Short- and long-term effects of UV radiation on the pigmentation of human skin
Open accessAbstract
The incidence of skin cancer, including cutaneous melanoma, has risen substantially in recent years, and epidemiological and laboratory studies show that UV radiation is a major causative factor of this increase. UV damage also underlies photoaging of the skin, and these deleterious effects of UV can be, in part, prevented in skin with higher levels of constitutive pigmentation. We review the clinical studies we have made in recent years regarding the rapid and the long-term responses of the pigmentary system in human skin to UV exposure.Journal of Investigative Dermatology Symposium Proceedings (2009) 14, 32-35; doi:10.1038/jidsymp.2009.10.
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Cumulative lifetime UVR exposure is the primary risk factor for squamous cell carcinoma, particularly in outdoor workers.
“whereas cumulative lifetime UVR exposure is the primary risk factor for squamous cell carcinoma, particularly in outdoor workers (Coelho et al, 2009;)”
From Effect of Repeated Low-Dose UVR Exposure on Skin Inflammation Threshold, Skin Biomarkers, and Vitamin D in Healthy Adults (2025) · cites this paper as Coelho et al, 2009
The Introduction (page not provided) identifies UV exposure as a major causative factor in melanoma and links increased UV exposure to rising skin-cancer incidence. It does not establish cumulative lifetime exposure as the primary risk factor for squamous cell carcinoma or address outdoor workers. (LLM, conf=0.82)
Experimental — accuracy not yet measuredThe effect of UVR on epidermal thickness described in the literature is inconsistent.
“The effect of UVR on epidermal thickness described in the literature is inconsistent (Coelho et al, 2009;Felton et al, 2020;Scott et al, 2012).”
From Effect of Repeated Low-Dose UVR Exposure on Skin Inflammation Threshold, Skin Biomarkers, and Vitamin D in Healthy Adults (2025) · cites this paper as Coelho et al, 2009
The Results and Discussion passages describe variation in UV-induced pigmentation and changes in melanocyte density, not epidermal thickness. Searches for “epidermal thickness” and UV-related epidermal thickening found no passage assessing whether the literature reports inconsistent effects on thickness. (LLM, conf=0.72)
Experimental — accuracy not yet measured
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- Authors
- Coelho, S. G., Choi, W., Brenner, M., Miyamura, Y., Yamaguchi, Y., Wolber, R., Smuda, C., Batzer, J., Kolbe, L., Ito, S., Wakamatsu, K., Zmudzka, B. Z., Beer, J. Z., Miller, S. A., & Hearing, V. J.
- Affiliations
- National Institutes of Health (US)
- Beiersdorf (Germany) (DE)
- Fujita Health University (JP)
- United States Food and Drug Administration (US)
- Corresponding author
- Hearing, Vincent J.
- ORCID
- Venue
- Journal of Investigative Dermatology Symposium Proceedings
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 14
- Issue
- 1
- Pages
- 32-35
- ISSN
- 1087-0024 (ISSN-L)
- PMC
- PMC2799903
- OpenAlex
- W2040227971
- Cited by
- 74
- References
- 30
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 8 · 2023: 5 · 2022: 5 · 2021: 11 · 2020: 7 · 2019: 4 · 2018: 6 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 5 · 2012: 2
- FWCI
- 12.95
- Type
- conference paper
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology Symposium Proceedings (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (ZIABC010784)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- ultraviolet radiation, skin pigmentation, melanin, photoaging, skin cancer, cutaneous melanoma, UV-induced skin damage
- MeSH terms
- Cell Count, Dose-Response Relationship, Radiation, Humans, Immunohistochemistry, Melanins, Melanocytes, Skin, Skin Pigmentation, Time Factors, Ultraviolet Rays
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