Cited by 179Epigenetics and DNA MethylationSchizophrenia research and treatmentGenetics and Neurodevelopmental Disorders

The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.

DNA methylation of the BDNF gene and its relevance to psychiatric disorders

Ikegame, Tempei, Bundo, Miki, Murata, Yui, Kasai, Kiyoto, Kato, Tadafumi, Iwamoto, Kazuya·2013·Journal of Human Genetics

DOI 10.1038/jhg.2013.65

Open this paper in CoChat — free account

Abstract

Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor, which is important for neuronal survival, development and synaptic plasticity. Accumulating evidence suggests that epigenetic modifications of BDNF are associated with the pathophysiology of psychiatric disorders, such as schizophrenia and mood disorders. Patients with psychiatric disorders generally show decreased neural BDNF levels, which are often associated with increased DNA methylation at the specific BDNF promoters. Importantly, observed DNA methylation changes are consistent across tissues including brain and peripheral blood, which suggests potential usefulness of these findings as a biomarker of psychiatric disorders. Here we review DNA methylation characteristics of BDNF promoters of cellular, animal and clinical samples and discuss future perspectives.

Integrity signals

Registry

Crossref · 10.1038/jhg.2013.65

Cites

69 of 69 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

Retracted: Aging is associated with altered inflammatory, arachidonic acid cascade, and synaptic markers, influenced by epigenetic modifications, in the human frontal cortex
Keleshian, V. L., Modi, H. R., Rapoport, S. I., & Rao, J. S. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12153 · Cited by 53
Retracted
Trk Receptors: Roles in Neuronal Signal Transduction
Huang, E. J., & Reichardt, L. F. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161629 · Cited by 2,537
DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation
Martinowich, K., Hattori, D., Wu, H., Fouse, S., He, F., Hu, Y., Fan, G., & Sun, Y. E. (2003) · Science · doi:10.1126/science.1090842 · Cited by 1,405
Lasting epigenetic influence of early-life adversity on the BDNF gene
Roth, T. L., Lubin, F. D., Funk, A. J., & Sweatt, J. D. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.028 · Cited by 1,273
Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2
Chen, W. G., Chang, Q., Lin, Y., Meissner, A., West, A. E., Griffith, E. C., Jaenisch, R., & Greenberg, M. E. (2003) · Science · doi:10.1126/science.1086446 · Cited by 1,232
Serum Brain-Derived Neurotrophic Factor, Depression, and Antidepressant Medications: Meta-Analyses and Implications
Sen, S., Duman, R., & Sanacora, G. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.005 · Cited by 1,232
Regional distribution of brain‐derived neurotrophic factor mRNA in the adult mouse brain.
Hofer, M., Pagliusi, S. R., Hohn, A., Leibrock, J., & Barde, Y. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07423.x · Cited by 1,039
ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75NTRand Sortilin
Teng, H. K., Teng, K. K., Lee, R., Wright, S., Tevar, S., Almeida, R. D., Kermani, P., Torkin, R., Chen, Z.-Y., Lee, F. S., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5123-04.2005 · Cited by 1,013
A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression
Brunoni, A. R., Lopes, M., & Fregni, F. (2008) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009309 · Cited by 972
Mouse and rat BDNF gene structure and expression revisited
Aid, T., Kazantseva, A., Piirsoo, M., Palm, K., & Timmusk, T. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21139 · Cited by 943
Variant Brain-Derived Neurotrophic Factor (BDNF) (Met66) Alters the Intracellular Trafficking and Activity-Dependent Secretion of Wild-Type BDNF in Neurosecretory Cells and Cortical Neurons
