Safety and efficacy of a multi-electrode renal sympathetic denervation system in resistant hypertension: the EnligHTN I trial
Open accessAbstract
AIMS: Catheter-based renal artery sympathetic denervation has emerged as a novel therapy for treatment of patients with drug-resistant hypertension. Initial studies were performed using a single electrode radiofrequency catheter, but recent advances in catheter design have allowed the development of multi-electrode systems that can deliver lesions with a pre-determined pattern. This study was designed to evaluate the safety and efficacy of the EnligHTN(™) multi-electrode system. METHODS AND RESULTS: We conducted the first-in-human, prospective, multi-centre, non-randomized study in 46 patients (67% male, mean age 60 years, and mean baseline office blood pressure 176/96 mmHg) with drug-resistant hypertension. The primary efficacy objective was change in office blood pressure from baseline to 6 months. Safety measures included all adverse events with a focus on the renal artery and other vascular complications and changes in renal function. Renal artery denervation, using the EnligHTN system significantly reduced the office blood pressure from baseline to 1, 3, and 6 months by -28/10, -27/10 and -26/10 mmHg, respectively (P < 0.0001). No acute renal artery injury or other serious vascular complications occurred. Small, non-clinically relevant, changes in average estimated glomerular filtration rate were reported from baseline (87 ± 19 mL/min/1.73 m2) to 6 months post-procedure (82 ± 20 mL/min/1.73 m2). CONCLUSION: Renal sympathetic denervation, using the EnligHTN multi-electrode catheter results in a rapid and significant office blood pressure reduction that was sustained through 6 months. The EnligHTN system delivers a promising therapy for the treatment of drug-resistant hypertension.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In humans, the renal nerves pass from the sympathetic chain and ganglia to the kidneys via the outer adventitia of the renal arteries, or just beyond in perirenal adipose tissue and connective tissue, potentially within reach of radiofrequency energy delivered by a catheter in the artery lumen.
“In humans, the nerves pass from the sympathetic chain and ganglia to the kidneys via the outer adventitia of the renal arteries, or just beyond in perirenal adipose tissue and connective tissue, potentially within reach of radiofrequency energy delivered by a catheter in the artery lumen120–124.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [122]
Efferent sympathetic renal denervation can be achieved with luminal delivery of radiofrequency and ultrasonic energy.
“Efferent sympathetic renal denervation can be achieved with luminal delivery of radiofrequency and ultrasonic energy.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [122]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Toprak, Ö., Kurt, H., Sarı, Y., Şarkış, C., Us, H., & Kırık, A. (2017) · Kidney & Blood Pressure Research · doi:10.1159/000468530 · Cited by 29,769 · see citing works
2013 ESH/ESC Guidelines for the management of arterial hypertension
Authors Task Force Members, Mancia, G., Fagard, R., Narkiewicz, K., Redon, J., Zanchetti, A., Böhm, M., Christiaens, T., Cífková, R., Backer, G. D., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht151 · Cited by 13,638 · see citing works
Self-citationChobanian, A. V., Bakris, G. L., Black, H. R., Cushman, W. C., Green, L. A., Izzo, J. L., Jones, D. W., Materson, B. J., Oparil, S., Wright, J. T., et al. (2003) · Hypertension · doi:10.1161/01.hyp.0000107251.49515.c2 · Cited by 13,271 · see citing works
Global burden of hypertension: analysis of worldwide data
Kearney, P. M., Whelton, M., Reynolds, K., Muntner, P., Whelton, P. K., & He, J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17741-1 · Cited by 8,578 · see citing works
2007 Guidelines for the Management of Arterial Hypertension
Mancia, G., Backer, G. D., Dominiczak, A. F., Cífková, R., Fagard, R. H., Germanò, G., Grassi, G. M., Heagerty, A. M., Kjeldsen, S. E., Laurent, S., et al. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e3281fc975a · Cited by 5,818 · see citing works
Heart Disease and Stroke Statistics—2010 Update: A Report From the American Heart Association
