EGFR (Trans)activation Mediates IL-8 and Distinct Human Antimicrobial Peptide and Protein Production following Skin Injury
Open accessAbstract
Antimicrobial peptides and proteins (AMPs) are tools of the innate immune system employed at injury sites to protect the host from invading microbes and to promote wound repair. In this issue, Roupé et al. characterize epidermal innate immune responses induced by skin injury and the involvement of EGFR for distinct AMPs and IL-8 induction.
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AMP expression is highly dependent on the cytokine milieu present in the skin and proinflammatory cytokines such as IL-1, IL-6, IL-8, and TNFα are typically strong inducers of AMPs, whereas IL-4, IL-13, and IL-10 have been shown to dampen AMP responses.
“AMP expression is highly dependent on the cytokine milieu present in the skin and proinflammatory cytokines, such as IL-1, IL-6, IL-8, and tumor necrosis factor α (TNFα), are typically strong inducers of AMPs, whereas IL-4, IL-13, and IL-10 have been shown to dampen AMP responses.33–35”
From The Innate Immune System in Acute and Chronic Wounds (2016) · cites this paper as [33]
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- Authors
- Büchau, A. S.
- Affiliations
- Scripps Research Institute (US)
- Corresponding author
- Büchau, Amanda S.
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 130
- Issue
- 4
- Pages
- 929-932
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W1996563914
- Cited by
- 17
- References
- 15
- Citations by year
- 2025: 3 · 2020: 1 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 3
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Arbeitsgemeinschaft Dermatologische Forschung
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- EGFR, epidermal growth factor receptor, interleukin-8, antimicrobial peptides, antimicrobial proteins, skin damage, wound healing, innate immunity, epidermis, host defense
- MeSH terms
- Humans, Skin, Wound Healing, Interleukin-8, Antimicrobial Cationic Peptides, ErbB Receptors
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