Cited by 233Hair Growth and DisordersTelomeres, Telomerase, and SenescenceSperm and Testicular Function

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Oxidative stress-associated senescence in dermal papilla cells of men with androgenetic alopecia

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Upton, James H., Hannen, Rosalind F., Bahta, Adiam W., Farjo, Nilofer, Farjo, Bessam, Philpott, Michael P.·2015·Journal of Investigative Dermatology

DOI 10.1038/jid.2015.28

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Abstract

Dermal papilla cells (DPCs) taken from male androgenetic alopecia (AGA) patients undergo premature senescence in vitro in association with the expression of p16(INK4a), suggesting that DPCs from balding scalp are more sensitive to environmental stress than nonbalding cells. As one of the major triggers of senescence in vitro stems from the cell "culture shock" owing to oxidative stress, we have further investigated the effects of oxidative stress on balding and occipital scalp DPCs. Patient-matched DPCs from balding and occipital scalp were cultured at atmospheric (21%) or physiologically normal (2%) O2. At 21% O2, DPCs showed flattened morphology and a significant reduction in mobility, population doubling, increased levels of reactive oxygen species and senescence-associated β-Gal activity, and increased expression of p16(INK4a) and pRB. Balding DPCs secreted higher levels of the negative hair growth regulators transforming growth factor beta 1 and 2 in response to H2O2 but not cell culture-associated oxidative stress. Balding DPCs had higher levels of catalase and total glutathione but appear to be less able to handle oxidative stress compared with occipital DPCs. These in vitro findings suggest that there may be a role for oxidative stress in the pathogenesis of AGA both in relation to cell senescence and migration but also secretion of known hair follicle inhibitory factors.

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Authors: Upton, J. H., Hannen, R. F., Bahta, A. W., Farjo, N., Farjo, B., & Philpott, M. P.
Affiliations: Queen Mary University of London (GB)
Corresponding author: Philpott, Michael P.
ORCID: Hannen, Rosalind F.
Farjo, Nilofer
Farjo, Bessam
Philpott, Michael P.
Venue: Journal of Investigative Dermatology
Publisher: Elsevier BV
Published: 2015-05
Volume: 135
Issue: 5
Pages: 1244-1252
ISSN: 0022-202X (ISSN-L)
DOI: 10.1038/jid.2015.28
OpenAlex: W1979998542
Cited by: 233
References: 56
Citations by year: 2026: 33 · 2025: 38 · 2024: 30 · 2023: 27 · 2022: 19 · 2021: 28 · 2020: 24 · 2019: 9 · 2018: 7 · 2017: 8 · 2016: 9
FWCI: 10.31
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: public-domain
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 366 d)
Locations: Journal of Investigative Dermatology (publishedVersion, public-domain)
PubMed (publishedVersion)
Funders: Biotechnology and Biological Sciences Research Council
Topics: Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords: androgenetic alopecia, dermal papilla cells, premature senescence, oxidative stress, p16INK4a, reactive oxygen species, hydrogen peroxide, TGF-β1, TGF-beta2, catalase, glutathione, hair follicle, cell migration
MeSH terms: Adult, Alopecia, Biopsy, Needle, Catalase, Cell Movement, Cells, Cultured, Glutathione, Humans, Male, Middle Aged, Oxygen, Scalp, Case-Control Studies, Cellular Senescence, Reactive Oxygen Species, Oxidative Stress, Cyclin-Dependent Kinase Inhibitor p16, Dermis, In Vitro Techniques

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Oxidative stress-associated senescence in dermal papilla cells of men with androgenetic alopecia

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