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Microcytic anemia secondary to intraperitoneal aluminum in normal and uremic rats
Open accessAbstract
Dialysis patients exposed to high aluminum (Al) dialysate develop a microcytic anemia which is reversed by deionization (DI) of the dialysate. Because DI removes substances in addition to Al which are known to cause anemia, these experiments were undertaken to determine if Al causes anemia and if the anemia of uremia can be enhanced by Al. Four groups of rats were studied: sham control (A) N = 6; uremic control (B) N = 6; Al-loaded non-uremic (C) N = 7; and Al-loaded uremic (D) N = 5. Aluminum treatment was 1 mg Al intraperitoneally daily for 6 weeks. Uremic rats (B+D) were 1 5/6 nephrectomized; non-uremic (A+C) were sham-operated. Blood samples (200 microliter) were obtained prior to (C1) and weekly during treatment (T1 to T6) and analyzed by Coulter Counter. No significant difference in hemoglobin (Hb), hematocrit (Hct), or mean cell volume (MCV) was noted at C1 X At T3, MCV of Al-treated rats (C+D) was significantly less than sham control (A) (55.1 +/- 0.5 and 53.0 +/- 0.8 vs. 60.8 +/- 1.5 mu3, P less than 0.05). At T6, MCV, Hb, and Hct of Al-loaded uremic rats (D) (49 +/- 0.5 mu3; 11.8 +/- 0.5 g/dl; 25.1 +/- 2%) were significantly less than both A (58.6 +/- 1.3 mu3; 16.1 +/- 0.4 g/dl; 44.8 +/- 0.3%) and B (58.7 +/- 1.4 mu3; 13.8 +/- 0.4 g/dl; 33.6 +/- 0.5%) (P less than 0.05) and MCV, Hb, and Hct of Al-loaded non-uremic rats (C) (51.7 +/- 1.7 mu3; 12.6 +/- 0.3 g/dl; 29.4 +/- 1.5%) was significantly less than A (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
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“Toxicosis due to Al accumulation in mammalian tissues was associated with various pathologic effects (Wills and Savory, 1983; Kaiser et al., 1984; Boyce et al., 1986; Drüeke et al., 1986; Hewitt et al., 1990; Bushinsky et al., 1995; Reinke et al., 2003; Abubakar et al., 2004; Bogdanović et al., 2008; Yousef and Salama, 2009; Khattab et al., 2010; Blaylock, 2012; Buraimoh and Ojo, 2013; Sumathi et”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Kaiser et al., 1984
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Research works printed but not linked: 24
- Caro, 1979, Erythropoietin levels in uremic nephric and anephric patients, J Lab Clin Med, 93, 449
- Linkesch, 1978, Heme synthesis in anemia of the uremia state, Is J Med Sci, 14, 1173
- Swamy, 1980, Iron supplements and hemosiderosis in chronic renal failure, Dialysis Transplant, 9, 1073
- Elliott, 1978, Aluminum toxicity during regular haemodialysis, Br Med J, 1, 1101, 10.1136/bmj.1.6120.1101 · DOI
- Short, 1980, Reversible microcytic hypochromic anaemia in dialysis patients due to aluminum intoxication, Proc Eur Dial Transplant Assoc, 17, 233
- Parkinson, 1981, Dialysis encephalopathy, bone disease and anaemia: The aluminum intoxication syndrome during regular haemodialysis, J Clin Pathol, 34, 1285, 10.1136/jcp.34.11.1285 · DOI
- O'Hare, 1982, Reversal of aluminum-induced hemodialysis anemia by low-aluminum dialysate, N Engl J Med, 306, 654, 10.1056/NEJM198203183061107 · DOI
- Alfrey, 1976, The dialysis encephalopathy syndrome: Possible aluminum intoxication, N Engl J Med, 294, 184, 10.1056/NEJM197601222940402 · DOI
- Elliott, 1980, Dialysis encephalopathy — Evidence implicating aluminum, Dialysis Transplant, 9, 1029
- McDermott, 1978, Brain aluminum concentration in dialysis encephalopathy, Lancet, 1, 901, 10.1016/S0140-6736(78)90681-5 · DOI
- Wills, 1983, Aluminum poisoning: Dialysis encephalopathy, osteomalacia, and anemia, Lancet, 2, 29, 10.1016/S0140-6736(83)90014-4 · DOI
- Ellis, 1979, Bone aluminum in haemodialysis patients and in rats injected with aluminum chloride: Relationship to impaired bone mineralization, J Clin Pathol, 32, 832, 10.1136/jcp.32.8.832 · DOI
