Medication adherence and resistant hypertension
Abstract
Non-adherence has been a major concern in the treatment of hypertension and is particularly important in understanding and intervening in patients who appear to have resistant hypertension. Relatively few studies have examined the role of non-adherence in resistant hypertension. This review will address issues related to measurement of adherence, adherence interventions and rates of non-adherence in general hypertensive populations and in patients classified as having resistant hypertension.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A review of studies of medication adherence in apparent treatment-resistant hypertension identified rates of nonadherence in this population ranging from 7% using pharmacy refill records in a managed care population to >60% using serum drug levels in a referral clinic.
“Although data are limited, a review of studies of medication adherence in aTRH identified rates of nonadherence in this population ranging from 7% using pharmacy refill records in a managed care population to >60% using serum drug levels in a referral clinic.102”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [102]
Adequate adherence necessary for patients to experience benefit from full exposure to prescribed pharmacological therapy is generally defined as taking at least 80% of doses, although the scientific basis for this cutoff is unclear.
“Adequate adherence necessary for patients to experience benefit from full exposure to prescribed pharmacological therapy is generally defined as taking at least 80% of doses, although the scientific basis for this cutoff is unclear.102”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [102]
Cites
James, P. A., Oparil, S., Carter, B. L., Cushman, W. C., Dennison-Himmelfarb, C., Handler, J., Lackland, D. T., LeFevre, M. L., MacKenzie, T. D., Ogedegbe, O., et al. (2014) · JAMA · doi:10.1001/jama.2013.284427 · Cited by 7,950 · see citing works
Update on Key Emerging Challenges in Cystic Fibrosis
Jennings, M. T., Riekert, K. A., & Boyle, M. (2014) · Medical Principles and Practice · doi:10.1159/000357646 · Cited by 3,667 · see citing works
Interventions for enhancing medication adherence
Nieuwlaat, R., Wilczynski, N., Navarro, T., Hobson, N., Jeffery, R., Keepanasseril, A., Agoritsas, T., Mistry, N., Iorio, A., Jack, S., et al. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000011.pub4 · Cited by 2,945 · see citing works
Interventions for enhancing medication adherence
Haynes, R. B., Ackloo, E., Sahota, N., McDonald, H. P., & Yao, X. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000011.pub3 · Cited by 1,244 · see citing works
Incidence and Prognosis of Resistant Hypertension in Hypertensive Patients
Daugherty, S. L., Powers, J. D., Magid, D. J., Tavel, H. M., Masoudi, F. A., Margolis, K. L., O'Connor, P. J., Selby, J. V., & Ho, P. M. (2012) · Circulation · doi:10.1161/circulationaha.111.068064 · Cited by 930 · see citing works
Viswanathan, M., Golin, C. E., Jones, C. D., Ashok, M., Blalock, S. J., Wines, R. C. M., Coker-Schwimmer, E. J. L., Rosen, D. L., Sista, P., & Lohr, K. N. (2012) · Annals of Internal Medicine · doi:10.7326/0003-4819-157-11-201212040-00538 · Cited by 754 · see citing works
Good and poor adherence: optimal cut-point for adherence measures using administrative claims data.
