The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
The emerging role of phosphate in vascular calcification
Open accessAbstract
Abstract/Summary Vascular calcification is recognized as a major contributor to cardiovascular disease (CVD) in end stage renal disease (ESRD) patients. Susceptibility to vascular calcification is genetically determined and actively regulated by diverse inducers and inhibitors. One of these inducers, hyperphosphatemia, promotes vascular calcification and is a nontraditional risk factor for CVD mortality in ESRD patients. Vascular smooth muscle cells (SMCs) respond to elevated phosphate levels by undergoing an osteochondrogenic phenotype change and mineralizing their extracellular matrix through a mechanism requiring sodium-dependent phosphate cotransporters. Disease states and cytokines can increase expression of sodium-dependent phosphate cotransporters in SMCs, thereby increasing susceptibility to calcification even at phosphate concentrations that are in the normal range.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
Coronary Calcium as a Predictor of Coronary Events in Four Racial or Ethnic Groups
Detrano, R., Guerci, A. D., Carr, J. J., Bild, D. E., Burke, G., Folsom, A. R., Liu, K., Shea, S., Szklo, M., Bluemke, D. A., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa072100 · Cited by 2,989
London, G. M. (2003) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfg414 · Cited by 1,859
Sevelamer attenuates the progression of coronary and aortic calcification in hemodialysis patients
Chertow, G. M., Burke, S. K., Raggi, P., & for the Treat to Goal Working Group (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00434.x · Cited by 1,462
Rumberger, J. A., Simons, D. B., Fitzpatrick, L. A., Sheedy, P. F., & Schwartz, R. S. (1995) · Circulation · doi:10.1161/01.cir.92.8.2157 · Cited by 1,459
Phosphate Regulation of Vascular Smooth Muscle Cell Calcification
Jono, S., McKee, M. D., Murry, C. E., Shioi, A., Nishizawa, Y., Mori, K., Morii, H., & Giachelli, C. M. (2000) · Circulation Research · doi:10.1161/01.res.87.7.e10 · Cited by 1,427
Self-citationSerum Phosphate Levels and Mortality Risk among People with Chronic Kidney Disease
Kestenbaum, B., Sampson, J. N., Rudser, K. D., Patterson, D. J., Seliger, S. L., Young, B., Sherrard, D. J., & Andress, D. L. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2004070602 · Cited by 1,226
Sarnak, M. J., Levey, A. S., Schoolwerth, A. C., Coresh, J., Culleton, B., Hamm, L. L., McCullough, P. A., Kasiske, B. L., Kelepouris, E., Klag, M. J., et al. (2003) · Hypertension · doi:10.1161/01.hyp.0000102971.85504.7c · Cited by 1,144
Bone Formation and Inflammation in Cardiac Valves
Mohler, E. R., Gannon, F., Reynolds, C., Zimmerman, R., Keane, M. G., & Kaplan, F. S. (2001) · Circulation · doi:10.1161/01.cir.103.11.1522 · Cited by 1,049
Impact of Aortic Stiffness Attenuation on Survival of Patients in End-Stage Renal Failure
Guerin, A. P., Blacher, J., Pannier, B., Marchais, S. J., Safar, M. E., & London, G. M. (2001) · Circulation · doi:10.1161/01.cir.103.7.987 · Cited by 1,040
Cited by
The dynamic nature of Bruch's membrane
Booij, J. C., Baas, D. C., Beisekeeva, J., Gorgels, T. G. M. F., & Bergen, A. A. B. (2010) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.08.003 · Cited by 581
Oral Phosphate Binders in Patients with Kidney Failure
Tonelli, M., Pannu, N., & Manns, B. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0912522 · Cited by 339
Vascular calcification in CKD-MBD: Roles for phosphate, FGF23, and Klotho
Yamada, S., & Giachelli, C. M. (2017) · Bone · doi:10.1016/j.bone.2016.11.012 · Cited by 316
Self-citationChronic Kidney Disease—Mineral and Bone Disorders: Pathogenesis and Management
Cannata-Andía, J. B., Martín-Carro, B., Martín-Vírgala, J., Rodríguez-Carrio, J., Bande-Fernández, J. J., Alonso-Montes, C., & Carrillo-López, N. (2021) · Calcified Tissue International · doi:10.1007/s00223-020-00777-1 · Cited by 156
Large animal models of cardiovascular disease
Tsang, H. G., Rashdan, N. A., Whitelaw, C. B. A., Corcoran, B. M., Summers, K. M., & MacRae, V. E. (2016) · Cell Biochemistry and Function · doi:10.1002/cbf.3173 · Cited by 154
Metadata
- Authors
- Giachelli, C. M.
- Venue
- Kidney International
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 75
- Issue
- 9
- Pages
- 890-897
- ISSN
- 0085-2538 (ISSN-L)
- OpenAlex
- W1973895552
- Cited by
- 493
- References
- 80
- FWCI
- 20.00
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The emerging role of phosphate in vascular calcification. https://app.cochat.ai/papers/10.1038/ki.2008.644
- The paper
- Giachelli, C. M. (2009). The emerging role of phosphate in vascular calcification. Kidney International. https://doi.org/10.1038/ki.2008.644
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
