychosis
Buckley, P. F., Pillai, A., Evans, D. R., Stirewalt, E., & Mahadik, S. P. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2006.12.026 · Cited by 157 · see citing works
Grunze, H., Vieta, E., Goodwin, G. M., Bowden, C., Licht, R. W., Möller, H.-J., Kasper, S., & WFSBP Task Force on Treatment Guidelines for Bipolar Disorders (2011) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.9.4.500 · Cited by 151 · see citing works
Molecular genetics of bipolar disorder
Craddock, N. J., & Jones, I. R. (2001) · The British Journal of Psychiatry · doi:10.1192/bjp.178.41.s128 · Cited by 140 · see citing works
Association study of the brain-derived neurotrophic factor (BDNF) gene with bipolar disorder
Nakata, K., Ujike, H., Sakai, A., Uchida, N., Nomura, A., Imamura, T., Katsu, T., Tanaka, Y., Hamamura, T., & Kuroda, S. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(02)01292-2 · Cited by 138 · see citing works
Chen, D. C., Wang, J., Wang, B., Yang, S. C., Zhang, C. X., Zheng, Y. L., Li, Y. L., Wang, N., Yang, K. B., Xiu, M. H., et al. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1665-6 · Cited by 136 · see citing works
Genetics and Epigenetics in Major Psychiatric Disorders
Abdolmaleky, H. M., Thiagalingam, S., & Wilcox, M. (2005) · American Journal of PharmacoGenomics · doi:10.2165/00129785-200505030-00002 · Cited by 132 · see citing works
Reelin promoter hypermethylation in schizophrenia
Grayson (2005) · Medical Entomology and Zoology · Cited by 130 · see citing works
Mutation detection using fluorescent hybridization probes and melting curve analysis
Lyon, E. (2001) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.1.1.92 · Cited by 121 · see citing works
Histone modifications, DNA methylation, and Schizophrenia
Gavin, D. P., & Sharma, R. P. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.10.010 · Cited by 121 · see citing works
Tost, J. (2010) · Molecular Biotechnology · doi:10.1007/s12033-009-9216-2 · Cited by 118 · see citing works
Pidsley, R., & Mill, J. S. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.03.029 · Cited by 115 · see citing works
Rizos, E. N., Παπαδοπούλου, Α., Laskos, E., Michalopoulou, P. G., Kastania, A., Vasilopoulos, D., Katsafouros, K., & Lykouras, L. P. (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622970802182733 · Cited by 113 · see citing works
Pandey, G. N., Rizavi, H. S., Dwivedi, Y., & Pavuluri, M. N. (2008) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e31817eecd9 · Cited by 93 · see citing works
Epigenetics and bipolar disorder: New opportunities and challenges
Petronis, A. (2003) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.20015 · Cited by 81 · see citing works
Bipolar illness and schizophrenia as oligogenic diseases: implications for the future
Gershon, E. S. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00299-1 · Cited by 78 · see citing works
Yasuda, M., Fukuchi, M., Tabuchi, A., Kawahara, M., Tsuneki, H., Azuma, Y., Chiba, Y., & Tsuda, M. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04851.x · Cited by 63 · see citing works
Methylation Analysis of the Fragile X Syndrome by PCR
Das, S., Kubota, T., Song, M., DANIEL, R., Berry‐Kravis, E., Prior, T. W., Popovich, B. W., Rosser, L., Arinami, T., & Ledbetter, D. H. (1997) · Genetic Testing · doi:10.1089/gte.1997.1.151 · Cited by 57 · see citing works
Gene expression and association analysis of LIM (PDLIM5) in major depression
Iga, J., Ueno, S., Yamauchi, K., Numata, S., Motoki, I., Shibuya‐Tayoshi, S., Kinouchi, S., Ohta, K., Song, H., Morita, K., et al. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.02.044 · Cited by 44 · see citing works
Differential regulation of CDX1 and CDX2 gene expression by deficiency in methyl group donors