WRITING GROUP MEMBERS, Lloyd-Jones, D., Adams, R. J., Brown, T. M., Carnethon, M., Dai, S., De Simone, G., Ferguson, T. B., Ford, E., Furie, K., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.192667 · Cited by 5,700 · see citing works
Resistant Hypertension: Diagnosis, Evaluation, and Treatment
Calhoun, D. A., Jones, D. W., Textor, S. C., Goff, D. C., Murphy, T. P., Toto, R. D., White, A. J., Cushman, W. C., White, W. B., Sica, D. A., et al. (2008) · Circulation · doi:10.1161/circulationaha.108.189141 · Cited by 2,232 · see citing works
US trends in prevalence, awareness, treatment, and control of hypertension, 1988–2008
Egan, B. M. (2010) · JAMA · doi:10.1001/jama.2010.650 · Cited by 2,197 · see citing works
Krum, H., Schlaich, M., Whitbourn, R., Sobotka, P. A., Sadowski, J., Bartus, K., Kapelak, B., Walton, A., Sievert, H., Thambar, S., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60566-3 · Cited by 2,108 · see citing works
Wolf-Maier, K. (2003) · JAMA · doi:10.1001/jama.289.18.2363 · Cited by 1,717 · see citing works
Resistant Hypertension: Diagnosis, Evaluation, and Treatment
Calhoun, D. A., Jones, D. W., Textor, S. C., Goff, D. C., Murphy, T. P., Toto, R. D., White, A. J., Cushman, W. C., White, W. B., Sica, D. A., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.189141 · Cited by 1,404 · see citing works
Executive Summary: Heart Disease and Stroke Statistics—2010 Update
WRITING GROUP MEMBERS, Lloyd‐Jones, D. M., Adams, R. J., Brown, T. M., Carnethon, M. R., Dai, S., SIMONE, G. D., Ferguson, T. B., Ford, E. S., Furie, K. L., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.192666 · Cited by 1,358 · see citing works
Catheter-Based Renal Sympathetic Denervation for Resistant Hypertension
Symplicity HTN-1 Investigators (2011) · Hypertension · doi:10.1161/hypertensionaha.110.163014 · Cited by 743 · see citing works
PIERDOMENICO, S., LAPENNA, D., BUCCI, A., DITOMMASO, R., DIMASCIO, R., MANENTE, B., CALDARELLA, M., NERI, M., CUCCURULLO, F., & MEZZETTI, A. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2005.05.014 · Cited by 409 · see citing works
The global cost of nonoptimal blood pressure
Gaziano, T. A., Bitton, A., Anand, S., & Weinstein, M. C. (2009) · Journal of Hypertension · doi:10.1097/hjh.0b013e32832a9ba3 · Cited by 303 · see citing works
Schmieder, R. E., Redón, J., Grassi, G. M., Kjeldsen, S. E., Mancia, G., Narkiewicz, K., Parati, G., Ruilope, L. M., van de Borne, P., & Tsioufis, C. P. (2012) · Journal of Hypertension · doi:10.1097/hjh.0b013e328352ce78 · Cited by 239 · see citing works
Self-citationMahfoud, F., Lüscher, T. F., Andersson, B., Baumgärtner, I., Cífková, R., Mario, C. D., Doevendans, P. A., Fagard, R. H., Fajadet, J. C., Michel Komajda, N., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht154 · Cited by 234 · see citing works
Ukena, C., Mahfoud, F., Spies, A., Kindermann, I., Linz, D., Cremers, B., Laufs, U., Neuberger, H., & Böhm, M. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.07.027 · Cited by 129 · see citing works
Blood Pressure Control Among US Veterans
Fletcher, R. D., AMDUR, R. L., Kolodner, R. M., McManus, C., Jones, R. E., Faselis, C. J., Kokkinos, P. F., Singh, S. N., & Papademetriou, V. (2012) · Circulation · doi:10.1161/circulationaha.111.029983 · Cited by 98 · see citing works
Self-citationIncremental Expenditure of Treating Hypertension in the United States
Balu, S., & THOMASIII, J. (2006) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2005.12.013 · Cited by 87 · see citing works
Renal Sympathetic Denervation for the Treatment of Difficult-to-Control or Resistant Hypertension
Papademetriou, V., Doumas, M. N., & Tsioufis, K. P. (2011) · International Journal of Hypertension · doi:10.4061/2011/196518 · Cited by 38 · see citing works
Self-citationDoumas, M. N., Guo, D., & Papademetriou, V. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220902780185 · Cited by 34 · see citing works
Self-citationDifficult-to-Treat or Resistant Hypertension: Etiology, Pathophysiology, and Innovative Therapies
Papademetriou, V., Tsioufis, C. P., Gradman, A. H., & Punzi, H. A. (2011) · International Journal of Hypertension · doi:10.4061/2011/438198 · Cited by 11 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [14]Guyton AC Hall JE Guyton and Hall Textbook of Medical Physiology with Student Consult Online Access 2006 11th ed Philadelphia Elsevier Saunders
Cited by
Sorted by citations