Karve, S., Cleves, M. A., Helm, M., Hudson, T. J., West, D. S., & Martin, B. C. (2009) · Current Medical Research and Opinion · doi:10.1185/03007990903126833 · Cited by 620 · see citing works
RANDOMISED CLINICAL TRIAL OF STRATEGIES FOR IMPROVING MEDICATION COMPLIANCE IN PRIMARY HYPERTENSION
Sackett, D., Gibson, E., Taylor, D. W., Haynes, R. B., Hackett, B. C., Roberts, R., & Johnson, A. (1975) · The Lancet · doi:10.1016/s0140-6736(75)92192-3 · Cited by 502 · see citing works
Resistant hypertension? Assessment of adherence by toxicological urine analysis
Jung, O., Gechter, J. L., Wunder, C., Paulke, A., Bartel, C., Geiger, H., & Toennes, S. W. (2013) · Journal of Hypertension · doi:10.1097/hjh.0b013e32835e2286 · Cited by 474 · see citing works
Treatment of Reflux Oesophagitis
COLE, P. V. (1988) · Inpharma Weekly · doi:10.1007/bf03308057 · Cited by 391 · see citing works
Bramley, T. J., Nightengale, B. S., Frech-Tamas, F., & Gerbino, P. P. (2006) · Journal of Managed Care Pharmacy · doi:10.18553/jmcp.2006.12.3.239 · Cited by 380 · see citing works
Kandzari, D. E., Bhatt, D. L., Sobotka, P. A., O’Neill, W. W., Esler, M., Flack, J. M., Katzen, B. T., Leon, M. B., Massaro, J. M., Negoita, M., et al. (2012) · Clinical Cardiology · doi:10.1002/clc.22008 · Cited by 304 · see citing works
Impact of Medication Nonadherence on Hospitalizations and Mortality in Heart Failure
Fitzgerald, A. A., Powers, J. D., Ho, P. M., Maddox, T. M., Peterson, P. N., Allen, L. A., Masoudi, F. A., Magid, D. J., & Havranek, E. P. (2011) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2011.04.011 · Cited by 282 · see citing works
Racial Differences in Blood Pressure Control: Potential Explanatory Factors
Bosworth, H. B., Dudley, T. K., Olsen, M. K., Voils, C. I., Powers, B. J., Goldstein, M. K., & Oddone, E. Ž. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.08.019 · Cited by 277 · see citing works
Apparent and true resistant hypertension: definition, prevalence and outcomes
Judd, E. K., & Calhoun, D. A. (2014) · Journal of Human Hypertension · doi:10.1038/jhh.2013.140 · Cited by 275 · see citing works
Worthley, S. G., Tsioufis, C. P., Worthley, M. I., Sinhal, A., Chew, D. P., Meredith, I. T., Malaiapan, Y., & Papademetriou, V. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht197 · Cited by 271 · see citing works
Burnier, M., Schneider, M. P., Chioléro, A., Stubi, C.-L. F., & Brunner, H. R. (2001) · Journal of Hypertension · doi:10.1097/00004872-200102000-00022 · Cited by 262 · see citing works
Resistant Hypertension Revisited: A Comparison of Two University-Based Cohorts
Garg, J. P., ELLIOTT, W., Folker, A., Izhar, M., & Black, H. R. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2004.11.021 · Cited by 258 · see citing works
Measuring, Analyzing, and Managing Drug Adherence in Resistant Hypertension
Burnier, M., Wuerzner, G., Struijker-Boudier, H., & Urquhart, J. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.00687 · Cited by 229 · see citing works
Antihypertensive Medication Adherence in the Department of Veterans Affairs
Siegel, D., Lopez, J., & Meier, J. L. (2007) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.06.028 · Cited by 227 · see citing works
Sim, J. J., Bhandari, S. K., Shi, J., Liu, I. L. A., Calhoun, D. A., McGlynn, E. A., Kalantar-Zadeh, K., & Jacobsen, S. J. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.06.017 · Cited by 206 · see citing works
Shi, L., Liu, J., Koleva, Y. N., Fonseca, V. A., Kalsekar, A., & Pawaskar, M. D. (2010) · PharmacoEconomics · doi:10.2165/11537400-000000000-00000 · Cited by 190 · see citing works
The Language of Medication-Taking
Steiner, J. F., & Earnest, M. A. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-132-11-200006060-00026 · Cited by 190 · see citing works
