Cited by 17Antimicrobial Peptides and ActivitiesWound Healing and TreatmentsDermatology and Skin Diseases

EGFR (Trans)activation Mediates IL-8 and Distinct Human Antimicrobial Peptide and Protein Production following Skin Injury

Open access
Büchau, Amanda S.·2010·Journal of Investigative Dermatology

Abstract

Antimicrobial peptides and proteins (AMPs) are tools of the innate immune system employed at injury sites to protect the host from invading microbes and to promote wound repair. In this issue, Roupé et al. characterize epidermal innate immune responses induced by skin injury and the involvement of EGFR for distinct AMPs and IL-8 induction.

Integrity signals

Registry

Crossref · 10.1038/jid.2009.371

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15 of 15 references verified0 citation errors · 0 not checkable

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  • AMP expression is highly dependent on the cytokine milieu present in the skin and proinflammatory cytokines such as IL-1, IL-6, IL-8, and TNFα are typically strong inducers of AMPs, whereas IL-4, IL-13, and IL-10 have been shown to dampen AMP responses.

    “AMP expression is highly dependent on the cytokine milieu present in the skin and proinflammatory cytokines, such as IL-1, IL-6, IL-8, and tumor necrosis factor α (TNFα), are typically strong inducers of AMPs, whereas IL-4, IL-13, and IL-10 have been shown to dampen AMP responses.33–35”

    From The Innate Immune System in Acute and Chronic Wounds (2016) · cites this paper as [33]

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Authors
Büchau, A. S.
Affiliations
Scripps Research Institute (US)
Corresponding author
Büchau, Amanda S.
Venue
Journal of Investigative Dermatology
Publisher
Elsevier BV
Published
2010-04
Volume
130
Issue
4
Pages
929-932
ISSN
0022-202X (ISSN-L)
OpenAlex
W1996563914
Cited by
17
References
15
Citations by year
2025: 3 · 2020: 1 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 3
FWCI
0.59
Type
journal article
Language
en
Open access
Locations
  • Journal of Investigative Dermatology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Arbeitsgemeinschaft Dermatologische Forschung
Topics
  • Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Keywords
EGFR, epidermal growth factor receptor, interleukin-8, antimicrobial peptides, antimicrobial proteins, skin damage, wound healing, innate immunity, epidermis, host defense
MeSH terms
Humans, Skin, Wound Healing, Interleukin-8, Antimicrobial Cationic Peptides, ErbB Receptors

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