UVB activates hypothalamic-pituitary-adrenal axis in C57BL/6 mice
Open accessAbstract
To test the hypothesis that UVB can activate the hypothalamic-pituitary-adrenal (HPA) axis, the shaved back skin of C57BL/6 mice was exposed to 400 mJ cm(-2) of UVB or was sham irradiated. After 12 and 24 hours of exposure, plasma, skin, brain, and adrenals were collected and processed to measure corticotropin-releasing hormone (CRH), urocortin (Ucn), β-endorphin (β-END), ACTH, and corticosterone (CORT) or the brain was fixed for immunohistochemical detection of CRH. UVB stimulated plasma levels of CRH, Ucn, β-END, ACTH, and CORT and increased skin expression of Ucn, β-END, and CORT at the gene and protein/peptide levels. UVB stimulated CRH gene and protein expression in the brain that was localized to the paraventricular nucleus of the hypothalamus. In adrenal glands, it increased mRNAs of melanocortin receptor type 2, steroidogenic acute regulatory protein (StAR), and gene coding of steroid 11β-hydroxylase (CYP11B1). Hypophysectomy abolished UVB stimulation of plasma, but not of skin CORT levels, and had no effect on UVB stimulation of CRH and Ucn levels in the plasma, demonstrating the requirement of an intact pituitary for the systemic effect. In conclusion, we identify mechanisms regulating body homeostasis by UVB through activation of the HPA axis that originate in the skin and require the pituitary for systemic effects.
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UVB upregulates expression of all elements of the HPA axis in mouse skin in vivo.
“Mechanistic studies of mouse skin in vivo demonstrate that UVB can upregulate the expression of all the elements of the HPA axis, including corticotrophin-releasing hormone, proopiomelanocortin, β-endorphin, melanocortin receptor 2, steroidogenic enzymes, and glucocorticoid (corticosterone) [85].”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [85]
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Cites
Selye, H. (1956) · Medical Entomology and Zoology · Cited by 5,224 · see citing works
Physiology and neurobiology of stress and adaptation: central role of the brain
McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 4,981 · cited 1× · see citing works
“…above), UVB stimulates cytokine production (IL1, IL6 and TNFα) and release into circulation (Kirnbauer et al., 1991; Muthusamy and Piva, 2010; Schwarz and Luger, 1989), all of which can activate the pituitary POMC (Chrousos, 2009; McEwen, 2007; Slominski et al., 2000c; Turnbull and Rivier, 1999).”
BackgroundVale, W., Spiess, J., Rivier, C., & Rivier, J. (1981) · Science · doi:10.1126/science.6267699 · Cited by 3,965 · see citing works
Vale, W., Spiess, J., RIVIER, C. L., & Rivier, J. (1982) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198205000-00013 · Cited by 3,904 · see citing works
Stress and disorders of the stress system
Chrousos, G. P. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.106 · Cited by 3,215 · see citing works
International Organization for Standardization (ISO)
Turner, B. (2003) · doi:10.1057/9780230271326_102 · Cited by 2,957 · see citing works
The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders
Miller, W. L., & Auchus, R. J. (2011) · Endocrine Reviews · doi:10.1210/er.2010-0013 · Cited by 2,458 · cited 2× · see citing works
“GC (i.e., cortisol (COR) in humans and corticosterone (CORT) in rodents) maintain metabolic and stress-responses, suppress immune activity and are self-regulated, with negative feedback to the hypothalamus and pituitary to mute the HPA axis (Chrousos, 2009; Miller and Auchus, 2011).”