Carey, R. M., Calhoun, D. A., Bakris, G. L., Brook, R. D., Daugherty, S. L., Dennison-Himmelfarb, C. R., Egan, B. M., Flack, J. M., Gidding, S. S., Judd, E., et al. (2018) · Hypertension · doi:10.1161/hyp.0000000000000084 · Cited by 1,153 · see citing works
Krum, H., Schlaich, M. P., Sobotka, P. A., Böhm, M., Mahfoud, F., Rocha‐Singh, K. J., Katholi, R. E., & Esler, M. (2013) · The Lancet · doi:10.1016/s0140-6736(13)62192-3 · Cited by 622 · see citing works
The Sympathetic Nervous System Alterations in Human Hypertension
Grassi, G., Mark, A., & Esler, M. (2015) · Circulation Research · doi:10.1161/circresaha.116.303604 · Cited by 616 · see citing works
Azizi, M., Sapoval, M., Gosse, P., Monge, M., Bobrie, G., Delsart, P., Midulla, M., Mounier-Véhier, C., Courand, P.-Y., Lantelme, P., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61942-5 · Cited by 519 · see citing works
Anatomic Assessment of Sympathetic Peri-Arterial Renal Nerves in Man
Sakakura, K., Ladich, E., Cheng, Q., Otsuka, F., Yahagi, K., Fowler, D. R., Kolodgie, F. D., Virmani, R., & Joner, M. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.03.059 · Cited by 406 · see citing works
Mahfoud, F., Böhm, M., Azizi, M., Pathak, A., Durand‐Zaleski, I., Ewen, S., Tsioufis, K., Andersson, B., Blankestijn, P. J., Burnier, M., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv192 · Cited by 180 · see citing works
Mahfoud, F., Urban, D., Teller, D. C. E., Linz, D., Stawowy, P., Hassel, J.-H., Fries, P., Dreysse, S. T., Wellnhofer, E., Schneider, G. K., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu093 · Cited by 162 · see citing works
Innervation Patterns May Limit Response to Endovascular Renal Denervation
Tzafriri, A. R., Mahfoud, F., Keating, J. H., Markham, P. M., Spognardi, A.-M., Wong, G., Fuimaono, K., Böhm, M., & Edelman, E. R. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.07.937 · Cited by 127 · see citing works
Esler, M. (2014) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2014.06.001 · Cited by 127 · see citing works
Device-based therapies for arterial hypertension
Lauder, L., Azizi, M., Kirtane, A. J., Böhm, M., & Mahfoud, F. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0364-1 · Cited by 123 · see citing works
Ewen, S., Ukena, C., Linz, D., Kindermann, I., Cremers, B., Laufs, U., Wagenpfeil, S., Schmieder, R. E., Böhm, M., & Mahfoud, F. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.04336 · Cited by 120 · see citing works
Should the sympathetic nervous system be a target to improve cardiometabolic risk in obesity?
Lambert, É., Straznicky, N. E., Dixon, J. B., & Lambert, G. W. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00096.2015 · Cited by 115 · see citing works
Renal Denervation Prevents Heart Failure Progression Via Inhibition of the Renin-Angiotensin System
Sharp, T. E., Polhemus, D. J., Li, Z., Spaletra, P. M., Jenkins, J. S., Reilly, J. P., White, C. J., Kapusta, D. R., Lefer, D. J., & Goodchild, T. T. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.08.2186 · Cited by 109 · see citing works
Hypertension: Pathophysiology and Treatment
Delacroix, S., & Chokka, R. G. (2014) · Journal of Neurology & Neurophysiology · doi:10.4172/2155-9562.1000250 · Cited by 94 · see citing works
Catheter-Based Radiorefrequency Renal Denervation Lowers Blood Pressure in Obese Hypertensive Dogs
Henegar, J. R., Zhang, Y., Rama, R. D., Hata, C., Hall, M. E., & Hall, J. E. (2014) · American Journal of Hypertension · doi:10.1093/ajh/hpu048 · Cited by 89 · see citing works
Renal Denervation for Treating Hypertension
Weber, M. A., Mahfoud, F., Schmieder, R. E., Kandzari, D. E., Tsioufis, K. P., Townsend, R. R., Kario, K., Böhm, M., Sharp, A. S. P., Davies, J. E., et al. (2019) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2019.02.050 · Cited by 88 · see citing works
Ewen, S., Meyer, M. R., Cremers, B., Laufs, U., Helfer, A. G., Linz, D., Kindermann, I., Ukena, C., Burnier, M., Wagenpfeil, S., et al. (2015) · Clinical Research in Cardiology · doi:10.1007/s00392-015-0905-5 · Cited by 82 · see citing works
Kandzari, D. E., Mahfoud, F., Weber, M. A., Townsend, R., Parati, G., Fisher, N. D. L., Lobo, M. D., Bloch, M., Böhm, M., Sharp, A. S. P., et al. (2022) · Circulation · doi:10.1161/circulationaha.121.057687 · Cited by 80 · see citing works
Self-citationRenal Denervation for the Treatment of Cardiovascular High Risk-Hypertension or Beyond?