Chen, Z.-Y., Patel, P. D., Sant, G., Meng, C.-X., Teng, K. K., Hempstead, B. L., & Lee, F. S. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0348-04.2004 · Cited by 874
Brain-derived neurotrophic factor in the control human brain, and in Alzheimer’s disease and Parkinson’s disease
Murer, M. G., Yan, Q., & Raisman-Vozari, R. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00014-9 · Cited by 874
Multiple promoters direct tissue-specific expression of the rat BDNF gene
Timmusk, T., Palm, K., Metsis, M., Reintam, T., Paalme, V., Saarma, M., & Persson, H. (1993) · Neuron · doi:10.1016/0896-6273(93)90335-o · Cited by 858
Activation of p75NTR by proBDNF facilitates hippocampal long-term depression
Woo, N. H., Teng, H. K., Siao, C.-J., Chiaruttini, C., Pang, P. T., Milner, T. A., Hempstead, B. L., & Lu, B. (2005) · Nature Neuroscience · doi:10.1038/nn1510 · Cited by 815
Epigenetic Regulation of bdnf Gene Transcription in the Consolidation of Fear Memory
Lubin, F. D., Roth, T. L., & Sweatt, J. D. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1786-08.2008 · Cited by 793
Epigenomic Profiling Reveals DNA-Methylation Changes Associated with Major Psychosis
Mill, J., Tang, T., Kaminsky, Z., Khare, T., Yazdanpanah, S., Bouchard, L., Jia, P., Assadzadeh, A., Flanagan, J., Schumacher, A., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.01.008 · Cited by 773
Dissecting the human BDNF locus: Bidirectional transcription, complex splicing, and multiple promoters
Pruunsild, P., Kazantseva, A., Aid, T., Palm, K., & Timmusk, T. (2007) · Genomics · doi:10.1016/j.ygeno.2007.05.004 · Cited by 699
Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood
Davies, M. N., Volta, M., Pidsley, R., Lunnon, K., Dixit, A., Lovestone, S., Coarfa, C., Harris, R. A., Milosavljevic, A., Troakes, C., et al. (2012) · Genome Biology · doi:10.1186/gb-2012-13-6-r43 · Cited by 630
Evidence That DNA (Cytosine-5) Methyltransferase Regulates Synaptic Plasticity in the Hippocampus
Levenson, J. M., Roth, T. L., Lubin, F. D., Miller, C. A., Huang, I.-C., Desai, P., Malone, L. M., & Sweatt, J. D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511767200 · Cited by 628
The neurotrophin receptor p75NTR: novel functions and implications for diseases of the nervous system
Dechant, G., & Barde, Y. (2002) · Nature Neuroscience · doi:10.1038/nn1102-1131 · Cited by 606
Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia
Weickert, C. S., Hyde, T. M., Lipska, B. K., Herman, M. M., Weinberger, D. R., & Kleinman, J. E. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001308 · Cited by 533
Human and rat brain-derived neurotrophic factor and neurotrophin-3: Gene structures, distributions, and chromosomal localizations
Maisonpierre, P. C., Beau, M. M. L., Espinosa, R., Ip, N. Y., Belluscio, L., de la Monte, S. M., Squinto, S. P., Furth, M. E., & Yancopoulos, G. D. (1991) · Genomics · doi:10.1016/0888-7543(91)90436-i · Cited by 514
Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR
Bibel, M., Hoppe, E., & Barde, Y. (1999) · The EMBO Journal · doi:10.1093/emboj/18.3.616 · Cited by 476
Brain-derived neurotrophic factor levels in schizophrenia: a systematic review with meta-analysis
Green, M. J., Matheson, S. L., Shepherd, A., Weickert, C. S., & Carr, V. J. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.88 · Cited by 453
Brain-Derived Neurotrophic Factor Val66Met and Psychiatric Disorders: Meta-Analysis of Case-Control Studies Confirm Association to Substance-Related Disorders, Eating Disorders, and Schizophrenia
Gratacòs, M., González, J. R., Mercader, J. M., de Cid, R., Urretavizcaya, M., & Estivill, X. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.08.025 · Cited by 428
Relationship of Brain-Derived Neurotrophic Factor and Its Receptor TrkB to Altered Inhibitory Prefrontal Circuitry in Schizophrenia
Hashimoto, T., Bergen, S. E., Nguyen, Q. L., Xu, B., Monteggia, L. M., Pierri, J. N., Sun, Z., Sampson, A. R., & Lewis, D. A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4035-04.2005 · Cited by 386