BackgroundThe role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress
Smith, S. M., & Vale, W. W. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.4/ssmith · Cited by 1,948 · see citing works
Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk
Cohen, S., Janicki-Deverts, D., Doyle, W. J., Miller, G. E., Frank, E., Rabin, B. S., & Turner, R. B. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118355109 · Cited by 1,419 · see citing works
Vitamin D: a millenium perspective
Holick, M. F. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10338 · Cited by 1,319 · see citing works
Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action
TURNBULL, A. V., & RIVIER, C. L. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.1 · Cited by 1,297 · see citing works
Slominski, A., Wortsman, J., Luger, T., Paus, R., & Solomon, S. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.3.979 · Cited by 776 · see citing works
Self-citationNeuroendocrinology of the Skin1
Slominski, A., & Wortsman, J. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.5.0410 · Cited by 727 · see citing works
Self-citationSlominski, A. T., Zmijewski, M. A., Skobowiat, C., Zbytek, B., Slominski, R. M., & Steketee, J. D. (2012) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-642-19683-6 · Cited by 502 · see citing works
Self-citationIto, N., Ito, T., Kromminga, A., Bettermann, A., Takigawa, M., Kees, F., Straub, R. H., & Paus, R. (2005) · The FASEB Journal · doi:10.1096/fj.04-1968fje · Cited by 498 · see citing works
Slominski (2012) · doi:10.1007/978-3-642-19683-6_1 · Cited by 461 · see citing works
Fritsche, E., Schäfer, C., Calles, C., Bernsmann, T., Bernshausen, T., Wurm, M., Hübenthal, U., Cline, J. E., Hajimiragha, H., Schroeder, P., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701764104 · Cited by 437 · see citing works
Key role of CRF in the skin stress response system
Slominski, A. T., Zmijewski, M. A., Zbytek, B., Tobin, D. J., Theoharides, T. C., & Rivier, J. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1092 · Cited by 400 · see citing works
Self-citationSteroidogenesis in the skin: Implications for local immune functions
Slominski, A., Zbytek, B., Nikolakis, G., Manna, P. R., Skobowiat, C., Zmijewski, M., Li, W., Janjetovic, Z., Postlethwaite, A., Zouboulis, C. C., et al. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.02.006 · Cited by 369 · see citing works
Self-citationProopiomelanocortin-derived peptides are synthesized and released by human keratinocytes.
Schauer, E., Trautinger, F., Köck, A., Schwarz, A., Bhardwaj, R. S., Simon, M. M., Ansel, J. C., Schwarz, T., & Luger, T. A. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117224 · Cited by 347 · see citing works
Neuroimmunoendocrine circuitry of the ‘brain-skin connection’
Paus, R., Theoharides, T. C., & Arck, P. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.10.002 · Cited by 346 · see citing works
Cutaneous expression of corticotropin-releasing hormone (CRH), urocortin, and CRH receptors
SLOMINSKI, A., WORTSMAN, J., PISARCHIK, A., ZBYTEK, B., LINTON, E. A., MAZURKIEWICZ, J. E., & WEI, E. T. (2001) · The FASEB Journal · doi:10.1096/fj.00-0850rev · Cited by 305 · cited 4× · see citing works
“Since the CRH gene is not expressed in C57BL/6 skin (Slominski et al., 2001; Slominski et al., 2013b), and can be replaced by Ucn in activating HPA axis elements (Slominski et al.”
BackgroundResultInfluentialSelf-citationSkin β-Endorphin Mediates Addiction to UV Light
Fell, G. L., Robinson, K. C., Mao, J., Woolf, C. J., & Fisher, D. E. (2014) · Cell · doi:10.1016/j.cell.2014.04.032 · Cited by 299 · see citing works
Slominski, A. T., & Paus, R. (1993) · Journal of Investigative Dermatology · doi:10.1016/0022-202x(93)90507-e · Cited by 290 · see citing works
Self-citationDifferential expression of HPA axis homolog in the skin
Slominski, A., Wortsman, J., Tuckey, R. C., & Paus, R. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.12.012 · Cited by 279 · see citing works
Self-citationCutaneous hypothalamic–pituitary–adrenal axis homolog: regulation by ultraviolet radiation
Skobowiat, C., Dowdy, J. C., Sayre, R. M., Tuckey, R. C., & Slominski, A. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00217.2011 · Cited by 269 · see citing works
Self-citationThe UV response of the skin: a review of the MAPK, NFκB and TNFα signal transduction pathways
Muthusamy, V., & Piva, T. J. (2010) · Archives of Dermatological Research · doi:10.1007/s00403-009-0994-y · Cited by 265 · see citing works
Ultraviolet radiation and immunology: something new under the sun--presidential address.