Böhm, M., Linz, D., Ukena, C., Esler, M., & Mahfoud, F. (2014) · Circulation Research · doi:10.1161/circresaha.115.302522 · Cited by 77 · see citing works
Catheter-Based Renal Denervation Is No Simple Matter
Mahfoud, F., Edelman, E. R., & Böhm, M. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.05.037 · Cited by 75 · see citing works
Renal safety of catheter-based renal denervation: systematic review and meta-analysis
Sanders, M. F., Reitsma, J. B., Morpey, M. I., Gremmels, H., Bots, M. L., Pisano, A., Bolignano, D., Zoccali, C., & Blankestijn, P. J. (2017) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfx088 · Cited by 73 · see citing works
Catheter-Based Renal Denervation for Resistant Hypertension
Papademetriou, V., Tsioufis, C. P., Sinhal, A. R., Chew, D. P., Meredith, I. T., Malaiapan, Y., Worthley, M. I., & Worthley, S. G. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03605 · Cited by 72 · see citing works
Self-citationDevice-Based Neuromodulation for Resistant Hypertension Therapy
Lohmeier, T. E., & Hall, J. E. (2019) · Circulation Research · doi:10.1161/circresaha.118.313221 · Cited by 71 · see citing works
Sievert, H., Schöfer, J., Ormiston, J. A., Hoppe, U. C., Meredith, I. T., Walters, D., Azizi, M., Diaz‐Cartelle, J., & Cohen-Mazor, M. (2015) · EuroIntervention · doi:10.4244/eijy14m12_01 · Cited by 64 · see citing works
Self-citationRenal denervation: symply trapped by complexity?
Mahfoud, F., & Lüscher, T. F. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu450 · Cited by 65 · see citing works
Eligibility for Renal Denervation
Persu, A., Jin, Y., Baelen, M., Vink, E. E., Verloop, W. L., Schmidt, B. M. W., Blicher, M. K., Severino, F., Wuerzner, G., Taylor, A. H. M., et al. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03194 · Cited by 63 · see citing works
Medication adherence and resistant hypertension
Hyman, D. J., & Pavlik, V (2015) · Journal of Human Hypertension · doi:10.1038/jhh.2014.73 · Cited by 61 · see citing works
The Sympathetic Nervous System in Hypertension: Back to the Future?
Esler, M. (2015) · Current Hypertension Reports · doi:10.1007/s11906-014-0519-8 · Cited by 60 · see citing works
Banek, C. T., Gauthier, M. M., Baumann, D. C., Van Helden, D., Asirvatham-Jeyaraj, N., Panoskaltsis-Mortari, A., Fink, G. D., & Osborn, J. W. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00416.2017 · Cited by 58 · see citing works
Sakakura, K., Tunev, S. S., Yahagi, K., O’Brien, A. J., Ladich, E. R., Kolodgie, F. D., Melder, R. J., Joner, M., & Virmani, R. (2015) · Circulation Cardiovascular Interventions · doi:10.1161/circinterventions.114.001813 · Cited by 56 · see citing works
Renal denervation for treatment of drug-resistant hypertension
Esler, M. (2015) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2014.09.014 · Cited by 55 · see citing works
Polhemus, D. J., Gao, J., Scarborough, A. L., Trivedi, R. K., McDonough, K. H., Goodchild, T. T., Smart, F. W., Kapusta, D. R., & Lefer, D. J. (2016) · Circulation Research · doi:10.1161/circresaha.115.308278 · Cited by 54 · see citing works
Interventional procedures and future drug therapy for hypertension
Lobo, M. D., Sobotka, P. A., & Pathak, A. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw303 · Cited by 54 · see citing works
Joint UK societies’ 2014 consensus statement on renal denervation for resistant hypertension
Lobo, M. D., de Belder, M., Cleveland, T., Collier, D., Dasgupta, I., Deanfield, J. E., Kapil, V., Knight, C. J., Matson, M. B., Moss, J. G., et al. (2014) · Heart · doi:10.1136/heartjnl-2014-307029 · Cited by 52 · see citing works
Effects of sympathetic modulation in metabolic disease
Carnagarin, R., Lambert, G. W., Kiuchi, M. G., Nolde, J. M., Matthews, V. B., Eikelis, N., Lambert, É., & Schlaich, M. P. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14217 · Cited by 52 · see citing works
Tsioufis, C. P., Mahfoud, F., Mancia, G., Redón, J., DAMASCELLI, B., Zeller, T., & Schmieder, R. E. (2014) · EuroIntervention · doi:10.4244/eijv9i9a175 · Cited by 50 · see citing works