Lu, X., Freund, J., Müller, M., Ravey, J., Nicolas, J., Guéant, J., & Namour, F. (2007) · Biochimie · doi:10.1016/j.biochi.2007.12.002 · Cited by 21 · see citing works
Arosio, B., Viazzoli, C., Mastronardi, L., et al. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-090814 · Cited by 20 · see citing works
Self-citationArosio, B., Mastronardi, L., Gussago, C., Nicolini, P., Casè, A., Ziglioli, E., & Bergamaschini, L. C. (2011) · International Journal of Alzheimer s Disease · doi:10.4061/2011/484021 · Cited by 19 · see citing works
Self-citationRizos, E. N., Παπαδοπούλου, Α., Laskos, E., et al. (2008) · The World Journal of Biological Psychiatry · doi:10.1080/15622970802182733 · Cited by 16 · see citing works
Nelson, W. M., Luo, M., Ma, J., et al. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-621 · Cited by 10 · see citing works
Lithium protection from glutamate excitotoxicity: therapeutic implications
Chuang, D. (2004) · Clinical Neuroscience Research · doi:10.1016/j.cnr.2004.09.016 · Cited by 10 · see citing works
The Relevance of Epigenetics to Major Psychosis
Mill, J. S., & Petronis, A. (2008) · Springer eBooks · doi:10.1007/978-1-4020-9187-2_23 · Cited by 7 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- First MB, Spitzer RL, Gibbon L, Williams JBV (2002). Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Non-Patient Edition (SCID-I/NP). New York State Psychiatric Institute, Biometric Research: New York.
- First MB, Spitzer RL, Gibbon L, Williams JBV (2002). Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition (SCID-I/P). New York State Psychiatric Institute, Biometric Research: New York.
Cited by
Sorted by citations
DNA methylation of BDNF as a biomarker of early-life adversity
Kundakovic, M., Gudsnuk, K., Herbstman, J. B., Tang, D., Perera, F. P., & Champagne, F. A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408355111 · Cited by 426 · see citing works
Response to psychotherapy in borderline personality disorder and methylation status of the BDNF gene
Perroud, N., Salzmann, A., Prada, P., Nicastro, R., Hoeppli, M.-E., Furrer, S., Ardu, S., Krejci, I., Karege, F., & Malafosse, A. (2013) · Translational Psychiatry · doi:10.1038/tp.2012.140 · Cited by 320 · see citing works
Early-life experience, epigenetics, and the developing brain
Kundakovic, M., & Champagne, F. A. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.140 · Cited by 304 · see citing works
Unternaehrer, E., Meyer, A. H., Burkhardt, S. C. A., Dempster, E., Staehli, S., Theill, N., Lieb, R., & Meinlschmidt, G. (2015) · Stress · doi:10.3109/10253890.2015.1038992 · Cited by 181 · see citing works
DNA methylation of the BDNF gene and its relevance to psychiatric disorders
Ikegame, T., Bundo, M., Murata, Y., Kasai, K., Kato, T., & Iwamoto, K. (2013) · Journal of Human Genetics · doi:10.1038/jhg.2013.65 · Cited by 179 · see citing works
Keil, K. P., & Lein, P. J. (2016) · Environmental Epigenetics · doi:10.1093/eep/dvv012 · Cited by 167 · see citing works
Oxidative stress in early stage Bipolar Disorder and the association with response to lithium
de Sousa, R. T., Zarate, C. A., Zanetti, M. V., Costa, A. C., Talib, L. L., Gattaz, W. F., & Machado-Vieira, R. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.11.011 · Cited by 169 · see citing works
Dell׳Osso, B., D׳Addario, C., Carlotta Palazzo, M., Benatti, B., Camuri, G., Galimberti, D., Fenoglio, C., Scarpini, E., Di Francesco, A., Maccarrone, M., et al. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.05.020 · Cited by 112 · see citing works
The Relationship between DNA Methylation and Antidepressant Medications: A Systematic Review
Webb, L. M., Phillips, K. E., Ho, M. C., Veldic, M., & Blacker, C. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030826 · Cited by 84 · see citing works