Kripke, M. L. (1994) · PubMed · Cited by 262 · see citing works
Beneficial effects of UV radiation other than via vitamin D production
Juzeniene, A., & Moan, J. E. (2012) · Dermato-Endocrinology · doi:10.4161/derm.20013 · Cited by 226 · see citing works
CRH stimulation of corticosteroids production in melanocytes is mediated by ACTH
Slominski, A., Zbytek, B., Szczesniewski, A., Semak, I., Kaminski, J., Sweatman, T., & Wortsman, J. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00519.2004 · Cited by 211 · see citing works
Self-citationBecklund, B. R., Severson, K. S., Vang, S. V., & DeLuca, H. F. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001119107 · Cited by 199 · see citing works
Wavelength specific patterns of p53 induction in human skin following exposure to UV radiation.
Campbell, C., Quinn, A., Angus, B., Farr, P. M., & Rees, J. L. (1993) · PubMed · Cited by 196 · see citing works
Cortisol synthesis in epidermis is induced by IL-1 and tissue injury
Vukelic, S., Stojadinovic, O., Pastar, I., Rabach, M., Krzyzanowska, A., Lebrun, E., Davis, S. C., Resnik, S., Brem, H., & Tomic-Canic, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.188268 · Cited by 193 · cited 2× · see citing works
“, 2000c), which, after interaction with MC2R, induces steroidogenesis with the final production of highly adaptable COR or CORT (Cirillo and Prime, 2011; Ito et al., 2005; Skobowiat et al., 2011; Slominski et al., 2000a; Slominski et al., 2013a; Slominski et al., 2005a; Slominski et al., 2005b; Slominski et al., 2006a…”
BackgroundRegulation of Epidermal Cell Interleukin-6 production by UV Light and Corticosteroids
Kirnbauer, R., Köck, A., Neuner, P., Förster‐Waldl, E., Krutmann, J., Urbanski, A., Schauer, E., Ansel, J. C., Schwarz, T., & Luger, T. A. (1991) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12470181 · Cited by 183 · see citing works
Differential Expression of a Cutaneous Corticotropin-Releasing Hormone System
Slominski, A. T., Pisarchik, A. V., Tobin, D. J., Mazurkiewicz, J. E., & Wortsman, J. (2003) · Endocrinology · doi:10.1210/en.2003-0851 · Cited by 180 · see citing works
Self-citationSchwarz, T., & Luger, T. A. (1989) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/1011-1344(89)80097-1 · Cited by 170 · see citing works
Corticotropin releasing hormone and the skin
Slominski, A. (2006) · Frontiers in bioscience · doi:10.2741/1966 · Cited by 157 · see citing works
Self-citationPepe, I. M., & Cugnoli, C. (1993) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/1011-1344(93)85018-4 · Cited by 153 · see citing works
Vink, A., Moodycliffe, A., Shreedhar, V., Ullrich, S. E., Roza, L., Yarosh, D. B., & Kripke, M. (1997) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.94.10.5255 · Cited by 152 · see citing works
Cutaneous Expression of CRH and CRH‐R: Is There a “Skin Stress Response System?”