Self-citationDetection, evaluation, and treatment of severe and resistant hypertension
White, W. B., Turner, J. R., Sica, D. A., Bisognano, J. D., Calhoun, D. A., Townsend, R. R., Aronow, H. D., Bhatt, D. L., & Bakris, G. L. (2014) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2014.06.005 · Cited by 48 · see citing works
Renal Nerve Ablation for Resistant Hypertension
Papademetriou, V., Rashidi, A. A., Tsioufis, C. P., & Doumas, M. N. (2014) · Circulation · doi:10.1161/circulationaha.113.005405 · Cited by 48 · see citing works
Self-citationRenal Denervation and Symplicity HTN-3
Papademetriou, V., Tsioufis, C. P., & Doumas, M. N. (2014) · Circulation Research · doi:10.1161/circresaha.115.304099 · Cited by 46 · see citing works
Self-citationPotential Reduction of Interstitial Myocardial Fibrosis With Renal Denervation
Doltra, A., Messroghli, D., Stawowy, P., Hassel, J., Gebker, R., Leppänen, O., Gräfe, M., Schneeweis, C., Schnackenburg, B., Fleck, E., et al. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.114.001353 · Cited by 45 · see citing works
Tsioufis, C. P., Dimitriadis, K. S., Kasiakogias, A., Kalos, T., Liatakis, I., Koutra, E., Nikolopoulou, L., Kordalis, A., Ella, R. O., Lau, E., et al. (2017) · Journal of Hypertension · doi:10.1097/hjh.0000000000001262 · Cited by 46 · see citing works
Self-citationFeyz, L., Theuns, D. A. M. J., Bhagwandien, R. E., Strachinaru, M., Kardys, I., Mieghem, N. M. V., & Daemen, J. (2018) · Clinical Research in Cardiology · doi:10.1007/s00392-018-1391-3 · Cited by 47 · see citing works
Fischell, T. A., Fischell, D. R., Ghazarossian, V. E., Vega, F., & Ebner, A. A. (2015) · Cardiovascular revascularization medicine · doi:10.1016/j.carrev.2015.04.008 · Cited by 44 · see citing works
Epstein, M., & de Marchena, E. (2014) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2014.12.002 · Cited by 42 · see citing works
Renal denervation for hypertension: observations and predictions of a founder
Esler, M. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu091 · Cited by 40 · see citing works
Stavropoulos, K., Patoulias, D., Imprialos, K. P., Doumas, M. N., Katsimardou, A., Dimitriadis, K. S., Tsioufis, C. P., & Papademetriou, V. (2020) · Journal of Clinical Hypertension · doi:10.1111/jch.13827 · Cited by 39 · see citing works
Self-citationOkada, T., Pellerin, O., Savard, S., Curis, E., Monge, M., Frank, M., Bobrie, G., Yamaguchi, M., Sugimoto, K., Plouin, P., et al. (2014) · CardioVascular and Interventional Radiology · doi:10.1007/s00270-014-0865-6 · Cited by 37 · see citing works
Tsioufis, C. P., Papademetriou, V., Tsiachris, D., Dimitriadis, K. S., Kasiakogias, A., Kordalis, A., Antonakis, V., Kefala, A., Thomopoulos, C., Kallikazaros, I. E., et al. (2014) · Journal of Human Hypertension · doi:10.1038/jhh.2014.14 · Cited by 37 · see citing works
Self-citationThe rise, fall, and possible resurrection of renal denervation
Gulati, R., Raphael, C. E., Negoita, M., Pocock, S., & Gersh, B. J. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.1 · Cited by 36 · see citing works
Renal denervation—implications for chronic kidney disease
Veelken, R. A., & Schmieder, R. E. (2014) · Nature Reviews Nephrology · doi:10.1038/nrneph.2014.59 · Cited by 36 · see citing works
Verheye, S., Ormiston, J. A., Bergmann, M., Sievert, H., Schwindt, A. G., Werner, N., Vogel, B., & Colombo, A. (2015) · EuroIntervention · doi:10.4244/eijy14m12_02 · Cited by 36 · see citing works
Bruno, R. M., Taddei, S., Borghi, C., Colivicchi, F., Desideri, G., Grassi, G. M., Mazza, A., Muiesan, M. L., Parati, G., Pontremoli, R., et al. (2020) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-020-00367-0 · Cited by 36 · see citing works
Renal Denervation after Symplicity HTN-3: An Update
Persu, A., Jin, Y., Elmula, F. E. M. F., Jacobs, L., Renkin, J. P., & Kjeldsen, S. E. (2014) · Current Hypertension Reports · doi:10.1007/s11906-014-0460-x · Cited by 35 · see citing works
Renal Denervation for Treatment of Hypertension: a Second Start and New Challenges
