Cited by 104Wound Healing and TreatmentsImmune cells in cancerMacrophage Migration Inhibitory Factor

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Reduced Il17a Expression Distinguishes a Ly6cloMHCIIhi Macrophage Population Promoting Wound Healing

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Rodero, Mathieu P., Hodgson, Samantha S., Hollier, Brett, Combadiere, Christophe, Khosrotehrani, Kiarash·2013·Journal of Investigative Dermatology

DOI 10.1038/jid.2012.368

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Abstract

Macrophages are the main components of inflammation during skin wound healing. They are critical in wound closure and in excessive inflammation, resulting in defective healing observed in chronic wounds. Given the heterogeneity of macrophage phenotypes and functions, we here hypothesized that different subpopulations of macrophages would have different and sometimes opposing effects on wound healing. Using multimarker flow cytometry and RNA expression array analyses on macrophage subpopulations from wound granulation tissue, we identified a Ly6c(lo)MHCII(hi) "noninflammatory" subset that increased both in absolute number and proportion during normal wound healing and was missing in Ob/Ob and MYD88-/- models of delayed healing. We also identified IL17 as the main cytokine distinguishing this population from proinflammatory macrophages and demonstrated that inhibition of IL17 by blocking Ab or in IL17A-/- mice accelerated normal and delayed healing. These findings dissect the complexity of the role and activity of the macrophages during wound inflammation and may contribute to the development of therapeutic approaches to restore healing in chronic wounds.

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Authors: Rodero, M. P., Hodgson, S. S., Hollier, B., Combadiere, C., & Khosrotehrani, K.
Affiliations: The University of Queensland (AU)
Queensland University of Technology (AU)
Corresponding author: Khosrotehrani, Kiarash
ORCID: Rodero, Mathieu P.
Hollier, Brett
Khosrotehrani, Kiarash
Venue: Journal of Investigative Dermatology
Publisher: Elsevier BV
Published: 2013-03
Volume: 133
Issue: 3
Pages: 783-792
ISSN: 0022-202X (ISSN-L)
DOI: 10.1038/jid.2012.368
OpenAlex: W1540897100
Cited by: 104
References: 36
Citations by year: 2026: 7 · 2025: 6 · 2024: 9 · 2023: 9 · 2022: 12 · 2021: 7 · 2020: 8 · 2019: 8 · 2018: 9 · 2017: 10 · 2016: 6 · 2015: 5 · 2014: 4 · 2013: 4
FWCI: 4.40
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1006 d)
Locations: Journal of Investigative Dermatology (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Faculty of Health; Institute of Health and Biomedical Innovation
Funders: University of Queensland
National Health and Medical Research Council (1023371)
Topics: Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › Macrophage Migration Inhibitory Factor
Keywords: macrophage heterogeneity, wound healing, chronic wounds, IL-17A, IL-17, Ly6C, MHC class II, granulation tissue, delayed wound healing, ob/ob mice, MyD88 knockout mice, skin inflammation
MeSH terms: Animals, Antibodies, Histocompatibility Antigens Class II, Antigens, Ly, Bone Marrow Cells, Cell Differentiation, Female, Macrophages, Male, Mice, Inbred C57BL, Mice, Obese, Wound Healing, Mice, Knockout, Interleukin-17, Leptin, Models, Animal, Mice, Myeloid Differentiation Factor 88

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Reduced Il17a Expression Distinguishes a Ly6cloMHCIIhi Macrophage Population Promoting Wound Healing

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