- McCormack, 1979, Effect of prenatal administration of aluminum and parathyroid hormone on fetal development of the rat, Proc Soc Exp Biol Med, 161, 74, 10.3181/00379727-161-40493 · DOI
- Kaufman, 1974, Compensatory adaptation of structure and function following progressive renal ablation, Kidney Int, 6, 10, 10.1038/ki.1974.72 · DOI
- Meredith, 1979, Changes in serum aluminum blood zinc, blood lead and erythrocyte δ-aminolaevulinic acid dehydratase activity during haemodialysis, Toxicol Letters, 4, 419, 10.1016/0378-4274(79)90055-9 · DOI
- Garnica, 1981, Trace metals and hemoglobin metabolism, Ann Clin Lab Sci, 11, 220
- Wingfield, 1982, Effects of alcohol and pH-activity relationship of erythrocytic δ-aminolevuinate dehydratase (ALA-D), J Anal Toxicol, 6, 123, 10.1093/jat/6.3.123 · DOI
- Hernberg, 1970, Enzyme inhibition by lead under normal urban conditions, Lancet, 1, 63, 10.1016/S0140-6736(70)91846-5 · DOI
- Harrison, 1972, Aluminum inhibition of hexokinase, Lancet, 1, 277, 10.1016/S0140-6736(72)91707-2 · DOI
- Lai, 1980, The effects of cadmium, manganese and aluminum on sodium-potassium-activated and magnesium-activated adenosine triphosphatase activity and choline uptake in rat brain synaptosomes, Biochem Pharmacol, 29, 141, 10.1016/0006-2952(80)90321-4 · DOI
- Trapp, 1980, Studies of aluminum interaction with enzymes and proteins—the inhibition of hexokinase, Neurotoxicology, 1, 89
- Marquis, 1982, Noncompetitive inhibition by aluminum, scandium and yitirium of acetylcholinesterase from electrophorous electrious, Biochem Pharmacol, 31, 1437, 10.1016/0006-2952(82)90040-5 · DOI
- Meredith, 1974, The effects of aluminum, lead and zinc on δ-aminolaevulinic acid dehydratase, Biochem Soc Trans, 2, 1243, 10.1042/bst0021243 · DOI
- Abdulla, 1979, Antagonistic effects of zinc and aluminum on lead inhibition of δ-aminolaevulinic acid dehydratase, Arch Environ Health, 34, 464, 10.1080/00039896.1979.12088658 · DOI
Cited by
Sorted by citations
Aluminium toxicosis: a review of toxic actions and effects
Igbokwe, I. O., Igwenagu, E., & Igbokwe, N. A. (2019) · Interdisciplinary Toxicology · doi:10.2478/intox-2019-0007 · Cited by 395
“Toxicosis due to Al accumulation in mammalian tissues was associated with various pathologic effects (Wills and Savory, 1983; Kaiser et al., 1984; Boyce et al., 1986; Drüeke et al., 1986; Hewitt et al., 1990; Bushinsky et al., 1995; Reinke et al., 2003; Abubakar et al., 2004; Bogdanović et al., 2008; Yousef and Salama…”
BackgroundVittori, D., Nesse, A., Pérez, G., & Garbossa, G. (1999) · Journal of Inorganic Biochemistry · doi:10.1016/s0162-0134(99)00122-1 · Cited by 66
Disturbances of morphological parameters in blood of rats orally exposed to aluminum chloride
Chmielnicka, J., Nasiadek, M., Pínkowski, R., & Paradowski, M. (1994) · Biological Trace Element Research · doi:10.1007/bf02911516 · Cited by 15
Metadata
- Authors
- Kaiser, L., Schwartz, K. A., Burnatowska-Hledin, M. A., & Mayor, G. H.
- Affiliations
- Michigan State University (US)
- Venue
- Kidney International
- Publisher
- Elsevier BV
- Published
- 1984-09
- Volume
- 26
- Issue
- 3
- Pages
- 269-274
- ISSN
- 0085-2538 (ISSN-L)
- OpenAlex
- W2045566868
- Cited by
- 52
- References
- 0
- Citations by year
- 2021: 1 · 2019: 1 · 2017: 1 · 2013: 1 · 2012: 1
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Kidney International (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2s07rr005772-18)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Keywords
- aluminum toxicity, microcytic anemia, uremia, hemodialysis, mean cell volume, nephrectomy, rats, hemoglobin, hematocrit, hemodialysis catheter
- MeSH terms
- Aluminum, Anemia, Hypochromic, Animals, Disease Models, Animal, Erythrocyte Count, Erythrocyte Indices, Hematocrit, Hemoglobins, Ions, Male, Peritoneal Dialysis, Rats, Inbred Strains, Time Factors, Uremia, Rats
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