Persu, A., Kjeldsen, S. E., Staessen, J. A., & Azizi, M. (2016) · Current Hypertension Reports · doi:10.1007/s11906-015-0610-9 · Cited by 35 · see citing works
Tsioufis, C. P., Papademetriou, V., Dimitriadis, K. S., Kasiakogias, A., Tsiachris, D., Worthley, M. I., Sinhal, A. R., Chew, D. P., Meredith, I. T., Malaiapan, Y., et al. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.08.069 · Cited by 34 · see citing works
Self-citationTsioufis, C. P., Ziakas, A., Dimitriadis, K. S., Davlouros, P. A., Marketou, M. E., Kasiakogias, A., Thomopoulos, C., Petroglou, D., Tsiachris, D., Doumas, M. N., et al. (2016) · Clinical Research in Cardiology · doi:10.1007/s00392-016-1056-z · Cited by 34 · see citing works
Self-citationRenal sympathetic nervous system and the effects of denervation on renal arteries
Kannan, A. (2014) · World Journal of Cardiology · doi:10.4330/wjc.v6.i8.814 · Cited by 33 · see citing works
Jacobs, L., Persu, A., Huang, Q., Lengelé, J., Thijs, L., Hammer, F., Yang, W., Zhang, Z., Renkin, J. P., Sinnaeve, P., et al. (2017) · Blood Pressure · doi:10.1080/08037051.2017.1320939 · Cited by 31 · see citing works
Targeting the Sympathetic Nervous System
Schlaich, M. P., Esler, M., Fink, G. D., Osborn, J. W., & Euler, D. E. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.02144 · Cited by 31 · see citing works
Worthley, S. G., WILKINS, G. T., Webster, M. W. I., Montarello, J. K., Delacroix, S., Whitbourn, R., & Warren, R. J. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.04.022 · Cited by 31 · see citing works
Self-citationWang, T., Lee, Y., Chang, S., Tung, Y., Yeh, C., Lin, Y., Pan, C., Hsu, C., Huang, C., Wu, C., et al. (2019) · PubMed Central · doi:10.6515/acs.201905_35(3).20190415a · Cited by 31 · see citing works
Beta blockers in patients with end‐stage renal disease—Evidence‐based recommendations
Weir, M. A., & Herzog, C. A. (2018) · Seminars in Dialysis · doi:10.1111/sdi.12691 · Cited by 29 · see citing works
Renal artery stenosis following renal denervation
Persu, A., Sapoval, M. R., Azizi, M., Monge, M., Danse, É., Hammer, F., & Renkin, J. P. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000323 · Cited by 28 · see citing works
DeCastro, C. M., Denning, S. M., Langdon, S., Vandenbark, G. R., Kurtzberg, J., Scearce, R. M., Haynes, B. F., & Kaufman, R. E. (1994) · PubMed · Cited by 27 · see citing works
Ewen, S., Dörr, O., Ukena, C., Linz, D., Cremers, B., Laufs, U., Hamm, C. W., NEF, H. M., Bauer, A., Mancia, G., et al. (2015) · Journal of Hypertension · doi:10.1097/hjh.0000000000000751 · Cited by 26 · see citing works
Prochnau, D., Heymel, S., Otto, S., Figulla, H., & Surber, R. (2014) · EuroIntervention · doi:10.4244/eijv10i5a110 · Cited by 26 · see citing works
Igreja, B., Pires, N. M., Bonifácio, M. J., Loureiro, A. I., Fernandes‐Lopes, C., Wright, L. C., & Soares-da-Silva, P. (2014) · Hypertension Research · doi:10.1038/hr.2014.143 · Cited by 25 · see citing works
Tsioufis, C. P., Papademetriou, V., Dimitriadis, K. S., Tsiachris, D., Thomopoulos, C., Kasiakogias, A., Kordalis, A., Kefala, A., Koutra, E., Lau, E., et al. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000408 · Cited by 23 · see citing works
Self-citationRenal sympathetic denervation for resistant hypertension: where do we stand after more than a decade
Fontes, M. A. P., Marzano, L. A. S., Silva, C. C., & Silva, A. C. S. E. (2020) · Brazilian Journal of Nephrology · doi:10.1590/2175-8239-jbn-2018-0213 · Cited by 22 · see citing works
Pires, N. M., Igreja, B., Moura, E., Wright, L. C., Serrão, P., & Soares-da-Silva, P. (2015) · Hypertension Research · doi:10.1038/hr.2015.50 · Cited by 22 · see citing works
Renal Denervation Therapy for Hypertension
Thukkani, A. K., & Bhatt, D. L. (2013) · Circulation · doi:10.1161/circulationaha.113.004660 · Cited by 22 · see citing works
Targeting GPCR-Gβγ-GRK2 signaling as a novel strategy for treating cardiorenal pathologies
Rudman-Melnick, V., & Blaxall, B. C. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.01.020 · Cited by 22 · see citing works