Increased BDNF Promoter Methylation in the Wernicke Area of Suicide Subjects
Keller, S., Sarchiapone, M., Zarrilli, F., Videtič, A., Ferraro, A., Carli, V., Sacchetti, S., Lembo, F., Angiolillo, A., Jovanovic, N., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.9 · Cited by 379
DNA Methylation Profiles of the Brain-Derived Neurotrophic Factor (BDNF) Gene as a Potent Diagnostic Biomarker in Major Depression
Fuchikami, M., Morinobu, S., Segawa, M., Okamoto, Y., Yamawaki, S., Ozaki, N., Inoue, T., Kusumi, I., Koyama, T., Tsuchiyama, K., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023881 · Cited by 378
Brain-derived neurotrophic factor Val66met polymorphism and volume of the hippocampal formation
Szeszko, P. R., Lipsky, R. H., Mentschel, C., Robinson, D. G., Gunduz‐Bruce, H., Sevy, S. M., Ashtari, M., Napolitano, B. A., Bilder, R. M., Kane, J. M., et al. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001656 · Cited by 378
Brain-derived neurotrophic factor and neurotrophin 3 in schizophrenic psychoses
Durany, N., Michel, T. M., Zöchling, R., Boissl, K. W., Cruz-Sánchez, F., Riederer, P. F., & Thome, J. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(00)00084-0 · Cited by 364
Decreased BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders
Ray, M. T., Weickert, C. S., Wyatt, E. J., & Webster, M. J. (2011) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.100048 · Cited by 356
Abnormal expression of brain-derived neurotrophic factor and its receptor in the corticolimbic system of schizophrenic patients
Takahashi, M., Shirakawa, O., Toyooka, K., Kitamura, N., Hashimoto, T., Maeda, K., Koizumi, S., Wakabayashi, K., Takahashi, H., Someya, T., et al. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000718 · Cited by 343
Epigenetic modification of hippocampal Bdnf DNA in adult rats in an animal model of post-traumatic stress disorder
Roth, T. L., Zoladz, P. R., Sweatt, J. D., & Diamond, D. M. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.01.013 · Cited by 333
Response to psychotherapy in borderline personality disorder and methylation status of the BDNF gene
Perroud, N., Salzmann, A., Prada, P., Nicastro, R., Hoeppli, M.-E., Furrer, S., Ardu, S., Krejci, I., Karege, F., & Malafosse, A. (2013) · Translational Psychiatry · doi:10.1038/tp.2012.140 · Cited by 320
Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients
Rao, J. S., Keleshian, V. L., Klein, S. L., & Рапопорт, С. И. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.55 · Cited by 305
Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine
Liu, Q., Lü, L., Zhu, X.-G., Gong, J.-P., Shaham, Y., & Uhl, G. R. (2005) · Brain Research · doi:10.1016/j.brainres.2005.10.004 · Cited by 297
Long‐lasting depression‐like behavior and epigenetic changes of BDNF gene expression induced by perinatal exposure to methylmercury
Onishchenko, N. R., Karpova, N. N., Sabri, F., Ċastrén, E., & Ceccatelli, S. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05484.x · Cited by 272
Dynamic changes in DNA methylation of stress-associated genes (OXTR, BDNF) after acute psychosocial stress
Unternaehrer, E., Luers, P., Mill, J., Dempster, E., Meyer, A. H., Staehli, S., Lieb, R., Hellhammer, D. H., & Meinlschmidt, G. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.77 · Cited by 250
Epigenetic Mediation of Environmental Influences in Major Psychotic Disorders
Rutten, B. P. F., & Mill, J. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp104 · Cited by 244
Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease
Liu, Q., Walther, D. M., Drgon, T., Polesskaya, O. O., Lesnick, T. G., Strain, K. J., de Andrade, M., Bower, J. H., Maraganore, D. M., & Uhl, G. R. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30109 · Cited by 235
Altered expression of apoptotic factors and synaptic markers in postmortem brain from bipolar disorder patients
