Skin under the (Spot)-Light: Cross-Talk with the Central Hypothalamic-Pituitary-Adrenal (HPA) Axis
Open accessAbstract
UV radiation is among the most prevalent stressors in humans and diurnal rodents, exerting direct and indirect DNA damage, free-radical production, and interaction with specific chromophores that affects numerous biological processes. In addition to its panoply of effects, UVB (290-320 nm) radiation can specifically affect various local neuroendocrine activities by stimulating the expression of corticotropin-releasing hormone (CRH), urocortin, proopiomelanocortin (POMC), and POMC-derived peptides. Although very little is known about the interplay between the central hypothalamic-pituitary-adrenal (HPA) axis and the skin HPA axis analog, in the current issue Skobowiat and Slominski propose a novel mechanism by which exposure to UVB activates a local HPA axis in skin, which in turn activates the central HPA axis, with the requirement of a functional pituitary gland. This is the first evidence of the local HPA axis in skin contributing to the central neuroendocrine response. This raises intriguing possibilities regarding how local production of cortisol and other HPA axis molecules in skin influence overall systemic levels of cortisol and help regulate local and central HPA axes in the context of homeostasis, skin injury, and inflammatory skin disorders.
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There is dynamic cross-talk between the skin and the central HPA axis.
“Jozic et al. highlight the dynamic cross-talk between the skin and the central HPA axis [69].”
From Chronic Stress and Autoimmunity: The Role of HPA Axis and Cortisol Dysregulation (2025) · cites this paper as [69]
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Cites
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Chronic Stress and Autoimmunity: The Role of HPA Axis and Cortisol Dysregulation
Nunez, S. G., Rabelo, S. P., Subotic, N., Caruso, J. W., & Knezevic, N. N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26209994 · Cited by 138 · see citing works
“Jozic et al. highlight the dynamic cross-talk between the skin and the central HPA axis [69].”
Lim, H.-S., Lee, S. H., Seo, H., Lee, H.-H., Yoon, K., Kim, Y.-U., Park, M.-K., Chung, J. H., Lee, Y.-S., Lee, D. H., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113716 · Cited by 10 · see citing works
- Authors
- Jozic, I., Stojadinovic, O., Kirsner, R. S. F., & Tomic-Canic, M.
- Affiliations
- University of Miami (US)
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 135
- Issue
- 6
- Pages
- 1469-1471
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W2115752042
- Cited by
- 38
- References
- 16
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 5 · 2023: 1 · 2022: 2 · 2021: 6 · 2020: 4 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 1
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- NSUWorks (Nova Southeastern University) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- UV-B radiation, hypothalamic-pituitary-adrenal axis, skin, corticotropin-releasing factor, urocortin, proopiomelanocortin, cortisol, neuroendocrine response, stress, skin damage, inflammatory skin diseases, homeostasis
- MeSH terms
- Animals, Female, Gene Expression Regulation, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Skin, Ultraviolet Rays
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