Wang, Y., Dinh, T. N., Nield, A., Krishna, S. M., Denton, K. M., & Golledge, J. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00215 · Cited by 21 · see citing works
Renal denervation in the antihypertensive arsenal – knowns and known unknowns
Messerli, F. H., Bavishi, C., Brguljan-Hitij, J., Burnier, M., Dobner, S., Elijovich, F., Ferdinand, K. C., Kjeldsen, S. E., Laffer, C. L., Ram, C. V. S., et al. (2022) · Journal of Hypertension · doi:10.1097/hjh.0000000000003171 · Cited by 20 · see citing works
Sievert, H., Schöfer, J., Ormiston, J. A., Hoppe, U. C., Meredith, I. T., Walters, D., Azizi, M., Diaz‐Cartelle, J., & on behalf of the REDUCE-HTN Investigators (2017) · Journal of Human Hypertension · doi:10.1038/jhh.2016.82 · Cited by 21 · see citing works
Self-citationEfficacy and Safety of Catheter-Based Radiofrequency Renal Denervation in Stented Renal Arteries
Mahfoud, F., Tunev, S. S., Ruwart, J., Schulz-Jander, D., Cremers, B., Linz, D., Zeller, T., Bhatt, D. L., Rocha‐Singh, K. J., Böhm, M., et al. (2014) · Circulation Cardiovascular Interventions · doi:10.1161/circinterventions.114.001506 · Cited by 20 · see citing works
Renal denervation in the era of HTN-3. Comprehensive review and glimpse into the future
Silva, J., Costa, M. A. D. S., Gersh, B. J., & Gonçalves, L. M. M. (2016) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2016.05.009 · Cited by 19 · see citing works
Hypertension and new treatment approaches targeting the sympathetic nervous system
Laffin, L. J., & Bakris, G. L. (2014) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2014.12.006 · Cited by 19 · see citing works
Renal denervation for the management of resistant hypertension
Patel, H. C., Hayward, C., Vassiliou, V. S., Patel, K., Howard, J. P., & Mario, C. D. (2015) · Integrated Blood Pressure Control · doi:10.2147/ibpc.s65632 · Cited by 18 · see citing works
Tsioufis, C. P., Papademetriou, V., Tsiachris, D., Kasiakogias, A., Kordalis, A., Thomopoulos, C., Dimitriadis, K. S., Tousoulis, D. M., Stefanadis, C., Parati, G., et al. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.11.121 · Cited by 19 · see citing works
Self-citationRenal Sympathetic Denervation: A Comprehensive Review
Akinseye, O. A., Ralston, W. F., Johnson, K., Ketron, L., Womack, C. R., & Ibebuogu, U. N. (2020) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2020.100598 · Cited by 19 · see citing works
Turner, J. R., & O'Brien, E. T. (2013) · Journal of Clinical Hypertension · doi:10.1111/jch.12200 · Cited by 17 · see citing works
Ten-year follow-up of very-high risk hypertensive patients undergoing renal sympathetic denervation
Li, W., Li, C., Li, Z., Li, Q., Liu, C., Sun, X., He, Q., Xia, D., Xia, D., & Lu, C. (2023) · Journal of Hypertension · doi:10.1097/hjh.0000000000003650 · Cited by 17 · see citing works
Renal denervation for treatment-resistant hypertension
Mafeld, S. C., Vasdev, N., & Haslam, P. J. (2012) · Therapeutic Advances in Cardiovascular Disease · doi:10.1177/1753944712468040 · Cited by 16 · see citing works
Zweiker, D., Lambert, T., Steinwender, C., Weber, T., Suppan, M., Brussee, H., Koppelstätter, C., Kerschbaum, J., Watschinger, B., Hohenstein-Scheibenecker, K., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161250 · Cited by 16 · see citing works
Ellenbroek, G. H. J. M., van Hout, G. P. J., de Jager, S. C. A., Timmers, L., Vink, A., Goldschmeding, R., van der Kraak, P. H., Pasterkamp, G., Hoefer, I. E., Doevendans, P. A., et al. (2017) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-017-9743-3 · Cited by 16 · see citing works
Stiermaier, T., Okon, T., Fengler, K., Mueller, U., Hoellriegel, R., Schuler, G. C., Desch, S., & Lurz, P. C. (2016) · EuroIntervention · doi:10.4244/eijv12i2a43 · Cited by 16 · see citing works
Hoye, N. A., Wilson, L. C., WILKINS, G. T., Jardine, D. L., Putt, T. L., Samaranayaka, A., Schollum, J. B. W., & Walker, R. J. (2017) · Kidney International Reports · doi:10.1016/j.ekir.2017.04.012 · Cited by 16 · see citing works
Mechanisms in hypertension and target organ damage: Is the role of the thymus key? (Review)