Resistant Hypertension in a Tertiary Care Clinic
Yakovlevitch, M. (1991) · Archives of Internal Medicine · doi:10.1001/archinte.1991.00400090078014 · Cited by 184 · see citing works
Therapeutic Drug Monitoring Facilitates Blood Pressure Control in Resistant Hypertension
Brinker, S. K., Pandey, A., Ayers, C., Price, A. L., Raheja, P., Arbique, D., Das, S. R., Halm, E., Kaplan, N., & Vongpatanasin, W. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.10.067 · Cited by 181 · see citing works
Ceral, J., Habrdová, V., Voříšek, V., Bima, M., Pelouch, R., & Solař, M. (2010) · Hypertension Research · doi:10.1038/hr.2010.183 · Cited by 170 · see citing works
Gwadry-Sridhar, F. H., Manias, E., Lal, L., Salas, M., Hughes, D. A., Ratzki-Leewing, A., & Grubisic, M. (2013) · Value in Health · doi:10.1016/j.jval.2013.03.1631 · Cited by 155 · see citing works
Adherence and persistence with taking medication to control high blood pressure
Hill, M. N., Miller, N. H., & Geest, S. D. (2011) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2011.01.001 · Cited by 146 · see citing works
Calhoun, D. A., & White, W. B. (2008) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2008.05.005 · Cited by 127 · see citing works
Elmula, F. E. M. F., Hoffmann, P., Fossum, E., Brekke, M., Gjønnæss, E., Hjørnholm, U., Kjær, V. N., Rostrup, M., Kjeldsen, S. E., Os, I., et al. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01452 · Cited by 112 · see citing works
Zeller, A., Ramseier, E., Teagtmeyer, A., & Battegay, E. (2008) · Hypertension Research · doi:10.1291/hypres.31.2037 · Cited by 111 · see citing works
Daugherty, S. L., Powers, J. D., Magid, D. J., Masoudi, F. A., Margolis, K. L., O’Connor, P. J., Schmittdiel, J. A., & Ho, P. M. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.192096 · Cited by 109 · see citing works
Pandey, A., Raza, F. S., Velasco, A., Brinker, S., Ayers, C. R., Das, S. R., Morisky, D. E., Halm, E. A., & Vongpatanasin, W. (2015) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2015.04.004 · Cited by 108 · see citing works
Moser, M., & Franklin, S. S. (2007) · Journal of Clinical Hypertension · doi:10.1111/j.1524-6175.2007.07152.x · Cited by 95 · see citing works
Grassi, D. G., O’Flaherty, M., Pellizzari, M., Bendersky, M., Rodriguez, P., Turri, D., Forcada, P. J., Ferdinand, K. C., Kotliar, C., & on behalf of the Group of Investigators of the REHASE Program (2008) · Journal of Clinical Hypertension · doi:10.1111/j.1751-7176.2008.00001.x · Cited by 93 · see citing works
Prevalence and Correlates of Low Medication Adherence in Apparent Treatment‐Resistant Hypertension
Irvin, M. R., Shimbo, D., Mann, D. M., Reynolds, K., Krousel-Wood, M. A., Limdi, N. A., Lackland, D. T., Calhoun, D. A., Oparil, S., & Muntner, P. (2012) · Journal of Clinical Hypertension · doi:10.1111/j.1751-7176.2012.00690.x · Cited by 80 · see citing works
The association of depression with adherence to antihypertensive medications: a systematic review
Eze-Nliam, C. M., Thombs, B. D., Lima, B. B., Smith, C. G., & Ziegelstein, R. C. (2010) · Journal of Hypertension · doi:10.1097/hjh.0b013e32833b4a6f · Cited by 70 · see citing works
Curtis, J. R., Larson, J. C., Delzell, E., Brookhart, M. A., Cadarette, S. M., Chlebowski, R. T., Judd, S. E., Safford, M. M., Solomon, D. H., & LaCroix, A. Z. (2011) · Medical Care · doi:10.1097/mlr.0b013e318207ed9e · Cited by 66 · see citing works
Intensive Monitoring of Adherence to Treatment Helps to Identify “True” Resistant Hypertension
de SOUZA, W. A., Sabha, M., Favero, F. D. F., Bergsten‐Mendes, G., Yugar‐Toledo, J. C., & Moreno, H. (2009) · Journal of Clinical Hypertension · doi:10.1111/j.1751-7176.2009.00102.x · Cited by 55 · see citing works
How common is true resistant hypertension?
