The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Using anesthetics and analgesics in experimental traumatic brain injury
Abstract
Valid modeling of traumatic brain injury (TBI) requires accurate replication of both the mechanical forces that cause the primary injury and the conditions that lead to secondary injuries observed in human patients. The use of animals in TBI research is justified by the lack of in vitro or computer models that can sufficiently replicate the complex pathological processes involved. Measures to reduce nociception and distress must be implemented, but the administration of anesthetics and analgesics can influence TBI outcomes, threatening the validity of the research. In this review, the authors present evidence for the interference of anesthetics and analgesics in the natural course of brain injury in animal models of TBI. They suggest that drugs should be selected for or excluded from experimental TBI protocols on the basis of IACUC-approved experimental objectives in order to protect animal welfare and preserve the validity of TBI models.
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“pre- or post-injury administration of analgesics can influence the nature of brain injury, as well as mitochondrial function and microRNA activity [38–40].”
From The Mitochondria-Associated ER Membranes Are Novel Subcellular Locations Enriched for Inflammatory-Responsive MicroRNAs (2020) · cites this paper as [38]
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Citations
Cites
Pathophysiology of traumatic brain injury
Werner, C., & Engelhard, K. (2007) · British Journal of Anaesthesia · doi:10.1093/bja/aem131 · Cited by 1,712
Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition
Simmons, D. L., Botting, R. M., & Hla, T. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.3.3 · Cited by 1,693
General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal
Franks, N. P. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2372 · Cited by 1,295
A new model of diffuse brain injury in rats: Part I: Pathophysiology and biomechanics
Marmarou, A., Foda, M. A. A.-E., Brink, W. V. D., Campbell, J., Kita, H., & Demetriadou, K. (1994) · Journal of Neurosurgery · doi:10.3171/jns.1994.80.2.0291 · Cited by 1,229
A controlled cortical impact model of traumatic brain injury in the rat
Edward Dixon, C., Clifton, G. L., Lighthall, J. W., Yaghmai, A. A., & Hayes, R. L. (1991) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(91)90104-8 · Cited by 1,141
Traumatic brain injury in the rat: Characterization of a lateral fluid-percussion model
McIntosh, T. K., Vink, R., Noble, L., Yamakami, I., Fernyak, S., Soares, H., & Faden, A. L. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90247-9 · Cited by 1,127
Mechanisms of Actions of Inhaled Anesthetics
Campagna, J. A., Miller, K. W., & Forman, S. A. (2003) · New England Journal of Medicine · doi:10.1056/nejmra021261 · Cited by 813
Responses to cortical injury: I. Methodology and local effects of contusions in the rat
Feeney, D. M., Boyeson, M. G., Linn, R. T., Murray, H. M., & Dail, W. G. (1981) · Brain Research · doi:10.1016/0006-8993(81)90067-6 · Cited by 731
Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin
Jevtović-Todorović, V., Todorovć, S. M., Mennerick, S., Powell, S., Dikranian, K., Benshoff, N., Zorumski, C. F., & Olney, J. W. (1998) · Nature Medicine · doi:10.1038/nm0498-460 · Cited by 676
Prevalence of Chronic Pain After Traumatic Brain Injury: A Systematic Review
Nampiaparampil, D. E. (2008) · JAMA · doi:10.1001/jama.300.6.711 · Cited by 673
Cited by
Wang, W.-X., Prajapati, P., Nelson, P. T., & Springer, J. E. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01937-y · Cited by 49
Metadata
- Authors
- Rowe, R. K., Harrison, J. L., Thomas, T. C., Pauly, J. R., Adelson, P. D., & Lifshitz, J.
- Venue
- Lab Animal
- Published
- 2013-07-22
- Volume
- 42
- Issue
- 8
- Pages
- 286-291
- ISSN
- 0093-7355
- 1548-4475
- PMC
- PMC3876742
- Cited by
- 58
- References
- 73
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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- CoChat. (2026). Citation check: Using anesthetics and analgesics in experimental traumatic brain injury. https://app.cochat.ai/papers/10.1038/laban.257
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- Rowe, R. K., Harrison, J. L., Thomas, T. C., Pauly, J. R., Adelson, P. D., & Lifshitz, J. (2013). Using anesthetics and analgesics in experimental traumatic brain injury. Lab Animal. https://doi.org/10.1038/laban.257
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