Dai, X., Hua, L., Chen, Y., Wang, J., Li, J., Wu, F., Zhang, Y., Su, J., Wu, Z., & Liang, C. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3605 · Cited by 16 · see citing works
Renal Artery Denervation in Resistant Hypertension: The Good, The Bad and The Future
Raisi, S. I. A., Pouliopoulos, J., Swinnen, J., Thiagalingam, A., & Kovoor, P. (2019) · Heart Lung and Circulation · doi:10.1016/j.hlc.2019.06.723 · Cited by 16 · see citing works
Proceedings from Duke Resistant Hypertension Think Tank
Vemulapalli, S., Ard, J. D., Bakris, G. L., Bhatt, D. L., Brown, A. S., Cushman, W. C., Ferdinand, K. C., Flack, J. M., Fleg, J. L., Katzen, B. T., et al. (2014) · American Heart Journal · doi:10.1016/j.ahj.2014.02.008 · Cited by 15 · see citing works
Townsend, R. R., & Epstein, M. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.07316 · Cited by 15 · see citing works
Treating resistant hypertension: role of renal denervation
Mahfoud, F., Urban, D., Ewen, S., Ukena, C., Linz, D., & Böhm, M. (2013) · Integrated Blood Pressure Control · doi:10.2147/ibpc.s33958 · Cited by 15 · see citing works
Vink, E. E., Boer, A., Verloop, W. L., Spiering, W., Voskuil, M., Vonken, E.-J. P. A., Hoogduin, J. M., Leiner, T., Bots, M. L., & Blankestijn, P. J. (2015) · European Radiology · doi:10.1007/s00330-014-3583-1 · Cited by 15 · see citing works
Percutaneous Renal Sympathetic Denervation: 2013 and Beyond
Froeschl, M. P. V., Hadziomerovic, A., & Ruzicka, M. (2013) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2013.11.003 · Cited by 15 · see citing works
Pan, T., Guo, J., & Teng, G. (2015) · Medicine · doi:10.1097/md.0000000000001932 · Cited by 15 · see citing works
Chandra, A. P., Marron, C. D., Puckridge, P., & Spark, J. I. (2014) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2013.11.005 · Cited by 14 · see citing works
Burchell, A. E., Chan, K., Ratcliffe, L. E. K., Hart, E. C., Saxena, M., Collier, D., Jain, A., Mathur, A., Knight, C. J., Caulfield, M. J., et al. (2016) · Journal of Clinical Hypertension · doi:10.1111/jch.12789 · Cited by 14 · see citing works
Wilson, A. L., Gandhi, J., Suh, Y., Joshi, G. S., Smith, N. L., & Khan, S. A. (2019) · Current Hypertension Reviews · doi:10.2174/1573402115666190301154100 · Cited by 13 · see citing works
Renal Denervation After SYMPLICITY HTN-3: Where Do We Go?
Briasoulis, Α., & Bakris, G. L. (2014) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2014.12.004 · Cited by 13 · see citing works
- Authors
- Worthley, S. G., Tsioufis, C. P., Worthley, M. I., Sinhal, A., Chew, D. P., Meredith, I. T., Malaiapan, Y., & Papademetriou, V.
- Affiliations
- Royal Adelaide Hospital (AU)
- National and Kapodistrian University of Athens (GR)
- Flinders University (AU)
- Monash University (AU)
- Georgetown University (US)
- Corresponding author
- Worthley, Stephen G.
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-06-19
- Volume
- 34
- Issue
- 28
- Pages
- 2132-2140
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- PMC
- PMC3717311
- OpenAlex
- W2096346609
- Cited by
- 271
- References
- 25
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 9 · 2022: 5 · 2021: 5 · 2020: 12 · 2019: 14 · 2018: 16 · 2017: 18 · 2016: 31 · 2015: 46 · 2014: 93 · 2013: 14 · 2012: 1
- FWCI
- 41.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- European Heart Journal (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion, cc-by-nc)
- HighWire Press Open Archive (submittedVersion)
- Funders
- St. Jude Medical
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Renal and Vascular Pathologies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- renal denervation, resistant hypertension, multielectrode catheter, renal artery injury, glomerular filtration rate
- MeSH terms
- Adolescent, Adult, Aged, Antihypertensive Agents, Blood Pressure, Creatinine, Electrodes, Female, Glomerular Filtration Rate, Humans, Hypertension, Male, Middle Aged, Postoperative Complications, Prospective Studies, Renal Artery, Sympathectomy, Treatment Outcome, Catheter Ablation, Blood Pressure Monitoring, Ambulatory, Cystatin C, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