SLOMINSKI, A. T., BOTCHKAREV, V., CHOUDHRY, M., FAZAL, N., FECHNER, K., FURKERT, J., KRAUSE, E., ROLOFF, B., SAYEED, M., WEI, E., et al. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb08686.x · Cited by 147 · see citing works
Self-citationSun Exposure: What Molecular Photodermatology Tells Us About Its Good and Bad Sides
Krutmann, J., Morita, A., & Chung, J. H. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.394 · Cited by 144 · see citing works
CRH stimulates POMC activity and corticosterone production in dermal fibroblasts
Slominski, A., Zbytek, B., Semak, I., Sweatman, T., & Wortsman, J. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.01.014 · Cited by 143 · see citing works
Tanning as a Behavioral Addiction
Kourosh, A. S., Harrington, C. R., & Adinoff, B. H. (2010) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952990.2010.491883 · Cited by 140 · see citing works
Animals under the sun: effects of ultraviolet radiation on mammalian skin
Slominski, A. T., & Pawelek, J. M. (1998) · Clinics in Dermatology · doi:10.1016/s0738-081x(98)00023-6 · Cited by 139 · see citing works
Self-citationSlominski, A. T., & Paus, R. (1993) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12362991 · Cited by 122 · see citing works
Self-citationProopiomelanocortin expression in the skin during induced hair growth in mice
Slominski, A. T., Paus, R., & Mazurkiewicz, J. E. (1992) · Cellular and Molecular Life Sciences · doi:10.1007/bf01923606 · Cited by 119 · see citing works
Self-citationKeratinocytes synthesize and activate cortisol
Cirillo, N., & Prime, S. S. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23081 · Cited by 118 · see citing works
Skobowiat, C., Sayre, R. M., Dowdy, J. C., & Slominski, A. T. (2013) · British Journal of Dermatology · doi:10.1111/bjd.12096 · Cited by 115 · see citing works
Self-citationMolecular Cascades in UV Induced Melanogenesis: A Central Role for Melanotropins?
Pawelek, J. M., Chakraborty, A. K., Osber, M. P., Orlow, S. J., MIN, K. K., ROSENZWEIG, K. E., & Bolognia, J. L. (1992) · Pigment Cell Research · doi:10.1111/j.1600-0749.1992.tb00561.x · Cited by 109 · see citing works
The role of corticotropin‐releasing hormone in immune‐mediated cutaneous inflammatory disease
Kane, M. O., Murphy, E. P., & Kirby, B. (2006) · Experimental Dermatology · doi:10.1111/j.1600-0625.2006.00382.x · Cited by 93 · see citing works
Slominski, A. T. (1996) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(95)00159-x · Cited by 93 · see citing works
Self-citationRoloff, B., Fechner, K., Slominski, A. T., Furkert, J., Botchkarev, V. A., Bulfone‐Paus, S., Zipper, J., Krause, E., & Paus, R. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.3.287 · Cited by 91 · see citing works
Self-citationChakraborty, A. K., Funasaka, Y., Slominski, A. T., Bolognia, J. L., Sodi, S., Ichihashi, M., & Pawelek, J. M. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb08668.x · Cited by 88 · see citing works
Self-citationSlominski, A. T., Roloff, B., Curry, J. L., Dahiya, M., Szczesniewski, A., & Wortsman, J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.2.6381 · Cited by 81 · see citing works
Self-citationRougier, A., Schiller, M., Brzoska, T., Böhm, M., Metze, D., Scholzen, T. E., & Luger, T. A. (2004) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2004.22239.x · Cited by 80 · see citing works
Cutaneous glucocorticosteroidogenesis: securing local homeostasis and the skin integrity
Slominski, A. T., Manna, P. R., & Tuckey, R. C. (2014) · Experimental Dermatology · doi:10.1111/exd.12376 · Cited by 79 · see citing works
Ultraviolet B stimulates production of corticotropin releasing factor (CRF) by human melanocytes
Slominski, A., Baker, J., Ermak, G., Chakraborty, A., & Pawelek, J. (1996) · FEBS Letters · doi:10.1016/s0014-5793(96)01315-4 · Cited by 78 · see citing works