Kim, H., Rapoport, S. I., & Rao, J. S. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.11.010 · Cited by 211
The role of BDNF in the pathophysiology and treatment of schizophrenia
Favalli, G. P. D. S., Li, J., Belmonte-de-Abreu, P. S., Wong, A. H. C., & Daskalakis, Z. J. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.09.022 · Cited by 207
Reductions in neurotrophin receptor mRNAs in the prefrontal cortex of patients with schizophrenia
Weickert, C. S., Ligons, D. L., Romanczyk, T. B., Ungaro, G., Hyde, T. M., Herman, M. M., Weinberger, D. R., & Kleinman, J. E. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001678 · Cited by 199
Selective DNA Methylation of BDNF Promoter in Bipolar Disorder: Differences Among Patients with BDI and BDII
D'Addario, C., Dell'Osso, B., Palazzo, M. C., Benatti, B., Lietti, L., Cattaneo, E., Galimberti, D., Fenoglio, C., Cortini, F., Scarpini, E., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.10 · Cited by 192
An immunohistochemical study of the distribution of brain-derived neurotrophic factor in the adult human brain, with particular reference to Alzheimer's disease
Murer, M. G., Boissière‐Michot, F., Yan, Q., Hunot, S., Villares, J., Faucheux, B. A., Agid, Y., Hirsch, É. C., & Raisman‐Vozari, R. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00219-x · Cited by 180
Maternal smoking during pregnancy is associated with epigenetic modifications of the brain‐derived neurotrophic factor‐6 exon in adolescent offspring
Toledo‐Rodriguez, M., Lotfipour, S., Leonard, G. T., Perron, M., Richer, L., Veillette, S., Pausová, Z., & Paus, T. (2010) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31109 · Cited by 176
Studies on the physiological role of brain-derived neurotrophic factor and neurotrophin-3 in knockout mice
Ernfors, P., Kučera, J., Lee, K., Loring, J. M., & Jaenisch, R. (1995) · The International Journal of Developmental Biology · doi:10.1387/ijdb.8645564 · Cited by 147
Reduced function of the serotonin transporter is associated with decreased expression of BDNF in rodents as well as in humans
Molteni, R., Cattaneo, A., Calabrese, F., Macchi, F., Olivier, J. D. A., Racagni, G., Ellenbroek, B. A., Gennarelli, M., & Riva, M. A. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.12.014 · Cited by 129
Role of brain-derived neurotrophic factor and NF-kappaB in neuronal plasticity and survival: From genes to phenotype.
Marini, A. M., Jiang, X., Wu, X., Tian, F., Zhu, D., Okagaki, P., & Lipsky, R. H. (2004) · PubMed · Cited by 128
Whither proBDNF?
Barker, P. A. (2009) · Nature Neuroscience · doi:10.1038/nn0209-105 · Cited by 110
A systematic review and meta‐analysis on the association between BDNF val 66 met and hippocampal volume—A genuine effect or a winners curse?
Molendijk, M. L., Bus, B. A. A., Spinhoven, P., Kaimatzoglou, A., Voshaar, R. C. O., Penninx, B. W. J. H., van IJzendoorn, M. H., & Elzinga, B. M. (2012) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32078 · Cited by 107
Immunohistochemical study of brain-derived neurotrophic factor and its receptor, TrkB, in the hippocampal formation of schizophrenic brains
Iritani, S., Niizato, K., Nawa, H., Ikeda, K., & Emson, P. C. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(03)00112-x · Cited by 101
Epigenetic Modulation of BDNF Gene in Patients with Major Depressive Disorder
D’Addario, C., Dell’Osso, B. M., Galimberti, D., Palazzo, C., Benatti, B., Francesco, A. D., Scarpini, E. A., Altamura, A. C., & Maccarrone, M. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.07.009 · Cited by 96
Promoter specific alterations of brain-derived neurotrophic factor mRNA in schizophrenia
Wong, J., Hyde, T. M., Cassano, H., Deep‐Soboslay, A., Kleinman, J. E., & Weickert, C. S. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.05.037 · Cited by 95
A longitudinal study of BDNF promoter methylation and genotype with poststroke depression
