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Cited by 193Dialysis and Renal Disease ManagementChronic Kidney Disease and DiabetesRenal Diseases and Glomerulopathies

Albumin homeostasis in patients undergoing continuous ambulatory peritoneal dialysis

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Kaysen, George A., Schoenfeld, Patricia Y.·1984·Kidney International
DOI 10.1038/ki.1984.15
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Abstract

Albumin and protein removal rates were studied in 18 patients undergoing continuous ambulatory peritoneal dialysis (CAPD). In nine patients simultaneous studies of albumin distribution and turnover were performed. Total albumin loss was 4.23 +/- 1.42 g/1.73 m2/24 hr; total protein removed was 8.79 +/- 4.21 g/1.73 m2/24 hr. Although these values were well within the range for severe nephrosis, serum albumin concentration remained nearly normal, 3.7 +/- 0.5 g/dl. Plasma albumin mass, 120.0 +/- 25.2 g/1.73 m2, and total albumin mass, 249 +/- 29.1 g/1.73 m2, did not differ from those of the control group. Compared with the control group, patients had reduced albumin catabolism, 9.76 +/- 1.74 g/1.73 m2/24 hr versus 13.8 +/- 0.77 g/1.73 m2/24 hr (P less than 0.001). Within the patient group albumin synthesis increased with increased albumin loss. Serum albumin concentration correlated negatively with albumin losses (P less than 0.001). The CAPD patients maintained albumin homeostasis through decreased albumin catabolism and increased synthesis. All major albumin pools were maintained despite massive albumin loss.

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Crossref · 10.1038/ki.1984.15

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  • In most disease states in which synthesis rates have been measured, fractional synthesis rate in plasma is normal or mildly increased.

    “However, in most disease states in which synthesis rates have been measured, fractional synthesis rate (FSR) in plasma has been reported to be normal or mildly increased (Table 1).63, 64, 65, 66, 67, 68, 69, 70, 71”

    From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [64]

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Authors
Kaysen, G. A., & Schoenfeld, P. Y.
Affiliations
San Francisco General Hospital (US)
Venue
Kidney International
Publisher
Elsevier BV
Published
1984-01
Volume
25
Issue
1
Pages
107-114
ISSN
0085-2538 (ISSN-L)
DOI
10.1038/ki.1984.15
OpenAlex
W2013261295
Cited by
193
References
33
Citations by year
2023: 2 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 1 · 2012: 10
FWCI
3.89
Type
journal article
Language
en
Open access
Licence
Locations
  • Kidney International (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
  • Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
Keywords
continuous ambulatory peritoneal dialysis, albumin catabolism, albumin synthesis, deproteinization, albumin loss, end-stage renal disease
MeSH terms
Adult, Aged, Albumins, Female, Homeostasis, Humans, Kidney Failure, Chronic, Male, Middle Aged, Peritoneal Dialysis, Peritoneal Dialysis, Continuous Ambulatory, Serum Albumin

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