The harmonizing outcome measures for eczema (HOME) roadmap: a methodological framework to develop core sets of outcome measurements in dermatology
Open accessAbstract
Core outcome sets (COSs) are consensus-derived minimum sets of outcomes to be assessed in a specific situation. COSs are being increasingly developed to limit outcome-reporting bias, allow comparisons across trials, and strengthen clinical decision making. Despite the increasing interest in outcomes research, methods to develop COSs have not yet been standardized. The aim of this paper is to present the Harmonizing Outcomes Measures for Eczema (HOME) roadmap for the development and implementation of COSs, which was developed on the basis of our experience in the standardization of outcome measurements for atopic eczema. Following the establishment of a panel representing all relevant stakeholders and a research team experienced in outcomes research, the scope and setting of the core set should be defined. The next steps are the definition of a core set of outcome domains such as symptoms or quality of life, followed by the identification or development and validation of appropriate outcome measurement instruments to measure these core domains. Finally, the consented COS needs to be disseminated, implemented, and reviewed. We believe that the HOME roadmap is a useful methodological framework to develop COSs in dermatology, with the ultimate goal of better decision making and promoting patient-centered health care.
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Self-citation
- Authors
- Schmitt, J., Apfelbacher, C., Spuls, P. I., Thomas, K. S., Simpson, E. L., Furue, M., Chalmers, J., & Williams, H. C.
- Affiliations
- University Hospital Carl Gustav Carus (DE)
- University of Regensburg (DE)
- Amsterdam UMC Location University of Amsterdam (NL)
- University of Nottingham (GB)
- Oregon Health & Science University (US)
- Kyushu University (JP)
- Corresponding author
- Schmitt, Jochen
- ORCID
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 135
- Issue
- 1
- Pages
- 24-30
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W2037799574
- Cited by
- 230
- References
- 29
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 9 · 2023: 18 · 2022: 21 · 2021: 21 · 2020: 30 · 2019: 18 · 2018: 21 · 2017: 28 · 2016: 27 · 2015: 17 · 2014: 3
- FWCI
- 81.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by)
- Repository@Nottingham (University of Nottingham) (submittedVersion)
- Funders
- National Institutes of Health (5K23AR057486)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- National Institute for Health Research (RP-PG-0407-10177)
- Topics
- Social Sciences › Sociology and Political Science › Delphi Technique in Research
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Keywords
- core outcome set, atopic dermatitis, outcome standardization, selective reporting, stakeholder consensus, outcome domains, quality of life, symptom assessment, patient-centered care
- MeSH terms
- Dermatology, Diffusion of Innovation, Eczema, Humans, Reproducibility of Results, Outcome Assessment, Health Care, Consensus
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