Kim, J., Stewart, R. J., Kang, H., Kim, S., Kim, S., Shin, I., Park, M., Kim, H., Shin, M., Cho, K.-H., et al. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.01.008 · Cited by 91
Primary Structure and Biological Activity of Human Brain-Derived Neurotrophic Factor
Rosenthal, A., Goeddel, D. V., NGUYEN, T., Martin, E., Burton, L., Shih, A., Laramee, G. R., Wurm, F. M., MASON, A., Nikolics, K., et al. (1991) · Endocrinology · doi:10.1210/endo-129-3-1289 · Cited by 88
Human neuroblastomas with unfavorable biologies express high levels of brain-derived neurotrophic factor mRNA and a variety of its variants
Aoyama, M., Asai, K., Shishikura, T., Kawamoto, T., Miyachi, T., Yokoi, T., Togari, H., Wada, Y., Kato, T., & Nakagawara, A. (2001) · Cancer Letters · doi:10.1016/s0304-3835(00)00715-1 · Cited by 85
Self-citation
DNA methylation changes in schizophrenia and bipolar disorder
Connor, C., & Akbarian, S. (2008) · Epigenetics · doi:10.4161/epi.3.2.5938 · Cited by 84
DNA methylation and expression profiles of the brain-derived neurotrophic factor (BDNF) and dopamine transporter (DAT1) genes in patients with schizophrenia
Kordi-Tamandani, D. M., Sahranavard, R., & Torkamanzehi, A. (2012) · Molecular Biology Reports · doi:10.1007/s11033-012-1986-0 · Cited by 77
Brain‐Derived Neurotrophic Factor Is More Highly Conserved in Structure and Function than Nerve Growth Factor During Vertebrate Evolution
Götz, R., Raulf, F., & Schartl, M. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09389.x · Cited by 77
Depolarization induces downregulation of DNMT1 and DNMT3 in primary cortical cultures
Sharma, R. P., Tun, N., & Grayson, D. R. (2008) · Epigenetics · doi:10.4161/epi.3.2.6103 · Cited by 63
TrkB gene expression and DNA methylation state in Wernicke area does not associate with suicidal behavior
Keller, S., Sarchiapone, M., Zarrilli, F., Tomaiuolo, R., Carli, V., Angrisano, T., Videtič, A., Amato, F., Pero, R., di Giannantonio, M., et al. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.07.003 · Cited by 56
Chromosomal mapping of brain-derived neurotrophic factor and neurotrophin-3 genes in man and mouse
Özçelık, T., Rosenthal, A., & Francke, U. (1991) · Genomics · doi:10.1016/0888-7543(91)90437-j · Cited by 53
Darkness Reduces BDNF Expression in the Visual Cortex and Induces Repressive Chromatin Remodeling at the BDNF Gene in Both Hippocampus and Visual Cortex
Karpova, N. N., Rantamäki, T., Lieto, A. D., Lindemann, L., Hoener, M. C., & Ċastrén, E. (2010) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-010-9544-6 · Cited by 52
Differential epigenetic regulation of BDNF and NT-3 genes by trichostatin A and 5-aza-2′-deoxycytidine in Neuro-2a cells
Ishimaru, N., Fukuchi, M., Hirai, A., Chiba, Y., Tamura, T., Takahashi, N., Tabuchi, A., Tsuda, M., & Shiraishi, M. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.02.139 · Cited by 47
Measurement Methods of BDNF Levels in Major Depression: A Qualitative Systematic Review of Clinical Trials
Teche, S. P., Nuernberg, G. L., Sordi, A. O., de Souza, L. H., Remy, L., Ceresér, K. M. M., & da Rocha, N. S. (2013) · Psychiatric Quarterly · doi:10.1007/s11126-013-9261-7 · Cited by 41
BDNF splice variants from the second promoter cluster support cell survival of differentiated neuroblastoma upon cytotoxic stress
Baj, G., & Tongiorgi, E. (2008) · Journal of Cell Science · doi:10.1242/jcs.033316 · Cited by 28
Alternative splicing variants and DNA methylation status of BDNF in inbred chicken lines
Yu, Y., Zhang, H., Byerly, M. S., Bacon, L. D., Porter, T. E., Liu, G. E., & Song, J. (2009) · Brain Research · doi:10.1016/j.brainres.2009.01.071 · Cited by 18
BDNF splice variants from the second promoter cluster support cell survival of differentiated neuroblastoma upon cytotoxic stress
Baj, G., & Tongiorgi, E. (2008) · Journal of Cell Science · doi:10.1242/jcs.03506 · Cited by 13

