The DOI matches its Crossref record; 35 of the 36 references it cites were found in a registry or an index.
Reduced Il17a Expression Distinguishes a Ly6cloMHCIIhi Macrophage Population Promoting Wound Healing
Open accessAbstract
Macrophages are the main components of inflammation during skin wound healing. They are critical in wound closure and in excessive inflammation, resulting in defective healing observed in chronic wounds. Given the heterogeneity of macrophage phenotypes and functions, we here hypothesized that different subpopulations of macrophages would have different and sometimes opposing effects on wound healing. Using multimarker flow cytometry and RNA expression array analyses on macrophage subpopulations from wound granulation tissue, we identified a Ly6c(lo)MHCII(hi) "noninflammatory" subset that increased both in absolute number and proportion during normal wound healing and was missing in Ob/Ob and MYD88-/- models of delayed healing. We also identified IL17 as the main cytokine distinguishing this population from proinflammatory macrophages and demonstrated that inhibition of IL17 by blocking Ab or in IL17A-/- mice accelerated normal and delayed healing. These findings dissect the complexity of the role and activity of the macrophages during wound inflammation and may contribute to the development of therapeutic approaches to restore healing in chronic wounds.
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“We and others have observed a persistent proinflammatory wound Mp phenotype in diabetic humans and mice (14,29) and in chronic venous ulcers (30).”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [29]
In the citing paper
“Recent studies have shown that Mp phenotypes change over the different phases of tissue repair and that the sequential appearance of these phenotypes may be required for efficient repair (11,14,29,49,50).”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [29]
In the citing paper
“In fact, either premature changes in phenotype or delayed/impaired changes in phenotype have been associated with impaired healing (14,29,49).”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [29]
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Cites
Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,504
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.
Adachi, O., Kawai, T., Takeda, K., Matsumoto, M., Tsutsui, H., Sakagami, M., Nakanishi, K., & Akira, S. (1998) · Immunity · doi:10.1016/s1074-7613(00)80596-8 · Cited by 2,358
Nahrendorf, M., Swirski, F. K., Aikawa, E., Stangenberg, L., Wurdinger, T., Figueiredo, J.-L., Libby, P., Weissleder, R., & Pittet, M. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070885 · Cited by 2,300
The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum.
(1975) · PubMed Central · Cited by 1,437
Differential Roles of Macrophages in Diverse Phases of Skin Repair
Lucas, T., Waisman, A., Ranjan, R., Roes, J., Krieg, T., Müller, W., Roers, A., & Eming, S. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903356 · Cited by 1,205
Sindrilaru, A., Peters, T., Wieschalka, S., Baican, C., Baican, A., Peter, H., Hainzl, A., Schatz, S., Qi, Y., Schlecht, A., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44490 · Cited by 1,100
Nakae, S., Komiyama, Y., Nambu, A., Sudo, K., Iwase, M., Homma, I., Sekikawa, K., Asano, M., & Iwakura, Y. (2002) · Immunity · doi:10.1016/s1074-7613(02)00391-6 · Cited by 1,053
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In vivo study of MAIT cell tissue repair function
du Halgouet, A. (2022) · theses.fr (ABES) · doi:10.70675/5bd792fdz047cz4857zb7f4z9c5ba10f02a6
Napoli, M. (2025) · theses.fr (ABES) · doi:10.70675/eebbc628zaec1z474dzbfa2z4fed39691cff
Cutaneous endothelial cells and their roles in wound healing
Li, H., Sormani, L., Sim, S.-L., Shafiee, A., & Khosrotehrani, K. (2026) · JID Innovations · doi:10.1016/j.xjidi.2026.100539
Self-citationMesenchymal-epidermal interactions in hair follicle cycling and regeneration
Legrand, J. M. D. (2015) · The University of Queensland · doi:10.14264/uql.2015.660
Metadata
- Authors
- Rodero, M. P., Hodgson, S. S., Hollier, B., Combadiere, C., & Khosrotehrani, K.
- Affiliations
- The University of Queensland (AU)
- Queensland University of Technology (AU)
- Corresponding author
- Khosrotehrani, Kiarash
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 133
- Issue
- 3
- Pages
- 783-792
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W1540897100
- Cited by
- 104
- References
- 36
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 9 · 2023: 9 · 2022: 12 · 2021: 7 · 2020: 8 · 2019: 8 · 2018: 9 · 2017: 10 · 2016: 6 · 2015: 5 · 2014: 4 · 2013: 4
- FWCI
- 4.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Faculty of Health; Institute of Health and Biomedical Innovation
- Funders
- University of Queensland
- National Health and Medical Research Council (1023371)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Macrophage Migration Inhibitory Factor
- Keywords
- macrophage heterogeneity, wound healing, chronic wounds, IL-17A, IL-17, Ly6C, MHC class II, granulation tissue, delayed wound healing, ob/ob mice, MyD88 knockout mice, skin inflammation
- MeSH terms
- Animals, Antibodies, Histocompatibility Antigens Class II, Antigens, Ly, Bone Marrow Cells, Cell Differentiation, Female, Macrophages, Male, Mice, Inbred C57BL, Mice, Obese, Wound Healing, Mice, Knockout, Interleukin-17, Leptin, Models, Animal, Mice, Myeloid Differentiation Factor 88
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