Numata, S., Ishii, K., Tajima, A., Iga, J.-I., Kinoshita, M., Watanabe, S., Umehara, H., Fuchikami, M., Okada, S., Boku, S., et al. (2015) · Epigenetics · doi:10.1080/15592294.2014.1003743 · Cited by 79 · see citing works
Longitudinal multi-level biomarker analysis of BDNF in major depression and bipolar disorder
Schröter, K., Brum, M., Brunkhorst-Kanaan, N., Tole, F., Ziegler, C., Domschke, K., Reif, A., & Kittel-Schneider, S. (2020) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-019-01007-y · Cited by 68 · see citing works
Zhou, J., Li, M., Wang, X., He, Y., Xia, Y., Sweeney, J. A., Kopp, R. F., Liu, C., & Chen, C. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.674273 · Cited by 56 · see citing works
Epigenetics in bipolar disorder: a critical review of the literature
Legrand, A., Iftimovici, A., Khayachi, A., & Chaumette, B. (2021) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000267 · Cited by 48 · see citing works
Thomas, M., Knoblich, N., Wallisch, A., Glowacz, K., Becker-Sadzio, J., Gundel, F., Brückmann, C., & Nieratschker, V. (2018) · Clinical Epigenetics · doi:10.1186/s13148-018-0544-6 · Cited by 51 · see citing works
Wrigglesworth, J., Ryan, J., Vijayakumar, N., & Whittle, S. (2019) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2018.12.012 · Cited by 34 · see citing works
A MIR4646 associated methylation locus is hypomethylated in adolescent depression
Boström, A. E., Ciuculete, D.-M., Attwood, M., Krattinger, R., Nikontovic, L., Titova, O. E., Kullak-Ublick, G. A., Mwinyi, J., & Schiöth, H. B. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.05.017 · Cited by 33 · see citing works
Epigenetic Mechanisms of Rapid-Acting Antidepressants
Inserra, A., Campanale, A., Rezai, T., Romualdi, P., & Rubino, T. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-03055-y · Cited by 27 · see citing works
Self-citationSlyepchenko, A., Brunoni, A. R., McIntyre, R. S., Quevedo, J., & Carvalho, A. F. (2016) · Current Molecular Medicine · doi:10.2174/1566524016666160126144601 · Cited by 14 · see citing works
Ahmed, O. G., Shehata, G. A., Ali, R. M., Makboul, R., Abd Allah, E. S. H., & Abd el-Rady, N. M. (2021) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2020-0923 · Cited by 14 · see citing works
- Authors
- D'Addario, C., Dell'Osso, B., Palazzo, M. C., Benatti, B., Lietti, L., Cattaneo, E., Galimberti, D., Fenoglio, C., Cortini, F., Scarpini, E., Arosio, B., Di Francesco, A., Di Benedetto, M., Romualdi, P., Candeletti, S., Mari, D., Bergamaschini, L., Bresolin, N., Maccarrone, M., & Altamura, A. C.
- Affiliations
- University of Milan (IT)
- University of Bologna (IT)
- University of Teramo (IT)
- ORCID
- Venue
- Neuropsychopharmacology
- Published
- 2012-02-22
- Volume
- 37
- Issue
- 7
- Pages
- 1647-1655
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC3358733
- OpenAlex
- W1994958608
- Cited by
- 192
- References
- 78
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 9 · 2023: 6 · 2022: 8 · 2021: 12 · 2020: 20 · 2019: 13 · 2018: 12 · 2017: 20 · 2016: 22 · 2015: 12 · 2014: 23 · 2013: 16 · 2012: 5
- FWCI
- 12.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- UniTERAMO Research Catalog (University of Teramo) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion)
- Funders
- Ministero della Salute
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- bipolar disorder, brain-derived neurotrophic factor, DNA methylation, promoter hypermethylation, epigenetics, bipolar I disorder, bipolar II disorder, mood stabilizers, antidepressants, lithium, valproic acid, gene downregulation, peripheral blood mononuclear cells
- MeSH terms
- Adult, Aged, Bipolar Disorder, Female, Genotype, Humans, Male, Middle Aged, Promoter Regions, Genetic, Antipsychotic Agents, Down-Regulation, DNA Methylation, Brain-Derived Neurotrophic Factor, Genetic Predisposition to Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