Flagged first, then by citations

Sorted by citations

Epigenetic mechanisms in neurogenesis
Yao, B., Christian, K. M., He, C., Jin, P., Ming, G., & Song, H. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.70 · Cited by 406
DNA extracted from saliva for methylation studies of psychiatric traits: evidence tissue specificity and relatedness to brain
Smith, A. K., Kilaru, V., Klengel, T., Mercer, K. B., Bradley, B., Conneely, K. N., Ressler, K. J., & Binder, E. B. (2015) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32278 · Cited by 355
Epigenetic basis of mental illness
Nestler, E. J., Peña, C. J., Kundakovic, M., Mitchell, A., & Akbarian, S. (2016) · The Neuroscientist · doi:10.1177/1073858415608147 · Cited by 342
Biomarkers in Psychiatry: Concept, Definition, Types and Relevance to the Clinical Reality
García-Gutiérrez, M. S., Navarrete, F., Sala, F., Gasparyan, A., Austrich-Olivares, A., & Manzanares, J. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00432 · Cited by 331
Prenatal stressors in rodents: Effects on behavior
Weinstock, M. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.08.004 · Cited by 264

See all 179

Authors: Ikegame, T., Bundo, M., Murata, Y., Kasai, K., Kato, T., & Iwamoto, K.
Affiliations: The University of Tokyo (JP)
RIKEN Center for Brain Science (JP)
Japan Science and Technology Agency (JP)
Corresponding author: Iwamoto, Kazuya
ORCID: Ikegame, Tempei
Bundo, Miki
Kasai, Kiyoto
Kato, Tadafumi
Iwamoto, Kazuya
Venue: Journal of Human Genetics
Publisher: Springer Science and Business Media LLC
Published: 2013-06-06
Volume: 58
Issue: 7
Pages: 434-438
ISSN: 1434-5161 (ISSN-L)
1435-232X
DOI: 10.1038/jhg.2013.65
OpenAlex: W1996375332
Cited by: 179
References: 69
Citations by year: 2026: 8 · 2025: 12 · 2024: 14 · 2023: 16 · 2022: 14 · 2021: 11 · 2020: 8 · 2019: 13 · 2018: 13 · 2017: 12 · 2016: 20 · 2015: 21 · 2014: 15 · 2013: 2
FWCI: 1.82
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Journal of Human Genetics (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Education, Culture, Sports, Science and Technology (CREST)
Core Research for Evolutional Science and Technology
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords: brain-derived neurotrophic factor, DNA methylation, epigenetics, mental illness, schizophrenia, mood disorders, promoter methylation, biomarkers, peripheral blood, brain, neurotrophic factors, synaptic plasticity
MeSH terms: Animals, Autopsy, Brain, Disease Models, Animal, Humans, Neurons, Promoter Regions, Genetic, Schizophrenia, DNA Methylation, Brain-Derived Neurotrophic Factor

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

DNA methylation of the BDNF gene and its relevance to psychiatric disorders

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks