Coronary Calcium as a Predictor of Coronary Events in Four Racial or Ethnic Groups
Abstract
Background In white populations, computed tomographic measurements of coronary-artery calcium predict coronary heart disease independently of traditional coronary risk factors. However, it is not known whether coronary-artery calcium predicts coronary heart disease in other racial or ethnic groups. Methods We collected data on risk factors and performed scanning for coronary calcium in a population-based sample of 6722 men and women, of whom 38.6% were white, 27.6% were black, 21.9% were Hispanic, and 11.9% were Chinese. The study subjects had no clinical cardiovascular disease at entry and were followed for a median of 3.8 years. Results There were 162 coronary events, of which 89 were major events (myocardial infarction or death from coronary heart disease). In comparison with participants with no coronary calcium, the adjusted risk of a coronary event was increased by a factor of 7.73 among participants with coronary calcium scores between 101 and 300 and by a factor of 9.67 among participants with scores above 300 (P Conclusions The coronary calcium score is a strong predictor of incident coronary heart disease and provides predictive information beyond that provided by standard risk factors in four major racial and ethnic groups in the United States. No major differences among racial and ethnic groups in the predictive value of calcium scores were detected.
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The manual calcium score has proven to be an important predictor of cardiovascular events across race and ethnicities.
“Although the manual calcium score has proven to be an important predictor of cardiovascular events across race and ethnicities, generalizability to other demographics will need to be investigated in future studies47.”
From Deep convolutional neural networks to predict cardiovascular risk from computed tomography (2021) · cites this paper as [47]
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Self-citation
- Authors
- Detrano, R., Guerci, A. D., Carr, J. J., Bild, D. E., Burke, G., Folsom, A. R., Liu, K., Shea, S., Szklo, M., Bluemke, D. A., O'Leary, D. H., Tracy, R., Watson, K., Wong, N. D., & Kronmal, R. A.
- Affiliations
- University of California, Irvine (US)
- St. Francis Hospital (US)
- Atrium Health Wake Forest Baptist (US)
- National Heart, Lung, and Blood Institute (US)
- University of Minnesota (US)
- Northwestern University (US)
- Columbia University (US)
- Johns Hopkins University (US)
- University of Vermont (US)
- University of California, Los Angeles (US)
- University of Washington (US)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2008-03-27
- Volume
- 358
- Issue
- 13
- Pages
- 1336-1345
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1969678022
- Cited by
- 2,989
- References
- 0
- Citations by year
- 2026: 142 · 2025: 132 · 2024: 146 · 2023: 149 · 2022: 168 · 2021: 188 · 2020: 193 · 2019: 169 · 2018: 159 · 2017: 166 · 2016: 192 · 2015: 189 · 2014: 159 · 2013: 142 · 2012: 139
- FWCI
- 139.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01hc95164-17-0-1, n01hc95165-34-0-1, n01hc95161-24-0-1, n01hc095169-003, n01hc95166-21-0-1, n01hc95162-31-0-1, n01hc95160-18-0-1, n01hc95163-22-0-1, n01hc95159-40-0-1)
- National Heart, Lung, and Blood Institute (N01 HC-95159, N01-HC-95160, (N01-HC-95163, N01 HC-95161, N01 HC95165, N01HC95164, N01‐HC‐95166, N01 HC-95162, N01 HC95169)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health Promotion and Cardiovascular Prevention
- Health Sciences › Medicine › Epidemiology › Healthcare Systems and Public Health
- Keywords
- coronary artery calcium, coronary artery disease, coronary artery calcium score, myocardial infarction, racial and ethnic differences, cardiovascular risk prediction, coronary risk factors, coronary events, Chinese Americans, Hispanic Americans, African Americans, White Americans
- MeSH terms
- Aged, Calcinosis, Calcium, Coronary Artery Disease, Coronary Disease, Coronary Vessels, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prognosis, Risk Factors, Severity of Illness Index, Tomography, X-Ray Computed, Coronary Angiography, Risk Assessment, Racial Groups, Kaplan-Meier Estimate
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