Bunker, J., Callister, W., Cl, C., & Sever, P. S. (2010) · Journal of Human Hypertension · doi:10.1038/jhh.2010.108 · Cited by 55 · see citing works
Revisiting the medication possession ratio threshold for adherence in lipid management
Watanabe, J. H., Bounthavong, M., & Chen, T. F. (2013) · Current Medical Research and Opinion · doi:10.1185/03007995.2013.766164 · Cited by 50 · see citing works
Grigoryan, L., Pavlik, V. N., & Hyman, D. J. (2013) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2013.06.004 · Cited by 48 · see citing works
Self-citationIntensifying Therapy for Hypertension Despite Suboptimal Adherence
Rose, A. J., Berlowitz, D. R., Manze, M., Orner, M. B., & Kressin, N. R. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.133389 · Cited by 47 · see citing works
Lowy, A. J., Munk, V. C., Ong, S. H., Burnier, M., Vrijens, B., Tousset, E., & Urquhart, J. (2010) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2010.02569.x · Cited by 45 · see citing works
Disparities in Adherence to Hypertensive Care in Urban Ambulatory Settings
Ndumele, C. D., Shaykevich, S., Williams, D. H., & Hicks, L. S. (2010) · Journal of Health Care for the Poor and Underserved · doi:10.1353/hpu.0.0259 · Cited by 45 · see citing works
Impact of Nonadherence to Antihypertensive Therapy
Chobanian, A. V. (2009) · Circulation · doi:10.1161/circulationaha.109.906164 · Cited by 42 · see citing works
Poor hypertension control: let's stop blaming the patients.
Hyman, D., & Pavlik, V. (2002) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.69.10.793 · Cited by 41 · see citing works
Self-citationOleen-Burkey, M. A., Dor, A., Castelli‐Haley, J., & Lage, M. J. (2011) · Journal of Medical Economics · doi:10.3111/13696998.2011.618517 · Cited by 40 · see citing works
50% adherence of patients suffering chronic conditions – where is the evidence?
Mathes, T., Pieper, D., Antoine, S., & Eikermann, M. (2012) · PubMed Central · doi:10.3205/000167 · Cited by 20 · see citing works
Pseudoresistant hypertension due to poor medication adherence
de Oliveira‐Filho, A. D., Costa, F. A., Neves, S. J. F., de Lyra, D. P., & Morisky, D. E. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.12.181 · Cited by 20 · see citing works
Ruzicka, M., McCormick, B. B., Leenen, F. H. H., et al. (2013) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2013.07.678 · Cited by 14 · see citing works
Rizkallah, J., Shen, S., Tischenko, A., et al. (2013) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2013.08.015 · Cited by 14 · see citing works
Biomarkers, Cardiovascular Disease, and Hypertension
Giles, T. D. (2012) · Journal of Clinical Hypertension · doi:10.1111/jch.12014 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Carey, R. M., Calhoun, D. A., Bakris, G. L., Brook, R. D., Daugherty, S. L., Dennison-Himmelfarb, C. R., Egan, B. M., Flack, J. M., Gidding, S. S., Judd, E., et al. (2018) · Hypertension · doi:10.1161/hyp.0000000000000084 · Cited by 1,153 · see citing works
Nonadherence to antihypertensive drugs: A systematic review and meta-analysis
Abegaz, T. M., Shehab, A., Gebreyohannes, E. A., Bhagavathula, A. S., & Elnour, A. A. (2017) · Medicine · doi:10.1097/md.0000000000005641 · Cited by 525 · see citing works
- Authors
- Hyman, D. J., & Pavlik, V
- Affiliations
- Baylor College of Medicine (US)
- Corresponding author
- Hyman, D J
- ORCID
- Pavlik, V
- Venue
- Journal of Human Hypertension
- Published
- 2014-09-11
- Volume
- 29
- Issue
- 4
- Pages
- 213-218
- ISSN
- 0950-9240 (ISSN-L)
- 1476-5527
- OpenAlex
- W1982941533
- Cited by
- 61
- References
- 55
- Citations by year
- 2026: 3 · 2024: 5 · 2023: 8 · 2022: 3 · 2021: 10 · 2020: 9 · 2019: 3 · 2018: 7 · 2017: 4 · 2016: 7 · 2015: 2
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Human Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacy and Medical Practices
- Keywords
- medication adherence, resistant hypertension, hypertension, non-compliance, adherence measurement, adherence interventions, antihypertensive therapy
- MeSH terms
- Antihypertensive Agents, Blood Pressure, Drug Resistance, Humans, Hypertension, Predictive Value of Tests, Referral and Consultation, Risk Factors, Treatment Outcome, Practice Guidelines as Topic, Medication Adherence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