Self-citationSkin, Reactive Oxygen Species, and Circadian Clocks
Ndiaye, M. A., Nihal, M., Wood, G. S., & Ahmad, N. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5645 · Cited by 71 · see citing works
Tanning as an addictive behavior: a literature review
Nolan, B. V., Taylor, S. L., Liguori, A., & Feldman, S. R. (2009) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/j.1600-0781.2009.00392.x · Cited by 69 · see citing works
Cultured human dermal fibroblasts do produce cortisol
Slominski, A., Zbytek, B., Szczesniewski, A., & Wortsman, J. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700204 · Cited by 66 · see citing works
Self-citationSchwarz, A., Navid, F., Sparwasser, T. D., Clausen, B. E., & Schwarz, T. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.06.005 · Cited by 66 · see citing works
Active steroidogenesis in the normal rat skin
Slominski, A. T. (2000) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(99)00215-9 · Cited by 63 · see citing works
Self-citationZbytek, B., Wortsman, J., & Slominski, A. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0116 · Cited by 60 · see citing works
Self-citationSchwarz, A., Navid, F., Sparwasser, T. D., Clausen, B. E., & Schwarz, T. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.238 · Cited by 55 · see citing works
Hair cycle-dependent production of ACTH in mouse skin
Slominski, A. T., Botchkareva, N. V., Botchkarev, V. A., Chakraborty, A. K., Luger, T. A., Uenalan, M., & Paus, R. (1998) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(98)00124-4 · Cited by 48 · see citing works
Self-citationGenetic variation of the cutaneous HPA axis: an analysis of UVB-induced differential responses
Skobowiat, C., Nejati, R., Lu, L., Williams, R. W., & Slominski, A. T. (2013) · Gene · doi:10.1016/j.gene.2013.08.035 · Cited by 42 · see citing works
Self-citationHiramoto, K., Yanagihara, N., Sato, E. F., & Inoue, M. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12004.x · Cited by 37 · see citing works
Hiramoto, K., Yamate, Y., Sugiyama, D., et al. (2014) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/phpp.12131 · Cited by 29 · see citing works
Hiramoto, K., Yamate, Y., Kobayashi, H., et al. (2012) · Clinical and Experimental Dermatology · doi:10.1111/j.1365-2230.2012.04439.x · Cited by 10 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Schwarz T Luger TA Effect of UV irradiation on epidermal cell cytokine production J Photochem Photobiol B 1989 4 1 13 2509656
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- Authors
- Skobowiat, C., & Slominski, A. T.
- Affiliations
- University of Tennessee Health Science Center (US)
- Corresponding author
- Slominski, Andrzej T.
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 135
- Issue
- 6
- Pages
- 1638-1648
- ISSN
- 0022-202X (ISSN-L)
- PMC
- PMC4398592
- OpenAlex
- W2023438823
- Cited by
- 126
- References
- 69
- Citations by year
- 2026: 3 · 2025: 15 · 2024: 9 · 2023: 7 · 2022: 8 · 2021: 18 · 2020: 9 · 2019: 8 · 2018: 8 · 2017: 13 · 2016: 21 · 2015: 7
- FWCI
- 6.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation (IOS-0918934)
- National Institutes of Health (1R01AR056666-01A2, R01AR052190)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- UV-B radiation, hypothalamic-pituitary-adrenal axis, corticotropin-releasing factor, urocortin, beta-endorphin, ACTH, corticosterone, paraventricular nucleus, skin, adrenal gland, steroidogenic acute regulatory protein, CYP11B1, hypophysectomy, C57BL/6 mice
- MeSH terms
- Adrenal Glands, Adrenocorticotropic Hormone, Animals, beta-Endorphin, Brain, Corticosterone, Corticotropin-Releasing Hormone, Female, Gene Expression Regulation, Hypothalamo-Hypophyseal System, Mice, Inbred C57BL, Pituitary Gland, Pituitary-Adrenal System, RNA, Messenger, Skin, Steroid 11-beta-Hydroxylase, Ultraviolet Rays, Mice, Urocortins
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